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Oxidant Stress Therapy For COPD
Inhibiting Stress Oxidant May Be New Therapy For COPD
Main Category: Respiratory / Asthma
Article Date: 18 Apr 2008 - 3:00 PDT
A study in Clinical and Experimental Pharmacology and Physiology
published by Wiley-Blackwell has showed that the generation of
oxidative stress increases pulmonary inflammation - thus encouraging
the development of airway obstruction associated with chronic
obstructive pulmonary disease (COPD).
The study "Oxidative Stress is an Important Component of Airway
Inflammation in Mice Exposed to Cigarette Smoke or Lipopolysaccharide"
investigates the inflammatory responses in oxidative stress-deficient
mice exposed to cigarette smoke. The authors employ a cigarette smoke
model to understand the role of oxidative stress in the pathogenesis
of COPD, and suggested that further investigations of the efficacy of
new compounds that may help treat respiratory disorders.
Cigarette smoking is the main cause of respiratory disorders such as
chronic bronchitis, emphysema and COPD. Smokers and patients with COPD
generally display an increased oxidative stress level as compared to
healthy patients.
Lead author Vincent Lagente, Professor of Pharmacology at the
University of Rennes 1 in France says, "Overwhelming evidence shows
that- compared to non-smokers and healthy patients - smokers and
patients with COPD display an increased level of oxidative stress, and
suffer from an imbalance in oxidants in airway inflammation. As
classic anti-inflammatory compounds are ineffective in treating
respiratory disorders, and the effects of cigarette smoke on COPD are
still not completely understood, we have developed a cigarette
exposure protocol that results in airway inflammation to better
understand the physiopathology of the inflammatory process."
In examining the response of mice exposed to cigarette smoke,
researchers found that those with reduced oxidative stress showed
lesser inflammatory symptoms - hence suggesting the association of
oxidative stress with COPD and supporting the development of anti-
oxidant therapy for smoking related-diseases.
About Clinical and Experimental Pharmacology and Physiology Clinical
and Experimental Pharmacology and Physiology provides a medium for the
rapid publication of original research papers, short communications,
rapid communications and theoretical articles (hypotheses) on the
results of clinical and experimental work in pharmacology and
physiology. Invited review articles are published occasionally.
About Wiley-Blackwell
Wiley-Blackwell was formed in February 2007 as a result of the
acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc.,
and its merger with Wiley's Scientific, Technical, and Medical
business. Together, the companies have created a global publishing
business with deep strength in every major academic and professional
field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-
reviewed journals and an extensive collection of books with global
appeal. For more information on Wiley-Blackwell, please visit
* w w w .blackwellpublishing . com or * interscience.wiley . com .
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of
information and understanding for 200 years, helping people around the
world meet their needs and fulfill their aspirations. Since 1901,
Wiley and its acquired companies have published the works of more than
350 Nobel laureates in all categories: Literature, Economics,
Physiology/Medicine, Chemistry and Peace.
Our core businesses include scientific, technical, medical and
scholarly journals, encyclopedias, books, and online products and
services; professional/trade publishes books, subscription products,
training materials, and online applications and websites; and
educational materials for undergraduate and graduate students and
lifelong learners. Wiley's global headquarters are located in Hoboken,
New Jersey, with operations in the U.S., Europe, Asia, Canada, and
Australia. The Company's Web site can be accessed at * w w w .wiley . com .
The Company is listed on the New York Stock Exchange under the symbols
JWa and JWb.
John Wiley & Sons, Inc.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Main Category: Respiratory / Asthma
Article Date: 18 Apr 2008 - 3:00 PDT
A study in Clinical and Experimental Pharmacology and Physiology
published by Wiley-Blackwell has showed that the generation of
oxidative stress increases pulmonary inflammation - thus encouraging
the development of airway obstruction associated with chronic
obstructive pulmonary disease (COPD).
The study "Oxidative Stress is an Important Component of Airway
Inflammation in Mice Exposed to Cigarette Smoke or Lipopolysaccharide"
investigates the inflammatory responses in oxidative stress-deficient
mice exposed to cigarette smoke. The authors employ a cigarette smoke
model to understand the role of oxidative stress in the pathogenesis
of COPD, and suggested that further investigations of the efficacy of
new compounds that may help treat respiratory disorders.
Cigarette smoking is the main cause of respiratory disorders such as
chronic bronchitis, emphysema and COPD. Smokers and patients with COPD
generally display an increased oxidative stress level as compared to
healthy patients.
Lead author Vincent Lagente, Professor of Pharmacology at the
University of Rennes 1 in France says, "Overwhelming evidence shows
that- compared to non-smokers and healthy patients - smokers and
patients with COPD display an increased level of oxidative stress, and
suffer from an imbalance in oxidants in airway inflammation. As
classic anti-inflammatory compounds are ineffective in treating
respiratory disorders, and the effects of cigarette smoke on COPD are
still not completely understood, we have developed a cigarette
exposure protocol that results in airway inflammation to better
understand the physiopathology of the inflammatory process."
In examining the response of mice exposed to cigarette smoke,
researchers found that those with reduced oxidative stress showed
lesser inflammatory symptoms - hence suggesting the association of
oxidative stress with COPD and supporting the development of anti-
oxidant therapy for smoking related-diseases.
About Clinical and Experimental Pharmacology and Physiology Clinical
and Experimental Pharmacology and Physiology provides a medium for the
rapid publication of original research papers, short communications,
rapid communications and theoretical articles (hypotheses) on the
results of clinical and experimental work in pharmacology and
physiology. Invited review articles are published occasionally.
About Wiley-Blackwell
Wiley-Blackwell was formed in February 2007 as a result of the
acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc.,
and its merger with Wiley's Scientific, Technical, and Medical
business. Together, the companies have created a global publishing
business with deep strength in every major academic and professional
field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-
reviewed journals and an extensive collection of books with global
appeal. For more information on Wiley-Blackwell, please visit
* w w w .blackwellpublishing . com or * interscience.wiley . com .
About Wiley
Founded in 1807, John Wiley & Sons, Inc. has been a valued source of
information and understanding for 200 years, helping people around the
world meet their needs and fulfill their aspirations. Since 1901,
Wiley and its acquired companies have published the works of more than
350 Nobel laureates in all categories: Literature, Economics,
Physiology/Medicine, Chemistry and Peace.
Our core businesses include scientific, technical, medical and
scholarly journals, encyclopedias, books, and online products and
services; professional/trade publishes books, subscription products,
training materials, and online applications and websites; and
educational materials for undergraduate and graduate students and
lifelong learners. Wiley's global headquarters are located in Hoboken,
New Jersey, with operations in the U.S., Europe, Asia, Canada, and
Australia. The Company's Web site can be accessed at * w w w .wiley . com .
The Company is listed on the New York Stock Exchange under the symbols
JWa and JWb.
John Wiley & Sons, Inc.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
