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Human lactoferrin inhibits cancer growth
Clin Cancer Res. 2007 Mar 1;13(5):1601-10. Links
Oral Lactoferrin Results in T Cell-Dependent Tumor Inhibition of Head
and Neck Squamous Cell Carcinoma In vivo.Wolf JS, Li G, Varadhachary
A, Petrak K, Schneyer M, Li D, Ongkasuwan J, Zhang X, Taylor RJ,
Strome SE, O'malley BW Jr.
Authors' Affiliations: Department of Otorhinolaryngology-Head and Neck
Surgery and Program in Oncology, Stewart and Marlene Greenebaum Cancer
Center, University of Maryland School of Medicine, Baltimore,
Maryland.
PURPOSE: Human lactoferrin is a naturally occurring glycoprotein that
inhibits cancer growth. Our purpose was to evaluate recombinant human
lactoferrin as a chemotherapeutic agent against head and neck squamous
cell carcinoma. EXPERIMENTAL DESIGN: Controlled experiments both in
vitro and in the murine model evaluating both the effect and mechanism
of lactoferrin on cancer growth. RESULTS: In both human and murine
cell lines, lactoferrin induced dose-dependent growth inhibition.
Using flow cytometric analysis, lactoferrin was shown to induce G(1)-
G(0) growth arrest. This arrest seemed to be modulated by down-
regulation of cyclin D1. In the in vitro model, luminex data revealed
that lactoferrin inhibited cellular release of proinflammatory and
prometastatic cytokines, including interleukin-8, interleukin-6,
granulocyte macrophage colony-stimulating factor, and tumor necrosis
factor-alpha. Lactoferrin up-regulated the cellular activation of
nuclear factor-kappaB within 4 h of cellular exposure. In C3h/HeJ mice
implanted with SCCVII tumors, orally delivered lactoferrin inhibited
tumor growth by 75% compared with control mice. Immunohistochemical
analysis of harvested tumors revealed up to 20-fold increases of
lymphocytes within treated animals. When mice were depleted of CD3(+)
cells, all lactoferrin-induced tumor inhibition was abrogated.
CONCLUSION: We conclude that human recombinant lactoferrin can inhibit
the growth of head and neck squamous cell carcinoma via direct
cellular inhibition as well as systemically via immunomodulation. Our
data support the study of human lactoferrin as an immunomodulatory
compound with therapeutic potential.
PMID: 17332307 [PubMed - in process]
Definitions of lactoferrin on the Web:
Iron binding protein of very high affinity (Kd 10exp 19 at pH 6.4, 26
fold greater than that of transferrin) found in milk and in the
specific granules of neutrophil leucocytes.
www.ventria.com/glossary.asp
A protein that is found in milk, tears, mucus, bile, and some white
blood cells and is being studied in the treatment and prevention of
cancer. It is involved in fighting against infection and inflammation
and it acts as an antioxidant.
www.stjude.org/glossary
(n.) lac·to·fer·rin a glycoprotein present in milk, esp. human milk,
and supplying iron to suckling infants.
www.allwords.com/glossaryPage.php
A protein found naturally within milk and saliva, for two examples, as
well as within white blood cells that has been shown in research to be
a natural antibiotic, antioxidant, anti-fungal, antiviral, and immune
booster.
www.nutros.com/nsr-05zzz.html
Lactoferrin is a globular protein found in milk and many mucosal
secretions such as tears. Its molecular atomic mass is 80,000 u (80
kD). This protein belongs to the transferrin family proteins
(transferrin, melanotransferrin, ovotransferin, etc.) showing a high
affinity by iron (ferric state). Lactoferrin is a multifunctional
protein with antimicrobial activity (bacteriocide, fungicide) and is
part of the innate defense proteins mainly at mucoses. ...
en.wikipedia.org/wiki/Lactoferrin
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Oral Lactoferrin Results in T Cell-Dependent Tumor Inhibition of Head
and Neck Squamous Cell Carcinoma In vivo.Wolf JS, Li G, Varadhachary
A, Petrak K, Schneyer M, Li D, Ongkasuwan J, Zhang X, Taylor RJ,
Strome SE, O'malley BW Jr.
Authors' Affiliations: Department of Otorhinolaryngology-Head and Neck
Surgery and Program in Oncology, Stewart and Marlene Greenebaum Cancer
Center, University of Maryland School of Medicine, Baltimore,
Maryland.
PURPOSE: Human lactoferrin is a naturally occurring glycoprotein that
inhibits cancer growth. Our purpose was to evaluate recombinant human
lactoferrin as a chemotherapeutic agent against head and neck squamous
cell carcinoma. EXPERIMENTAL DESIGN: Controlled experiments both in
vitro and in the murine model evaluating both the effect and mechanism
of lactoferrin on cancer growth. RESULTS: In both human and murine
cell lines, lactoferrin induced dose-dependent growth inhibition.
Using flow cytometric analysis, lactoferrin was shown to induce G(1)-
G(0) growth arrest. This arrest seemed to be modulated by down-
regulation of cyclin D1. In the in vitro model, luminex data revealed
that lactoferrin inhibited cellular release of proinflammatory and
prometastatic cytokines, including interleukin-8, interleukin-6,
granulocyte macrophage colony-stimulating factor, and tumor necrosis
factor-alpha. Lactoferrin up-regulated the cellular activation of
nuclear factor-kappaB within 4 h of cellular exposure. In C3h/HeJ mice
implanted with SCCVII tumors, orally delivered lactoferrin inhibited
tumor growth by 75% compared with control mice. Immunohistochemical
analysis of harvested tumors revealed up to 20-fold increases of
lymphocytes within treated animals. When mice were depleted of CD3(+)
cells, all lactoferrin-induced tumor inhibition was abrogated.
CONCLUSION: We conclude that human recombinant lactoferrin can inhibit
the growth of head and neck squamous cell carcinoma via direct
cellular inhibition as well as systemically via immunomodulation. Our
data support the study of human lactoferrin as an immunomodulatory
compound with therapeutic potential.
PMID: 17332307 [PubMed - in process]
Definitions of lactoferrin on the Web:
Iron binding protein of very high affinity (Kd 10exp 19 at pH 6.4, 26
fold greater than that of transferrin) found in milk and in the
specific granules of neutrophil leucocytes.
www.ventria.com/glossary.asp
A protein that is found in milk, tears, mucus, bile, and some white
blood cells and is being studied in the treatment and prevention of
cancer. It is involved in fighting against infection and inflammation
and it acts as an antioxidant.
www.stjude.org/glossary
(n.) lac·to·fer·rin a glycoprotein present in milk, esp. human milk,
and supplying iron to suckling infants.
www.allwords.com/glossaryPage.php
A protein found naturally within milk and saliva, for two examples, as
well as within white blood cells that has been shown in research to be
a natural antibiotic, antioxidant, anti-fungal, antiviral, and immune
booster.
www.nutros.com/nsr-05zzz.html
Lactoferrin is a globular protein found in milk and many mucosal
secretions such as tears. Its molecular atomic mass is 80,000 u (80
kD). This protein belongs to the transferrin family proteins
(transferrin, melanotransferrin, ovotransferin, etc.) showing a high
affinity by iron (ferric state). Lactoferrin is a multifunctional
protein with antimicrobial activity (bacteriocide, fungicide) and is
part of the innate defense proteins mainly at mucoses. ...
en.wikipedia.org/wiki/Lactoferrin
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
