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Ribavirin promotes liver fibrosis
Ribavirin promotes liver fibrosis
Ribavirin causes .. hemolysis / glorified bloodletting .. but it
seems .. MUCH .. more .. **deadly**.
<<snip>>
hemolysis is responsible for iron overload, liver iron deposition, and
an acceleration in the progression of liver fibrosis
<<snip>>
Ribavirin promotes liver fibrosis in HCV-positive kidney recipients
Hepatitis Weekly via NewsEdge Corporation :
2005 MAY 23 - (NewsRx . com ) -- Ribavirin promotes liver fibrosis in HCV-
positive kidney recipients.
According to published research from France, "in untreated hepatitis
virus (HCV)-positive renal transplant patients, the rate of liver
fibrosis progression is low. In contrast, in those treated by
ribavirin monotherapy, liver fibrosis score increased significantly
after only 1 year of ribavirin monotherapy. The aim of this study was
to identify the factors that might contribute to accelerate liver
fibrosis progression in this population."
"Eleven patients were included in the study. Intrahepatic transforming
growth factor (TGF)-beta, interferon (IFN)-gamma, and interleukin
(IL)-10 mRNA quantification determined by real-time reverse
transcription-polymerase chain reaction (RT-PCR) were similar before
and after ribavirin therapy," according to N. Kamar and colleagues,
CHU Rangueil, Department of Nephrology, Dialysis and Transplantation.
"The number of amino acid substitutions observed in the hypervariable
region (HVR)-1 of the HCV genome between baseline and 1 year after
ribavirin monotherapy was low, i.e, 3 (1-11) amino acid substitutions,
suggesting the absence of a high selection pressure induced by
ribavirin. In contrast, due to ribavirin-induced hemolysis, there was
a significant increase in serum ferritin levels (p=0.02) and in
intrahepatic iron deposition (p=0.04). Transferrin level and total
iron-binding capacity decreased significantly during ribavirin
monotherapy (p=0.004).
"The increased liver fibrosis observed in renal transplant patients
receiving ribavirin monotherapy could be related to ribavirin-induced
anemia. Severe chronic hemolysis is responsible for iron overload,
liver iron deposition, and an acceleration in the progression of liver
fibrosis," study authors suggested.
Kamar and colleagues published their findings in the Journal of
Medical Virology (Factors accelerating liver fibrosis progression in
renal transplant patients receiving ribavirin monotherapy for chronic
hepatitis C. J Med Virol, 2005;76(1):61-68).
Additional information can be obtained by contacting N. Kamar, CHU
Rangueil, Department Nephrology, Dialysis & Transplantation, 1, Avenue
Jean Poulhes, TSA 50032, F-50032 Toulouse, France.
The publisher of the Journal of Medical Virology can be contacted at:
Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken,
NJ 07030, USA.
Keywords: Toulouse, France, Biotechnology, Hepatitis C Virus,
Hepatology, Liver Fibrosis, Renal Transplantation, Transplantation
Medicine, Virology.
This article was prepared by Hepatitis Weekly editors from staff and
other reports. Copyright 2005, Hepatitis Weekly via NewsRx . com .
<<Hepatitis Weekly -- 05/24/05>>
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Ribavirin causes .. hemolysis / glorified bloodletting .. but it
seems .. MUCH .. more .. **deadly**.
<<snip>>
hemolysis is responsible for iron overload, liver iron deposition, and
an acceleration in the progression of liver fibrosis
<<snip>>
Ribavirin promotes liver fibrosis in HCV-positive kidney recipients
Hepatitis Weekly via NewsEdge Corporation :
2005 MAY 23 - (NewsRx . com ) -- Ribavirin promotes liver fibrosis in HCV-
positive kidney recipients.
According to published research from France, "in untreated hepatitis
virus (HCV)-positive renal transplant patients, the rate of liver
fibrosis progression is low. In contrast, in those treated by
ribavirin monotherapy, liver fibrosis score increased significantly
after only 1 year of ribavirin monotherapy. The aim of this study was
to identify the factors that might contribute to accelerate liver
fibrosis progression in this population."
"Eleven patients were included in the study. Intrahepatic transforming
growth factor (TGF)-beta, interferon (IFN)-gamma, and interleukin
(IL)-10 mRNA quantification determined by real-time reverse
transcription-polymerase chain reaction (RT-PCR) were similar before
and after ribavirin therapy," according to N. Kamar and colleagues,
CHU Rangueil, Department of Nephrology, Dialysis and Transplantation.
"The number of amino acid substitutions observed in the hypervariable
region (HVR)-1 of the HCV genome between baseline and 1 year after
ribavirin monotherapy was low, i.e, 3 (1-11) amino acid substitutions,
suggesting the absence of a high selection pressure induced by
ribavirin. In contrast, due to ribavirin-induced hemolysis, there was
a significant increase in serum ferritin levels (p=0.02) and in
intrahepatic iron deposition (p=0.04). Transferrin level and total
iron-binding capacity decreased significantly during ribavirin
monotherapy (p=0.004).
