Iron in memory dysfunction

Neurobiol Aging. 2007 Mar 6; [Epub ahead of print]Reversion of age-
related recognition memory impairment by iron chelation in rats.de
Lima MN, Dias CP, Torres JP, Dornelles A, Garcia VA, Scalco FS,
Guimaraes MR, Petry RC, Bromberg E, Constantino L, Budni P, Dal-Pizzol
F, Schroder N.
Neurobiology and Developmental Biology Laboratory, Faculty of
Biosciences, Pontifical Catholic University, 90619-900 Porto Alegre,
RS, Brazil; Graduate Program in Biomedical Gerontology, Institute for
Geriatrics and Gerontology, Sao Lucas Hospital, Pontifical Catholic
University, 90619-900 Porto Alegre, RS, Brazil.

It is now generally accepted that iron accumulates in the brain during
the ageing process. Increasing evidence demonstrate that iron
accumulation in selective regions of the brain may generate free
radicals, thereby possessing implications for the etiology of
neurodegenerative disorders. In a previous study we have reported that
aged rats present recognition memory deficits. The aim of the present
study was to evaluate the effect of desferoxamine (DFO), an iron
chelator agent, on age-induced memory impairment. Aged Wistar rats
received intraperitoneal injections of saline or DFO (300mg/kg) for 2
weeks. The animals were submitted to a novel object recognition task
24h after the last injection. DFO-treated rats showed normal
recognition memory while the saline group showed long-term recognition
memory deficits. The results show that DFO is able to reverse age-
induced recognition memory deficits. We also demonstrated that DFO
reduced the oxidative damage to proteins in cortex and hippocampus.
Thus, the present findings provide the first evidence that iron
chelators might prevent age-related memory dysfunction.

PMID: 17346856 [PubMed - as supplied by publisher]


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