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Bloodletting Versus Drugs
Journal of Veterinary Internal Medicine
Volume 15 Issue 4 Page 418-421, July 2001
Hydroxyurea for Treatment of Polycythemia Secondary to Right-to-Left
Shunting Patent Ductus Arteriosus in 4 Dogs
Kenneth W. Moore, Rebecca L. Stepien (2001)
Abstract
Hydroxyurea for Treatment of Polycythemia Secondary to Right-to-Left
Shunting Patent Ductus Arteriosus in 4 Dogs
Kenneth W. Moore11Department of Surgical Sciences, School of
Veterinary Medicine, University of Wisconsin, Madison, WI.,3,44Coral
Springs Animal Hospital, 1730 University Drive, Coral Springs, FL
33071; e-mail: kenmoore112@hotmail . com . and Rebecca L.
Stepien22Department of Medical Sciences, School of Veterinary
Medicine, University of Wisconsin, Madison, WI.1Department of Surgical
Sciences, School of Veterinary Medicine, University of Wisconsin,
Madison, WI. 2Department of Medical Sciences, School of Veterinary
Medicine, University of Wisconsin, Madison, WI.
4Coral Springs Animal Hospital, 1730 University Drive, Coral Springs,
FL 33071; e-mail: kenmoore112@hotmail . com .
3Coral Springs Animal Hospital, Coral Springs, FL.
Abstract
Four adult dogs with polycythemia secondary to reversed patent ductus
arteriosus (rPDA) were treated with hydroxyurea, a myelosuppressive
agent, for 6=9622 months. Regardless of initial hematocrit, clinical
signs attributed to the presence of polycythemia improved with
hydroxyurea treatment. Chronic hydroxyurea therapy (40=9650 mg/kg PO
q48h) was well tolerated in this group of animals; mild, clinically
silent thrombocytopenia and leukopenia were detected in some animals
but resolved with decreased dosage or dose frequency. Chronic
hydroxyurea therapy may provide an alternative to repeated phlebotomy
for therapy of polycythemia secondary to rPDA.
Journal of Veterinary Internal Medicine 15 (4) , 418=96421 doi:10.1111/j.
1939-1676.2001.tb01567.x
------------------------------------------------
Long-Term Clinical Management of Right-to-Left ("Reversed") Patent
Ductus Arteriosus in 3 Dogs
Etienne C=F4t=E911California Animal Hospital, Los Angeles, CA,22Section of
Cardiology, Angell Memorial Animal Hospital, 350 S Huntington Avenue,
Boston, MA 02130. and Stephen J. Ettinger11California Animal Hospital,
Los Angeles, CA1California Animal Hospital, Los Angeles, CA
2Section of Cardiology, Angell Memorial Animal Hospital, 350 S
Huntington Avenue, Boston, MA 02130.
Abstract
A small number of dogs with patent ductus arteriosus (PDA) have right-
to-left flow of blood through the ductus, leading to polycythemia and
clinical signs associated with hyperviscosity. Three dogs with right-
to-left-shunting PDA are described. Treatment consisted solely of
phlebotomy, performed on an outpatient basis when indicated by
exacerbation of clinical signs, for a total of 11=9668 times on each
dog. Each treatment entailed the removal of a mean of 19% (maximum
28%) of circulating blood volume, divided into 2 phlebotomies several
hours apart, without intravenous fluid replacement. Subjectively,
marked clinical improvement was noted. Intermittent clinical signs
decreased in frequency and severity in all dogs. Adverse effects were
rare (1 for 98 phlebotomies) and reversible. Dogs lived >2 to >8 years
during treatment. Outpatient phlebotomy without fluid replacement was
safe, and was associated with subjective improvement and prolonged
survival in these dogs.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Volume 15 Issue 4 Page 418-421, July 2001
Hydroxyurea for Treatment of Polycythemia Secondary to Right-to-Left
Shunting Patent Ductus Arteriosus in 4 Dogs
Kenneth W. Moore, Rebecca L. Stepien (2001)
Abstract
Hydroxyurea for Treatment of Polycythemia Secondary to Right-to-Left
Shunting Patent Ductus Arteriosus in 4 Dogs
Kenneth W. Moore11Department of Surgical Sciences, School of
Veterinary Medicine, University of Wisconsin, Madison, WI.,3,44Coral
Springs Animal Hospital, 1730 University Drive, Coral Springs, FL
33071; e-mail: kenmoore112@hotmail . com . and Rebecca L.
