Oxidative Stress In Vitiligo

Oxidative stress in the blood of patients with active localized
vitiligo.
Arican O, Kurutas EB
Acta Dermatovenerol Alp Panonica Adriat 2008 Mar; 17(1):12-6.

OBJECTIVES: Vitiligo is an acquired skin disease characterized by
white areas on the skin. The pathogenesis of the disease is still
unclear. Some findings show that oxidative stress could be an
important phenomenon in the pathophysiology of vitiligo.
METHODS: We evaluated 16 consecutive localized vitiligo patients and
16 healthy controls of a similar age and sex distribution. We measured
their indicators of oxidative stress such as catalase (CAT),
superoxide dismutase (SOD), glucose 6-phosphate dehydrogenase (G6PD)
in erythrocytes, and plasma malondialdehyde (MDA) by
spectrophotometry.
RESULTS: SOD activities and MDA levels of patients were significantly
higher than controls (p < 0.001). CAT and G6PD activities of patients
were significantly lower than controls (p < 0.05 and p < 0.001,
respectively).
CONCLUSION: Our results confirmed that oxidative stress may play an
important role in the pathogenesis of vitiligo. Melanocyte damage in
vitiligo might be linked to generalized oxidative stress. This study
is the first report on some antioxidant parameters of localized-type
vitiligo patients.

Acta dermatovenerologica Alpina, Panonica, et Adriatica [Acta
Dermatovenerol Alp Panonica Adriat]
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