Iron and liver cancer

Iron and liver cancer

<<snip>>
iron deposition might accelerate hepatocarcinogenesis
<<snip>>

J Gastroenterol. 2007 Mar;42(3):225-35. Epub 2007 Mar 30.Possible
correlation between iron deposition and enhanced proliferating
activity in hepatitis C virus-positive hepatocellular carcinoma in
Myanmar (Burma).Soe K, Hishikawa Y, Fukuzawa Y, Win N, Yin KS, Win KM,
Myint AA, Koji T.
Department of Histology and Cell Biology, Unit of Basic Medical
Science, Nagasaki University Graduate School of Biomedical Sciences,
1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

BACKGROUND: The aim of this study was to survey the effect of
deposited iron on the cell kinetics of hepatitis C virus (HCV)-
positive hepatocellular carcinoma (HCC) in Myanmar (Burmese) patients.
METHODS: Formalin-fixed and paraffin-embedded liver tissues from 34
Myanmar patients with HCC were used. To detect iron deposition,
Prussian blue staining was performed. Cell proliferation and apoptosis
were assessed by Ki-67 staining and by the terminal deoxynucleotidyl
transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL)
assay, respectively. HCV RNA was detected by in situ hybridization,
and HCV protein, Fas and Fas ligand (FasL) were localized by
immunohistochemistry. To identify the subtype of lymphocytes, CD8 was
used as a surface marker. RESULTS: Iron deposition was found in 43% of
the HCC cases, and was heavier in moderately differentiated HCC than
in well-differentiated HCC. The Ki-67 labeling index (LI) in cancer
cells was higher in Prussian blue-positive-HCC than in -negative HCC
(3.8 +/- 2.2 vs 1.5 +/- 1.7, mean +/- SD; P = 0.0067), whereas there
was no significant difference between these groups in TUNEL LI. HCV
protein was localized in cancer cells, and was found in 89% of the
patients. In addition, Fas was expressed in HCC cells, and FasL was
localized in HCC cells as well as in infiltrating CD8+ T lymphocytes.
The frequency of apoptosis of HCC cells was correlated significantly
with the population density of infiltrating CD8+ T lymphocytes.
CONCLUSIONS: Our results indicated that, in Myanmar patients with HCC,
iron deposition might accelerate hepatocarcinogenesis, by promoting
cancer cell proliferation, without affecting the Fas/FasL apoptotic
system.

PMID: 17380281 [PubMed - in process]


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