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How to spin a vaccine study?
How to spin a vaccine study?
Tuesday, July 17, 2007
Research on Hib vaccine 'dubious'
This amazing letter documents the skewed and often bogus data vaccine
researchers generate to get a vaccine approved for use.
Congratulations to Dr. Puliyel for having the courage to correct the
journalist's mistake and kudos to the Editor for printing his letter.
Dr. Sherri
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Letter to the Editor:
I was quoted in the Hib vaccine news story from 4 July (see Hib
vaccine could save thousands in Asia), but perhaps due to constraints
of column space, I feel justice was not done to what I said.
My main argument against the research findings from Bangladesh is not
that it does not make economic sense, but that the study is seriously
flawed. The visible enthusiasm of the sponsors of the study must not
be allowed to cloud scientific objectivity.
In the study, cases of pneumonia were compared with a control group
without pneumonia. Because more children in the control group received
the Hib vaccine, the researchers considered the vaccine to prevent
pneumonia. But closer reading of the paper suggests that the Hib
vaccination status in the control children was only coincidental.
The control children were significantly richer, lived in better houses
and their mothers were better educated. With their greater affluence,
more children in the control group probably wore branded T-shirts, but
we would not expect Nike or Reebok to suggest that wearing their
apparel is protective against pneumonia.
Where starvation and cholera kill thousands of children each year,
international agencies such as the GAVI Alliance, USAID and the WHO
are busy spending millions on dubious research to emphasise the harm
from a disease that local doctors hardly ever come across. All this so
that vaccine manufacturers can fill their coffers. This situation can
only be described as scandalous. It is unfortunate that five resource
poor countries -- Afghanistan, Bangladesh, Bhutan, Pakistan and Sri
Lanka -- have been persuaded to undertake the expensive intervention on
the basis of flawed research.
Jacob M Puliyel, M.D.
Head of Paediatrics
St Stephens Hospital
* sayingnotovaccines.blogspot . com /2007/07/research-on-hib-vaccine-dubious.html
Tuesday, July 17, 2007
Research on Hib vaccine 'dubious'
This amazing letter documents the skewed and often bogus data vaccine
researchers generate to get a vaccine approved for use.
Congratulations to Dr. Puliyel for having the courage to correct the
journalist's mistake and kudos to the Editor for printing his letter.
Dr. Sherri
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Letter to the Editor:
I was quoted in the Hib vaccine news story from 4 July (see Hib
vaccine could save thousands in Asia), but perhaps due to constraints
of column space, I feel justice was not done to what I said.
My main argument against the research findings from Bangladesh is not
that it does not make economic sense, but that the study is seriously
flawed. The visible enthusiasm of the sponsors of the study must not
be allowed to cloud scientific objectivity.
In the study, cases of pneumonia were compared with a control group
without pneumonia. Because more children in the control group received
the Hib vaccine, the researchers considered the vaccine to prevent
pneumonia. But closer reading of the paper suggests that the Hib
vaccination status in the control children was only coincidental.
The control children were significantly richer, lived in better houses
and their mothers were better educated. With their greater affluence,
more children in the control group probably wore branded T-shirts, but
we would not expect Nike or Reebok to suggest that wearing their
apparel is protective against pneumonia.
Where starvation and cholera kill thousands of children each year,
international agencies such as the GAVI Alliance, USAID and the WHO
are busy spending millions on dubious research to emphasise the harm
from a disease that local doctors hardly ever come across. All this so
that vaccine manufacturers can fill their coffers. This situation can
only be described as scandalous. It is unfortunate that five resource
poor countries -- Afghanistan, Bangladesh, Bhutan, Pakistan and Sri
Lanka -- have been persuaded to undertake the expensive intervention on
the basis of flawed research.
Jacob M Puliyel, M.D.
Head of Paediatrics
St Stephens Hospital
* sayingnotovaccines.blogspot . com /2007/07/research-on-hib-vaccine-dubious.html
Re: How to spin a vaccine study?
"bigvince" <Vince.Miraglia@gmail . com > wrote in message
news:1193956946.480434.169240@k79g2000hse.googlegroups . com ...
