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hemoglobin
hemoglobin
hemoglobin [hemo + L. globus, globe]
The iron-containing pigment of red blood cells that carries oxygen from
the lungs to the tissues. The amount of hemoglobin in the blood
averages 16 g/100 ml in women, 14 to 18 g/100 ml in men. Hemoglobin
is a crystallizable, conjugated protein consisting of heme, an iron-
containing pigment, and globin, a simple protein. In the lungs, 1 g of
hemoglobin combines readily with 1.36 cc of oxygen, by a process
called oxygenation, to form oxyhemoglobin, an unstable compound.
In the tissues where oxygen concentration is low and carbon dioxide
concentration is high [low pH], hemoglobin releases its oxygen.
Hemoglobin also acts as a buffer for the hydrogen ions produced in red
blood cells when carbon dioxide is converted to bicarbonate ions for
transport in the plasma.
When old RBCs are phagocytized by macrophages in the liver, spleen,
and red bone marrow, the iron of hemoglobin is resused immediately to
produce new RBCs or is stored in the liver until needed. The globin is
converted to animo acids for the synthesis of other proteins. The heme
portion is of no further use and is converted to bilirubin, a bile
pigment excreted by the liver in bile.
Hemoglobin combines with carbon monoxide to form the stable compound
carboxyhemoglobin, which renders hemoglobin unable to bond with oxygen
and results in hypoxia of tissues. Oxidation of the ferrous iron or
hemoglobin to the ferric state produces methemoglobin.
Hundreds of different types of hemoglobin have been discovered. Some
of these, such as hemoglobin S, are described in subentries that
follow.
h.Atc...Hemoblogin A that contains a glucose group linked to the
terminal animo acid of the beta chains of the molecule.
h.C disease...A genetic variant of the hemoglobin molecule that causes
a chronic hemolytic anemia.
h.E disease...A genetic variant of hemoglobin that produces a mild form
of hemolytic anemia. It is primarily in persons of SE Asian origin, in
whom it may provide protection against falciparum malaria.
h.H disease...A genetic variant of hemoglobin that causes a chronic
hemolytic anemia.
h.M disorder...A genetic variant of hemoglobin that causes cyanosis and
methemoglobinemia.
h.S disease...A genetic variant of hemoglobin that causes sickle cell
trait in heterozygotes, and sickle cell disease in hemozygotes. It is
common, especially in persons of African ancestry in whom sickle cell
trait is found in 8%-10% of the population.
h.SC disease...A disease of persons who have inherited two abnormal
forms of hemoglobin, S and C. Affected person my have vaso-occlusive
crises similar to those seen in sickle cell anemia, with bony and
viaceral infarcts.
hemoglobin [hemo + L. globus, globe]
The iron-containing pigment of red blood cells that carries oxygen from
the lungs to the tissues. The amount of hemoglobin in the blood
averages 16 g/100 ml in women, 14 to 18 g/100 ml in men. Hemoglobin
is a crystallizable, conjugated protein consisting of heme, an iron-
containing pigment, and globin, a simple protein. In the lungs, 1 g of
hemoglobin combines readily with 1.36 cc of oxygen, by a process
called oxygenation, to form oxyhemoglobin, an unstable compound.
In the tissues where oxygen concentration is low and carbon dioxide
concentration is high [low pH], hemoglobin releases its oxygen.
Hemoglobin also acts as a buffer for the hydrogen ions produced in red
blood cells when carbon dioxide is converted to bicarbonate ions for
transport in the plasma.
When old RBCs are phagocytized by macrophages in the liver, spleen,
and red bone marrow, the iron of hemoglobin is resused immediately to
produce new RBCs or is stored in the liver until needed. The globin is
converted to animo acids for the synthesis of other proteins. The heme
portion is of no further use and is converted to bilirubin, a bile
pigment excreted by the liver in bile.
Hemoglobin combines with carbon monoxide to form the stable compound
carboxyhemoglobin, which renders hemoglobin unable to bond with oxygen
and results in hypoxia of tissues. Oxidation of the ferrous iron or
hemoglobin to the ferric state produces methemoglobin.
