Vitamin D so many benefits ;time to raise the RDA?

Vitamin D so many benefits ;time to raise the RDA?

1: Am J Clin Nutr. 2007 Jan;85(1):6-18. Links
Risk assessment for vitamin D.Hathcock JN, Shao A, Vieth R, Heaney R.
Council for Responsible Nutrition, Washington, DC 20036-5114, USA.
jhathcock@crnusa.org

The objective of this review was to apply the risk assessment
methodology used by the Food and Nutrition Board (FNB) to derive a
revised safe Tolerable Upper Intake Level (UL) for vitamin D. New data
continue to emerge regarding the health benefits of vitamin D beyond
its role in bone. The intakes associated with those benefits suggest a
need for levels of supplementation, food fortification, or both that
are higher than current levels. A prevailing concern exists, however,
regarding the potential for toxicity related to excessive vitamin D
intakes. The UL established by the FNB for vitamin D (50 microg, or
2000 IU) is not based on current evidence and is viewed by many as
being too restrictive, thus curtailing research, commercial
development, and optimization of nutritional policy. Human clinical
trial data published subsequent to the establishment of the FNB
vitamin D UL published in 1997 support a significantly higher UL. We
present a risk assessment based on relevant, well-designed human
clinical trials of vitamin D. Collectively, the absence of toxicity in
trials conducted in healthy adults that used vitamin D dose > or = 250
microg/d (10,000 IU vitamin D3) supports the confident selection of
this value as the UL.

PMID: 17209171 [PubMed - indexed for MEDLINE]

Thanks Vince

Re: Vitamin D so many benefits ;time to raise the RDA?

>> On Sep 22, 5:28 am, bigvince <Vince.Mirag...@gmail . com > wrote: New data
continue to emerge regarding the health benefits of vitamin D beyond
its role in bone. <<

Astronauts when they go to altitude manage to get .. vitamin D
deficiency.

* w w w .nasa.gov/mission_pages/station/science/experiments/Clinical-Nutrition-Assessment.html

<<snip>>
However, blood concentrations of some nutrients, such as vitamin D,
continue to be low even when astronauts receive supplements during
flight.
<<snip>>

When astronauts go to altitude they ALSO manifest a hemolytic
anemia .. an **iron loading** anemia.
Iron destroys vitamin D .. evidenced in those when supplemented iron
have a decrease in vitamin D and when people are bloodlet /
phlebotomized they have an INCREASE in vitamin D.

Coincidentally people in the mountains / altitude .. also manifest
vitamin D deficiency.

They also .. coincidentally manifest **iron loading** polycythemia ..

Elderly manifest vitamin D deficiency .. and there is a syndrome newly
discovered called ..

age related **iron accumulation**.

Coincidences .. all .. coincidences ..

Who loves ya.
Tom


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> 1: Am J Clin Nutr. 2007 Jan;85(1):6-18. Links
> Risk assessment for vitamin D.Hathcock JN, Shao A, Vieth R, Heaney R.
> Council for Responsible Nutrition, Washington, DC 20036-5114, USA.
> jhathc...@crnusa.org
>
> The objective of this review was to apply the risk assessment
> methodology used by the Food and Nutrition Board (FNB) to derive a
> revised safe Tolerable Upper Intake Level (UL) for vitamin D. New data
> continue to emerge regarding the health benefits of vitamin D beyond
> its role in bone. The intakes associated with those benefits suggest a
> need for levels of supplementation, food fortification, or both that
> are higher than current levels. A prevailing concern exists, however,
> regarding the potential for toxicity related to excessive vitamin D
> intakes. The UL established by the FNB for vitamin D (50 microg, or
> 2000 IU) is not based on current evidence and is viewed by many as
> being too restrictive, thus curtailing research, commercial
> development, and optimization of nutritional policy. Human clinical
> trial data published subsequent to the establishment of the FNB
> vitamin D UL published in 1997 support a significantly higher UL. We
> present a risk assessment based on relevant, well-designed human
> clinical trials of vitamin D. Collectively, the absence of toxicity in
> trials conducted in healthy adults that used vitamin D dose > or = 250
> microg/d (10,000 IU vitamin D3) supports the confident selection of
> this value as the UL.
>
> PMID: 17209171 [PubMed - indexed for MEDLINE]
>
> Thanks Vince

Re: Vitamin D so many benefits ;time to raise the RDA?


In support of the proposal " Vitamin D so many benefits ;time to raise
the RDA? Options " I would like to point out that for the last 18
months I've been taking 5000iu/daily/cholecalciferol Vitamin D3. The
only days I miss a capsule are when I am sure I will get 20minutes
full body sun exposure. My vitamin D status August was 147nmol/L. I
am satisfied this is an appropriate level for the end of summer. At
latitude 52N there will now be no back up from UVB sun exposure so
continuing with 5000iu/d should allow my level to drop down slowly
over the winter and still be over 100 in March.

Each 400iu/d raises 9nmol/L
4000iu/d raises 90nmol/L
5000iu/d raised 112.5nmol/L
The amount generally stated for casual sun exposure is in my view
generally overstated. * jcem.endojournals.org/cgi/content/full/87/11/4952
Effects of Above Average Summer Sun Exposure on Serum 25-
Hydroxyvitamin D and Calcium Absorption shows Outdoor workers in Omaha
getting relatively little Vit d when averaged over the year. 2800iu
average plus the amount they get from fortified milk and food sources
isn't a big deal. If people who are outdoors all day every day
(wearing work clothes) the idea that we can get all we need from
casual exposure walking to the car and back is ludicrous.