Iron and Metabolic Syndrome

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first prospective study associating ferritin and transferrin with the
metabolic syndrome
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Diabetes Care. 2007 Apr 6; [Epub ahead of print]Ferrritin and
transferrin are associated with metabolic syndrome abnormalities and
their change over time in a general population. The D.E.S.I.R.
Study.Vari IS, Balkau B, Kettaneh A, Andre P, Tichet J, Fumeron F,
Caces E, Marre M, Grandchamp B, Ducimetiere P.
INSERM Unite 780-IFR69, Epidemiological and Biostatistical Research,
Villejuif, France.

OBJECTIVE To study cross-sectional and longitudinal relations between
iron stocks (ferritin) and the iron transport protein (transferrin)
with the metabolic syndrome and its abnormalities. METHODS 469 men,
278 pre- and 197 post-menopausal women from the French D.E.S.I.R.
cohort, aged 30-65 years, were followed over six years. RESULTS Higher
concentrations of both ferritin and transferrin were associated with
the IDF, NCEP-ATP III original and revised metabolic syndromes at
baseline: for the IDF metabolic syndrome the standardized, age-
adjusted odds ratios (95% CI) for log(ferritin) were: 1.49 (1.14-1.94)
for men, 2.10 (1.27-3.48) for pre-menopausal women, 1.80 (1.21-2.68)
for post-menopausal women; for transferrin they were respectively:
1.94 (1.53-2.47), 2.22 (1.32-3.75), 2.14 (1.47-3.10). After 6-years of
follow-up, the change in the presence of the metabolic syndrome was
associated with higher baseline log(ferritin) in all three groups:
1.46 (1.13-1.89), 1.28 (0.85-1.94), 1.62 (1.10-2.38), and transferrin:
1.41 (1.10-1.81), 1.63 (1.05-2.52), 1.51 (1.02-2.22). Among syndrome
components, hypertriglyceridemia at 6 years was the component most
strongly associated with baseline ferritin and transferrin. The odds
of an incident IDF-defined metabolic syndrome after 6 years, was more
than four-fold higher when ferritin and transferrin were both above
the group-specific top tertile, in comparison with participants with
both parameters below these thresholds. CONCLUSIONS This is the first
prospective study associating ferritin and transferrin with the
metabolic syndrome and its components. When both markers of the iron
metabolism are elevated, the incidence of the metabolic syndrome is
increased in men and both pre- and post-menopausal women.

PMID: 17416791 [PubMed - as supplied by publisher]


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