Help Is Here!!!

Help Is Here!!!

DO YOU KNOW ANYONE THAT IS SUFFERING FROM...

HEART DISEASE, STROKES, HIGH BLOOD PRESSURE, ANY FORM OF CANCER,
DIABETEAS, ASTHMA, ANY FORM OF SKIN DISEASE (ACHNY, ECZEMA,ECT),
CARDIOVASCULAR DISEASE, UMNIPETANT, HAY FEVER, VARICOSE VAINS, ACHES &
PAINS, MEMORY DISORDERS, BONE PROBLEMS, OBESITY, HAIR LOSS, TIREDNESS,
ETC?

A UNIQUELY FORMULATED PRODUCT

There is a product that may help these symptoms. This product has a
unique formula one ingredient in it is Arginine when taking the pink
drink reacts with the liver to produce nitric oxide.

On October 12th 1998, a team of scientists won the Nobel Prize in
medicine for their discoveries about a gas molecule called Nitric
Oxide. Nitric Oxide (labelled as the miracle molecule) is a powerful
vasodilator, which simply means, it helps to keep your arteries open
and helps maintain their smooth, Teflon like texture so blood can flow
normally, which has so many positive affects it's unbelievable.
Only in the UK at the moment.

Message me back if you are interested.
Look forward to hearing from you shortly

Re: Help Is Here!!!

Seyhan wrote:
> DO YOU KNOW ANYONE THAT IS SUFFERING FROM...
>
> HEART DISEASE, STROKES, HIGH BLOOD PRESSURE, ANY FORM OF CANCER,
> DIABETEAS, ASTHMA, ANY FORM OF SKIN DISEASE (ACHNY, ECZEMA,ECT),
> CARDIOVASCULAR DISEASE, UMNIPETANT, HAY FEVER, VARICOSE VAINS, ACHES &
> PAINS, MEMORY DISORDERS, BONE PROBLEMS, OBESITY, HAIR LOSS, TIREDNESS,

You forgot buck teeth, global warming, political rhetoric, and spam.

I.P.

Re: Help Is Here!!!

Seyhan the spammer wrote:

> DO YOU KNOW ANYONE THAT IS SUFFERING FROM... (ACHNY,>

What is this "achny" thing? The product of an uneducated spammer/onager?


> On October 12th 1998, a team of scientists won the Nobel Prize in medicine

Who were they?



> Only in the UK at the moment.

Because the US FDA won't approve it?

Re: Help Is Here!!!

Path:
be06.lga!hwmnpeer02.lga!hw-filter.lga!hwmnpeer01.lga!news.highwinds-media.co
m!news.glorb . com !border1.nntp.dca.giganews . com !nntp.giganews . com !postnews.go
ogle . com !q75g2000hsh.googlegroups . com !not-for-mail
From: Seyhan <seyhan mustafa@hotmail . com >
Newsgroups: sci.med.prostate.cancer
Subject: Help Is Here!!!
Date: Sun, 10 Jun 2007 10:46:46 -0000
Organization: * groups.google . com
Lines: 25
Message-ID: <1181472406.443456.82510@q75g2000hsh.googlegroups . com >
NNTP-Posting-Host: 82.40.182.80
Mime-Version: 1.0
Content-Type: text/plain; charset="iso-8859-1"
X-Trace: posting.google . com 1181472406 21249 127.0.0.1 (10 Jun 2007 10:46:46
GMT)
X-Complaints-To: groups-abuse@google . com
NNTP-Posting-Date: Sun, 10 Jun 2007 10:46:46 +0000 (UTC)
User-Agent: G2/1.0
X-HTTP-UserAgent: Mozilla/4.0 (compatible; MSIE 7.0; Windows NT 5.1; (R1
1.5); . net CLR 1.1.4322),gzip(gfe),gzip(gfe)
Complaints-To: groups-abuse@google . com
Injection-Info: q75g2000hsh.googlegroups . com ; posting-host=82.40.182.80;
posting-account=v2UyTA0AAABUuhviyKw-hB0iEk39RPRX
Xref: Hurricane-Charley sci.med.prostate.cancer:2761
X-Received-Date: Sun, 10 Jun 2007 03:46:47 MST (be06.lga)

"Seyhan" seyhan mustafa@hotmail . com wrote:

> DO YOU KNOW ANYONE THAT IS SUFFERING FROM...
> A UNIQUELY FORMULATED PRODUCT
> Message me back if you are interested.


Better yet, message to numbnutz' ISP 82.40.182.80:

inetnum: 82.32.0.0 - 82.47.255.255
org: ORG-CIL2-RIPE
netname: UK-CABLEINET-20030131
descr: PROVIDER Local Registry
descr: Cable Internet Ltd
country: GB
org-name: Cable Internet Ltd
org-type: LIR
address: Telewest Broadband,
address: 4 Bankhead Avenue
address: Bankhead Industrial Estate
address: KY7 6JG
address: Glenrothes, Fife
address: United Kingdom
phone: +44 (0)2920305411
fax-no: +44 (0)2920305377
e-mail: hostmaster@cableinet . net
e-mail: david.lumb@telewest.co.uk
e-mail: Planninginformation.management@ntl . com

role: Telewest Broadband NCMC
address: Communications House
address: Mayfair Business Park
address: Broad Lane
address: Bradford
address: BD4 8PW
e-mail: capacity@telewest.co.uk

role: Telewest Broadband IP Network Services
address: Genesis Business Park
address: Albert Drive
address: Woking
address: Surrey UK
address: GU21 5RW
address:
remarks: Report abuse to w w w .virginmedia . com /netreport
remarks: +44(0)1633 710142
e-mail: ripe@telewest . net

descr: Telewest Broadband
descr: UK Broadband ISP
remarks: report abuse to w w w .virginmedia . com /netreport
remarks: +44(0)1633 710142

Re: Help Is Here!!!

