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The Fluoroquinolone Drugs are the most toxic and dangerous antibiotic in clinical practice today.
The Fluoroquinolone Drugs are the most toxic and dangerous antibiotic in clinical practice today.
Thank you John, for bringing this to public attention further ...
looks like another industry cover-up that people need to be warned
about.
http :// ilena-rosenthal.blogspot,com
Health Lover
Pseudoskeptic, Brandon C Stahl made this unsubstantiated, Pharma
Propaganda false claim:
"They're actually one of the safe, more effective antibiotics
available today."
~~~~~~~~~~~~~
He also hawks the now admittedly dangerous flu vaccinations ...
http :// groups.google,com /group/sci.med.nutrition/browse_thread/thread/c1e2396e813b6d69/e1a42f7671703084?lnk=st&q=author%3Askeptic+influenza+OR+flu#e1a42f7671703084
Sun, 14 Jan 2007 17:36:53 GMT
Brandon C Stahl, pseudo Skeptic made this absurd, Vaccination Lobby
claim:
Lots of things are not "needed". Getting the flu shot, however,
reduces the likelihood of getting the flu and if you do get it,
reduces it the severity and duration of symptoms. For a pretty benign
shot, the effects are overwhelmingly positive. Why take a chance of
getting the flu if you can avoid it? Seems like only an idiot would
do that. Are you an idiot? No need to answer.
~~~~~~~~~~~`
God help his patients who are faced with the cowardly pharma shill as
a medical doctor.
Read this information about FQ drugs that Fake Skeptic Stahl dismisses
with one grunt.
"They're actually one of the safe, more effective antibiotics
available today."
~~~~~~~~~~~~~~~~~
http :// www .fqresearch.org/
The Adverse Drug Reactions (ADRS) Associated with the Fluoroquinolones
include:
Tendon and Muscle Pain Insomnia Burning Pain Digestion
Disorders Anxiety Heart Problems Vision Disorders Ringing
in the Ears Rashes Hyperglycemia Depersonalization Mental
Disorders Seizures PAIN Liver Failure Stroke Other Adverse
Reactions
Thank you John, for bringing this to public attention further ...
looks like another industry cover-up that people need to be warned
about.
http :// ilena-rosenthal.blogspot,com
Health Lover
Pseudoskeptic, Brandon C Stahl made this unsubstantiated, Pharma
Propaganda false claim:
"They're actually one of the safe, more effective antibiotics
available today."
~~~~~~~~~~~~~
He also hawks the now admittedly dangerous flu vaccinations ...
http :// groups.google,com /group/sci.med.nutrition/browse_thread/thread/c1e2396e813b6d69/e1a42f7671703084?lnk=st&q=author%3Askeptic+influenza+OR+flu#e1a42f7671703084
Sun, 14 Jan 2007 17:36:53 GMT
Brandon C Stahl, pseudo Skeptic made this absurd, Vaccination Lobby
claim:
Lots of things are not "needed". Getting the flu shot, however,
reduces the likelihood of getting the flu and if you do get it,
reduces it the severity and duration of symptoms. For a pretty benign
shot, the effects are overwhelmingly positive. Why take a chance of
getting the flu if you can avoid it? Seems like only an idiot would
do that. Are you an idiot? No need to answer.
~~~~~~~~~~~`
God help his patients who are faced with the cowardly pharma shill as
a medical doctor.
Read this information about FQ drugs that Fake Skeptic Stahl dismisses
with one grunt.
"They're actually one of the safe, more effective antibiotics
available today."
~~~~~~~~~~~~~~~~~
http :// www .fqresearch.org/
The Adverse Drug Reactions (ADRS) Associated with the Fluoroquinolones
include:
Tendon and Muscle Pain Insomnia Burning Pain Digestion
Disorders Anxiety Heart Problems Vision Disorders Ringing
in the Ears Rashes Hyperglycemia Depersonalization Mental
Disorders Seizures PAIN Liver Failure Stroke Other Adverse
Reactions
Re: The Fluoroquinolone Drugs are the most toxic and dangerous antibiotic in clinical practice today
In addition to inducing MMP-3 and sometimes damaging tendons after long
use, this class also blocks carnitine transport. I suspect this makes
them a bad idea for autoimmune patients since you need carnitine to
absorb butyrate in the gut and butyrate to acetylate histones and induce
FOXP3 in regulatory T cells. I wouldn't be surprised if long-term use
of fluoroquinolones caused some epigenetic regulatory issues. If you're
concerned about this class of drug, you should keep an eye out in the
literature.
