Hepatitis B and iron

Hepatitis B and iron

Hepatol Res. 2007 Mar;37(3):172-8.Serum measures of iron status and
HFE gene mutations in patients with hepatitis B virus
infection.Ghaziani T, Alavian SM, Zali MR, Shahraz S, Agah M, Jensen
KP, Ansari S, Sendi H, Lambrecht RW, Covault J, Bonkovsky HL.
Department of Medicine, University of Connecticut Health Center,
Farmington, USA.

Aim: We tested associations between HFE mutations and hepatitis B
virus (HBV) infection. We also explored measures of total body iron
status and their association with chronic HBV infection. Methods:
Serum measures of iron status and HFE mutations (C282Y, H63D, and
S65C) were assessed in 344 Iranian patients with chronic HBV infection
(214 asymptomatic carriers, 130 patients with chronic progressive
liver disease [CPLD]) and 302 controls. Results: Frequencies of HFE
mutations did not differ between patients with chronic HBV infection
and controls (C282Y: P=0.9, H63D: P= 0.8, S65C: P=0.9). By logistic
regression, advanced hepatic fibrosis was associated with HFE H63D
mutation (OR=13.1, P=0.006; 95% CI=2.0-84.1). Higher levels of serum
ferritin and transferrin saturation were observed in patients with
CPLD than in healthy controls (P=0.0001 and 0.01, respectively,
adjusted for age and sex). None of the serum iron measures was related
to liver fibrosis stage or necroinflammatory grade. Conclusion: Serum
iron measures are associated with chronic progressive hepatitis B.
Carriage of HFE mutations is not associated with the presence of
chronic HBV infection or values of serum iron measures in this
population, although HFE H63D is associated with more advanced hepatic
fibrosis.

PMID: 17362299 [PubMed - in process]Who loves ya.
Tom


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