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Testosterone and negative symptoms of schizophrenia
Testosterone and negative symptoms of schizophrenia
Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
Association between serum testosterone levels and the severity of
negative symptoms in male patients with chronic schizophrenia.
* Ko YH,
* Jung SW,
* Joe SH,
* Lee CH,
* Jung HG,
* Jung IK,
* Kim SH,
* Lee MS.
Department of Psychiatry, Korea University College of Medicine, Ansan
Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
Korea.
OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
contribute to the pathophysiology of schizophrenia. Recent
neuroendocrinological studies have suggested that gonadal sex hormones,
including androgens and estrogen, play a significant role in the
pathophysiology of schizophrenia. The purpose of this study was to
determine any correlation between negative symptoms and the plasma levels
of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
estradiol, and prolactin with consideration to depressive symptoms,
extrapyramidal symptoms (EPS), and other factors including differences in
age, diurnal variation of the serum hormone levels, and body fat
composition. METHODS: The subjects were 35 male inpatients with chronic
schizophrenia aged 20-39 years. The patients' psychopathology was assessed
using the Positive and Negative Syndrome Scale (PANSS). The Calgary
Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
(DIEPSS) were also used to exclude the effects of depression or
drug-induced movement disorders. RESULTS: The PANSS negative scores had a
significant inverse correlation with the serum total and free testosterone
levels. The other hormone levels were not correlated with the PANSS
negative scores. Moreover, a partial correlation analysis showed an inverse
correlation between the PANSS negative subscores and the serum total and
free testosterone levels after controlling for the DIEPSS and/or CDSS
scores and age. CONCLUSIONS: This study indicates that total and free
testosterone may play an important role in the severity of negative
symptoms in male patients with schizophrenia.
Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
Association between serum testosterone levels and the severity of
negative symptoms in male patients with chronic schizophrenia.
* Ko YH,
* Jung SW,
* Joe SH,
* Lee CH,
* Jung HG,
* Jung IK,
* Kim SH,
* Lee MS.
Department of Psychiatry, Korea University College of Medicine, Ansan
Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
Korea.
OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
contribute to the pathophysiology of schizophrenia. Recent
neuroendocrinological studies have suggested that gonadal sex hormones,
including androgens and estrogen, play a significant role in the
pathophysiology of schizophrenia. The purpose of this study was to
determine any correlation between negative symptoms and the plasma levels
of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
estradiol, and prolactin with consideration to depressive symptoms,
extrapyramidal symptoms (EPS), and other factors including differences in
age, diurnal variation of the serum hormone levels, and body fat
composition. METHODS: The subjects were 35 male inpatients with chronic
schizophrenia aged 20-39 years. The patients' psychopathology was assessed
using the Positive and Negative Syndrome Scale (PANSS). The Calgary
Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
(DIEPSS) were also used to exclude the effects of depression or
drug-induced movement disorders. RESULTS: The PANSS negative scores had a
significant inverse correlation with the serum total and free testosterone
levels. The other hormone levels were not correlated with the PANSS
negative scores. Moreover, a partial correlation analysis showed an inverse
correlation between the PANSS negative subscores and the serum total and
free testosterone levels after controlling for the DIEPSS and/or CDSS
scores and age. CONCLUSIONS: This study indicates that total and free
testosterone may play an important role in the severity of negative
symptoms in male patients with schizophrenia.
Re: Testosterone and negative symptoms of schizophrenia
"James Michael Howard" <jmhoward@anthropogeny,com > wrote in message
news:5ac213t2l160cuvojpqe6hv7pjd1eg6fvq@4ax,com ...
>
> Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
>
> Association between serum testosterone levels and the severity of
> negative symptoms in male patients with chronic schizophrenia.
>
> * Ko YH,
> * Jung SW,
> * Joe SH,
> * Lee CH,
> * Jung HG,
> * Jung IK,
> * Kim SH,
> * Lee MS.
>
> Department of Psychiatry, Korea University College of Medicine, Ansan
> Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
> Korea.
