Cromolyn and pancreatic cancer question.

Cromolyn and pancreatic cancer question.

My mom was recently diagnosed with pancreatic cancer. The chemo of
choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
know this is only moderately effective.

There was a study on mice at M.D. Anderson medical center in which
they realized Cromolyn, in combination with the Gemcitibane, had a
MUCH more powerful impact on the tumors than the Gemcitibane alone.


Since no human studies have been approved yet- I think they are
trying
to improve the method of delivering it to the tumor- it is
frustrating
to know that there is this OTC medication that could help her, and
almost certainly cant hurt (compared to the near-certain prognosis of
pancreatic cancer).


My question is, if we wanted to simply add OTC chromalyn (sold for
allergies and asthma) to her regimen, what is the best method to get
a substantial amount into her body. The inhaler, or should we try to
convince a doctor to prescribe the tablet (cromolyn sodium) that gets
mixed in water? I read that absorbtion through the intestines is only
1% which is why, perhaps, they are trying to work on delivery. Would
inhalation be more effective? They also have eyedrops which I assume
are not effectively absorbed?


Thanks. Below is some of the info from abstract.
-


Background: We previously found that S100P, a member of the S100
protein family, is expressed in more than 90% of pancreatic tumors
and
is associated with tumor growth and invasion. In the current study,
we
investigated the ability of the antiallergy drug, cromolyn, to block
S100P function. Methods: Interactions between cromolyn and S100P were
investigated using a drug affinity column and by examining cromolyn's
effects on coimmunoprecipitation of S100P and receptor for advanced
glycation end-products (RAGE). The effects of cromolyn on cell
growth,
invasion, and nuclear factor-B (NFB) activity of pancreatic cancer
cells with (BxPC-3 and MPanc-96) and without (Panc-1) endogenous
S100P
were investigated by cell proliferation assay, by cell invasion
assay,
and by luciferase reporter gene assay, respectively. The effects of
cromolyn on tumor growth in vivo were investigated in three
orthotopic
models (n = 20 mice per model) by administration of cromolyn (5 mg/kg
body weight, daily) with and without gemcitabine (125 mg/kg body
weight, biweekly), the drug currently used to treat pancreatic
cancer.
Tumor growth was assayed by reporter gene expression. All statistical
tests were two-sided. Results: S100P was retained on a cromolyn
affinity column. Cromolyn blocked the coimmunoprecipitation of S100P
and RAGE. In vitro, cromolyn (100 µM) inhibited S100P-stimulated
Panc-1 cell proliferation (S100P, mean = 0.93 U, versus S100P +
cromolyn, mean = 0.56 U, difference = 0.37 U; 95% confidence interval
[CI] = 0.24 to 0.49 U; P = .001, n = 3), invasion (S100P, mean =
58.0%, versus S100P + cromolyn, mean = 9.4%, difference = 48.6%; 95%
CI = 38.8% to 58.8%; P<.001, n = 3), and NFB activity (S100P, mean =
14 460, versus S100P + cromolyn, mean = 7360 photons/s, difference =
7100 photons/s; 95% CI = 3689 to 10 510 photons/s; P = .005, n = 3).
In vivo, cromolyn inhibited tumor growth in mice bearing tumor with
endogenous S100P (BxPC-3: control, mean = 1.6 x 109 photons/s, versus
cromolyn, mean = 4.4 x 108 photons/s, difference = 1.2 x 109 photons/
s; 95% CI = 6.2 x 108 to 1.6 x 109 photons/s; P<.001, n = 5;
MPanc-96:
control, mean = 1.1 x 1010 photons/s, versus cromolyn, mean = 4.8 x
109 photons/s, difference = 6.2 x 109 photons/s; 95% CI = 1.9 x 109
to
1.0 x 1010 photons/s; P = .009, n = 5) and increased the
effectiveness
of gemcitabine (BxPC-3: gemcitabine, mean = 9.2 x 108 photons/s,
versus combination, mean = 1.8 x 108 photons/s, difference = 7.4 x
108
photons/s; 95% CI = 4.5 x 108 to 1.0 x 109 photons/s; P<.001;
MPanc-96: gemcitabine, mean = 4.1 x 109 photons/s, versus
combination,
mean = 2.0 x 109 photons/s, difference = 2.1 x 109 photons/s; 95% CI
=
4.4 x 108 to 3.8 x 109 photons/s; P<.001). However, cromolyn had no
effect on growth of tumors lacking S100P (Panc-1). Conclusion:
Cromolyn binds S100P, prevents activation of RAGE, inhibits tumor
growth, and increases the effectiveness of gemcitabine in
experimental
models.