What would you do if you had a product that will change lives?
Would you stay quiet about it or try and give it to as many people as
you could?
What if your family members are sick would you starve them from or
help them?

Re: Help Is Here!!!


"Seyhan" <seyhan__mustafa@hotmail . com > wrote in message
news:1181589183.790614.197970@p47g2000hsd.googlegroups . com ...
> What would you do if you had a product that will change lives?

I wouldn't write "message me," dork.

> Would you stay quiet about it or try and give it to as many people as
> you could?

You're giving it away. FREE? NO COST?

But you won't state what it is, will you?


> What if your family members are sick would you starve them from or
> help them?

Where did you learn English grammar? Or are you still in kindergarten?

Do mommy and daddy know you're pounding on the keyboard, little boy?

Re: Help Is Here!!!

hay chef your very funny..... I like your sence of humour.
c.palmer I would love to say there is a cure for cancer.... But
because it is found in your genetics, it cannot be cured. This is
somthing Allah s.w.t had prescribed for us.
But what this product does is it treats the cause rather than the
symptom.
You want some scientific proof.
I hope you enjoy this.

Nitric Oxide:
Nitric Oxide (NO) is a very important signaling molecule that acts in
many tissues to
regulate a wide range of physiological processes. It was first
discovered several years
ago by a group that was attempting to identify the agent responsible
for promoting blood
vessel relaxation and the regulation of vascular tone. This particular
agent was named
endothelium-derived relaxing factor (EDRF), and was initially assumed
to be a protein
like most of the other signaling factors previously discovered. The
discovery that EDRF
was in fact nitric oxide, a small gaseous molecule, has led to many
publications over the
years including our NOSTM discovery. Our scientist found that besides
promoting blood
vessel relaxation and the regulation of vascular tone, NO plays a key
role in many
biological processes including immune defense, neurotransmission, and
the regulation
of cell death (apoptosis). Since NO is such a very small molecule, it
is able to diffuse
rapidly across cell membrane and depending on the conditions, is able
to travel several
hundred microns. Nitric oxide is produced by enzymes known as nitric
oxide syntheses
(NOS).
Nitric Oxide Syntheses:
Nitric Oxide (NO) is produced by a group of enzymes called nitric
oxide syntheses
(NOS). These enzymes (present in body) convert the Arginine in our
Arginine alpha-
Ketoglutarate (AKG) into citrulline, producing NO in the process.
Oxygen and NADPH
are necessary co-factors. The pure and simple science starts with the
correct form of
AKG.
There are three isoforms of NOS which have been named according to
their activity.
They are neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible
NOS (iNOS).
Our scientists commonly refer to these enzymes by number so that nNOS
is known as
NOS1, iNOS is NOS2, and eNOS is NOS3. Although there are three names,
these
isoforms can be found in a variety of tissues and cell types working
toward the same
biological functions. The general function of NO production from NOS
is illustrated
below in figure 1.
Figure 1:
L- Arginine-alpha- Ketoglutarate
NO
nNOS
NADPH iNOS NADP
eNOS
O2 L-citrulline
nNOS & eNOS synthesizes nitric oxide in response to intracellular
calcium levels. In
other words, like all NOS isoforms, its activity is dependent on the
binding of calmodulin.
Increases in cellular calcium leads to increases in levels of
calmodulin and the
increased binding of calmodulin to eNOS and nNOS which then leads to
an increase in
NO production by these enzymes. The binding of calmodulin is required
for the activity
of all the NOS isoforms to convert our Arginine alpha-Ketoglutarate to
nitric oxide.
Physiological Roles of Nitric Oxide:
Since the initial discovery that NO is able to induce vasodilation, a
large number of other
roles have also been found, as described below.
Role in immune system: NO can be produced by numerous cells involved
in immune
response. In particular cytokine-activated macrophages can produce
high levels of NO
in order to kill targeted cells such as tumors and bacteria.
Role in inflammation: NO has shown to act as a mediator of
inflammatory processes.
This process has enhanced the effect of cyclooxygenases and stimulates
the production
of pro-inflammatory eiconosoids.
Role in nervous system: NO behaves as a neurotransmitter in the
central and
peripheral nervous systems, and because of this function, is has shown
to be involved
in regulating apoptosis in neurons.
Role in blood flow: NO relaxes the smooth muscle in the walls of the
arterioles. At
each systole, the complex endothelial cells that line the blood
vessels, will release a puff
of NO, which then diffuses into the underlying smooth muscle cells.
This process
causes these cells to relax, which permits the surge of blood to pass
through easily.
L-Arginine-alpha-Ketoglutarate:
This amino acid compound was discovered by Rocky Mountain Chemical
Company
(RMC), back in the 1980's, as being a superior form for delivering L-
Arginine to the
human system. RMC is the only domestic manufacture for this compound,
along with
21 other amino acids that are bound to alpha-Ketoglutarate.
Our research scientist discovered that L-Arginine-alpha-Ketoglutarate
was a fuel for
nitric oxide synthases (NOS). In laymen's terms, we discovered a
natural, non-drug
method of creating nitric oxide in the human body. This mechanism is
complex, but the
trigger-mechanism is very elemental. In order to stimulate or produce
nitric oxide in the
body, a terminal nitrogen atom must combine with an oxygen molecule in
the blood. An
enzyme called nitric oxide synthase controls this reaction and NADPH
(a niacincontaining
redox-active electron storage compound), mediates the reaction. The
reaction is accomplished and controlled by oral ingestion of L-
Arginine-alpha-
Ketoglutarate. The left-handed molecule, called L-Arginine, is the
primary source for
nitric oxide in humans. When NO is produced in the body by this
process, scientists
have referred to this as ADNO or Arginine-Derived-Nitric-Oxide.
Additional clinically proven benefits of pure Arginine are:
*Improved blood flow in men with elevated serum cholesterol and early
coronary artery
disease.
Circulation
*Reduced pathological increases in the thickness of plaque-lined walls
in people with
elevated cholesterol.
*Lowered plasma cholesterol levels in subjects with advanced
hypertension.
New England Journal of Medicine
*Elderly patient's oral treatments resulted in significant improvement
in lipid profiles,
with no side effects.
Journal of Perenteral & Enternal Nutrition
*Enhanced coronary artery blood flow in heart patients.
Journal of the American College of Cardiology
*Improved blood-vessel relaxation
Circulation
L-Arginine-alpha-Ketoglutarate has several other important functions
besides the above.
Remember biology 101, which taught that this compound is essential to
the metabolism
of ammonia that is generated from protein breakdown and the
transportation of nitrogen
used in muscle metabolism. L-Arginine also influences several hormone
functions, like
the stimulation to the pituitary gland for the production of growth
hormone. Human
growth hormone helps in muscle building, leading to increased muscle
size, strength,
tone, along with strengthening tendons and ligaments. Growth hormone,
in general,
decreases body fat and increases metabolism which results in more
energy. Back in
the 1980's a book called Life Extension (Pearson & Shaw) proved that
adequate
amounts of the amino acid L-Arginine did stimulate growth hormone
production.
References:
1).Barbul, Fishel, Shimazu, Wasserkrug, Yoshimura, Tao,
And Efron, Intravenous Alimentation with High Arginine
levels Improves Would Healing and Immune Function.,
Journal of Surgical Research, 38 (1985), 228-334.
2).Jay Lombard, board Certified Neurologist; The Brain
Wellness Plan, Breakthrough Medical, Nutritional, and
Immune-Boosting Therapies, 1998.
3). Bath PMW, Willmont M, Leonardi-Bee, Bath FJ, Nitric
oxide donors, L-Arginine, or nitric oxide synthase inhibitors
for acute stroke, Cochrane Review, March 2002.
4).R.M.J. Palmer, A.G. Ferrige, S. Moncada, "Nitric Oxide
release accounts for the biological activity of endotheliumderived
relaxing factor," Nature, 327:524-526, 1987.
5). S. Monada, R.M.J. Palmer, E.A. Higgs, "Nitric oxidephysiology,
pathophysiology, and pharmacology,"
Pharmacological Reviews, 43:109-142, 1992.
6). R.M.J. Palmer, D.S. Ashton, S. Monada, "Vascular
endothelial cells synthesize nitric oxide from l-Arginine,"
Nature, 333:664-666, 1988.
7).Monada, S. , Higgs A., "The L-Arginine-nitric oxide
pathway, New England J. Med, 329:2002-2012, 1993.
8).Hishikawa, Nakaki, Tsuda, Esumi, Ohshima, Suzuli,
Saruta and Kato, Effect of Systemic L-Arginine
administration on hemodynamis and nitric oxide release in
men, Japan Heart Journal, 33:41-48, 1992.
9).1998 FDA Public records department.
10).M.W. Radomski, S. Moncada, R.M.J. Palmer,"The role of
nitric oxide and cGMP in platelet adhesion to vascular
endothelium," Biochem. Biophys. Res. Comml, 148:1482-
1489, 1987.
11).S.Moncada, "L-Arginine-nitric oxide pathway," Acta
Physiological Scandinavia, 145:201-227, 1992.
12).M.R.Shaffer, U. Tatry, R.A. Van Wesep, A. Brabul, "Nitric
oxide metabolism in wounds. Journal Surgical Res,
71:25:31, 1997.
13).Schmidt, Hofman, Shindler, Shutenkl, "NO from NO
synthases, Proc Nati Aad Sil, 93:14492-14497, 1997.
14).D. D. Rees, R.M.J. Palmer, S. Moncads, "Role of
endothelium-derived nitric oxide in the regulation of blood
pressure", Proceedings of the National Academy of
Sciences, 86:3375-3378, 1989.
15).R.J. Gryglewski, S. Moncada, R.M.J. Palmer,
"Superoxide anion is involved in the breakdown of
endothelium-derived vascular relaxing factor", Nature,
320:454-456, 1986.

Re: Help Is Here!!!

One Min. That is explaining NO. But now is a explaination on L-
Arginine.