>
> OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
> contribute to the pathophysiology of schizophrenia. Recent
> neuroendocrinological studies have suggested that gonadal sex hormones,
> including androgens and estrogen, play a significant role in the
> pathophysiology of schizophrenia. The purpose of this study was to
> determine any correlation between negative symptoms and the plasma levels
> of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
> estradiol, and prolactin with consideration to depressive symptoms,
> extrapyramidal symptoms (EPS), and other factors including differences in
> age, diurnal variation of the serum hormone levels, and body fat
> composition. METHODS: The subjects were 35 male inpatients with chronic
> schizophrenia aged 20-39 years. The patients' psychopathology was assessed
> using the Positive and Negative Syndrome Scale (PANSS). The Calgary
> Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
> (DIEPSS) were also used to exclude the effects of depression or
> drug-induced movement disorders. RESULTS: The PANSS negative scores had a
> significant inverse correlation with the serum total and free testosterone
> levels. The other hormone levels were not correlated with the PANSS
> negative scores. Moreover, a partial correlation analysis showed an
> inverse
> correlation between the PANSS negative subscores and the serum total and
> free testosterone levels after controlling for the DIEPSS and/or CDSS
> scores and age. CONCLUSIONS: This study indicates that total and free
> testosterone may play an important role in the severity of negative
> symptoms in male patients with schizophrenia.
Just imagine a world with no testosterone. With zero tolerance for
testosterone? Where would all the mammals be?
"James Michael Howard" <jmhoward@anthropogeny,com > wrote in message
news:5ac213t2l160cuvojpqe6hv7pjd1eg6fvq@4ax,com ...
>
> Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
>
> Association between serum testosterone levels and the severity of
> negative symptoms in male patients with chronic schizophrenia.
>
> * Ko YH,
> * Jung SW,
> * Joe SH,
> * Lee CH,
> * Jung HG,
> * Jung IK,
> * Kim SH,
> * Lee MS.
>
> Department of Psychiatry, Korea University College of Medicine, Ansan
> Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
> Korea.
>
> OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
> contribute to the pathophysiology of schizophrenia. Recent
> neuroendocrinological studies have suggested that gonadal sex hormones,
> including androgens and estrogen, play a significant role in the
> pathophysiology of schizophrenia. The purpose of this study was to
> determine any correlation between negative symptoms and the plasma levels
> of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
> estradiol, and prolactin with consideration to depressive symptoms,
> extrapyramidal symptoms (EPS), and other factors including differences in
> age, diurnal variation of the serum hormone levels, and body fat
> composition. METHODS: The subjects were 35 male inpatients with chronic
> schizophrenia aged 20-39 years. The patients' psychopathology was assessed
> using the Positive and Negative Syndrome Scale (PANSS). The Calgary
> Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
> (DIEPSS) were also used to exclude the effects of depression or
> drug-induced movement disorders. RESULTS: The PANSS negative scores had a
> significant inverse correlation with the serum total and free testosterone
> levels. The other hormone levels were not correlated with the PANSS
> negative scores. Moreover, a partial correlation analysis showed an
> inverse
> correlation between the PANSS negative subscores and the serum total and
> free testosterone levels after controlling for the DIEPSS and/or CDSS
> scores and age. CONCLUSIONS: This study indicates that total and free
> testosterone may play an important role in the severity of negative
> symptoms in male patients with schizophrenia.
Just imagine a world with no testosterone. With zero tolerance for
testosterone? Where would all the mammals be?
Re: Testosterone and negative symptoms of schizophrenia
On Thu, 5 Apr 2007 18:56:14 -0400, "Dr. Wayne Simon"
<wayne.simon@comcast,net > wrote:
>
>"James Michael Howard" <jmhoward@anthropogeny,com > wrote in message
>news:5ac213t2l160cuvojpqe6hv7pjd1eg6fvq@4ax,com ...
>>
>> Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
>>
>> Association between serum testosterone levels and the severity of
>> negative symptoms in male patients with chronic schizophrenia.
>>
>> * Ko YH,
>> * Jung SW,
>> * Joe SH,
>> * Lee CH,
>> * Jung HG,
>> * Jung IK,
>> * Kim SH,
>> * Lee MS.
>>
>> Department of Psychiatry, Korea University College of Medicine, Ansan
>> Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
>> Korea.
