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Antioxidant Decreases Nerve Degradation
Antioxidant Decreases Nerve Degradation
Public release date: 13-Mar-2008
[ Print Article | E-mail Article | Close Window ]
Contact: Karen Honey
press releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
New drug protects nerve cells from damage in mice
Multiple sclerosis (MS) is a chronic inflammatory disease of the brain
and spinal cord. Individuals with MS develop progressive neurological
disability, and this is thought to be caused by degradation of the
nerve cells. It is therefore hoped that treatments that protect nerve
cells might help individuals with the progressive form of MS. Data to
support this hypothesis has now been generated using a chronic
progressive EAE mouse model of MS by Howard Weiner and colleagues at
the Brigham and Women's Hospital, Harvard Medical School, Boston.
In the study, treatment of mice after the onset of disease with a
water-soluble agent known as ABS-75, which has antioxidant properties
and blocks the stimulation of the subset of nerve cells that express
the NMDA receptor, markedly reduced disease progression. This
beneficial effect was associated with decreased nerve cell
degradation, and a similar protective effect was observed for ABS-75
when it was added to cultured nerve cells exposed to damaging
reagents. These data led the authors to suggest that agents similar to
ABS-75 might provide a new approach to treating individuals with MS
and other neurodegenerative disorders.
###
TITLE: Reversal of axonal loss and disability in a mouse model of
progressive multiple sclerosis
--------------------------------------------------------------------------------------------------------------
Genistein protects primary cortical neurons from iron-induced lipid
peroxidation
Journal Molecular and Cellular Biochemistry
Publisher Springer Netherlands
ISSN 0300-8177 (Print) 1573-4919 (Online)
Subject Biomedical and Life Sciences
Genistein protects primary cortical neurons from iron-induced lipid
peroxidation
Kwok Ping Ho1, Lin Li1, 2, Li Zhao2 and Zhong Ming Qian1
(1) Laboratory of Brain Iron Metabolism, Department of Applied
Biology
and Chemical Technology, The Hong Kong Polytechnic University,
Kowloon,
Hong Kong
(2) Institute of Gerontology, Shanxi Medical University, Taiyuan,
Peoples Republic of China
Abstract Neuroprotective role of isoflavones in particular genistein
might be resulted from their antioxidant activities in addition to
their estrogenic actions. In the present study, we investigated
effect
of genistein on iron-induced free radical reaction in cultured
cortical
neurons. Thiobarbituric-acid-reactive species (TBARS) and superoxide
dismutase (SOD) were measured after incubation of the cells with
different concentrations of genistein in the absence or presence of
iron (12.5 M) for 24 h. Genistein at 100 M significantly reduced the
iron-induced TBARS, implying that genistein has an inhibitory role on
iron-induced lipid peroxidation. Also, genistein (100 M) led to a
relatively higher SOD level than that in iron treatment although no
significant difference was found. The findings imply that the
antioxidative effect of genistein is partly associated with its
neuroprotective function.
genistein - iron - thiobarbituric-acid-reactive species - superoxide
dismutase - primary cortical neurons - SD rats
---------------------------------------------------------------------------------
Zhong Ming Qian
Email: bezmq...@polyu.edu.hk
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Public release date: 13-Mar-2008
[ Print Article | E-mail Article | Close Window ]
Contact: Karen Honey
press releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
New drug protects nerve cells from damage in mice
Multiple sclerosis (MS) is a chronic inflammatory disease of the brain
and spinal cord. Individuals with MS develop progressive neurological
disability, and this is thought to be caused by degradation of the
nerve cells. It is therefore hoped that treatments that protect nerve
cells might help individuals with the progressive form of MS. Data to
support this hypothesis has now been generated using a chronic
progressive EAE mouse model of MS by Howard Weiner and colleagues at
the Brigham and Women's Hospital, Harvard Medical School, Boston.
In the study, treatment of mice after the onset of disease with a
water-soluble agent known as ABS-75, which has antioxidant properties
and blocks the stimulation of the subset of nerve cells that express
the NMDA receptor, markedly reduced disease progression. This
beneficial effect was associated with decreased nerve cell
degradation, and a similar protective effect was observed for ABS-75
when it was added to cultured nerve cells exposed to damaging
reagents. These data led the authors to suggest that agents similar to
ABS-75 might provide a new approach to treating individuals with MS
and other neurodegenerative disorders.
###
TITLE: Reversal of axonal loss and disability in a mouse model of
progressive multiple sclerosis
--------------------------------------------------------------------------------------------------------------
Genistein protects primary cortical neurons from iron-induced lipid
peroxidation
Journal Molecular and Cellular Biochemistry
Publisher Springer Netherlands
ISSN 0300-8177 (Print) 1573-4919 (Online)
Subject Biomedical and Life Sciences
Genistein protects primary cortical neurons from iron-induced lipid
peroxidation
Kwok Ping Ho1, Lin Li1, 2, Li Zhao2 and Zhong Ming Qian1
(1) Laboratory of Brain Iron Metabolism, Department of Applied
Biology
and Chemical Technology, The Hong Kong Polytechnic University,
Kowloon,
Hong Kong
(2) Institute of Gerontology, Shanxi Medical University, Taiyuan,
Peoples Republic of China
Abstract Neuroprotective role of isoflavones in particular genistein
might be resulted from their antioxidant activities in addition to
their estrogenic actions. In the present study, we investigated
effect
of genistein on iron-induced free radical reaction in cultured
cortical
neurons. Thiobarbituric-acid-reactive species (TBARS) and superoxide
dismutase (SOD) were measured after incubation of the cells with
different concentrations of genistein in the absence or presence of
iron (12.5 M) for 24 h. Genistein at 100 M significantly reduced the
iron-induced TBARS, implying that genistein has an inhibitory role on
iron-induced lipid peroxidation. Also, genistein (100 M) led to a
relatively higher SOD level than that in iron treatment although no
significant difference was found. The findings imply that the
antioxidative effect of genistein is partly associated with its
neuroprotective function.
genistein - iron - thiobarbituric-acid-reactive species - superoxide
dismutase - primary cortical neurons - SD rats
---------------------------------------------------------------------------------
Zhong Ming Qian
Email: bezmq...@polyu.edu.hk
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
