Intestinal Mucus?

Intestinal Mucus?

Hello,

Greetings!!

Can there be some instabilty or abnormality in intestinal mucus
generation which can interfere in normal absorption of glucose and
other nutrients (non-Cystic Fibrosis related) impacting on blood
levels?

Best wishes.

Re: Intestinal Mucus?

Kumar wrote:
> Hello,
>
> Greetings!!
>
> Can there be some instabilty or abnormality in intestinal mucus
> generation which can interfere in normal absorption of glucose and
> other nutrients (non-Cystic Fibrosis related) impacting on blood
> levels?

Vitamin A deficiency increases mucus production in general. If excess
mucus production can interfere in normal absorption of glucose and other
nutrients I do not know. But since so much is interconnected in human
body, it may be worth looking into that.

--
Dawid Michalczyk
* w w w .selfgrowth . com /experts/dawid michalczyk.html

Re: Intestinal Mucus?

On Mar 14, 7:57 pm, Dawid Michalczyk <d...@eonworks . com > wrote:
> Kumar wrote:
> > Hello,
>
> > Greetings!!
>
> > Can there be some instabilty or abnormality in intestinal mucus
> > generation which can interfere in normal absorption of glucose and
> > other nutrients (non-Cystic Fibrosis related) impacting on blood
> > levels?
>
> Vitamin A deficiency increases mucus production in general. If excess
> mucus production can interfere in normal absorption of glucose and other
> nutrients I do not know. But since so much is interconnected in human
> body, it may be worth looking into that.
>
> --
> Dawid Michalczyk * w w w .selfgrowth . com /experts/dawid michalczyk.html

Thanks.

Three aspects can be thought;

1. Decreased absorption of glucose and other nutrients esp. big
molecules due to thick mucus layer in intestines.

2. Enhanced absorption due to trapping of nutrient's molecules in
intestinal mucus for prolonged time.

3. Decreased satiety of one or few nutrients due to decreased
absorption caused by thick intestinal mucus resulting continual and
excess cravings leading to overeating and increased levels in blood.

Its role in respiratory and reproductive system loos to be well
sutudied but in digestive tract--pancreas, intestines etc. look to be
not yet clear. Ingestion of phelgum and post nasal drips in few
patients can also have some relevance. Mucolytic and mucus forming
agents an cystic fibrosis, mucus in stool can be checked for this
purpose.

Re: Intestinal Mucus?

On Mar 15, 12:00 pm, Kumar <lordshiva5...@gmail . com > wrote:
> On Mar 14, 7:57 pm, Dawid Michalczyk <d...@eonworks . com > wrote:
>
>
>
>
>
> > Kumar wrote:
> > > Hello,
>
> > > Greetings!!
>
> > > Can there be some instabilty or abnormality in intestinal mucus
> > > generation which can interfere in normal absorption of glucose and
> > > other nutrients (non-Cystic Fibrosis related) impacting on blood
> > > levels?
>
> > Vitamin A deficiency increases mucus production in general. If excess
> > mucus production can interfere in normal absorption of glucose and other=

> > nutrients I do not know. But since so much is interconnected in human
> > body, it may be worth looking into that.
>
> > --
> > Dawid Michalczyk * w w w .selfgrowth . com /experts/dawid michalczyk.html
>
> Thanks.
>
> Three aspects can be thought;
>
> 1. Decreased absorption of glucose and other nutrients esp. big
> molecules due to thick mucus layer in intestines.
>
> 2. Enhanced absorption due to trapping of nutrient's molecules in
> intestinal mucus for prolonged time.
>
> 3. Decreased satiety of one or few nutrients due to decreased
> absorption caused by thick intestinal mucus resulting continual and
> excess cravings leading to overeating and increased levels in blood.
>
> Its role in respiratory and reproductive system loos to be well
> sutudied but in digestive tract--pancreas, intestines etc. look to be
> not yet clear. Ingestion of phelgum and post nasal drips in few
> patients can also have some relevance. Mucolytic and mucus forming
> agents an cystic fibrosis, mucus in stool can be checked for this
> purpose.- Hide quoted text -
>
> - Show quoted text -

I am not sure, whether pepsin and other protease enzyme by their
proeolysis and mcolytic action can break down mucus and nutralize
effectiveness of thick or excess mucus in digestive tract. If so, some
abnormality in digestive enzymes can also be responible for intestinal
mucus. Do anyone know about it?

