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Obesity Causes Iron Deficiency
Obesity Causes Iron Deficiency
What they conclude here is overeating causes iron deficiency.
One might think a person who eat that much wouldn't BE iron
deficient .. ?
Using logic.
Hepcidin goes up as iron stores go up.
One might therefore conclude obese people may be iron overloaded as
opposed to iron deficient.
Also evidenced by 42% iron deficient Indian and Moroccan children,
when others find no iron deficiency at all;
The iron deficiency actually being anemia of chronic disease.
"Higher hepcidin levels in obesity"
Adiposity in women and children from transition countries predicts
decreased iron absorption, iron deficiency and a reduced response to
iron fortification.
Int J Obes (Lond) 2008 Apr 22.
Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli
I, Hurrell RF
Background:Overweight is increasing in transition countries, while
iron deficiency remains common. In industrialized countries, greater
adiposity increases risk of iron deficiency. Higher hepcidin levels in
obesity may reduce dietary iron absorption. Therefore, we investigated
the association between body mass index (BMI) and iron absorption,
iron status and the response to iron fortification in populations from
three transition countries (Thailand, Morocco and India).
Methods:In Thai women (n=92), we examined the relationship between BMI
and iron absorption from a reference meal containing approximately 4
mg of isotopically labeled fortification iron. We analyzed data from
baseline (n=1688) and intervention (n=727) studies in children in
Morocco and India to look for associations between BMI Z-scores and
baseline hemoglobin, serum ferritin and transferrin receptor, whole
blood zinc protoporphyrin and body iron stores, and changes in these
measures after provision of iron.
Results:In the Thai women, 20% were iron deficient and 22% were
overweight. Independent of iron status, a higher BMI Z-score was
associated with decreased iron absorption (P=0.030). In the Indian and
Moroccan children, 42% were iron deficient and 6.3% were overweight. A
higher BMI Z-score predicted poorer iron status at baseline (P<0.001)
and less improvement in iron status during the interventions
(P<0.001).
Conclusions:Adiposity in young women predicts lower iron absorption,
and pediatric adiposity predicts iron deficiency and a reduced
response to iron fortification. These data suggest the current surge
in overweight in transition countries may impair efforts to control
iron deficiency in these target groups. Interactions of the 'double
burden' of malnutrition during the nutrition transition may have
adverse consequences.International Journal of Obesity advance online
publication, 22 April 2008; doi:10.1038/ijo.2008.43.
International journal of obesity (2005) [Int J Obes (Lond)]
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
What they conclude here is overeating causes iron deficiency.
One might think a person who eat that much wouldn't BE iron
deficient .. ?
Using logic.
Hepcidin goes up as iron stores go up.
One might therefore conclude obese people may be iron overloaded as
opposed to iron deficient.
Also evidenced by 42% iron deficient Indian and Moroccan children,
when others find no iron deficiency at all;
The iron deficiency actually being anemia of chronic disease.
"Higher hepcidin levels in obesity"
Adiposity in women and children from transition countries predicts
decreased iron absorption, iron deficiency and a reduced response to
iron fortification.
Int J Obes (Lond) 2008 Apr 22.
Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli
I, Hurrell RF
Background:Overweight is increasing in transition countries, while
iron deficiency remains common. In industrialized countries, greater
adiposity increases risk of iron deficiency. Higher hepcidin levels in
obesity may reduce dietary iron absorption. Therefore, we investigated
the association between body mass index (BMI) and iron absorption,
iron status and the response to iron fortification in populations from
three transition countries (Thailand, Morocco and India).
Methods:In Thai women (n=92), we examined the relationship between BMI
and iron absorption from a reference meal containing approximately 4
mg of isotopically labeled fortification iron. We analyzed data from
baseline (n=1688) and intervention (n=727) studies in children in
Morocco and India to look for associations between BMI Z-scores and
baseline hemoglobin, serum ferritin and transferrin receptor, whole
blood zinc protoporphyrin and body iron stores, and changes in these
measures after provision of iron.
Results:In the Thai women, 20% were iron deficient and 22% were
overweight. Independent of iron status, a higher BMI Z-score was
associated with decreased iron absorption (P=0.030). In the Indian and
Moroccan children, 42% were iron deficient and 6.3% were overweight. A
higher BMI Z-score predicted poorer iron status at baseline (P<0.001)
and less improvement in iron status during the interventions
(P<0.001).
Conclusions:Adiposity in young women predicts lower iron absorption,
and pediatric adiposity predicts iron deficiency and a reduced
response to iron fortification. These data suggest the current surge
in overweight in transition countries may impair efforts to control
iron deficiency in these target groups. Interactions of the 'double
burden' of malnutrition during the nutrition transition may have
adverse consequences.International Journal of Obesity advance online
publication, 22 April 2008; doi:10.1038/ijo.2008.43.
International journal of obesity (2005) [Int J Obes (Lond)]
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
