Iron In Alzheimer's

Iron In Alzheimer's

A potential pathogenetic role of iron in Alzheimer's Disease.
Silvestri L, Camaschella C

J Cell Mol Med 2008 May 1.

The role of iron in the pathogenesis of Alzheimer's disease (AD) is
still unclear, despite the evidence that it accumulates in the same
brain regions characterized by the amyloid beta peptide (Abeta)
accumulation. Here we propose that iron directly influences the Abeta
production through the modulation of furin, a proconvertase involved
in the regulation of the alpha-secretase-dependent processing of the
amyloid protein precursor (APP).
Journal of cellular and molecular medicine [J Cell Mol Med]

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