JohnDoe@WrongISP.gov wrote:
> "johngohde@naturalhealthperspective . com "
> <zxcvb@naturalhealthperspective . com > wrote:
>
>> Hydrocodone is another name for ibuprofen."
>
> Wrong.
>
> Hydrocodone:
>
> "Hydrocodone bitartrate is a phenanthrene-derivative opiate agonist
> that is used as an antitussive and analgesic agent. Hydrocodone is a
> hydrogenated ketone derivative of codeine. Hydrocodone bitartrate
> occurs as fine, white crystals or crystalline powder and is soluble in
> water and slightly soluble in alcohol. Hydrocodone polistirex consists
> of hydrocodone with a cation-exchange resin copolymer complex of
> sulfonated styrene-divinylbenzene. Hydrocodone bitartrate and
> hydrocodone polistirex are currently commercially available only in
> combination products."
>
> Ibuprofen:
>
> "Ibuprofen is a prototypical nonsteroidal anti-inflammatory agent
> (NSAIA). Ibuprofen is commercially available as the acid and as the
> potassium salt. Ibuprofen is a racemic mixture of 2 optical isomers.
> In vivo and in vitro studies indicate that only the l-isomer of
> ibuprofen has clinical activity. However, the d-isomer, which is
> considered clinically inactive, is slowly and incompletely (by about
> 60%) converted to the l-isomer in adults; the degree of such
> conversion is believed to be similar in children. It also has been
> suggested that the d-isomer serves as a circulating reservoir to
> maintain concentration of the active drug. Ibuprofen occurs as a white
> to off-white, crystalline powder having a slight, characteristic odor
> and is practically insoluble in water and very soluble in alcohol. The
> apparent pKa of ibuprofen is about 4.4."
>
> Note the last sentence of the Hydrocodone paragraph. The "combination
> products" include Ibuprofen. There's a long list of others though. The
> idea of the combination is so that nanny can prevent us getting high,
> somthing you'd doubtless approve of.
>
Wait a minute! If Ibuprofen is a racemic mixture of two optical
isomers, how can it be a "combination product"?
(Hydrocodone is number 4806 in the Merck Index, and Ibuprofen is number
4906.) The former has a molecular weight of 299.36, and the latter,
206.28. Neither of them is a combination product.
Hydrocodone's a habit-forming, opiate, narcotic, controlled substance
made from codeine; Ibuprofen is a common, over-the-counter
anti-inflammatory analgesic.
On the other hand, perhaps you didn't imply that Ibuprofen is a
combination product, but that certain, unnamed combination products
"include" (i.e., contain) it.
Oh, well. Never mind.
Moving right along now... :-)
--
Marshall Price of Miami
Known to Yahoo as d021317c