A Report On Arginine
By Harry Elwardt, N.D., PhD.
"=2E.. A few grams of prevention is worth a ton of cure." 1
So just what is Nitric Oxide (NO)? Over 20,000 articles in the medical
literature since 1980 attest that "absolutely everything in the body
depends
on it." Its function in human physiology is so important that the
American
Academy of Science named Nitric Oxide the "Molecule of the year" in
1992. The Nobel Peace prize in Medicine was awarded to scientists who
began the research on Nitric Oxide in 1998 and now NO has been
referred
to as "The Molecule of the Millennium". Dr. Jonathan S. Stamler, a
professor of medicine at Duke University Medical Center, put it best
when
he said of Nitric Oxide:
"It does everything, everywhere. You cannot name a major cellular
response or
physiological effect in which [Nitric Oxide] is not implicated today.
It's involved in
complex behavioral changes in the brain, airway relaxation, beating of
the heart,
dilation of blood vessels, regulation of intestinal movement, function
of blood
cells, the immune system, even how fingers and arms move."
There are three types of NO. Endothelial-derived NO diffuses out of
endothelial cells
(cells lining arteries and veins) and into smooth muscle cells of
arteries enhancing
relaxation and other properties of vascular physiology.
Endothelial-derived NO also functions in platelets (blood cells
responsible for blood clots)
to inhibit aggregation or blood clotting. Brain-derived NO affects
several types of nerve
cells and appears to be important in neurotransmitter pathways in both
the central as well
as peripheral nervous system and regulates the production and release
of many
hormones. Macrophage-derived NO is important in the immune system.
This type of NO
helps macrophages (a type of immune cell) kill bacteria and tumor
cells. So, NO is
important to the nervous system, the immune system and the vascular
system, which
supplies nutrients to all parts of the body. Arginine, when combined
with Oxygen, forms
NO. Arginine, as found in Ark1=99 is the source of all forms of NO.2, 3
NO decreases with age 4, 5, 6, various age related conditions and many
medications7,8.
Among the most common disease states to affect NO and therefore sexual
function are:
=B7 Diabetes
=B7 Heart disease
=B7 Hypertension (high blood pressure)
=B7 Peripheral Vascular Disease
=B7 Neurological Damage
=B7 Peptic Ulcer
=B7 Arthritis
=B7 Allergy
=B7 Low HDL
2
=B7 Some of the most common drugs affecting NO and/or sexual functions
are
antidepressants - many common drugs like Elavil=AE, Prozac=AE. Paxil=AE,
Zoloft=AE, etc.
=B7 Anti-anxiety drugs, including Xanax=AE and Valium=AE
=B7 Anti-psychotic drugs
=B7 Blood Pressure medications
=B7 Other Cardiac drugs, like lanoxin or other drugs that affect cardiac
rhythm
=B7 Anti-heartburn drugs like Tagamet=AE and Zantac=AE
=B7 Opioids especially chronic use of legal (e.g., Lortab=AE, codeine,
etc.) and illegal
(e.g., heroin) narcotics and pain medicines
=B7 Alcohol, especially chronic use
=B7 Tobacco
The use of many of these drugs and the incidence of most of this
disease conditions
increase after the age of 40. Obviously it is also the age group most
likely to benefit from
the use of Ark1=99, though any age group can benefit. The 40 and above
age group is
also the most likely age group (both men and women) to want to use
Ark1=99 for the
treatment of sexual dysfunction. In the genital tissue, NO triggers
the release of c-GMP,
which is a molecule that causes engorgement of this tissue. The
arginine found in Ark1=99
releases NO to make sure there is plenty of c-GMP. Viagra, on the
other hand, is a drug
that blocks an enzyme to make sure there is plenty of c-GMP. Arginine
has been shown
to be a safe and effective alternative to Viagra=AE. Viagra=AE has been
reported to be safe;
however, the FDA public records suggest the opposite. These records
reported that
between April of 1998 and May of 1999 there were 1,473 adverse events
including 255
serious heart rhythm disturbances, 53 episodes of congestive heart
failure (weakened
heart) 119 strokes, 517 heart attacks and 522 deaths.9
Every major disease process today is directly or indirectly related to
lack of NO.
Diabetes, Hypertension, Hyperlipidemia, Hypercholesterolemia, Cancer,
Peripheral
Vascular Disease, Coronary Artery Disease, Sickle Cell, Scleroderma,
Renal
Failure, Pulmonary Hypertension and Atherosclerosis are all associated
with
decreased levels of NO. (With the exception of cancer, where NO
functions in the
immune system, most of these disease processes involve the vascular
system and
endothelial derived NO).
The primary function of endothelial derived NO is vascular
homeostasis, or balance. NO
maintains vascular health by enhancing endothelial reactivity. The
endothelium is the
inner lining of the blood vessels and as long as the endothelium
remains reactive, they
are supple, pliable and flexible. They are able to respond
appropriately to the various
changes that occur in blood vessels in the course of normal and
abnormal physiology,
when NO decreases, the vessels become stiff and rigid.
This is called atherosclerosis or hardening of the arteries. When we