> Tuesday, July 17, 2007
> Research on Hib vaccine 'dubious'
> This amazing letter documents the skewed and often bogus data vaccine
> researchers generate to get a vaccine approved for use.
The vaccine was approved for use in most countries long before the present
study was published (it also suggests a 90% reduction in cases of
Haemophilus meningitis, but that doesn't get a mention). The approval was
properly based on well-designed randomised controlled trials, which this
trial is not.
Case control studies like this are less reliable in determining vaccine
efficacy, but presumably intended to give some idea how cost-effective the
"real world" use of such vaccines will be in underdeveloped countries where
there is otherwise not much information about the incidence and morbidity
of the conditions that the vaccine prevents.
There will always be some subjectivity in judging when a vaccine is
worthwhile and where scarce resources will be best spent. I don't think
anyone here including myself can make that judgment on this information.
PM
> Congratulations to Dr. Puliyel for having the courage to correct the
> journalist's mistake and kudos to the Editor for printing his letter.
>
> Dr. Sherri
> +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
> Letter to the Editor:
>
> I was quoted in the Hib vaccine news story from 4 July (see Hib
> vaccine could save thousands in Asia), but perhaps due to constraints
> of column space, I feel justice was not done to what I said.
>
> My main argument against the research findings from Bangladesh is not
> that it does not make economic sense, but that the study is seriously
> flawed. The visible enthusiasm of the sponsors of the study must not
> be allowed to cloud scientific objectivity.
>
> In the study, cases of pneumonia were compared with a control group
> without pneumonia. Because more children in the control group received
> the Hib vaccine, the researchers considered the vaccine to prevent
> pneumonia. But closer reading of the paper suggests that the Hib
> vaccination status in the control children was only coincidental.
>
> The control children were significantly richer, lived in better houses
> and their mothers were better educated. With their greater affluence,
> more children in the control group probably wore branded T-shirts, but
> we would not expect Nike or Reebok to suggest that wearing their
> apparel is protective against pneumonia.
>
> Where starvation and cholera kill thousands of children each year,
> international agencies such as the GAVI Alliance, USAID and the WHO
> are busy spending millions on dubious research to emphasise the harm
> from a disease that local doctors hardly ever come across. All this so
> that vaccine manufacturers can fill their coffers. This situation can
> only be described as scandalous. It is unfortunate that five resource
> poor countries -- Afghanistan, Bangladesh, Bhutan, Pakistan and Sri
> Lanka -- have been persuaded to undertake the expensive intervention on
> the basis of flawed research.
>
> Jacob M Puliyel, M.D.
> Head of Paediatrics
> St Stephens Hospital
>
> * sayingnotovaccines.blogspot . com /2007/07/research-on-hib-vaccine-dubious.html
>
"bigvince" <Vince.Miraglia@gmail . com > wrote in message
news:1193956946.480434.169240@k79g2000hse.googlegroups . com ...
> Tuesday, July 17, 2007
> Research on Hib vaccine 'dubious'
> This amazing letter documents the skewed and often bogus data vaccine
> researchers generate to get a vaccine approved for use.
The vaccine was approved for use in most countries long before the present
study was published (it also suggests a 90% reduction in cases of
Haemophilus meningitis, but that doesn't get a mention). The approval was
properly based on well-designed randomised controlled trials, which this
trial is not.
Case control studies like this are less reliable in determining vaccine
efficacy, but presumably intended to give some idea how cost-effective the
"real world" use of such vaccines will be in underdeveloped countries where
there is otherwise not much information about the incidence and morbidity
of the conditions that the vaccine prevents.
There will always be some subjectivity in judging when a vaccine is
worthwhile and where scarce resources will be best spent. I don't think
anyone here including myself can make that judgment on this information.
PM
> Congratulations to Dr. Puliyel for having the courage to correct the
> journalist's mistake and kudos to the Editor for printing his letter.