Int J Pharm. 2007 Sep 25; [Epub ahead of print] Related Articles, LinkOut
The inhibitory effects of fluoroquinolones on l-carnitine transport in
placental cell line BeWo.
Hirano T, Yasuda S, Osaka Y, Asari M, Kobayashi M, Itagaki S, Iseki K.
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of
Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome,
Kita-ku, Sapporo 060-0812, Japan.
l-Carnitine plays an important role in lipid metabolism by facilitating
the transport of long-chain fatty acids across the mitochondrial inner
membrane followed by fatty acid beta-oxidation. It is known that members
of the OCTN family play an important role in l-carnitine transport in
the placenta. Investigation of drug-drug or drug-nutrient interaction in
the placenta is important for establishment of safety drug medication
during pregnancy. The aim of this study was to determine the effects of
fluoroquinolones, inhibitors of OCTN2, on l-carnitine transport in the
placenta which is known to have a high expression level of OCTN2. We
investigated the inhibitory effect of five fluoroquinolones,
ciprofloxacin (CPFX), gatifloxacin (GFLX), ofloxacin (OFLX),
levofloxacin (LVFX) and grepafloxacin (GPFX), on l-carnitine transport
mediated by OCTN2 in placental cell line BeWo cells. We found that all
of the fluoroquinolones inhibited l-carnitine transport, GPFX being the
strongest inhibitor. We also found that the inhibitory effects of LVFX
and GPFX depended on their existence ratio of zwitterionic forms as, we
reported previously. Furthermore, we elucidated the LVFX transport
mechanism in BeWo cells. LVFX was transported actively by transporters.
However, we found that LVFX transport was Na(+)-independent and
l-carnitine had no inhibitory effect on LVFX transport, suggesting that
LVFX acts as inhibitor of OCTN2, not as a substrate for OCTN2.
PMID: 17977676
In addition to inducing MMP-3 and sometimes damaging tendons after long
use, this class also blocks carnitine transport. I suspect this makes
them a bad idea for autoimmune patients since you need carnitine to
absorb butyrate in the gut and butyrate to acetylate histones and induce
FOXP3 in regulatory T cells. I wouldn't be surprised if long-term use
of fluoroquinolones caused some epigenetic regulatory issues. If you're
concerned about this class of drug, you should keep an eye out in the
literature.
Int J Pharm. 2007 Sep 25; [Epub ahead of print] Related Articles, LinkOut
The inhibitory effects of fluoroquinolones on l-carnitine transport in
placental cell line BeWo.
Hirano T, Yasuda S, Osaka Y, Asari M, Kobayashi M, Itagaki S, Iseki K.
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of
Pharmaceutical Sciences, Hokkaido University, Kita-12-jo, Nishi-6-chome,
Kita-ku, Sapporo 060-0812, Japan.
l-Carnitine plays an important role in lipid metabolism by facilitating
the transport of long-chain fatty acids across the mitochondrial inner
membrane followed by fatty acid beta-oxidation. It is known that members
of the OCTN family play an important role in l-carnitine transport in
the placenta. Investigation of drug-drug or drug-nutrient interaction in
the placenta is important for establishment of safety drug medication
during pregnancy. The aim of this study was to determine the effects of
fluoroquinolones, inhibitors of OCTN2, on l-carnitine transport in the
placenta which is known to have a high expression level of OCTN2. We
investigated the inhibitory effect of five fluoroquinolones,
ciprofloxacin (CPFX), gatifloxacin (GFLX), ofloxacin (OFLX),
levofloxacin (LVFX) and grepafloxacin (GPFX), on l-carnitine transport
mediated by OCTN2 in placental cell line BeWo cells. We found that all
of the fluoroquinolones inhibited l-carnitine transport, GPFX being the
strongest inhibitor. We also found that the inhibitory effects of LVFX
and GPFX depended on their existence ratio of zwitterionic forms as, we
reported previously. Furthermore, we elucidated the LVFX transport
mechanism in BeWo cells. LVFX was transported actively by transporters.
However, we found that LVFX transport was Na(+)-independent and
l-carnitine had no inhibitory effect on LVFX transport, suggesting that
LVFX acts as inhibitor of OCTN2, not as a substrate for OCTN2.
PMID: 17977676
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