develop
atherosclerosis, the results are high blood pressure, heart attack and
stroke and
ultimately death. As long as we have plenty of NO, as can be supplied
by the arginine in
Ark1=99, our blood pressure remains low and we have protection from many
of the
consequences of the aging process.
To date arginine has been shown in animal as well as human trials that
it may be
effective in the following:
3
=B7 Decreasing and reversing atherosclerosis by decreasing intimal
thickening and
monocyte accumulation 9,10,11,12,13,14
=B7 Restore normal endothelial function in hypercholesterolemia
14,15,16,17,18,19,20,21
=B7 Reversing consequences of coronary artery disease
22,23,24,25,26,27,28,29,30
=B7 Decreasing cholesterol and triglycerides 32
=B7 Improves walking distance in peripheral vascular disease
31,33,34,35,36
=B7 Improves pain in interstitial cystitis 37,38
=B7 Prolonged administration of arginine reverses adverse effects of
high blood
pressure 39,40,41,42
=B7 Decreases high blood pressure 43
=B7 Decreases post operative infection and length of stay 44
=B7 Increases human growth hormone 45,46,47,48,49,50,116
=B7 Improves outcome after bypass surgery 51
=B7 Improves sexual function 52
=B7 Improves exercise tolerance 53,54
=B7 Improves renal function 55,56,57,58,59,60
=B7 Improves glucose uptake in muscle cells 61
=B7 Improves asthma 61,62,63,64,65,66
=B7 Improves cell mediated immunity 67,68,69,70,71
=B7 Improves pituitary responsiveness and modulates hormonal control
72,73,74
=B7 Improves muscle performance 75
=B7 Improves diabetes and reverses damage 76,77,78,79
=B7 May prevent diabetes 78
=B7 Reduces blood clots and strokes 80,81,82
=B7 Helps prevent restenosis after angioplasty and bypass 83,84,85
=B7 Helps prevent post surgical damage after intestinal manipulation 86
=B7 May improve irritable bowel syndrome 87
=B7 Improves osteoporosis 88
=B7 May improve prostate function 89
=B7 May give protection against size of heart attack 90
=B7 Helps protect in cardiac transplants 91,92
=B7 Improve scleroderma 93
=B7 Improve sickle cell disease 94
=B7 Prevent pre-eclampsia 95
=B7 Improves exercise capacity in pulmonary hypertension 96,117,118
=B7 Improves wound healing 97,98,99
=B7 Reduces ulcers 101,102
=B7 Improves peripheral vascular disease 103,104
=B7 Improves outcome in sepsis 105
=B7 Improves heart failure 106
=B7 Improves outcome of cancer treatment 107,108
=B7 Improve alzheimer's 109,110,111,112
=B7 Improves memory and cognitive functions 113,114,115
=B7 L-arginine has been shown to safe in the above studies as well as
others 100,116
To summarize, arginine by virtue of being a safe and natural Nitric
Oxide donor can be an
extremely significant factor in the treatment and reversal of most
major diseases.
4
The impact of the arginine in Ark1=99 on preventative healthcare and
anti-aging is
profound, not to mention that it is a safe and effective replacement
for the Viagra=AE type
drugs.
References
1=2E Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner
Books, 1999.
2=2E Coffee, C J: Metabolism. Madison, Ct: Fence Creek Publishing,
1998.pp388-389
3=2E Catt KJ: Molecular Mechanisms of Hormone Action. In Endocrinology
and Metabolism, 3rd ed. Edited by Felig P,
Baxter JD, Frohman LA. New York, NY: McGraw-Hill, 1995, pp 138-139
4=2E Gerhard M, et al. Aging progressively impairs endothelium-dependent
vasodilation in forearm resistance vessels of
humans. Hypertension 1996 Apr;27(4):849-53
5=2E Toprakci M, et al. Age-associated changes in nitric oxide
metabolites, nitrite and nitrate. Int J Clin Lab Res
2000;30(2):83-5
6=2E Sakuma I, et al. Identification of arginine as a precursor of
endothelium-derived relaxing factor. Proc Natl Acad Sci
USA 1988 Nov;85(22):8664-7
7=2EVallance P, Moncada S. Nitric Oxide-from mediator to medicines. J R
Coll Physicians Lond 1994 May-Jun;28 (3):
209-219
8=2E Kam PC, Govender G. Nitric oxide: basic science and clinical
applications. Anaesthesia 1994 Jun;49(6): 515-21
9=2E Sinha G. Viagra: ups and downs. Popular Science 2000 July: page 35
10. Boger RH, Bode-Boger SM, Kienke S, et al. Dietary L-arginine
decreases myointimal cell proliferation and vascular
monocyte accumulation in cholesterol-fed rabbits.Atherosclerosis 1998
Jan;136(1) 67-77
11. Cheng JW, Balwin SN. L-Arginine in the management of
cardiovascular diseases. Ann Pharmacother 2001
Jun;35(6):755-64
12. Tentolouris C, Tousoulis D, et al. L-Arginine in coronary
atherosclerosis. Int J Cardiol 2000 Sep 15;75(2-3):123-8
13. Wang B, Ho HV, et al. Regression of atherosclerosis. Circulation
1999;99(9):1236-41
14. Boger RH, Bode-Boger SM, et al. Dietary L-arginine reduces the
progression of atherosclerosis in cholesterol fed
rabbits: comparison with lovastatin. Circulation 1997; 96(4):1282-90
15. Schuschke DA, Miller FN, Lominadze DG, Feldhoff RC. L-arginine
restores cholesterol-attenuated micro vascular
responses in the rat cremaster. Int J Micricirc Clin Exp 1994 Jul-Aug;
14(4): 204-11
16. Orlandi A, Marcellini M Spagnoli LG. Aging influences development
and progression of earl aortic atherosclerosis
lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasac Biol
2000 Apr;20