Re: Cromolyn and pancreatic cancer question.

I am interested here too. Will stomach acids negate effectiveness when
using pill for tumor? Does inhaling have any chance to get to pancreas?


on 3/27/08 1:09 PM Phil said the following:
> My mom was recently diagnosed with pancreatic cancer. The chemo of
> choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
> know this is only moderately effective.
>
> There was a study on mice at M.D. Anderson medical center in which
> they realized Cromolyn, in combination with the Gemcitibane, had a
> MUCH more powerful impact on the tumors than the Gemcitibane alone.
>
>
> Since no human studies have been approved yet- I think they are
> trying
> to improve the method of delivering it to the tumor- it is
> frustrating
> to know that there is this OTC medication that could help her, and
> almost certainly cant hurt (compared to the near-certain prognosis of
> pancreatic cancer).
>
>
> My question is, if we wanted to simply add OTC chromalyn (sold for
> allergies and asthma) to her regimen, what is the best method to get
> a substantial amount into her body. The inhaler, or should we try to
> convince a doctor to prescribe the tablet (cromolyn sodium) that gets
> mixed in water? I read that absorbtion through the intestines is only
> 1% which is why, perhaps, they are trying to work on delivery. Would
> inhalation be more effective? They also have eyedrops which I assume
> are not effectively absorbed?
>
>
> Thanks. Below is some of the info from abstract.
> -
>
>
> Background: We previously found that S100P, a member of the S100
> protein family, is expressed in more than 90% of pancreatic tumors
> and
> is associated with tumor growth and invasion. In the current study,
> we
> investigated the ability of the antiallergy drug, cromolyn, to block
> S100P function. Methods: Interactions between cromolyn and S100P were
> investigated using a drug affinity column and by examining cromolyn's
> effects on coimmunoprecipitation of S100P and receptor for advanced
> glycation end-products (RAGE). The effects of cromolyn on cell
> growth,
> invasion, and nuclear factor-B (NFB) activity of pancreatic cancer
> cells with (BxPC-3 and MPanc-96) and without (Panc-1) endogenous
> S100P
> were investigated by cell proliferation assay, by cell invasion
> assay,
> and by luciferase reporter gene assay, respectively. The effects of
> cromolyn on tumor growth in vivo were investigated in three
> orthotopic
> models (n = 20 mice per model) by administration of cromolyn (5 mg/kg
> body weight, daily) with and without gemcitabine (125 mg/kg body
> weight, biweekly), the drug currently used to treat pancreatic
> cancer.
> Tumor growth was assayed by reporter gene expression. All statistical
> tests were two-sided. Results: S100P was retained on a cromolyn
> affinity column. Cromolyn blocked the coimmunoprecipitation of S100P
> and RAGE. In vitro, cromolyn (100 µM) inhibited S100P-stimulated
> Panc-1 cell proliferation (S100P, mean = 0.93 U, versus S100P +
> cromolyn, mean = 0.56 U, difference = 0.37 U; 95% confidence interval
> [CI] = 0.24 to 0.49 U; P = .001, n = 3), invasion (S100P, mean =
> 58.0%, versus S100P + cromolyn, mean = 9.4%, difference = 48.6%; 95%
> CI = 38.8% to 58.8%; P<.001, n = 3), and NFB activity (S100P, mean =
> 14 460, versus S100P + cromolyn, mean = 7360 photons/s, difference =
> 7100 photons/s; 95% CI = 3689 to 10 510 photons/s; P = .005, n = 3).
> In vivo, cromolyn inhibited tumor growth in mice bearing tumor with
> endogenous S100P (BxPC-3: control, mean = 1.6 x 109 photons/s, versus
> cromolyn, mean = 4.4 x 108 photons/s, difference = 1.2 x 109 photons/
> s; 95% CI = 6.2 x 108 to 1.6 x 109 photons/s; P<.001, n = 5;
> MPanc-96:
> control, mean = 1.1 x 1010 photons/s, versus cromolyn, mean = 4.8 x
> 109 photons/s, difference = 6.2 x 109 photons/s; 95% CI = 1.9 x 109
> to
> 1.0 x 1010 photons/s; P = .009, n = 5) and increased the
> effectiveness
> of gemcitabine (BxPC-3: gemcitabine, mean = 9.2 x 108 photons/s,
> versus combination, mean = 1.8 x 108 photons/s, difference = 7.4 x
> 108
> photons/s; 95% CI = 4.5 x 108 to 1.0 x 109 photons/s; P<.001;
> MPanc-96: gemcitabine, mean = 4.1 x 109 photons/s, versus
> combination,
> mean = 2.0 x 109 photons/s, difference = 2.1 x 109 photons/s; 95% CI
> =
> 4.4 x 108 to 3.8 x 109 photons/s; P<.001). However, cromolyn had no
> effect on growth of tumors lacking S100P (Panc-1). Conclusion:
> Cromolyn binds S100P, prevents activation of RAGE, inhibits tumor
> growth, and increases the effectiveness of gemcitabine in
> experimental
> models.
>
>

