Oxidative stress and nonalcoholic fatty liver disease (NAFLD)

Oxidative stress and nonalcoholic fatty liver disease (NAFLD)

Int J Mol Med. 2007 Jan;19(1):17-22. Links
Pulmonary exposure to diesel exhaust particles enhances fatty change of
the liver in obese diabetic mice.Tomaru M, Takano H, Inoue K,
Yanagisawa R, Osakabe N, Yasuda A, Shimada A, Kato Y, Uematsu H.
Gerodontology, Department of Gerodontology, Division of Gerontology and
Gerodontology, Graduate School, Tokyo Medical and Dental University,
Tokyo, Japan.

In epidemiological studies, exposure to ambient particulate matter (PM)
has been reported to be positively associated with mortality in
subjects with diabetes mellitus. Diesel exhaust particles (DEP) are
major constituents of atmospheric PM. However, there is no experimental
evidence for the relation of DEP to diabetes mellitus and its
complications. We investigated the effects of DEP inoculated
intratracheally on diabetic changes and nonalcoholic fatty liver
disease (NAFLD) in diabetic obese and control mice. db/db mice and the
corresponding nondiabetic db/+m mice received exposure to vehicle or
DEP every two weeks. Animals were examined with biochemistry,
histology, and immunohistochemistry for hexanoyl-lysine (HEL) in the
liver. In the db/+m mice, pulmonary exposure to DEP did not increase
levels of aspartate aminotransferase (AST) or alanine aminotransferase
(ALT) compared to that to vehicle. In the db/db mice, however, the
exposure to DEP increased the levels of AST and ALT compared to that to
vehicle. Only in the db/db mice, DEP enhanced the magnitude of
steatosis and formation of HEL, a marker of oxidative stress, in the
liver compared to vehicle. These results suggest that pulmonary
exposure to DEP, PM, enhances steatosis in the liver of obese diabetic
subjects possibly via enhanced oxidative stress.

PMID: 17143543 [PubMed - in process]

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Toxicol In Vitro. 2006 Sep;20(6):851-7. Epub 2006 Feb 13. Links
The role of iron in reactive oxygen species generation from diesel
exhaust particles.Park S, Nam H, Chung N, Park JD, Lim Y.
Department of Biochemistry and Molecular Biology, Mayo Clinic and
Foundation, Rochester, MN 55905, USA.

Diesel exhaust particles (DEP) are known to produce reactive oxygen
species (ROS), which induce oxidative stress and inflammation in the
lung and respiratory tract. DEP are composed of polycyclic aromatic
hydrocarbons (PAH) and their derivatives, redox active semi-quinones,
and trace amounts of heavy metals. ROS production was measured by
thiobarbituric acid-reactive substances of deoxyribose (TBARS)
formation from DEP samples obtained from Korea (DEP-KO), and the
Standard Reference Material (SRM) 2975 to explore the role of
transition metals. Both DEP-KO and SRM2975 had similar amounts of
transition metals, whereas DEP-KO contained more iron, but less copper
and zinc, than SRM2975. The water-soluble fraction from SRM2975, but
not that from DEP-KO, had a broad absorption in the visible region, but
not from DEP-KO, obscuring an accurate absorption measurement of TBARS.
Fluorescence measurements of TBARS generation in a water-soluble
extract showed that SRM2975 produces more TBARS, but the addition of
hydrogen peroxide (H2O2) generated more TBARS in DEP-KO than in
SRM2975, consistent with the higher amounts of iron in DEP-KO. The
incubation of DEP with iron chelators inhibited the production of
TBARS. Finally, a novel use of the fluorogenic spin trap probe, proxyl
fluorescamine, enabled the detection of the ROS production from both
DEP-KO and SRM2975. Our findings suggested that careful consideration
is needed to measure TBARS production in DEP, and that iron in DEP
seems to be more important than other transition metals in H2O2-induced
ROS generation.

PMID: 16473492 [PubMed - indexed for MEDLINE]


Who loves ya.
Tom


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Re: Oxidative stress and nonalcoholic fatty liver disease (NAFLD)


ironjustice wrote:
> Int J Mol Med. 2007 Jan;19(1):17-22. Links
> Pulmonary exposure to diesel exhaust particles enhances fatty change of
> the liver in obese diabetic mice.Tomaru M, Takano H, Inoue K,
> Yanagisawa R, Osakabe N, Yasuda A, Shimada A, Kato Y, Uematsu H.
> Gerodontology, Department of Gerodontology, Division of Gerontology and
> Gerodontology, Graduate School, Tokyo Medical and Dental University,
> Tokyo, Japan.
>
> In epidemiological studies, exposure to ambient particulate matter (PM)
> has been reported to be positively associated with mortality in...