I read in one drug index, one cough mixture claiming to increase
effectiveness of antibiotics by mucosupperessive, mucolytic and
mucokinetic action of cough syrup. Ths can address my thoughts about
possible link of intestinal mucus with absorption. ??

Re: Intestinal Mucus?

On Mar 16, 5:41 pm, Kumar <lordshiva5...@gmail . com > wrote:
> On Mar 15, 12:00 pm, Kumar <lordshiva5...@gmail . com > wrote:
>
>
>
>
>
> > On Mar 14, 7:57 pm, Dawid Michalczyk <d...@eonworks . com > wrote:
>
> > > Kumar wrote:
> > > > Hello,
>
> > > > Greetings!!
>
> > > > Can there be some instabilty or abnormality in intestinal mucus
> > > > generation which can interfere in normal absorption of glucose and
> > > > other nutrients (non-Cystic Fibrosis related) impacting on blood
> > > > levels?
>
> > > Vitamin A deficiency increases mucus production in general. If excess
> > > mucus production can interfere in normal absorption of glucose and oth=
er
> > > nutrients I do not know. But since so much is interconnected in human
> > > body, it may be worth looking into that.
>
> > > --
> > > Dawid Michalczyk * w w w .selfgrowth . com /experts/dawid michalczyk.htm=
l
>
> > Thanks.
>
> > Three aspects can be thought;
>
> > 1. Decreased absorption of glucose and other nutrients esp. big
> > molecules due to thick mucus layer in intestines.
>
> > 2. Enhanced absorption due to trapping of nutrient's molecules in
> > intestinal mucus for prolonged time.
>
> > 3. Decreased satiety of one or few nutrients due to decreased
> > absorption caused by thick intestinal mucus resulting continual and
> > excess cravings leading to overeating and increased levels in blood.
>
> > Its role in respiratory and reproductive system loos to be well
> > sutudied but in digestive tract--pancreas, intestines etc. look to be
> > not yet clear. Ingestion of phelgum and post nasal drips in few
> > patients can also have some relevance. Mucolytic and mucus forming
> > agents an cystic fibrosis, mucus in stool can be checked for this
> > purpose.- Hide quoted text -
>
> > - Show quoted text -
>
> I am not sure, whether pepsin and other protease enzyme by their
> proeolysis and mcolytic action can break down mucus and nutralize
> effectiveness of thick or excess mucus in digestive tract. If so, some
> abnormality in digestive enzymes can also be responible for intestinal
> mucus. Do anyone know about it?
>
> I read in one drug index, one cough mixture claiming to increase
> effectiveness of antibiotics by mucosupperessive, mucolytic and
> mucokinetic action of cough syrup. Ths can address my thoughts about
> possible link of intestinal mucus with absorption. ??- Hide quoted text -
>
> - Show quoted text -

One manufacturer of a cough syrup, composed of ambroxol, terbutaline,
guaiphenesin & menthol, claimed that their syrup Xpect-B 1. enhances
antibiotic penetration and is mucolytic & mucokinetic 2. Improve
airway clearance & added antiallergic action, 3. US FDA approved
expectorant 4. Local soothing & counter irritant action respectively
to its composition mentioned above.

If intestinal mucus quality and quantity can be related to motality,
digestion and absorption of foods, the claim can be relevant. Such
proteolytic, mucolytic, Mucokinetic & muco-expectorant can also be
linked to digestive enzymes(pepsin, trypsin etc.) whose secretions can
be effected by digestive evironment/pH. Digestive microorganisms/GUT
flora or Probiotics can also be related to breakdown of protiens,
mucus etc. I am bit surprised, whether this issue is suitably attended
or not inspite of having prime importance as "acid, base & water
(mucus) balance" can also be related to , environmental,
constitutional and immune mediators.

