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New data on type 2 diabetes and serum ferritin
New data on type 2 diabetes and serum ferritin
Investigators at Kochi University release new data on type 2 diabetes
2007 JAN 15 -- Scientists discuss in "Association between serum
ferritin and circulating oxidized low-density lipoprotein levels in
patients with type 2 diabetes" new findings in type 2 diabetes.
According to recent research published in the Endocrine Journal, "The
oxidative modification of low-density lipoproteins (LDL) plays a
central role in the initiation and acceleration of atherosclerosis.
Iron plays a part in the formation of highly toxic free radicals such
as hydroxide and superoxide anions, which can induce lipid
peroxidation."
<<snip>>
We investigated whether serum iron status was associated with
circulating oxidized LDL (oxLDL) levels in type 2 ... serum ferritin is
associated with circulating oxLDL levels in patients with type 2
diabetes
<<snip>>
Endocr J. 2006 Oct;53(5):665-70. Epub 2006 Aug 11. Related Articles,
Links
Association between serum ferritin and circulating oxidized low-density
lipoprotein levels in patients with type 2 diabetes.
Ikeda Y, Suehiro T, Yamanaka S, Kumon Y, Takata H, Inada S, Ogami N,
Osaki F, Inoue M, Arii K, Hashimoto K.
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical
School, Kochi University, Kohasu, Kochi, Japan.
The oxidative modification of low-density lipoproteins (LDL) plays a
central role in the initiation and acceleration of atherosclerosis.
Iron plays a part in the formation of highly toxic free radicals such
as hydroxide and superoxide anions, which can induce lipid
peroxidation. We investigated whether serum iron status was associated
with circulating oxidized LDL (oxLDL) levels in type 2 diabetic
patients, in whom oxidative stress and susceptibility to lipid
oxidation were supposedly increased. Serum ferritin levels were
significantly correlated with plasma oxLDL concentrations in both male
and female patients (p<0.02 and p<0.05, respectively). No correlation
was detected between ferritin and LDL-cholesterol (LDL-C)
concentrations despite the close correlation between LDL-C and oxLDL
concentrations (p<0.0001). Stepwise regression analysis showed that
ferritin concentration was an independent positive determinant of oxLDL
level, in addition to triglyceride concentration, body mass index and
sex. This is the first report to show that serum ferritin is associated
with circulating oxLDL levels in patients with type 2 diabetes. Further
work is required to establish a causative link between iron excess and
the development of diabetic vascular complications.
PMID: 16902260 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Investigators at Kochi University release new data on type 2 diabetes
2007 JAN 15 -- Scientists discuss in "Association between serum
ferritin and circulating oxidized low-density lipoprotein levels in
patients with type 2 diabetes" new findings in type 2 diabetes.
According to recent research published in the Endocrine Journal, "The
oxidative modification of low-density lipoproteins (LDL) plays a
central role in the initiation and acceleration of atherosclerosis.
Iron plays a part in the formation of highly toxic free radicals such
as hydroxide and superoxide anions, which can induce lipid
peroxidation."
<<snip>>
We investigated whether serum iron status was associated with
circulating oxidized LDL (oxLDL) levels in type 2 ... serum ferritin is
associated with circulating oxLDL levels in patients with type 2
diabetes
<<snip>>
Endocr J. 2006 Oct;53(5):665-70. Epub 2006 Aug 11. Related Articles,
Links
Association between serum ferritin and circulating oxidized low-density
lipoprotein levels in patients with type 2 diabetes.
Ikeda Y, Suehiro T, Yamanaka S, Kumon Y, Takata H, Inada S, Ogami N,
Osaki F, Inoue M, Arii K, Hashimoto K.
Department of Endocrinology, Metabolism and Nephrology, Kochi Medical
School, Kochi University, Kohasu, Kochi, Japan.
The oxidative modification of low-density lipoproteins (LDL) plays a
central role in the initiation and acceleration of atherosclerosis.
Iron plays a part in the formation of highly toxic free radicals such
as hydroxide and superoxide anions, which can induce lipid
peroxidation. We investigated whether serum iron status was associated
with circulating oxidized LDL (oxLDL) levels in type 2 diabetic
patients, in whom oxidative stress and susceptibility to lipid
oxidation were supposedly increased. Serum ferritin levels were
significantly correlated with plasma oxLDL concentrations in both male
and female patients (p<0.02 and p<0.05, respectively). No correlation
was detected between ferritin and LDL-cholesterol (LDL-C)
concentrations despite the close correlation between LDL-C and oxLDL
concentrations (p<0.0001). Stepwise regression analysis showed that
ferritin concentration was an independent positive determinant of oxLDL
level, in addition to triglyceride concentration, body mass index and
sex. This is the first report to show that serum ferritin is associated
with circulating oxLDL levels in patients with type 2 diabetes. Further
work is required to establish a causative link between iron excess and
the development of diabetic vascular complications.
PMID: 16902260 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