>>
>> OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
>> contribute to the pathophysiology of schizophrenia. Recent
>> neuroendocrinological studies have suggested that gonadal sex hormones,
>> including androgens and estrogen, play a significant role in the
>> pathophysiology of schizophrenia. The purpose of this study was to
>> determine any correlation between negative symptoms and the plasma levels
>> of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
>> estradiol, and prolactin with consideration to depressive symptoms,
>> extrapyramidal symptoms (EPS), and other factors including differences in
>> age, diurnal variation of the serum hormone levels, and body fat
>> composition. METHODS: The subjects were 35 male inpatients with chronic
>> schizophrenia aged 20-39 years. The patients' psychopathology was assessed
>> using the Positive and Negative Syndrome Scale (PANSS). The Calgary
>> Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
>> (DIEPSS) were also used to exclude the effects of depression or
>> drug-induced movement disorders. RESULTS: The PANSS negative scores had a
>> significant inverse correlation with the serum total and free testosterone
>> levels. The other hormone levels were not correlated with the PANSS
>> negative scores. Moreover, a partial correlation analysis showed an
>> inverse
>> correlation between the PANSS negative subscores and the serum total and
>> free testosterone levels after controlling for the DIEPSS and/or CDSS
>> scores and age. CONCLUSIONS: This study indicates that total and free
>> testosterone may play an important role in the severity of negative
>> symptoms in male patients with schizophrenia.
>
>Just imagine a world with no testosterone. With zero tolerance for
>testosterone? Where would all the mammals be?
>
I think the emergence of primates is a result of increases in testosterone
in mammalia:
http :// www .anthropogeny,com /Mitochondrial%20Eve,%20Y%20Chromosome%20Adam,%20Testosterone%20and%20Human%20Evolution.htm
On Thu, 5 Apr 2007 18:56:14 -0400, "Dr. Wayne Simon"
<wayne.simon@comcast,net > wrote:
>
>"James Michael Howard" <jmhoward@anthropogeny,com > wrote in message
>news:5ac213t2l160cuvojpqe6hv7pjd1eg6fvq@4ax,com ...
>>
>> Psychoneuroendocrinology. 2007 Mar 27; [Epub ahead of print]
>>
>> Association between serum testosterone levels and the severity of
>> negative symptoms in male patients with chronic schizophrenia.
>>
>> * Ko YH,
>> * Jung SW,
>> * Joe SH,
>> * Lee CH,
>> * Jung HG,
>> * Jung IK,
>> * Kim SH,
>> * Lee MS.
>>
>> Department of Psychiatry, Korea University College of Medicine, Ansan
>> Hospital, Gojan-1(il)-dong, Danwon-gu, Ansan-si, Gyeonggi-do 425-707,
>> Korea.
>>
>> OBJECTIVES: Dysfunction of the hypothalamic-pituitary-gonadal axis may
>> contribute to the pathophysiology of schizophrenia. Recent
>> neuroendocrinological studies have suggested that gonadal sex hormones,
>> including androgens and estrogen, play a significant role in the
>> pathophysiology of schizophrenia. The purpose of this study was to
>> determine any correlation between negative symptoms and the plasma levels
>> of free testosterone, total testosterone, dehydroepiandrosterone sulfate,
>> estradiol, and prolactin with consideration to depressive symptoms,
>> extrapyramidal symptoms (EPS), and other factors including differences in
>> age, diurnal variation of the serum hormone levels, and body fat
>> composition. METHODS: The subjects were 35 male inpatients with chronic
>> schizophrenia aged 20-39 years. The patients' psychopathology was assessed
>> using the Positive and Negative Syndrome Scale (PANSS). The Calgary
>> Depression Scale for Schizophrenia (CDSS) and the Drug-induced EPS scale
>> (DIEPSS) were also used to exclude the effects of depression or
>> drug-induced movement disorders. RESULTS: The PANSS negative scores had a
>> significant inverse correlation with the serum total and free testosterone
>> levels. The other hormone levels were not correlated with the PANSS
>> negative scores. Moreover, a partial correlation analysis showed an
>> inverse
>> correlation between the PANSS negative subscores and the serum total and
>> free testosterone levels after controlling for the DIEPSS and/or CDSS
>> scores and age. CONCLUSIONS: This study indicates that total and free
>> testosterone may play an important role in the severity of negative
>> symptoms in male patients with schizophrenia.
>
>Just imagine a world with no testosterone. With zero tolerance for
>testosterone? Where would all the mammals be?
>
I think the emergence of primates is a result of increases in testosterone
in mammalia:
http :// www .anthropogeny,com /Mitochondrial%20Eve,%20Y%20Chromosome%20Adam,%20Testosterone%20and%20Human%20Evolution.htm
