Oxidative Stress and Diabetes

Oxidative Stress and Diabetes

Evaluation of the effect of oxidative stress and vitamin E
supplementation on renal function in rats with streptozotocin-induced
Type 1 diabetes.
Haidara MA, Mikhailidis DP, Rateb MA, Ahmed ZA, Yassin HZ, Ibrahim IM,
Rashed LA
J Diabetes Complications 2008 Apr 22.

We investigated the possible role of reactive oxygen species (ROS) on
renal function in experimental diabetes.
MATERIALS AND METHODS: Seven groups of male rats were studied. Group I
consisted of control animals. Diabetes was induced (by streptozotocin)
in the animals in the other groups and they received either insulin or
vitamin E (300 or 600 mg/kg), both insulin and vitamin E, or no
treatment for 4 weeks. At the end of the study, blood pressure was
measured and parameters of kidney function and oxidative stress were
evaluated in serum and kidney tissue samples.
RESULTS: Diabetic animals had higher blood pressures; increased serum
glucose, urea, creatinine, cyclic guanosine monophosphate (cGMP);
increased kidney tissue levels of malondialdehyde and inducible nitric
oxide synthetase (iNOS); and reduced serum glutathione peroxidase when
compared with control animals. Blood glucose levels in diabetic
animals were controlled by insulin and not by any dose of vitamin E
alone. However, all other measured parameters improved towards control
levels with either insulin or vitamin E in either dose. An additive
beneficial effect was observed on the levels of iNOS and cGMP when
both forms of treatment were used in diabetic animals.
CONCLUSIONS: We conclude that ROS may play an important role in
diabetes-induced nephropathy in this rat model. Vitamin E
supplementation in addition to insulin can have additive protective
effects against deterioration of renal function in this model.
Journal of diabetes and its complications [J Diabetes Complications]


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