>
> Dr. Sherri
> +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
> Letter to the Editor:
>
> I was quoted in the Hib vaccine news story from 4 July (see Hib
> vaccine could save thousands in Asia), but perhaps due to constraints
> of column space, I feel justice was not done to what I said.
>
> My main argument against the research findings from Bangladesh is not
> that it does not make economic sense, but that the study is seriously
> flawed. The visible enthusiasm of the sponsors of the study must not
> be allowed to cloud scientific objectivity.
>
> In the study, cases of pneumonia were compared with a control group
> without pneumonia. Because more children in the control group received
> the Hib vaccine, the researchers considered the vaccine to prevent
> pneumonia. But closer reading of the paper suggests that the Hib
> vaccination status in the control children was only coincidental.
>
> The control children were significantly richer, lived in better houses
> and their mothers were better educated. With their greater affluence,
> more children in the control group probably wore branded T-shirts, but
> we would not expect Nike or Reebok to suggest that wearing their
> apparel is protective against pneumonia.
>
> Where starvation and cholera kill thousands of children each year,
> international agencies such as the GAVI Alliance, USAID and the WHO
> are busy spending millions on dubious research to emphasise the harm
> from a disease that local doctors hardly ever come across. All this so
> that vaccine manufacturers can fill their coffers. This situation can
> only be described as scandalous. It is unfortunate that five resource
> poor countries -- Afghanistan, Bangladesh, Bhutan, Pakistan and Sri
> Lanka -- have been persuaded to undertake the expensive intervention on
> the basis of flawed research.
>
> Jacob M Puliyel, M.D.
> Head of Paediatrics
> St Stephens Hospital
>
> * sayingnotovaccines.blogspot . com /2007/07/research-on-hib-vaccine-dubious.html
>
Re: How to spin a vaccine study?
bigvince wrote:
> Tuesday, July 17, 2007
> Research on Hib vaccine 'dubious'
> This amazing letter documents the skewed and often bogus data vaccine
> researchers generate to get a vaccine approved for use.
> Congratulations to Dr. Puliyel for having the courage to correct the
> journalist's mistake and kudos to the Editor for printing his letter.
>
> Dr. Sherri
Nakken? A nut
bigvince wrote:
> Tuesday, July 17, 2007
> Research on Hib vaccine 'dubious'
> This amazing letter documents the skewed and often bogus data vaccine
> researchers generate to get a vaccine approved for use.
> Congratulations to Dr. Puliyel for having the courage to correct the
> journalist's mistake and kudos to the Editor for printing his letter.
>
> Dr. Sherri
Nakken? A nut
Re: How to spin a vaccine study?
Mark Probert <markprobert@lumbercartel . com > wrote:
>bigvince wrote:
>> Tuesday, July 17, 2007
>> Research on Hib vaccine 'dubious'
>> This amazing letter documents the skewed and often bogus data vaccine
>> researchers generate to get a vaccine approved for use.
>> Congratulations to Dr. Puliyel for having the courage to correct the
>> journalist's mistake and kudos to the Editor for printing his letter.
>>
>> Dr. Sherri
>
>Nakken? A nut
I don't think she has ever claimed to be a doctor. After all, it would
make he look bad to be one of those people.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
Mark Probert <markprobert@lumbercartel . com > wrote:
>bigvince wrote:
>> Tuesday, July 17, 2007
>> Research on Hib vaccine 'dubious'
>> This amazing letter documents the skewed and often bogus data vaccine
>> researchers generate to get a vaccine approved for use.
>> Congratulations to Dr. Puliyel for having the courage to correct the
>> journalist's mistake and kudos to the Editor for printing his letter.
>>
>> Dr. Sherri
>
>Nakken? A nut
I don't think she has ever claimed to be a doctor. After all, it would
make he look bad to be one of those people.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
Re: How to spin a vaccine study?
"Peter Bowditch" <myfirstname@ratbags . com > wrote
> Mark Probert <markprobert@lumbercartel . com > wrote:
And Peter Bpw-itch NON doctor is eager to repeat the ramblings of Mark
Probert.
Both of them are proven liars.