Stepien22Department of Medical Sciences, School of Veterinary
Medicine, University of Wisconsin, Madison, WI.1Department of Surgical
Sciences, School of Veterinary Medicine, University of Wisconsin,
Madison, WI. 2Department of Medical Sciences, School of Veterinary
Medicine, University of Wisconsin, Madison, WI.
4Coral Springs Animal Hospital, 1730 University Drive, Coral Springs,
FL 33071; e-mail: kenmoore112@hotmail . com .
3Coral Springs Animal Hospital, Coral Springs, FL.
Abstract
Four adult dogs with polycythemia secondary to reversed patent ductus
arteriosus (rPDA) were treated with hydroxyurea, a myelosuppressive
agent, for 6=9622 months. Regardless of initial hematocrit, clinical
signs attributed to the presence of polycythemia improved with
hydroxyurea treatment. Chronic hydroxyurea therapy (40=9650 mg/kg PO
q48h) was well tolerated in this group of animals; mild, clinically
silent thrombocytopenia and leukopenia were detected in some animals
but resolved with decreased dosage or dose frequency. Chronic
hydroxyurea therapy may provide an alternative to repeated phlebotomy
for therapy of polycythemia secondary to rPDA.
Journal of Veterinary Internal Medicine 15 (4) , 418=96421 doi:10.1111/j.
1939-1676.2001.tb01567.x
------------------------------------------------
Long-Term Clinical Management of Right-to-Left ("Reversed") Patent
Ductus Arteriosus in 3 Dogs
Etienne C=F4t=E911California Animal Hospital, Los Angeles, CA,22Section of
Cardiology, Angell Memorial Animal Hospital, 350 S Huntington Avenue,
Boston, MA 02130. and Stephen J. Ettinger11California Animal Hospital,
Los Angeles, CA1California Animal Hospital, Los Angeles, CA
2Section of Cardiology, Angell Memorial Animal Hospital, 350 S
Huntington Avenue, Boston, MA 02130.
Abstract
A small number of dogs with patent ductus arteriosus (PDA) have right-
to-left flow of blood through the ductus, leading to polycythemia and
clinical signs associated with hyperviscosity. Three dogs with right-
to-left-shunting PDA are described. Treatment consisted solely of
phlebotomy, performed on an outpatient basis when indicated by
exacerbation of clinical signs, for a total of 11=9668 times on each
dog. Each treatment entailed the removal of a mean of 19% (maximum
28%) of circulating blood volume, divided into 2 phlebotomies several
hours apart, without intravenous fluid replacement. Subjectively,
marked clinical improvement was noted. Intermittent clinical signs
decreased in frequency and severity in all dogs. Adverse effects were
rare (1 for 98 phlebotomies) and reversible. Dogs lived >2 to >8 years
during treatment. Outpatient phlebotomy without fluid replacement was
safe, and was associated with subjective improvement and prolonged
survival in these dogs.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
On Apr 28, 7:17 pm, J666 <jeaa...@gmail . com > wrote:
* medicalantiques . com /medical/Scarifications_and_Bleeder_Medical...
.htm <<
You know when the url wraps like that it means the url doesn't
work .. ?
Did you know that .. ?
Now you do ..
Heh .. heh ..
You don't know a whole .. lot .. do ya ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
* medicalantiques . com /medical/Scarifications_and_Bleeder_Medical...