Re: Cromolyn and pancreatic cancer question.

Phil wrote:

> My mom was recently diagnosed with pancreatic cancer. The chemo of
> choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
> know this is only moderately effective.
>
> There was a study on mice at M.D. Anderson medical center in which
> they realized Cromolyn, in combination with the Gemcitibane, had a
> MUCH more powerful impact on the tumors than the Gemcitibane alone.
>
> Since no human studies have been approved yet- I think they are
> trying
> to improve the method of delivering it to the tumor- it is
> frustrating
> to know that there is this OTC medication that could help her, and
> almost certainly cant hurt (compared to the near-certain prognosis of
> pancreatic cancer).
>
> My question is, if we wanted to simply add OTC chromalyn (sold for
> allergies and asthma) to her regimen, what is the best method to get
> a substantial amount into her body. The inhaler, or should we try to
> convince a doctor to prescribe the tablet (cromolyn sodium) that gets
> mixed in water? I read that absorbtion through the intestines is only
> 1% which is why, perhaps, they are trying to work on delivery. Would
> inhalation be more effective? They also have eyedrops which I assume
> are not effectively absorbed?
>
> Thanks. Below is some of the info from abstract.
> ____________________________________-
>
> Background: We previously found that S100P, a member of the S100
> protein family, is expressed in more than 90% of pancreatic tumors
> and
> is associated with tumor growth and invasion. In the current study,
> we
> investigated the ability of the antiallergy drug, cromolyn, to block
> S100P function. Methods: Interactions between cromolyn and S100P were
> investigated using a drug affinity column and by examining cromolyn's
> effects on coimmunoprecipitation of S100P and receptor for advanced
> glycation end-products (RAGE). The effects of cromolyn on cell
> growth,
> invasion, and nuclear factor-B (NFB) activity of pancreatic cancer
> cells with (BxPC-3 and MPanc-96) and without (Panc-1) endogenous
> S100P
> were investigated by cell proliferation assay, by cell invasion
> assay,
> and by luciferase reporter gene assay, respectively. The effects of
> cromolyn on tumor growth in vivo were investigated in three
> orthotopic
> models (n = 20 mice per model) by administration of cromolyn (5 mg/kg

I'm sorry to hear of your mother's diagnosis.
If I were you, I'd leave the mice research to MD Anderson and the mice.
Best,
J

Re: Cromolyn and pancreatic cancer question.


"Phil" <thinkofanamefast@aol . com > wrote
My mom was recently diagnosed with pancreatic cancer. The chemo of
choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
know this is only moderately effective. There was a study on mice at M.D.
Anderson medical center in which
they realized Cromolyn, in combination with the Gemcitibane, had a
MUCH more powerful impact on the tumors than the Gemcitibane alone.
-----
Sorry I can't help you about Cromolyn but there's one thing you need to know
about Gemcitibane - it greatly increases NFkappaB activity which is like
trying to put out a fire using gasoline - it makes cancer cells much more
proliferative, invasive, and angiogenic.

So you need to have your mother take something that will greatly lower
NFkappaB activity which will make Gemcitibane much more effective (why
oncologists don't address this in treatment when using Gemcitabine is
nothing short of bizarre). I'll post two Pubmed abstracts showing that, in
mice, curcumin and genistein (individually) both greatly increased the
effectiveness of Gem in panc cancer via inhibition of NFkappaB activity.

