Guadalajara, Mexico Hotels

My wife, myself and my 11 yr old son and 18 yr daughter are planning a
week in Guadalajara this summer. I have seen several good hotels in
downtown and also seen some nice places in Tlaquepaque. I am looking
for some recommendations- is it better to stay in the downtown area
being its closer to all the main attractions or is it better to stay
in Tlaquepaque and take a cab to town? If we stay in Guadalajara are
there any recommendations for a hotel that would be nice for our
family to stay at. We may want to go out and leave my son with our
daughter one or 2 nights and go to a nice place for entertainment so
maybe staying in downtown would be better. Any suggestions will be
appreciated