Vitamin E therapy / dialysis

Vitamin E therapy / dialysis

Effect of vitamin E therapy on oxidative stress and erythrocyte osmotic
fragility in patients on peritoneal dialysis and hemodialysis.
Uzum A, Toprak O, Gumustas MK, Ciftci S, Sen S
J Nephrol. 2006 Nov-Dec ; 19(6): 739-45

Background: Several medications have been tested with the aim of
decreasing oxidative stress and erythrocyte osmotic fragility in
patients on dialysis. The aim of the present study was to assess the
influence of vitamin E therapy on oxidative stress and erythrocyte
osmotic fragility in patients on hemodialysis (HD) and peritoneal
dialysis (PD). Methods: This was a placebo-controlled study. The study
was performed on 34 HD patients, 13 PD patients and 22 he-althy
volunteers with a mean age of 45.57 +/- 8.54 years. HD patients were
divided into 2 groups: treatment (n=19) and control (n=15). Vitamin E
was administered, 300 mg/day, to the HD treatment group and PD patients
for 20 weeks. Lipid peroxidation, antioxidant condition and erythrocyte
osmotic fragility (EOF) were examined before and after treatment.
Results:Before the treatment, the levels of EOF (p<0.001) and
malondialdehyde (MDA) (p<0.001) were significantly lower, and
erythrocyte superoxide dismutase (SOD) (p=0.001) and vitamin E levels
(p<0.001) were significantly higher in the healthy group than PD and HD
groups. Serum vitamin E increased from 0.93 +/- 0.16 to 1.09 +/- 0.14
mg/dL (p=0.001), EOF decreased from 0.49% +/- 0.03% to 0.42% +/- 0.04%
NaCl (p<0.001), and plasma MDA values decreased from 2.77 +/- 0.87 to
2.20 +/- 0.767 nmol/mL (p=0.018) in the HD treatment group after
vitamin E treatment. Levels of EOF decreased from 0.51% +/- 0.09% to
0.43% +/- 0.03% NaCl in the PD treatment group after vitamin E
treatment (p=0.021). Conclusion: Vitamin E therapy is effective in
decreasing the levels of EOF in patients on HD and PD, and it is also
effective in decreasing lipid peroxidation in patients on HD.


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