"The increased liver fibrosis observed in renal transplant patients
receiving ribavirin monotherapy could be related to ribavirin-induced
anemia. Severe chronic hemolysis is responsible for iron overload,
liver iron deposition, and an acceleration in the progression of liver
fibrosis," study authors suggested.
Kamar and colleagues published their findings in the Journal of
Medical Virology (Factors accelerating liver fibrosis progression in
renal transplant patients receiving ribavirin monotherapy for chronic
hepatitis C. J Med Virol, 2005;76(1):61-68).
Additional information can be obtained by contacting N. Kamar, CHU
Rangueil, Department Nephrology, Dialysis & Transplantation, 1, Avenue
Jean Poulhes, TSA 50032, F-50032 Toulouse, France.
The publisher of the Journal of Medical Virology can be contacted at:
Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken,
NJ 07030, USA.
Keywords: Toulouse, France, Biotechnology, Hepatitis C Virus,
Hepatology, Liver Fibrosis, Renal Transplantation, Transplantation
Medicine, Virology.
This article was prepared by Hepatitis Weekly editors from staff and
other reports. Copyright 2005, Hepatitis Weekly via NewsRx . com .
<<Hepatitis Weekly -- 05/24/05>>
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Re: Ribavirin promotes liver fibrosis
On Apr 2, 7:28 pm, "ironjust...@aol . com " <ironjust...@aol . com > wrote:
> Ribavirin causes .. hemolysis / glorified bloodletting .. but it
> seems .. MUCH .. more .. **deadly**.
>
The Ribavirin is a nasty drug to have to take,I was taking it for a
year over four years ago and some of the side effects are
still with me !!!.Same as the Interferon I suppose we are stuck with
them until something better comes along.All I would say to anyone
taking it now is just stick with it,I know it cleaned me up and
chances are it will do the same for you.
On Apr 2, 7:28 pm, "ironjust...@aol . com " <ironjust...@aol . com > wrote:
> Ribavirin causes .. hemolysis / glorified bloodletting .. but it
> seems .. MUCH .. more .. **deadly**.
>
The Ribavirin is a nasty drug to have to take,I was taking it for a
year over four years ago and some of the side effects are
still with me !!!.Same as the Interferon I suppose we are stuck with
them until something better comes along.All I would say to anyone
taking it now is just stick with it,I know it cleaned me up and
chances are it will do the same for you.
Re: Ribavirin promotes liver fibrosis
In article <1175601583.087706.186270@y80g2000hsf.googlegroups . com >,
"*GED*" <flanneryged@yahoo.co.uk> wrote:
> On Apr 2, 7:28 pm, "ironjust...@aol . com " <ironjust...@aol . com > wrote:
> > Ribavirin causes .. hemolysis / glorified bloodletting .. but it
> > seems .. MUCH .. more .. **deadly**.
> >
> The Ribavirin is a nasty drug to have to take,I was taking it for a
> year over four years ago and some of the side effects are
> still with me !!!.Same as the Interferon I suppose we are stuck with
> them until something better comes along.All I would say to anyone
> taking it now is just stick with it,I know it cleaned me up and
> chances are it will do the same for you.
~~~~~~~~~~~~~~~~~~~~
Statins are another drug that can cause side effects that can effect
patients for the rest of their lives. For example, thousands of people now
have a terrible disorder called Rhabdomyolysis and serious memory problems
as a direct result of statins. I was shocked when I read the book
mentioned below about the dangers of statins. However, millions of people
do not suffer from side effects as a result of taking statins.
WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES
by Jay S. Cohen, M.D.
Also visit this site:
w w w .spacedoc . net
In article <1175601583.087706.186270@y80g2000hsf.googlegroups . com >,
"*GED*" <flanneryged@yahoo.co.uk> wrote:
> On Apr 2, 7:28 pm, "ironjust...@aol . com " <ironjust...@aol . com > wrote:
> > Ribavirin causes .. hemolysis / glorified bloodletting .. but it
> > seems .. MUCH .. more .. **deadly**.
> >
> The Ribavirin is a nasty drug to have to take,I was taking it for a
> year over four years ago and some of the side effects are
> still with me !!!.Same as the Interferon I suppose we are stuck with
> them until something better comes along.All I would say to anyone
> taking it now is just stick with it,I know it cleaned me up and
> chances are it will do the same for you.
~~~~~~~~~~~~~~~~~~~~
Statins are another drug that can cause side effects that can effect
patients for the rest of their lives. For example, thousands of people now
have a terrible disorder called Rhabdomyolysis and serious memory problems
as a direct result of statins. I was shocked when I read the book
mentioned below about the dangers of statins. However, millions of people
do not suffer from side effects as a result of taking statins.
WHAT YOU MUST KNOW ABOUT STATIN DRUGS AND THEIR NATURAL ALTERNATIVES
by Jay S. Cohen, M.D.
Also visit this site:
w w w .spacedoc . net