Re: Intestinal Mucus?

> Can there be some instabilty or abnormality in intestinal mucus
> generation which can interfere in normal absorption of glucose and
> other nutrients (non-Cystic Fibrosis related) impacting on blood
> levels?

Yes. When you lose gut barrier function, you can get undigested food
coming into contact with the immune system. The resulting
inflammation/autoimmunity can further damage angiogenesis and cause
nutritional deficiency.

This happens through several routes. In many autoimmune gut conditions,
butyrate uptake is defective. Without butyrate (and enough carnitine to
properly metabolize it), you lose the histone acetylation you need to
make more mucous (via mucin genes). Turns out vitamin D3 also needs
histone acetylation to make the innate antimicrobial peptide
cathelicidin which is vital for gut barrier function - and it just so
happens cathelicidin has antiinflammatory/antiallergy properties.
(HIF-1a is a crucial intermediary gene in this chain.)

Since symbiotic bacteria living in the gut produce butyrate from
undigested fiber, you can set this whole ugly process in motion by
taking antibiotics long enough - especially if you combine it with a
crappy American diet rich in sugar and low in fiber.

Re: Intestinal Mucus?

On Mar 21, 7:43 am, Kofi <k...@anon.un> wrote:
> > Can there be some instabilty or abnormality in intestinal mucus
> > generation which can interfere in normal absorption of glucose and
> > other nutrients (non-Cystic Fibrosis related) impacting on blood
> > levels?
>
> Yes.  When you lose gut barrier function, you can get undigested food
> coming into contact with the immune system.  The resulting
> inflammation/autoimmunity can further damage angiogenesis and cause
> nutritional deficiency.
>
> This happens through several routes.  In many autoimmune gut conditions,=

> butyrate uptake is defective.  Without butyrate (and enough carnitine to=

> properly metabolize it), you lose the histone acetylation you need to
> make more mucous (via mucin genes).  Turns out vitamin D3 also needs
> histone acetylation to make the innate antimicrobial peptide
> cathelicidin which is vital for gut barrier function - and it just so
> happens cathelicidin has antiinflammatory/antiallergy properties.  
> (HIF-1a is a crucial intermediary gene in this chain.)
>
> Since symbiotic bacteria living in the gut produce butyrate from
> undigested fiber, you can set this whole ugly process in motion by
> taking antibiotics long enough - especially if you combine it with a
> crappy American diet rich in sugar and low in fiber.

Thanks. Three possibilities can be thought; 1. Normal intestinnal
mucus in nature and quantity 2. Excess mucus in nature(thick or thin)
and quantity and 3. lesser mucus in nature(watery) and quantity.

This may cause, normal and abnormal motility, digestion and
absorptions of food. One one side, there can be normacy whereas
defficiencies or decreased satiety OR excesses on other side. How it
can be related to excessive cravings, decreased hunger and abnormal
digestion, motality and absorptions in intestines?

Re: Intestinal Mucus?

> This may cause, normal and abnormal motility, digestion and
> absorptions of food. One one side, there can be normacy whereas
> defficiencies or decreased satiety OR excesses on other side. How it
> can be related to excessive cravings, decreased hunger and abnormal
> digestion, motality and absorptions in intestines?

I think you're asking about how mucous thickness affects the transit
time of food through the gut and how that time affects feelings of
hunger or fullness. The answer is, I haven't looked at it like that. I
do know the mu opioid receptor can get screwed up in the gut, which is
why low-dose naltrexone is helpful and why morphine affects gut transit
time. The mu opioid receptor is under control of butyrate via HDAC
inhibition and thus under control of probiotics.

