Iron exposure and transmission of HHV-8 infection

Iron exposure and transmission of HHV-8 infection

Cancer Lett. 2006 Nov 28;244(1):1-7. Epub 2006 Mar 20. Links
Role of environmental factors in the pathogenesis of classic and
African-endemic Kaposi sarcoma.Simonart T.
Department of Dermatology, Erasme University Hospital, Route de Lennik
808, B-1070 Brussels, Belgium. tsimonar@ulb.ac.be

Kaposi sarcoma (KS) is a mesenchymal tumour associated with human
herpesvirus-8 (HHV-8) infection. However, the incidence of HHV-8
infection is far higher than the prevalence of KS, suggesting that
viral infection per se is not sufficient for the development of
aggressive phenotype and that one or more additional cofactors are
required. The great geographical variation in African-endemic and
classic KS incidence points to a role for environmental factors in the
etiology of Kaposi sarcoma. However, there are few unequivocably
established environmental factors involved in KS pathogenesis. This
review focuses on the environmental factors thought to be associated
with KS, more particularly iron exposure and facilitation of
transmission of HHV-8 infection by contact with blood-sucking
arthropods.

PMID: 16542773 [PubMed - in process]

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