Brain iron removal in muscular dystrophy

Blood. 2007 Mar 22; [Epub ahead of print]Selective iron chelation in
Friedreich ataxia. Biological and clinical implications.Boddaert N, Le
Quan Sang KH, Rotig A, Leroy-Willig A, Gallet S, Brunelle F, Sidi D,
Thalabard JC, Munnich A, Cabantchik ZI.
Pediatric Radiology Unit, ERM0205, Hopital Necker-Enfants Malades &
Universite Paris V Rene Descartes, Paris, France.

Genetic disorders of iron metabolism and chronic inflammation often
evoke local iron accumulation. In Friedreich-ataxia, decreased iron-
sulphur-cluster and haem formation leads to mitochondrial iron
accumulation and ensuing oxidative damage that affect primarily
sensory neurons, myocardium and endocrine glands. We assessed the
possibility of reducing brain iron accumulation in Friedreich-ataxia
patients with a membrane-permeant chelator capable of shuttling
chelated-iron from cells to transferrin, using regimens suitable for
patients with no systemic iron overload. Brain MRI of Friedreich-
ataxia patients compared to age-matched controls revealed smaller and
irregularly shaped dentate-nuclei with significantly (p<0.027) higher
H-relaxation rates R2*, indicating regional iron accumulation. A six-
month treatment with 20-30mg/kg/d deferiprone applied on 11/20
adolescent patients with no overt cardiomyopathy reduced R2* from
18.3+/-1.6 to 15.7+/-0.7msec(-1) (p<0.002) specifically in dentate
nuclei and proportionally to the initial R2* (r=0.90). Chelator-
treatment caused no apparent haematological or neurological side-
effects, while reducing neuropathy and ataxic-gait in the youngest
patients. To our knowledge, this is the first clinical demonstration
of chelation removing labile iron accumulated in a specific brain area
implicated in a neurodegenerative disease. The use of moderate
chelation for relocating iron from areas of deposition to areas of
deprivation has clinical implications for various neurodegenerative
and haematological disorders.

PMID: 17379741 [PubMed - as supplied by publisher]


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Mar 26, 6:17 am, "ironjustice" <teamtan...@hotmail.com> wrote:
> Blood. 2007 Mar 22; [Epub ahead of print]Selective iron chelation in
> Friedreich ataxia. Biological and clinical implications.Boddaert N, Le
> Quan Sang KH, Rotig A, Leroy-Willig A, Gallet S, Brunelle F, Sidi D,
> Thalabard JC, Munnich A, Cabantchik ZI.
> Pediatric Radiology Unit, ERM0205, Hopital Necker-Enfants Malades &
> Universite Paris V Rene Descartes, Paris, France.
>
> Genetic disorders of iron metabolism and chronic inflammation often
> evoke local iron accumulation. In Friedreich-ataxia, decreased iron-
> sulphur-cluster and haem formation leads to mitochondrial iron
> accumulation and ensuing oxidative damage that affect primarily
> sensory neurons, myocardium and endocrine glands. We assessed the
> possibility of reducing brain iron accumulation in Friedreich-ataxia
> patients with a membrane-permeant chelator capable of shuttling
> chelated-iron from cells to transferrin, using regimens suitable for
> patients with no systemic iron overload. Brain MRI of Friedreich-
> ataxia patients compared to age-matched controls revealed smaller and
> irregularly shaped dentate-nuclei with significantly (p<0.027) higher
> H-relaxation rates R2*, indicating regional iron accumulation. A six-
> month treatment with 20-30mg/kg/d deferiprone applied on 11/20
> adolescent patients with no overt cardiomyopathy reduced R2* from
> 18.3+/-1.6 to 15.7+/-0.7msec(-1) (p<0.002) specifically in dentate
> nuclei and proportionally to the initial R2* (r=0.90). Chelator-
> treatment caused no apparent haematological or neurological side-
> effects, while reducing neuropathy and ataxic-gait in the youngest
> patients. To our knowledge, this is the first clinical demonstration
> of chelation removing labile iron accumulated in a specific brain area
> implicated in a neurodegenerative disease. The use of moderate
> chelation for relocating iron from areas of deposition to areas of
> deprivation has clinical implications for various neurodegenerative
> and haematological disorders.
>
> PMID: 17379741 [PubMed - as supplied by publisher]
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://jesuswasavegetarian.7h.com
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

I had a friend who had heart disease and chose to treat it with
kelation therapy he seemed to think it was working but the heart is a
muscle and maybe he built it up thru extercise because he kept telling
himself he was better .

>>On Mar 28, 10:26 am, "doggie007farn...@gmail.com" <doggie007farn...@gmail.com> wrote: I had a friend who had heart disease and chose to treat it with
kelation therapy he seemed to think it was working but the heart is a
muscle and maybe he built it up thru extercise because he kept
telling
himself he was better .<<

Chelation for the heart is becoming pretty main stream now .. soo ..
he was a little ahead of his time ..

About Thalassemia Excess iron must be removed through a process known
as "chelation. ... All patients had their cardiac iron content
measured by a new technique called ...
www.cooleysanemia.org/bodies/body325.php - 35k - Cached - Similar
pages

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

For more information on thalassemia you can visit a moderated
Thalassemia Patients discussions forum -
Thalforum - A Thalassemia Community Forum for discussions on various
topics connected to Thalassemia.

http://www.thalforum.ca/forums