Hundreds of different types of hemoglobin have been discovered. Some
of these, such as hemoglobin S, are described in subentries that
follow.
h.Atc...Hemoblogin A that contains a glucose group linked to the
terminal animo acid of the beta chains of the molecule.
h.C disease...A genetic variant of the hemoglobin molecule that causes
a chronic hemolytic anemia.
h.E disease...A genetic variant of hemoglobin that produces a mild form
of hemolytic anemia. It is primarily in persons of SE Asian origin, in
whom it may provide protection against falciparum malaria.
h.H disease...A genetic variant of hemoglobin that causes a chronic
hemolytic anemia.
h.M disorder...A genetic variant of hemoglobin that causes cyanosis and
methemoglobinemia.
h.S disease...A genetic variant of hemoglobin that causes sickle cell
trait in heterozygotes, and sickle cell disease in hemozygotes. It is
common, especially in persons of African ancestry in whom sickle cell
trait is found in 8%-10% of the population.
h.SC disease...A disease of persons who have inherited two abnormal
forms of hemoglobin, S and C. Affected person my have vaso-occlusive
crises similar to those seen in sickle cell anemia, with bony and
viaceral infarcts.
Re: hemoglobin
On Apr 13, 5:03=EF=BF=BDam, "california_chief"
<Fire_Chief@Jamacha_Junction_FD.ca.us> wrote:
> hemoglobin [hemo + L. globus, globe]
>
> =A0The iron-containing pigment of red blood cells that carries oxygen from
> =A0the lungs to the tissues. =A0The amount of hemoglobin in the blood
> =A0averages 16 g/100 ml in women, 14 to 18 g/100 ml in men. =A0Hemoglobin
> =A0is a crystallizable, conjugated protein consisting of heme, an iron-
> =A0containing pigment, and globin, a simple protein. =A0In the lungs, 1 g=
of
> =A0 hemoglobin combines readily with 1.36 cc of oxygen, by a process
> =A0called oxygenation, to form oxyhemoglobin, an unstable compound.
> =A0In the tissues where oxygen concentration is low and carbon dioxide
> =A0concentration is high [low pH], hemoglobin releases its oxygen.
> =A0Hemoglobin also acts as a buffer for the hydrogen ions produced in red
> =A0blood cells when carbon dioxide is converted to bicarbonate ions for
> =A0transport in the plasma.
>
> =A0When old RBCs are phagocytized by macrophages in the liver, spleen,
> =A0and red bone marrow, the iron of hemoglobin is resused immediately to
> =A0produce new RBCs or is stored in the liver until needed. =A0The globin=
is
> =A0converted to animo acids for the synthesis of other proteins. =A0The h=
eme
> =A0portion is of no further use and is converted to bilirubin, a bile
> =A0pigment excreted by the liver in bile.
>
> =A0Hemoglobin combines with carbon monoxide to form the stable compound
> =A0carboxyhemoglobin, which renders hemoglobin unable to bond with oxygen
> =A0and results in hypoxia of tissues. =A0Oxidation of the ferrous iron or
> =A0hemoglobin to the ferric state produces methemoglobin.
>
> =A0Hundreds of different types of hemoglobin have been discovered. =A0Some
> =A0of these, such as hemoglobin S, are described in subentries that
> =A0follow.
>
> =A0h.Atc...Hemoblogin A that contains a glucose group linked to the
> =A0terminal animo acid of the beta chains of the molecule.
>
> =A0h.C disease...A genetic variant of the hemoglobin molecule that causes
> =A0a chronic hemolytic anemia.
>
> =A0h.E disease...A genetic variant of hemoglobin that produces a mild form
> =A0of hemolytic anemia. =A0It is primarily in persons of SE Asian origin,=
in
> =A0whom it may provide protection against falciparum malaria.
>
> =A0h.H disease...A genetic variant of hemoglobin that causes a chronic
> =A0hemolytic anemia.
>
> =A0h.M disorder...A genetic variant of hemoglobin that causes cyanosis and
> =A0methemoglobinemia.
