Conversion of lipids limited by QUANTITY of lipids

Conversion of alpha-linolenic acid in humans is influenced by the
absolute amounts of alpha-linolenic acid and linoleic acid in the diet
and not by their ratio; 2006

Goyens, P.L.L.

Titel Conversion of alpha-linolenic acid in humans is influenced by
the absolute amounts of alpha-linolenic acid and linoleic acid in the
diet and not by their ratio
Auteur(s) Goyens, P.L.L. Spilker, M.E.
Zock, P.L.
Katan, M.B.
Mensink, R.P.

Datum 2006
Trefwoord(en) Afdeling Humane voeding
Samenvatting BACKGROUND: Human in vivo data on dietary determinants
of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce.
OBJECTIVE: We examined whether intakes of ALA or linoleic acid (LA;
18:2n-6) or their ratio influences ALA metabolism. DESIGN: During 4
wk, 29 subjects received a control diet (7% of energy from LA, 0.4% of
energy from ALA, ALA-to-LA ratio = 1:19). For the next 6 wk, a control
diet, a low-LA diet (3% of energy from LA, 0.4% of energy from ALA,
ratio = 1:7), or a high-ALA diet (7% of energy from LA, 1.1% of energy
from ALA, ratio = 1:7) was consumed. Ten days before the end of each
dietary period, [U-13C]ALA was administered orally for 9 d. ALA
oxidation was determined from breath. Conversion was estimated by
using compartmental modeling of [13C]- and [12C]n-3 fatty acid
concentrations in fasting plasma phospholipids. RESULTS: Compared with
the control group, ALA incorporation into phospholipids increased by
3.6% in the low-LA group (P = 0.012) and decreased by 8.0% in the high-
ALA group (P < 0.001). In absolute amounts, it increased by 34.3 mg (P
= 0.020) in the low-LA group but hardly changed in the high-ALA group.
Nearly all ALA from the plasma phospholipid pool was converted into
eicosapentaenoic acid. Conversion of eicosapentaenoic acid into
docosapentaenoic acid and docosahexaenoic acid hardly changed in the 3
groups and was <0.1% of dietary ALA. In absolute amounts, it was
unchanged in the low-LA group, but increased from 0.7 to 1.9 mg (P =
0.001) in the high-ALA group. ALA oxidation was unchanged by the
dietary interventions. CONCLUSION: The amounts of ALA and LA in the
diet, but not their ratio, determine ALA conversion

Link http://library.wur.nl/wasp/bestanden/LUWPUBRD_00348072_A502_001.pdf
Objecttype Article/Letter to editor
Objectformaat application/pdf

Bron American Journal of Clinical Nutrition 84 (2006) 1 ISSN:
0002-9165

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