Genistein can be purchased from Life Extension Foundation (w w w .lef.org).
Curcumin is a fat soluble molecule so she should take it mixed in fat
(preferably not an omega 6 fat). She should heat up the fat some (but don't
boil it) to increase the bioavailability of it. There's a lady on the net
who's taken 8 g of it daily for the last two years to treat myeloma.

Here's a source for inexpensive bulk curcumin:
* w w w .shfnatural . com /Merchant2/merchant.mvc?Screen=CTGY&Category_Code=I
NG

A few other things you need to know about for panc cancer.

The statin drugs are potent anti-pancreatic cancer drugs because they
prevent the Ras protein from being activated. An activated Ras protein makes
cancer cells much more proliferative (see abstract below on the anti-pc
nature of statins). Lovastatin can be obtained for cheap so she needs to
take it.

Have her cut out all intake of omega 6 fats. The cox-2 and lipoxygenase
enzymes modify omega 6 fats and turn them into potent panc cancer cell
proliferators. Have her take 10 g or so of omega 3 fats so the cox and lox
enzymes (5-lox and 12-lox) only see the omega 3 fats instead of the omega 6.

You want her to restrict expression of the cox-2 enzyme (for the reason
above) and the 5-lox and 12-lox enzymes (two lipoxygenase enzymes) for the
reason above. She should take aspirin or ibuprofen throughout the day to
lower cox-2 expression. A supplement called Zyflamend from New Chapter
(available in any vitamin store) will inhib 5-lox and 12-lox expression.
I'll post an abstract below showing that. She should take at least 6 of
those a day (spread throughout the day).

You want to keep her insulin growth factor expression low so she should not
eat any foods that cause a big surge in blood sugar.

Here's the links to Pubmed abstracts:

Genistein and Gemcitibane in panc cancer:
* w w w .ncbi.nlm.nih.gov/pubmed/16204081?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

Curcumin and Gemcitibane in panc cancer:
* w w w .ncbi.nlm.nih.gov/pubmed/17440100?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

Statins are potent anti-panc cancer agents
* w w w .ncbi.nlm.nih.gov/pubmed/18027870?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Three abstracts on Zyflamend
* w w w .ncbi.nlm.nih.gov/pubmed/17516865?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

* w w w .ncbi.nlm.nih.gov/pubmed/17218785?ordinalpos=4&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

* w w w .ncbi.nlm.nih.gov/pubmed/16201851?ordinalpos=5&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Re: Cromolyn and pancreatic cancer question.


"Phil" <thinkofanamefast@aol . com > wrote in message
news:d40f193f-e140-4523-b40d-b9efebf9d538@s37g2000prg.googlegroups . com ...
My mom was recently diagnosed with pancreatic cancer. The chemo of
choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
know this is only moderately effective.

--------

I should have mentioned this in my reply. At the Grouppe Kurosawa website,
Steven Martin tells how a 67 year old man with panc cancer has done well
using luteolin, EGCG, and ChrySyn. Specifically he used 4-100mg Lutimax
lozenges 4 times a day, 1 gram of EGCGSyn twice a day, and 1 gram of ChrySyn
twice a day. Those products are made and sold by Tom Lahey at Lutimax
Nutraceuticals. He can be reached at 949-492-6642.

Here's two blogs Mr. Martin wrote on how and why the 67 year old is doing so
well taking these products (he has links to Pubmed there to back up what he
says). The second link has the latest 5 CA19-9 readings he had done - each
one decreased from the previous one - a very good sign. I talked to Mr.
Lahey a week ago and the 67 year old is still alive today (now probably 70
years old).

(scroll down to the heading that says, "Excellent News About Pancreatic
Cancer")
* grouppekurosawa . com /blog/2005_08_17_

* grouppekurosawa . com /blog/2005_09_11_

Re: Cromolyn and pancreatic cancer question.

Steve,

Can't thank you enough, especially for the links to abstracts. My mom
is an 81 year old RN who doesnt go in for anything "natural"- so these
abstracts will help me and my RN sister convince her.

I think she might already be on a statin, so that is covered.