17. Chong PH, Bachenheimer BS. Current, New and future treatments in
dyslipidemia and atherosclerosis. Drugs
2000 Jul;60(1):55-93
18. Phivthong-ngam L, Bode-Boger SM, Boger RH, et al. Dietary L-
arginine normalizes endothelial induced vascular
contractions in cholesterol-fed rabbits. J Cardiovasc Pharmacol 1998
Aug;32(2): 300-7
19. Maxwell AJ, Anderson B Zapien MP, Cooke JP. Endothelial
dysfunction in hypercholesterolemia is reversed by:
nutritional product designed to enhance nitric oxide activity.
Cardiovasc Drugs Ther 2000 Jun;14(3):309-16
20. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves
endothelial-dependent dilation in
hypercholesterolemic young adults. J Clin Invest 1996 April; 97(8):
1989-94
21. Cooke JP, Dzau J, Creager A. Endothelial dysfunction in
hypercholesterolemia is corrected by L-arginine. Basic
Res Cardiol 1991; 86 Suppl 2: 173-81
22. Fraser GE. Diet and coronary heart disease: beyond dietary fats
and low-density-lipoprotein cholesterol. Am J Clin
Nutr 1994 May;59(5 Suppl) 1117s-1142sand atherosclerosis. Drugs 2000
Jul;60(1):55-93
23. Quyyumi AA. Does acute improvement of endothelial dysfunction in
coronary arterydisease improve myocardial
ischemia? J Am Coll Cardiol 1998 Oct;32(4):904-11
24. Lerman A, Burnett JC Jr, Higano ST, et al. Long-term L-arginine
supplementation improves small vessel coronary
endothelial function in humans. Circulation 1998 Jun 2;97(21):1648-9
25. Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K. Effect of
supplemental oral L-arginine on exercise capacity
in patients with stable angina pectoris. Am J Cardiol 1997 Aug 1;
80(3):331-3
26. Desrois M, Sciaky M, Lan C, et al. L-arginine during long-term
ischemia: effects on cardiac function, energetic
metabolism and endothelial damage. J Heart Lung Transplant 2000 April;
19(4): 367-76
27. Quyyumi AA, Dakak N, Dodati JG, et al. Effect of L-arginine on
human coronary endothelium-dependent and
physiologic vasodilation, J AM Coll Cardiol 1997 Nov 1; 30(5):1220-7
28. Egashira K, et al. Effects of L-arginine supplementation on
endothelium-dependent coronary vasodilation in
patients with angina pectoris and normal coronary arteriograms.
Circulation 1996;94(2):130-4
29. Tentoluris C, et al. L-arginine in coronary atherosclerosis. Int J
Cardiol 2000 Sep15;75(2-3):123-8
5
30. Tretjakovs P, Kalnins U, Dabina I, et al. Plasma HDL-cholesterol
has an effect on nitric oxide production and
arachidonic production in the platelet membranes of coronary artery
disease patients without LDLhypercholesterolemia.
Med Sci Monitor 2000 May- Jun;6(3):507-11
31. Bode-Boger SM, Boger RH, Galland A, Tsikas D Frolich JC. L-
arginine induced vasodilatation in healthy humans:
pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998
Nov; 46(5): 489-97
32. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric
oxide synthase inhibitor, L-N(omega) nitroarginine,
elevates serum triglycerides and cholesterol and lowers hepatic fatty
acid oxidation. J Nutr 1996 Oct;126(10):2563-
7
33. Boger RH, Bode-Boger SM, Theil W, et al. Restoring vascular nitric
oxide formation by L-arginine improves
symptoms of intermittent claudication in patients with Peripheral
arterial occlusive disease. J Am Col Cardiol 1998
Nov;32(5):1336-44
34. Maxwell AJ, Anderson BE Cooke JP. Nutritional therapy for
peripheral artery disease. Vasc Med 2000;5(1):11-19
35. Hiatt WR. New treatment options in intermittent claudication: the
US experience. Int J Clin Pract Suppl 2001
Apr;(119):20-27
36. Creager MA. Medical management of peripheral artery disease.
Cardiol Rev 2001 Jul-Aug;9(4):238-45
37. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A
randomized double-blind study of oral L-arginine for
treatment of interstitial cystitis. J Urol 1999 Feb; 161(2):558-65
38. Cartledge JJ, Davies AM, Eardley I. A randomized double-blind
placebo-controlled crossover trial of the efficacy of
L-arginine in the treatment of interstitial cystitis. BJU Int 2000
Mar; 85(4):421-6
39. Sisic D, Francishetti A, Frolich ED. Prolonged L-arginine on
cardiovascular mass and myocardial hemodynamics
and collagen in aged spontaneously hypertensive and normal rats.
Hypertension 1999 Jan;33(1 Pt 2):451-5
40. Higashi Y, et al. Effects of L-arginine infusion on renal
hemodynamics in patients with mild hypertension.
Hypertension1995;25(4):898-902
41. Hishikawa K, et al. Role of L-arginine-nitric oxide pathway in
hypertension. J Hypertens 1993 Jun; 11(6):639-45
42. Dominiczak AF, Bohr DF. Nitric oxide and its' putative role in
hypertension. Hypertension 1995;25(6):1202-11
43. Nakaki T, et al. L-arginine induced hypotension. Lancet 1990Oct
20; 336(8721):1016-7
44. Braga M, Gianotti L Raedelli G, et al. Perioperative
immunonutrition in patients undergoing cancer surgery: results
of a randomized double-blind phase 3 trial. Arch Surg 1999 Apr;134(4):
428-33
45. Ghigo E, Aimaretti G, Cornelli G, et al. Diagnosis of GH
deficiency in adults. Growth Hormone IGF Res 1998 Feb;8
Suppl A:55-8
46. Wideman L Weltman JY, Patrie JY, et al. Synergy of L-arginine and
GHRP-2 stimulation of growth hormone in men
and women: modulation by exercise. Am J Physiol Regul Integr Comp
Physiol 2000 Oct;279(4):R1467-77
47. Gianotti L,