.htm <<
You know when the url wraps like that it means the url doesn't
work .. ?
Did you know that .. ?
Now you do ..
Heh .. heh ..
You don't know a whole .. lot .. do ya ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
On Tue, 29 Apr 2008 2:08:55 -0500, ironjustice wrote
(in message
<f21cc45c-91c8-4403-9e93-beafb127372d@k10g2000prm.googlegroups . com >):
> On Apr 28, 7:17 pm, J666 <jeaa...@gmail . com > wrote:
> * medicalantiques . com /medical/Scarifications_and_Bleeder_Medical...
> .htm <<
>
> You know when the url wraps like that it means the url doesn't
> work .. ?
>
Lame attempt at trying to be cute - stick to FEces - you are making yourself
even dumber than iron doornails.
(in message
<f21cc45c-91c8-4403-9e93-beafb127372d@k10g2000prm.googlegroups . com >):
> On Apr 28, 7:17 pm, J666 <jeaa...@gmail . com > wrote:
> * medicalantiques . com /medical/Scarifications_and_Bleeder_Medical...
> .htm <<
>
> You know when the url wraps like that it means the url doesn't
> work .. ?
>
Lame attempt at trying to be cute - stick to FEces - you are making yourself
even dumber than iron doornails.
On Apr 29, 6:14 am, J666 <jeaa...@gmail . com > wrote:Lame attempt at
trying to be cute - stick to FEces - you are making yourself
even dumber than iron doornails. <<
Cute .. ?
I was .. seriously .. commenting .. on one of your many .. flaws ..
You know .. 'commenting' ..
Sorta like your .. comments only .. better ..
More .. truthful ..
This flaw was .. stupidity ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
trying to be cute - stick to FEces - you are making yourself
even dumber than iron doornails. <<
Cute .. ?
I was .. seriously .. commenting .. on one of your many .. flaws ..
You know .. 'commenting' ..
Sorta like your .. comments only .. better ..
More .. truthful ..
This flaw was .. stupidity ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
On Apr 29, 2:08 am, ironjustice <teamtan...@hotmail . com > wrote:
> On Apr 28, 7:17 pm, J666 <jeaa...@gmail . com > wrote:
> * medicalantiques . com /medical/Scarifications_and_Bleeder_Medical..=
.
> .htm <<
>
> You know when the url wraps like that it means the url doesn't
> work .. ?
>
> Did you know that .. ?
>
> Now you do ..
>
> Heh .. heh ..
>
> You don't know a whole .. lot .. do ya ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
Maybe on your lame news reader it does. I suppose you are capable of
curing the bent URL.
> On Apr 28, 7:17 pm, J666 <jeaa...@gmail . com > wrote:
> * medicalantiques . com /medical/Scarifications_and_Bleeder_Medical..=
.
> .htm <<
>
> You know when the url wraps like that it means the url doesn't
> work .. ?
>
> Did you know that .. ?
>
> Now you do ..
>
> Heh .. heh ..
>
> You don't know a whole .. lot .. do ya ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * tinyurl . com /2r2nkh
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
Maybe on your lame news reader it does. I suppose you are capable of
curing the bent URL.
On Tue, 29 Apr 2008 15:13:12 -0500, Mike Mordant wrote
(in message
<ea568950-3c9b-4b81-9462-3bb1c10ca2c5@f36g2000hsa.googlegroups . com >):
> Maybe on your lame news reader it does. I suppose you are capable of
> curing the bent URL.
Maybe it is not the news reader that is lame but FEeble. Maybe there is some
rust blocking the neural transmissions..
(in message
<ea568950-3c9b-4b81-9462-3bb1c10ca2c5@f36g2000hsa.googlegroups . com >):
> Maybe on your lame news reader it does. I suppose you are capable of
> curing the bent URL.
Maybe it is not the news reader that is lame but FEeble. Maybe there is some
rust blocking the neural transmissions..