As for the Genistein, that sounds almost as effective in animal
studies as the Cromolyn I originally posted about. I am going to push
her to add the Gerstein, or a soy product rich in it, and "snort" some
of the Cromolyn inhaler, while she is taking her Gemcitibane chemo.

As for the Curcimin, I don't think she will want to get involved in
cooking it up, but I will see if it is in supplement form.

I also read that other one...was that also Curcimin?- but since that
gentleman was already on Gemcitibane there is no way to gauge whether
the tumor marker decreased due to one or the other- that tumor marker
seems to usually decrease substantially while the Gemcitibane is still
effective- as I understand it.

Again, great information, and I appreciate it a lot.
Phil

Steve wrote:
> "Phil" <thinkofanamefast@aol . com > wrote in message
> news:d40f193f-e140-4523-b40d-b9efebf9d538@s37g2000prg.googlegroups . com ...
> My mom was recently diagnosed with pancreatic cancer. The chemo of
> choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
> know this is only moderately effective.
>
> --------
>
> I should have mentioned this in my reply. At the Grouppe Kurosawa website,
> Steven Martin tells how a 67 year old man with panc cancer has done well
> using luteolin, EGCG, and ChrySyn. Specifically he used 4-100mg Lutimax
> lozenges 4 times a day, 1 gram of EGCGSyn twice a day, and 1 gram of ChrySyn
> twice a day. Those products are made and sold by Tom Lahey at Lutimax
> Nutraceuticals. He can be reached at 949-492-6642.
>
> Here's two blogs Mr. Martin wrote on how and why the 67 year old is doing so
> well taking these products (he has links to Pubmed there to back up what he
> says). The second link has the latest 5 CA19-9 readings he had done - each
> one decreased from the previous one - a very good sign. I talked to Mr.
> Lahey a week ago and the 67 year old is still alive today (now probably 70
> years old).
>
> (scroll down to the heading that says, "Excellent News About Pancreatic
> Cancer")
> * grouppekurosawa . com /blog/2005 08 17
>
> * grouppekurosawa . com /blog/2005 09 11

Re: Cromolyn and pancreatic cancer question.


"Phil" <thinkofanamefast@aol . com > wrote in message
news:57e5c566-1a57-4938-96c4-95bb2d7b9f96@e39g2000hsf.googlegroups . com ...
> Steve,
>
> Can't thank you enough, especially for the links to abstracts. My mom
> is an 81 year old RN who doesnt go in for anything "natural"- so these
> abstracts will help me and my RN sister convince her.
>
> I think she might already be on a statin, so that is covered.
>
> As for the Genistein, that sounds almost as effective in animal
> studies as the Cromolyn I originally posted about. I am going to push
> her to add the Gerstein, or a soy product rich in it, and "snort" some
> of the Cromolyn inhaler, while she is taking her Gemcitibane chemo.
>
> As for the Curcimin, I don't think she will want to get involved in
> cooking it up, but I will see if it is in supplement form.
>
> I also read that other one...was that also Curcimin?- but since that
> gentleman was already on Gemcitibane there is no way to gauge whether
> the tumor marker decreased due to one or the other- that tumor marker
> seems to usually decrease substantially while the Gemcitibane is still
> effective- as I understand it.
>
> Again, great information, and I appreciate it a lot.
> Phil
>

The important question, as always, is "what do you hope treatment (with
cromolyn or curcumin, or whatever) will achieve?"

Re: Cromolyn and pancreatic cancer question.


"Phil" <thinkofanamefast@aol . com > wrote
> Steve,
>
> Can't thank you enough, especially for the links to abstracts.

No problem. Give me an email addy to reach you at and I will send you a lot
more stuff. If you have to, get a temporary Yahoo email account.

My mom
> is an 81 year old RN who doesnt go in for anything "natural"- so these
> abstracts will help me and my RN sister convince her.
>
> I think she might already be on a statin, so that is covered.
>
> As for the Genistein, that sounds almost as effective in animal
> studies as the Cromolyn I originally posted about. I am going to push
> her to add the Gerstein, or a soy product rich in it, and "snort" some
> of the Cromolyn inhaler, while she is taking her Gemcitibane chemo.

Here are three Pubmed abstracts indicating how much Genistein a person needs
to take and how often during the day (for two of the apbstracts, you can
read the entire paper for free at the Pubmed link).