>
> =A0h.S disease...A genetic variant of hemoglobin that causes sickle cell
> =A0trait in heterozygotes, and sickle cell disease in hemozygotes. =A0It =
is
> =A0common, especially in persons of African ancestry in whom sickle cell
> =A0trait is found in 8%-10% of the population.
>
> =A0h.SC disease...A disease of persons who have inherited two abnormal
> =A0forms of hemoglobin, S and C. =A0Affected person my have vaso-occlusive
> =A0crises similar to those seen in sickle cell anemia, with bony and
> =A0viaceral infarcts.
I said do it "100" times - and I want it before lunch please.
On Apr 13, 5:03=EF=BF=BDam, "california_chief"
<Fire_Chief@Jamacha_Junction_FD.ca.us> wrote:
> hemoglobin [hemo + L. globus, globe]
>
> =A0The iron-containing pigment of red blood cells that carries oxygen from
> =A0the lungs to the tissues. =A0The amount of hemoglobin in the blood
> =A0averages 16 g/100 ml in women, 14 to 18 g/100 ml in men. =A0Hemoglobin
> =A0is a crystallizable, conjugated protein consisting of heme, an iron-
> =A0containing pigment, and globin, a simple protein. =A0In the lungs, 1 g=
of
> =A0 hemoglobin combines readily with 1.36 cc of oxygen, by a process
> =A0called oxygenation, to form oxyhemoglobin, an unstable compound.
> =A0In the tissues where oxygen concentration is low and carbon dioxide
> =A0concentration is high [low pH], hemoglobin releases its oxygen.
> =A0Hemoglobin also acts as a buffer for the hydrogen ions produced in red
> =A0blood cells when carbon dioxide is converted to bicarbonate ions for
> =A0transport in the plasma.
>
> =A0When old RBCs are phagocytized by macrophages in the liver, spleen,
> =A0and red bone marrow, the iron of hemoglobin is resused immediately to
> =A0produce new RBCs or is stored in the liver until needed. =A0The globin=
is
> =A0converted to animo acids for the synthesis of other proteins. =A0The h=
eme
> =A0portion is of no further use and is converted to bilirubin, a bile
> =A0pigment excreted by the liver in bile.
>
> =A0Hemoglobin combines with carbon monoxide to form the stable compound
> =A0carboxyhemoglobin, which renders hemoglobin unable to bond with oxygen
> =A0and results in hypoxia of tissues. =A0Oxidation of the ferrous iron or
> =A0hemoglobin to the ferric state produces methemoglobin.
>
> =A0Hundreds of different types of hemoglobin have been discovered. =A0Some
> =A0of these, such as hemoglobin S, are described in subentries that
> =A0follow.
>
> =A0h.Atc...Hemoblogin A that contains a glucose group linked to the
> =A0terminal animo acid of the beta chains of the molecule.
>
> =A0h.C disease...A genetic variant of the hemoglobin molecule that causes
> =A0a chronic hemolytic anemia.
>
> =A0h.E disease...A genetic variant of hemoglobin that produces a mild form
> =A0of hemolytic anemia. =A0It is primarily in persons of SE Asian origin,=
in
> =A0whom it may provide protection against falciparum malaria.
>
> =A0h.H disease...A genetic variant of hemoglobin that causes a chronic
> =A0hemolytic anemia.
>
> =A0h.M disorder...A genetic variant of hemoglobin that causes cyanosis and
> =A0methemoglobinemia.
>
> =A0h.S disease...A genetic variant of hemoglobin that causes sickle cell
> =A0trait in heterozygotes, and sickle cell disease in hemozygotes. =A0It =
is
> =A0common, especially in persons of African ancestry in whom sickle cell
> =A0trait is found in 8%-10% of the population.
>
> =A0h.SC disease...A disease of persons who have inherited two abnormal
> =A0forms of hemoglobin, S and C. =A0Affected person my have vaso-occlusive
> =A0crises similar to those seen in sickle cell anemia, with bony and
> =A0viaceral infarcts.
I said do it "100" times - and I want it before lunch please.
