Colchicine and Vitamin ESoooo .. if one were to mix this plant with a lecithin topical ..
would this colichicine STILL .. kill ya .. ?
Gulbahar O, Adisen H, Koca C, Aricioglu A, Gulekon A
Changes in serum carbonyl and malondialdehyde levels following
colchicine and vitamin E treatment in Behcet's disease. [Journal
Article]
Methods Find Exp Clin Pharmacol 2007 Oct; 29(8):521-4.
Behcet's disease (BD) is an inflammatory disorder of an unknown cause,
but growing evidence indicates that the oxidative stress is increased
in BD, owing to the overproduction of reactive oxygen species (ROS)
and decreased efficiency of antioxidant defenses. ROS affect proteins
and lipids and cause their oxidation, therefore, contributing to the
formation of oxidation products: carbonyl, a marker of protein
oxidation, and malondialdehyde (MDA), a marker of lipid peroxidation.
The investigation was undertaken to evaluate protein oxidation
(carbonyl group) levels and lipid peroxidation (MDA) levels, and the
role of colchicine and vitamin E therapy on protein carbonyl group and
MDA levels in serum samples of patients with BD. In this study,
subjects were classified as control group, colchicine therapy group
alone and colchicine and vitamin E therapy group. Protein carbonyl and
MDA levels at the beginning of the study were significantly (p < 0.05)
higher in both therapy groups compared with those of the control
group. We found that the protein carbonyl and MDA levels at the end of
the study showed no significant (p > 0.05) differences between the
therapy groups and control group. These results provide some evidence
for a potential effect of colchicine and vitamin E therapies on
increased protein oxidation and lipid peroxidation in BD. (c) 2007
Prous Science. All rights reserved.
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