* w w w .ncbi.nlm.nih.gov/pubmed/11368927?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

* w w w .ncbi.nlm.nih.gov/pubmed/12399289?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

* w w w .ncbi.nlm.nih.gov/pubmed/11756070?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

>
> As for the Curcimin, I don't think she will want to get involved in
> cooking it up, but I will see if it is in supplement form.

It's bioavailability is extremely poor in supplement form because it is very
insoluble in water (blood is mostly water). Read this lady's writings on
curcumin - she takes it for her multiple myeloma and has been doing it for
years so something is keeping her alive. You can learn tons about the best
way to take it there (look at the links on the right side).

* margaret.healthblogs.org/life-with-myeloma/discovery-of-curcumin/bioa
vailability-of-curcumin/


> I also read that other one...was that also Curcimin?-

The 67 year old (his age then, now he's gotta be about 70) takes Lutimax
which is a bioavailable form of luteolin (he's also taking a bioavailable
form of chrysin, another anticancer agent). Luteolin is a very potent
anticancer agent but its bioavailability is apparently poor so the Lutimax
form of it makes it bioavailable according to the owner of the company and
Stephen Martin who runs the Grouppe Kurosawa website (you should read all
the blogs there too - there's an incredible amount of info there that's all
backed up with Pubmed abstracts).

Here's a few Pubmed abstracts on luteolin. Note that the EGF (epidermal
growth factor) receptor is extremely important in pancreatic cancer
proliferation. Inhibiting it should be a top priority because it activates
the PI3K enzyme which activates the Akt enzyme which activates the
transcription factor, NFkappaB (PI3K, Akt, and NFkappaB can be activated
independently so your strategy must be to inhibit ALL four of those enzymes:
EGFR, PI3K, Akt, NFkappaB, and also the ERK enzyme - those five enzymes are
the engine of panc cancer growth).

* w w w .ncbi.nlm.nih.gov/pubmed/12168845?ordinalpos=2&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

* w w w .ncbi.nlm.nih.gov/pubmed/17410645?ordinalpos=8&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

but since that
> gentleman was already on Gemcitibane there is no way to gauge whether
> the tumor marker decreased due to one or the other- that tumor marker
> seems to usually decrease substantially while the Gemcitibane is still
> effective- as I understand it.

But the difference is most people don't survive panc cancer despite taking
Gem. He has survived it for three years so if it was me, I'd do whatever he
did. You should go to the Lutimax website and call the number there. You
will be able to discuss his treatment with the owner of the company.
Another thing I think he was / is taking is a bioavailable form of apigenin,
another potent anticancer agent. Here's an abstract showing that in mice
with panc cancer, it increased the tumor inhibition of Gemcitabine by
inhibiting NFkappaB and Akt.

* w w w .ncbi.nlm.nih.gov/pubmed/17967505?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Another thing I would take if it was me is EGCG. I don't believe there's an
agent that inhibits cancer in the number of ways that EGCG does. Instead of
drinking it from tea, she should take it in supplement form but it has poor
bioavailability according to this abstract:

* w w w .ncbi.nlm.nih.gov/pubmed/17483343?ordinalpos=3&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum.

That Lutimax company sells a bioavailable form of EGCG - at least it's
bioavailable according to the owner. After talking to him on the phone, I
believe him (you could call him and ask him why his is bioavailable).

I have no afiliation with Lutimax. I did call the number there and talked to
the owner for about a half hour. I was very impressed with the guy's
knowledge of cancer treatment using natural ingredients including needed
body concentrations. Never was he pushing me to buy anything.

If it was me and I had pc and I could afford what Lutimax charges for
Lutimax and the EGCG formulation, I'd probably buy it. It's not enough to
take something, you have to make sure it's bioavailable, that the dose is
high enough, and that it's being taken often enough during the day (you need
to know it's half life in the body). He's quite knowledgeable in those
areas. You should call the number there and talk to him.

Another strategy that should be employed is depleting the panc cells of
glutathione. Without glutathione, they die. Cancer cells have increased
levels of ROS (reactive oxygen species) so they need extra glutathione or
else the high levels of ROS would kill them.

There's this wheat germ extract product called Avemar that depletes
glutathione from cancer cells. It alone doesn't do much to cancer cells but
it potently increases the cancer killing effects of chemo. If it was me, I'd
be taking it.