It may indicate crowded/polluted cities effect resulting persisting
hyperglycemia or medicines are less effective in cities. To understand;

Whether diabetics living in non-polluted areas don't get non-alcoholic
fatty liver?

Whether/why oxidative stress cause fatty changes?

Sorry, other question on iron;

Can iron make a person more intelligent whereas Mg. lesser...animal
type/plant type...lion/meat eating animals more intelligent than plant
eating animals?

Re: Oxidative stress and nonalcoholic fatty liver disease (NAFLD)


>>Kumar wrote:It may indicate crowded/polluted cities effect resulting persisting
hyperglycemia or medicines are less effective in cities. To understand;
<<

It would increase the .. rate / earlier induction .. as in the asthma
patients who manifest / are exacerbated BY pollution DUE TO the ..
**increased** oxidative stress ..

Sooo .. the oxidative stress .. COMPOUNDS the .. already .. present ..
presymptoms ..

>>Whether diabetics living in non-polluted areas don't get non-alcoholic
fatty liver? <<

One can pretty much discern that they .. do ..


>>Whether/why oxidative stress cause fatty changes? <<

The association has been made .. somewhat ..

Increased oxidative stress by diesal particulates have been shown to ..
INCREASE .. fatty liver disease ..


>>Sorry, other question on iron;


Can iron make a person more intelligent whereas Mg. lesser...animal
type/plant type...lion/meat eating animals more intelligent than plant
eating animals? <<

YOU eat .. meat .. which leads to increased iron ..

YOU asked a question on a thread .. about .. "type 2 diabetes" and
asked .. "is this about type 1 .. ?"

The question you posed .. "Can iron make a person more intelligent" ..
it seems you have already .. answered .. somewhat ..

That would be .. no ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com


Man Is A Herbivore!
* tinyurl . com /a3cc3


DEAD PEOPLE WALKING
* tinyurl . com /zk9fk

Re: Oxidative stress and nonalcoholic fatty liver disease (NAFLD)


ironjustice wrote:
> >>Kumar wrote:It may indicate crowded/polluted cities effect resulting persisting
> hyperglycemia or medicines are less effective in cities. To understand;
> <<
>
> It would increase the .. rate / earlier induction .. as in the asthma
> patients who manifest / are exacerbated BY pollution DUE TO the ..
> **increased** oxidative stress ..
>
> Sooo .. the oxidative stress .. COMPOUNDS the .. already .. present ..
> presymptoms ..
>
> >>Whether diabetics living in non-polluted areas don't get non-alcoholic
> fatty liver? <<
>
> One can pretty much discern that they .. do ..
>
>
> >>Whether/why oxidative stress cause fatty changes? <<
>
> The association has been made .. somewhat ..
>
> Increased oxidative stress by diesal particulates have been shown to ..
> INCREASE .. fatty liver disease ..
>
>
> >>Sorry, other question on iron;
>
>
> Can iron make a person more intelligent whereas Mg. lesser...animal
> type/plant type...lion/meat eating animals more intelligent than plant
> eating animals? <<
>
> YOU eat .. meat .. which leads to increased iron ..
Can't acidity in stomach also lead to increased iron digestion so
absorption?
> YOU asked a question on a thread .. about .. "type 2 diabetes" and
> asked .. "is this about type 1 .. ?"
Type2..but different question from this topic.
> The question you posed .. "Can iron make a person more intelligent" ..
> it seems you have already .. answered .. somewhat ..
>
> That would be .. no ..
Let us consider Veg people absorbing more iron due to acidity(may be
more nowadays) and non-veg people. In anyway, it looks iron is related
to intelligency and meat eating type behaviour..
> Who loves ya.
> Tom
>
>
> Jesus Was A Vegetarian!
> * jesuswasavegetarian.7h . com
>
>
> Man Is A Herbivore!
> * tinyurl . com /a3cc3
>
>
> DEAD PEOPLE WALKING
> * tinyurl . com /zk9fk