Re: Help Is Here!!!

Seyhan wrote:
> The Nobel Peace prize in Medicine was awarded to scientists who
> began the research on Nitric Oxide

The entire Nobel prize concept was forever and irrevocably tainted
beyond all credibility by its awards to Jimmy Carter and Yasser Arafat.


> NO has been referred to as "The Molecule of the Millennium"

The molecule N-methyl-1-phenyl-propan-2-amine has had an infinitely
greater impact on our nation than has nitric oxide. Its common name is
meth, and we ain't seen nothing yet.

HOWEVER
. . .
> 118.Nitric oxide and pulmonary hypertension. Coron Artery Dis 1999
> Jul; 10(5):287-94

We gotta admit, this is probably the first time a spammer has responded
to a reference challenge with 118 of 'em. Hell, this will give Steve
Jordan an orgasm . . . and a whole lot of homework to do. ;-)

I.P.

Re: Help Is Here!!!

This what you say meth is a drug. What does that mean? It means there
is two things wrong with it, there will aways be side effects and
secondly you can over dose. Now you may say no. But here is the proof
for meth or chemically known as Methamphetamine.

Methamphetamine is a potent central nervous system stimulant which
affects neurochemical mechanisms responsible for regulating heart
rate, body temperature, blood pressure, appetite, attention, mood and
responses associated with alertness or alarm conditions. The acute
effects of the drug closely resemble the physiological and
psychological effects of an epinephrine-provoked fight-or-flight
response, including increased heart rate and blood pressure,
vasoconstriction (constriction of the arterial walls),
bronchodilation, and hyperglycemia (increased blood sugar). Users
experience an increase in focus, increased mental alertness, and the
elimination of fatigue, as well as a decrease in appetite.

Users must also take caution and avoid being showered by cold water,
riding high-speed roller coasters, consuming caffeine powered drinks,
or exercising and weight lifting, as these actions can trigger
hypertension, nervousness, extreme rapid heartbeat, dilated heartbeat,
or sudden death.

The methyl group is responsible for the potentiation of effects as
compared to the related compound amphetamine, rendering the substance
on the one hand more lipid soluble and easing transport across the
blood brain barrier, and on the other hand more stable against
enzymatic degradation by MAO. Methamphetamine causes the
norepinephrine, dopamine and, serotonin(5HT) transporters to reverse
their direction of flow. This inversion leads to a release of these
transmitters from the vesicles to the cytoplasm and from the cytoplasm
to the synapse (releasing monoamines in rats with ratios of about
NE:DA = 1:2, NE:5HT= 1:60), causing increased stimulation of post-
synaptic receptors. Methamphetamine also indirectly prevents the
reuptake of these neurotransmitters, causing them to remain in the
synaptic cleft for a prolonged period (inhibiting monoamine reuptake
in rats with ratios of about: NE:DA = 1:2.35, NE:5HT = 1:44.5[10]).

Recent research published in the Journal of Pharmacology And
Experimental Therapeutics (2007)[1], indicates that methamphetamine
binds to a group of receptors called TAAR. TAAR is a newly discovered
receptor system which seems to be affected by a range of amphetamine-
like substances called trace amines.


Range of Effects
Common immediate side effects.:[17]

Euphoria
Increased energy and attentiveness
Diarrhea, nausea
Loss of appetite, insomnia, tremor, jaw-clenching (Bruxism)
Agitation, compulsive fascination with repetitive tasks (Punding)
Talkativeness, irritability, panic attacks
Increased libido
Dilated pupils
Side effects associated with chronic use:

Drug craving
Weight loss
Withdrawal-related depression and anhedonia
Rapid tooth decay ("meth mouth")
Amphetamine psychosis, mainly due to sleep deprivation
Side effects associated with overdose:

Brain damage (Neurotoxicity)
Formication (sensation of flesh crawling with bugs, with possible
associated compulsive picking and infecting sores)
Paranoia, delusions, hallucinations
Rhabdomyolysis (Muscle breakdown) which leads to Kidney failure
Death from over dose is usually due to stroke or heart failure, but
can also be caused by hyperthermia or kidney failure.


