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Iron chelation and nutrient absorption
Iron chelation and nutrient absorption
It seems iron in our foods inhibits nutrient absorption and by
including a natural iron chelator nutrient absorption is ..
enhanced ..
J Agric Food Chem. 2007 Feb 24; [Epub ahead of print] Links
Enhanced Absorption of Anthocyanins after Oral Administration of
Phytic Acid in Rats and Humans.Matsumoto H, Ito K, Yonekura K, Tsuda
T, Ichiyanagi T, Hirayama M, Konishi T.
Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., 5-3-1,
Chiyoda, Sakado-shi, Saitama 350-0289, Japan, Department of Food and
Nutritional Sciences, College of Bioscience and Biotechnology, Chubu
University, Kasugai, Aichi 487-8501, Japan, and Faculty of
Pharmaceutical Sciences and Faculty of Applied Life Sciences, Niigata
University of Pharmacy and Applied Life Sciences, 265-1, Higashijima,
Niigata 956-8603, Japan.
Many studies on the bioavailability of polyphenols have been reported.
However, the relative urinary excretions of AC are also low, ranging
from 0.004% to 0.1%. By contrast, other polyphenols show higher
urinary excretion levels. Here, we studied the enhancing effects of
phytic acid (IP6) on absorption of blackcurrant anthocyanins (BCAs) in
rats and humans. In rats after oral administration of BCAs (as 241 mg
of AC/kg body weight) in IP6 (0%, 0.25%, 0.5%, 1%, 2.5%) solution, the
ACs recovery in urine was increased dependent on IP6 dose. These
results suggest that the IP6 enhances gastrointestinal absorption of
ACs. At the further analysis of IP6 enhancement effect in rat, whereas
BCAs were normally passed through the stomach and duodenum within 2 h,
in IP6 group, after 2-6 h post-administration, stomach and jejunum
content's weights were specifically heavy, and large amounts of ACs
were also detected in stomach, duodenum, and jejunum. These results
suggested that the mixture of BCAs and IP6 reduced the
gastrointestinal motility. Prolongation of ACs residue in
gastrointestinal tract then caused the enhancing effects of IP6 on
absorption of AC. In the human study, each subject was orally
administrated a BCA beverage containing BCA concentrate (AC 4 mg/kg
body weight), 1% of IP6, and 1% of sodium citrate as a pH stabilizer.
Both the plasma level and the urinary excretion of AC were increased
as compared to BCA administration without IP6. AC intake with IP6 may
increase the bioavailability of AC to the comparative level as other
polyphenols. Yet, phytic acid, being a strong chelator of important
minerals, contributes to mineral deficiencies. An interference with
iron uptake has been reported. Safety tests are therefore necessary
before high dose IP6 can be used in foods. Keywords: Anthocyanin;
absorption; blackcurrant; phytic acid; bioavailability.
PMID: 17319688 [PubMed - as supplied by publisher]
-----------------------------------------------------------------------------------------
ScienceDirect - The American Journal of Surgery :
Combination ...Anthocyanins chelate iron, scavenge oxygen free
radicals, and protect against lipid peroxidation [10]. They also
promote the recycling of glutathione ...
linkinghub.elsevier . com /retrieve/pii/S0002961005001583 - Similar
pages
-------------------------------------------------------------------------------------------
Phytic acid as antioxidantThis article describes the benefits of
phytic acid. Phytic acid forms a chelate with iron, thereby preventing
the radical formation and oxidative damage. ...
w w w .phytochemicals.info/abstracts/phytic-acid-antioxidant.php - 10k -
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
It seems iron in our foods inhibits nutrient absorption and by
including a natural iron chelator nutrient absorption is ..
enhanced ..
J Agric Food Chem. 2007 Feb 24; [Epub ahead of print] Links
Enhanced Absorption of Anthocyanins after Oral Administration of
Phytic Acid in Rats and Humans.Matsumoto H, Ito K, Yonekura K, Tsuda
T, Ichiyanagi T, Hirayama M, Konishi T.
Food and Health R&D Laboratories, Meiji Seika Kaisha, Ltd., 5-3-1,
Chiyoda, Sakado-shi, Saitama 350-0289, Japan, Department of Food and
Nutritional Sciences, College of Bioscience and Biotechnology, Chubu
University, Kasugai, Aichi 487-8501, Japan, and Faculty of
Pharmaceutical Sciences and Faculty of Applied Life Sciences, Niigata
University of Pharmacy and Applied Life Sciences, 265-1, Higashijima,
Niigata 956-8603, Japan.
Many studies on the bioavailability of polyphenols have been reported.
However, the relative urinary excretions of AC are also low, ranging
from 0.004% to 0.1%. By contrast, other polyphenols show higher
urinary excretion levels. Here, we studied the enhancing effects of
phytic acid (IP6) on absorption of blackcurrant anthocyanins (BCAs) in
rats and humans. In rats after oral administration of BCAs (as 241 mg
of AC/kg body weight) in IP6 (0%, 0.25%, 0.5%, 1%, 2.5%) solution, the
ACs recovery in urine was increased dependent on IP6 dose. These
results suggest that the IP6 enhances gastrointestinal absorption of
ACs. At the further analysis of IP6 enhancement effect in rat, whereas
BCAs were normally passed through the stomach and duodenum within 2 h,
in IP6 group, after 2-6 h post-administration, stomach and jejunum
content's weights were specifically heavy, and large amounts of ACs
were also detected in stomach, duodenum, and jejunum. These results
suggested that the mixture of BCAs and IP6 reduced the
gastrointestinal motility. Prolongation of ACs residue in
gastrointestinal tract then caused the enhancing effects of IP6 on
absorption of AC. In the human study, each subject was orally
administrated a BCA beverage containing BCA concentrate (AC 4 mg/kg
body weight), 1% of IP6, and 1% of sodium citrate as a pH stabilizer.
Both the plasma level and the urinary excretion of AC were increased
as compared to BCA administration without IP6. AC intake with IP6 may
increase the bioavailability of AC to the comparative level as other
polyphenols. Yet, phytic acid, being a strong chelator of important
minerals, contributes to mineral deficiencies. An interference with
iron uptake has been reported. Safety tests are therefore necessary
before high dose IP6 can be used in foods. Keywords: Anthocyanin;
absorption; blackcurrant; phytic acid; bioavailability.
PMID: 17319688 [PubMed - as supplied by publisher]
-----------------------------------------------------------------------------------------
ScienceDirect - The American Journal of Surgery :
Combination ...Anthocyanins chelate iron, scavenge oxygen free
radicals, and protect against lipid peroxidation [10]. They also
promote the recycling of glutathione ...
linkinghub.elsevier . com /retrieve/pii/S0002961005001583 - Similar
pages
-------------------------------------------------------------------------------------------
Phytic acid as antioxidantThis article describes the benefits of
phytic acid. Phytic acid forms a chelate with iron, thereby preventing
the radical formation and oxidative damage. ...
w w w .phytochemicals.info/abstracts/phytic-acid-antioxidant.php - 10k -
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