"Peter Bowditch" <myfirstname@ratbags . com > wrote
> Mark Probert <markprobert@lumbercartel . com > wrote:
And Peter Bpw-itch NON doctor is eager to repeat the ramblings of Mark
Probert.
Both of them are proven liars.
Re: How to spin a vaccine study?
"Jan Drew" <jdrew1374@sbcglobal . net > wrote:
>
>"Peter Bowditch" <myfirstname@ratbags . com > wrote
>> Mark Probert <markprobert@lumbercartel . com > wrote:
>
>And Peter Bpw-itch NON doctor is eager to repeat the ramblings of Mark
>Probert.
>
>Both of them are proven liars.
Get help, Jan. We are worried about you.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
"Jan Drew" <jdrew1374@sbcglobal . net > wrote:
>
>"Peter Bowditch" <myfirstname@ratbags . com > wrote
>> Mark Probert <markprobert@lumbercartel . com > wrote:
>
>And Peter Bpw-itch NON doctor is eager to repeat the ramblings of Mark
>Probert.
>
>Both of them are proven liars.
Get help, Jan. We are worried about you.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
Re: How to spin a vaccine study?
"My final conclusion after forty years or more in this business [medicine]
is that the unofficial policy of the World Health Organization and the
unoffical policy of the 'Save the Children's Fund' and ... [other vaccine
promoting] organizations is one of murder and genocide."--Dr K
* w w w .whale.to/v/kalokerinos.html
"My final conclusion after forty years or more in this business [medicine]
is that the unofficial policy of the World Health Organization and the
unoffical policy of the 'Save the Children's Fund' and ... [other vaccine
promoting] organizations is one of murder and genocide."--Dr K
* w w w .whale.to/v/kalokerinos.html
Re: How to spin a vaccine study?
"JOHN" <john@nospam . com > wrote:
>"My final conclusion after forty years or more in this business [medicine]
>is that the unofficial policy of the World Health Organization and the
>unoffical policy of the 'Save the Children's Fund' and ... [other vaccine
>promoting] organizations is one of murder and genocide."--Dr K
> * w w w .whale.to/v/kalokerinos.html
>
I was about to go into an anti-vaccination liar festival once where
Kalokerinos was going to be a speaker, and I said to my companion that
I was going to ask K if he still believed this. I didn't have to ask
because the lunatic repeated it from the stage. He said that WHO and
Save the Children "put Hitler and Stalin in the shade". I have visited
patients in very secure mental asylums, but I never saw anyone inside
one of them who was as dangerously mad as Kalokerinos.
Thanks, john, for reminding us of how seriously insane a person can be
and still manage to talk.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
"JOHN" <john@nospam . com > wrote:
>"My final conclusion after forty years or more in this business [medicine]
>is that the unofficial policy of the World Health Organization and the
>unoffical policy of the 'Save the Children's Fund' and ... [other vaccine
>promoting] organizations is one of murder and genocide."--Dr K
> * w w w .whale.to/v/kalokerinos.html
>
I was about to go into an anti-vaccination liar festival once where
Kalokerinos was going to be a speaker, and I said to my companion that
I was going to ask K if he still believed this. I didn't have to ask
because the lunatic repeated it from the stage. He said that WHO and
Save the Children "put Hitler and Stalin in the shade". I have visited
patients in very secure mental asylums, but I never saw anyone inside
one of them who was as dangerously mad as Kalokerinos.
Thanks, john, for reminding us of how seriously insane a person can be
and still manage to talk.
--
Peter Bowditch aa #2243
The Millenium Project * w w w .ratbags . com /rsoles
Australian Council Against Health Fraud * w w w .acahf.org.au
Australian Skeptics * w w w .skeptics . com .au
To email me use my first name only at ratbags . com
Re: How to spin a vaccine study?
"Peter Bowditch" <myfirstname@ratbags . com > wrote:
anti-vaccination liars
1000000000000000000000000000000000000000000000000000 times
PLONK!
"Peter Bowditch" <myfirstname@ratbags . com > wrote:
anti-vaccination liars
1000000000000000000000000000000000000000000000000000 times
PLONK!