Here's three abstracts on it. The third abstract pertains to panc cancer
cells and says Avemar increases fatty acid synthesis in those cells. EGCG is
a potent fatty acid synthase inhibitor and you want that enzyme inhibited so
both agents should be used.

(you can read the entire paper of the first abstract for free at Pubmed):
* w w w .ncbi.nlm.nih.gov/pubmed/12351627?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_R
A

* w w w .ncbi.nlm.nih.gov/pubmed/16126993?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

(If you want to read the entire paper for the above abstract, go here:

* w w w .avemar . com /docs/43_Boros_et_al-NY.pdf

* w w w .ncbi.nlm.nih.gov/pubmed/11484916?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Here's another site you should check out. I don't know if you read the news
articles in the last year about the cancer researcher from Canada who found
a way to make cancer cells use the mitochondria for energy (instead of
glycolysis) and in turn caused those cancer cells to die.

Here's the Pubmed abstract that researcher and his colleages wrote on it:

* w w w .ncbi.nlm.nih.gov/pubmed/17222789?ordinalpos=1&itool=EntrezSystem2
.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Well cancer patients have set up a website to exchange info on what's the
best way to use this cheap, unpatented substance. Some are having great
success with it including a panc cancer patient. Apparently caffeine needs
to be taken with it also to make it effective. Go here to read the
testimonials of those using it and how to get it:

* w w w .thedcasite . com

>
> Again, great information, and I appreciate it a lot.
> Phil

My pleasure and I wish your mother good luck.

Steve

>
> Steve wrote:
> > "Phil" <thinkofanamefast@aol . com > wrote in message
> >
news:d40f193f-e140-4523-b40d-b9efebf9d538@s37g2000prg.googlegroups . com ...
> > My mom was recently diagnosed with pancreatic cancer. The chemo of
> > choice is Gemox, which is Gemcitibane with Oxyplatin (sp?). You may
> > know this is only moderately effective.
> >
> > --------
> >
> > I should have mentioned this in my reply. At the Grouppe Kurosawa
website,
> > Steven Martin tells how a 67 year old man with panc cancer has done well
> > using luteolin, EGCG, and ChrySyn. Specifically he used 4-100mg Lutimax
> > lozenges 4 times a day, 1 gram of EGCGSyn twice a day, and 1 gram of
ChrySyn
> > twice a day. Those products are made and sold by Tom Lahey at Lutimax
> > Nutraceuticals. He can be reached at 949-492-6642.
> >
> > Here's two blogs Mr. Martin wrote on how and why the 67 year old is
doing so
> > well taking these products (he has links to Pubmed there to back up what
he
> > says). The second link has the latest 5 CA19-9 readings he had done -
each
> > one decreased from the previous one - a very good sign. I talked to Mr.
> > Lahey a week ago and the 67 year old is still alive today (now probably
70
> > years old).
> >
> > (scroll down to the heading that says, "Excellent News About Pancreatic
> > Cancer")
> > * grouppekurosawa . com /blog/2005_08_17_
> >
> > * grouppekurosawa . com /blog/2005_09_11_

Re: Cromolyn and pancreatic cancer question.

Steve,

Thanks again. The issue with my mom is that being an 81 year old
former RN, she is very cautious and conservative, despite the current
prognosis. We have to pick our battles with her, and since Curcimin
and Genisten at least have those medical journal articles, they are
probably our best bet. One issue with Curcimin is that they warn you,
right on the bottle, not to use if if you have biliary obstruction
since it increases flow of fluid. This is probably the most common
indicator of PC, biliary blockage leading to jaundice. The question is
whether her having a stent in her duct to open it up makes it safe to
use Curimin. However since there have been a few trials of Curicmin,
including a Phase III I believe in Israel, and one at MD Anderson,
perhaps it is safe assuming many patients in the study must have
stents. I wrote to the people running study, but havent heard back.

As for the ECGC, we can at least get her drinking green tea, in that
she probably wouldnt object to such a "normal" food being added to her
diet.

The other substances are all interesting also- if it was me I'd
certainly be taking most of them on the theory that they likely do no
harm, and any studies as to their effectiveness in humans with PC are
likely years away- one could be an effective treatment and very few
people would know it till then. I will print out most of those and
show them to my sis and mom- thanks again.
Phil

>