Hunger itself is regulated by peptide hormones secreted from the gut
lining running back and forth to the brain. Excess hunger can be curbed
by eliminating part of the gut producing those hunger signals - i.e.,
gastric stapling. There's literally less stomach around to produce
hunger signals and send "feel hungry" signals to the brain after the
surgery.

Since I came across research indicating obese people are more likely to
have certain viral infections and another abstract indicating the
existence of autoantibodies to hunger hormones, it's possible that
certain obese patients are simply autoimmune to their own fullness
hormone signals. Guy gets food-borne virus. Virus shares a protein
sequence with leptin or ghrelin or a PYY. Immune system attacks that
sequence to eliminate the virus but ends up eliminating the "full"
signal, thus causing the poor guy to overeat the very food that has the
virus. Smart strategy for the virus, hell for the autoimmune guy.

Finally, stress and lack of sleep enhance hunger for sweet, salty and
fatty foods so problems in the HPA stress axis or in circadian rhythms
can affect hunger levels - which isn't surprising since the central
circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.
Mutations in Clock and elsewhere along the clock pathway can affect
general cravings for a wide range of addictions like cocaine.

Re: Intestinal Mucus?

On Mar 24, 3:50 pm, Kofi <k...@anon.un> wrote:
> > This may cause, normal and abnormal motility, digestion and
> > absorptions of food. One one side, there can be normacy whereas
> > defficiencies or decreased satiety OR excesses on other side. How it
> > can be related to excessive cravings, decreased hunger and abnormal
> > digestion, motality and absorptions in intestines?
>
> I think you're asking about how mucous thickness affects the transit
> time of food through the gut and how that time affects feelings of
> hunger or fullness.  The answer is, I haven't looked at it like that. =
 I
> do know the mu opioid receptor can get screwed up in the gut, which is
> why low-dose naltrexone is helpful and why morphine affects gut transit
> time.  The mu opioid receptor is under control of butyrate via HDAC
> inhibition and thus under control of probiotics.

I am also looking at decreased digestion & absorption of all or few
nutrients due to altered mucus resulting decreased satiety & hunger/
craving to eat more.
> Hunger itself is regulated by peptide hormones secreted from the gut
> lining running back and forth to the brain.  Excess hunger can be curbed=

> by eliminating part of the gut producing those hunger signals - i.e.,
> gastric stapling.  There's literally less stomach around to produce
> hunger signals and send "feel hungry" signals to the brain after the
> surgery.
Can't decreased satiety due to decreased absorptions as a result of
altered mucus in intestines also cause more & **continual hunger?
> Since I came across research indicating obese people are more likely to
> have certain viral infections and another abstract indicating the
> existence of autoantibodies to hunger hormones, it's possible that
> certain obese patients are simply autoimmune to their own fullness
> hormone signals.  Guy gets food-borne virus.  Virus shares a protein
> sequence with leptin or ghrelin or a PYY.  Immune system attacks that
> sequence to eliminate the virus but ends up eliminating the "full"
> signal, thus causing the poor guy to overeat the very food that has the
> virus.  Smart strategy for the virus, hell for the autoimmune guy.
Thanks, this is good research. It may also indicate, a biochemical
abnomality for getting any infection, somewhat miasma vs. gene
theory.

> Finally, stress and lack of sleep enhance hunger for sweet, salty and
> fatty foods so problems in the HPA stress axis or in circadian rhythms
> can affect hunger levels - which isn't surprising since the central
> circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
> Mutations in Clock and elsewhere along the clock pathway can affect
> general cravings for a wide range of addictions like cocaine.

It is also good findings and may be relevant to modern/big cities
changed life-style with chronic stress, late sleep etc.

Btw, whether it is lack of sleep or late sleep & late getting up
resulting altered light exposures?

Re: Intestinal Mucus?