Meth Mouth

Methamphetamine addicts may lose their teeth abnormally quickly, a
condition known as "meth mouth". This effect is not caused by any
corrosive effects of the drug itself, as per commonly repeated myth.
According to the American Dental Association, meth mouth "is probably
caused by a combination of drug-induced psychological and
physiological changes resulting in xerostomia (dry mouth), extended
periods of poor oral hygiene, frequent consumption of high calorie,
carbonated beverages and tooth grinding and clenching."[18] Similar,
though far less severe symptoms have been reported in clinical use of
other amphetamines, where effects are not exacerbated by a lack of
oral hygiene for extended periods.[19]

Like other substances which stimulate the sympathetic nervous system,
methamphetamine causes decreased production of acid-fighting saliva
and increased thirst, resulting in increased risk for tooth decay,
especially when thirst is quenched by high-sugar drinks.[20]


Sexual Behaviour

Users may exhibit sexually compulsive behaviour while under the
influence. This disregard for the potential dangers of unprotected sex
or other reckless sexual behavior may contribute to the spread of
sexually transmitted infections (STIs) or sexually transmitted
diseases (STDs).

Among the effects reported by methamphetamine users is an increase in
the need and urgency for sex, the ability to have sex for extended
periods of time, and an inability to ejaculate or reach orgasm or
physical release. In addition to increasing the need for sex and
enabling the user to engage in marathon sex sessions, methamphetamine
lowers inhibitions and may cause users to behave recklessly or to
become forgetful. Additionally, many chronic users find themselves
engaging in excessive and repeated masturbation. This type of behavior
often includes the use of fetish type pornography and also may include
experimentation with dangerous behaviors such as auto-erotic
asphyxiation.

According to a recent San Diego study[citation needed],
methamphetamine users often engage in unsafe sexual activities, and
forget or choose not to use condoms. The study found that
methamphetamine users were six times less likely to use condoms. The
urgency for sex combined with the inability to achieve release
(ejaculation) can result in tearing, chafing, and trauma (such as
rawness and friction sores) to the sex organs, the rectum and mouth,
dramatically increasing the risk of transmission of HIV and other
sexually transmitted diseases. Methamphetamine also causes erectile
dysfunction due to vasoconstriction.

Addiction

In an article about his son's addiction to methamphetamine, California
writer and former methamphetamine user David Schiff said:

" This drug has a unique, horrific quality. "

In an interview, Stephan Jenkins, the singer in the band Third Eye
Blind, said that methamphetamine makes you feel 'bright and shiny.'

" It also makes you paranoid, incoherent and both destructive and
pathetically and relentlessly self-destructive. Then you will do
unconscionable things in order to feel bright and shiny again.[21] "

Methamphetamine is potentially addictive, particularly when injected
or smoked.[22] While not life-threatening, withdrawal is often intense
and, as with all addictions, relapse is common. To combat relapse,
many recovering addicts attend 12 Step meetings, such as Crystal Meth
Anonymous.

Former users have noted that they feel stupid or dull when they quit
using methamphetamine. This is because the brain is adapting a need
for methamphetamine to think faster, or at what seems to be a higher
level. It is possible that daily administration of the amino acids L-
Tyrosine and L-5HTP/Tryptophan can aid in the recovery process by
making it easier for the body to reverse the depletion of Dopamine,
Norepinephrine, and Serotonin. Although studies involving the use of
these amino acids have shown some success, this method of recovery has
not been shown to be consistently effective.

It is shown that taking ascorbic acid prior to using methamphetamine
may help reduce acute toxicity to the brain, as rats given the human
equivalent of 5-10 grams of ascorbic acid 30 minutes prior to
methamphetamine dosage had toxicity mediated, yet this will likely be
of little avail in solving the serious behavioral problems associated
with methamphetamine use that create many of the problems the users
experience
________________________________________________________________________________________

United Kingdom
As of 18 January 2007,[30] methamphetamine is classified as a Class A
drug under the Misuse of Drugs Act 1971 following a recommendation
made by the Advisory Council on the Misuse of Drugs in June 2006.[31]
It had previously been classified as a Class B drug, except when
prepared for injection

New Zealand
Methamphetamine is a Class A controlled drug under the New Zealand
Misuse of Drugs Act 1500. The maximum penalty for production and
distribution is imprisonnment for life. While in theory a doctor could
prescribe it for an appropriate indication, this would require case-by-
case approval by the director-general of public health. In New
Zealand, Methamphetamine is most commonly referred to by the street
name P[27] (short for "pure methamphetamine"[28]).

The Netherlands
Methamphetamine is not approved for medical use in The Netherlands. It
falls under Schedule I of the Opium Act. Although production and
distribution of this drug are prohibited, few people who were caught
with a small amount for personal use have been prosecuted.

Australia
The medical use of methamphetamine is recognised in Australia. It is
also known as Ice and has become the focus of a nation-wide crackdown.
As of 2007, this has become part of the election agenda for both major
political parties.

Canada
Methamphetamine is not approved for medical use in Canada. The maximum
penalty for the production and distribution is imprisonment for life.


And your right that it has had an infinatly greater impact on our
nation. You are also right that we have not seen nothing yet. It just
gets worse.




My product is all natural and organic which means you can have as much
of it as you like with no overdose and there are only positive side
effects. Why? Because you are feeding the body with what it already
has but it is starving for more.
AND IT IS HELPING PEOPLE - NOT KILLING PEOPLE.
You be the judge.

Re: Help Is Here!!!

I nearly forgot. The people that won the Nobel Science Prize were
three american pharmacologists here are there names:
Robert Furchgott, Ferid Murad, and Louis Ignarro