> > I think you're asking about how mucous thickness affects the transit
> > time of food through the gut and how that time affects feelings of
> > hunger or fullness.  The answer is, I haven't looked at it like that.  I
> > do know the mu opioid receptor can get screwed up in the gut, which is
> > why low-dose naltrexone is helpful and why morphine affects gut transit
> > time.  The mu opioid receptor is under control of butyrate via HDAC
> > inhibition and thus under control of probiotics.
>
> I am also looking at decreased digestion & absorption of all or few
> nutrients due to altered mucus resulting decreased satiety & hunger/
> craving to eat more.

You're interested in the barrier function literature and it's not
primarily focused on mucous so that's not going to get you very far.
You're looking for work on tight gap junction proteins like zonulin and
the recent stuff on HIF-1/vitamin D. Barrier dysfunction will affect
nutritional absorption. Malnutrition can enhance or lower your appetite
depending on what part of your metabolism takes a hit.


>
> > Finally, stress and lack of sleep enhance hunger for sweet, salty and
> > fatty foods so problems in the HPA stress axis or in circadian rhythms
> > can affect hunger levels - which isn't surprising since the central
> > circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.  
> > Mutations in Clock and elsewhere along the clock pathway can affect
> > general cravings for a wide range of addictions like cocaine.
>
> It is also good findings and may be relevant to modern/big cities
> changed life-style with chronic stress, late sleep etc.
>
> Btw, whether it is lack of sleep or late sleep & late getting up
> resulting altered light exposures?

I don't know exactly what you're asking but it's easily remedied in part
by sleeping with something covering your eyes to minimize your light
exposure.

Re: Intestinal Mucus?

Kofi wrote:
>>> I think you're asking about how mucous thickness affects the transit
>>> time of food through the gut and how that time affects feelings of
>>> hunger or fullness. The answer is, I haven't looked at it like that. I
>>> do know the mu opioid receptor can get screwed up in the gut, which is
>>> why low-dose naltrexone is helpful and why morphine affects gut transit
>>> time. The mu opioid receptor is under control of butyrate via HDAC
>>> inhibition and thus under control of probiotics.
>> I am also looking at decreased digestion & absorption of all or few
>> nutrients due to altered mucus resulting decreased satiety & hunger/
>> craving to eat more.
>
> You're interested in the barrier function literature and it's not
> primarily focused on mucous so that's not going to get you very far.
> You're looking for work on tight gap junction proteins like zonulin and
> the recent stuff on HIF-1/vitamin D. Barrier dysfunction will affect
> nutritional absorption. Malnutrition can enhance or lower your appetite
> depending on what part of your metabolism takes a hit.
>
>
>>> Finally, stress and lack of sleep enhance hunger for sweet, salty and
>>> fatty foods so problems in the HPA stress axis or in circadian rhythms
>>> can affect hunger levels - which isn't surprising since the central
>>> circadian rhythm gene Clock is also an HDAC inhibitor like butyrate.
>>> Mutations in Clock and elsewhere along the clock pathway can affect
>>> general cravings for a wide range of addictions like cocaine.
>> It is also good findings and may be relevant to modern/big cities
>> changed life-style with chronic stress, late sleep etc.
>>
>> Btw, whether it is lack of sleep or late sleep & late getting up
>> resulting altered light exposures?
>
> I don't know exactly what you're asking but it's easily remedied in part
> by sleeping with something covering your eyes to minimize your light
> exposure.

Don't confuse mucus (the noun) with mucous (the adjective).

--
Marshall Price of Miami
Known to Yahoo as d021317c

Re: Intestinal Mucus?

On Apr 4, 6:40 pm, Marshall Price <d0213...@yahoo . com > wrote:
> Kofi wrote:
> >>> I think you're asking about how mucous thickness affects the transit
> >>> time of food through the gut and how that time affects feelings of
> >>> hunger or fullness.  The answer is, I haven't looked at it like that=
.  I
> >>> do know the mu opioid receptor can get screwed up in the gut, which is=

> >>> why low-dose naltrexone is helpful and why morphine affects gut transi=
t
> >>> time.  The mu opioid receptor is under control of butyrate via HDAC
> >>> inhibition and thus under control of probiotics.
> >> I am also looking at decreased digestion & absorption of all or few
> >> nutrients due to altered mucus resulting decreased satiety & hunger/
> >> craving to eat more.
>
> > You're interested in the barrier function literature and it's not
> > primarily focused on mucous so that's not going to get you very far.  =

> > You're looking for work on tight gap junction proteins like zonulin and
> > the recent stuff on HIF-1/vitamin D.  Barrier dysfunction will affect
> > nutritional absorption.  Malnutrition can enhance or lower your appeti=
te
> > depending on what part of your metabolism takes a hit.
>
> >>> Finally, stress and lack of sleep enhance hunger for sweet, salty and
> >>> fatty foods so problems in the HPA stress axis or in circadian rhythms=

> >>> can affect hunger levels - which isn't surprising since the central
> >>> circadian rhythm gene Clock is also an HDAC inhibitor like butyrate. =
 
> >>> Mutations in Clock and elsewhere along the clock pathway can affect
> >>> general cravings for a wide range of addictions like cocaine.
> >> It is also good findings and may be relevant to modern/big cities
> >> changed life-style with chronic stress, late sleep etc.
>
> >> Btw, whether it is lack of sleep or late sleep & late getting up
> >> resulting altered light exposures?
>
> > I don't know exactly what you're asking but it's easily remedied in part=

> > by sleeping with something covering your eyes to minimize your light
> > exposure.
>
> Don't confuse mucus (the noun) with mucous (the adjective).
>
> --
> Marshall Price of Miami
> Known to Yahoo as d021317c- Hide quoted text -
>
> - Show quoted text -

Thanks. Somotimes this language is bit confusing to people whose first
language was not english. Still, pls try to manage.

Re: Intestinal Mucus?

On Apr 3, 10:53 am, Kofi <k...@anon.un.org> wrote:
> > > I think you're asking about how mucous thickness affects the transit
> > > time of food through the gut and how that time affects feelings of
> > > hunger or fullness.  The answer is, I haven't looked at it like that=
.  I
> > > do know the mu opioid receptor can get screwed up in the gut, which is=

> > > why low-dose naltrexone is helpful and why morphine affects gut transi=
t
> > > time.  The mu opioid receptor is under control of butyrate via HDAC
> > > inhibition and thus under control of probiotics.
>
> > I am also looking at decreased digestion & absorption of all or few
> > nutrients due to altered mucus resulting decreased satiety & hunger/
> > craving to eat more.
>
> You're interested in the barrier function literature and it's not
> primarily focused on mucous so that's not going to get you very far.  
> You're looking for work on tight gap junction proteins like zonulin and
> the recent stuff on HIF-1/vitamin D.  Barrier dysfunction will affect
> nutritional absorption.  Malnutrition can enhance or lower your appetite=

> depending on what part of your metabolism takes a hit.

Yes thanks. What are the usual abnormalities/instabilties related to
barrier dysfunctions in intestines? Why it can't be mucous
instabilties related?
>
>
> > > Finally, stress and lack of sleep enhance hunger for sweet, salty and
> > > fatty foods so problems in the HPA stress axis or in circadian rhythms=

> > > can affect hunger levels - which isn't surprising since the central
> > > circadian rhythm gene Clock is also an HDAC inhibitor like butyrate. =
 
> > > Mutations in Clock and elsewhere along the clock pathway can affect
> > > general cravings for a wide range of addictions like cocaine.
>
> > It is also good findings and may be relevant to modern/big cities
> > changed life-style with chronic stress, late sleep etc.
>
> > Btw, whether it is lack of sleep or late sleep & late getting up
> > resulting altered light exposures?
>
> I don't know exactly what you're asking but it's easily remedied in part
> by sleeping with something covering your eyes to minimize your light
> exposure.

I meant, can late sleep and late waking up OR just lack of sleep is
related to above indicated instabilties?