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New research information about cancer: an old cheap drug, Dichloroacetic acid, offers big hope
New research information about cancer: an old cheap drug, Dichloroacetic acid, offers big hope
This is not prostate cancer specific information, but I don't
currently see any reason, why it couldn't apply also for PC.
Cancer cells make their energy throughout the main body of the cell,
rather than in the mitochondria. This process, glycolysis, is
inefficient and uses up vast amounts of sugar. Until now it had been
assumed that cancer cells used glycolysis because their mitochondria
were irreparably damaged. However, Dr. Evangelos Michelakis of the
University of Alberta in Edmonton, Canada, and his colleagues
tested Dichloroacetic acid (DCA) on human lung, breast, brain cancer
cells and healthy cells cultured outside the body, and found that DCA
reawakened the mitochondria in cancer cells. The cancer cells then
withered and died. The healthy cells were unaffected. Tumours in rats
deliberately infected with human cancer also shrank drastically when
they were fed DCA-laced water for several weeks.
Although there is still a very long way to go, and financing
the research of an unpatentable(?) drug could cause a problem, it
certainly looks interesting, IMHO.
The study is
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C,
Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G,
Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.
A mitochondria-k(+) channel axis is suppressed in cancer and its
normalization promotes apoptosis and inhibits cancer growth.
Cancer Cell. 2007 Jan;11(1):37-51.
PMID: 17222789 [PubMed - in process]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17222789>
< * w w w .cancercell.org/content/article/abstract?uid=PIIS1535610806003722>
University of Alberta news releases:
Small molecule offers big hope against cancer
University of Alberta, News release January 16, 2007
< * w w w .expressnews.ualberta.ca/article.cfm?id=8153>
Small molecule offers big hope against cancer- Information and Videos
Videos of Dr.Michelakis' interview.
University of Alberta, Faculty of Medicine & Dentistry, News release
January 17, 2007
< * w w w .med.ualberta.ca/news-publications/article.cfm?id=123>
News articles:
The Why Files: Small molecule could be a big cancer fighter
< * whyfiles.org/shorties/225cancer_drug/>
Cheap, safe drug kills most cancers
New Scientist, 17 January 2007
< * w w w .newscientist . com /article/dn10971-cheap-safe-drug-kills-most-cancers.html>
Editorial: No patent? No cancer drug development
New Scientist, 20 January 2007
< * w w w .newscientist . com /channel/opinion/mg19325873.000-editorial-no-patent-no-cancer-drug-development.html>
Small Molecule Offers Big Hope Against Cancer
Medical News Today, 19 January 2007
< * w w w .medicalnewstoday . com /medicalnews.php?newsid=60958>
Small Molecule Offers Big Hope Against Cancer
ScienceDaily, January 17, 2007
< * w w w .sciencedaily . com /releases/2007/01/070116134001.htm>
Cramping tumours
The Economist, Jan 18th 2007
< * w w w .economist . com /science/displaystory.cfm?story_id=8548706>
Small molecule offers big hope against cancer
physorg . com , January 16, 2007
< * w w w .physorg . com /news88194392.html>
--
Matti Narkia
This is not prostate cancer specific information, but I don't
currently see any reason, why it couldn't apply also for PC.
Cancer cells make their energy throughout the main body of the cell,
rather than in the mitochondria. This process, glycolysis, is
inefficient and uses up vast amounts of sugar. Until now it had been
assumed that cancer cells used glycolysis because their mitochondria
were irreparably damaged. However, Dr. Evangelos Michelakis of the
University of Alberta in Edmonton, Canada, and his colleagues
tested Dichloroacetic acid (DCA) on human lung, breast, brain cancer
cells and healthy cells cultured outside the body, and found that DCA
reawakened the mitochondria in cancer cells. The cancer cells then
withered and died. The healthy cells were unaffected. Tumours in rats
deliberately infected with human cancer also shrank drastically when
they were fed DCA-laced water for several weeks.
Although there is still a very long way to go, and financing
the research of an unpatentable(?) drug could cause a problem, it
certainly looks interesting, IMHO.
The study is
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C,
Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G,
Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.
A mitochondria-k(+) channel axis is suppressed in cancer and its
normalization promotes apoptosis and inhibits cancer growth.
Cancer Cell. 2007 Jan;11(1):37-51.
PMID: 17222789 [PubMed - in process]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17222789>
< * w w w .cancercell.org/content/article/abstract?uid=PIIS1535610806003722>
University of Alberta news releases:
Small molecule offers big hope against cancer
University of Alberta, News release January 16, 2007
< * w w w .expressnews.ualberta.ca/article.cfm?id=8153>
Small molecule offers big hope against cancer- Information and Videos
Videos of Dr.Michelakis' interview.
University of Alberta, Faculty of Medicine & Dentistry, News release
January 17, 2007
< * w w w .med.ualberta.ca/news-publications/article.cfm?id=123>
News articles:
The Why Files: Small molecule could be a big cancer fighter
< * whyfiles.org/shorties/225cancer_drug/>
Cheap, safe drug kills most cancers
New Scientist, 17 January 2007
< * w w w .newscientist . com /article/dn10971-cheap-safe-drug-kills-most-cancers.html>
Editorial: No patent? No cancer drug development
New Scientist, 20 January 2007
< * w w w .newscientist . com /channel/opinion/mg19325873.000-editorial-no-patent-no-cancer-drug-development.html>
Small Molecule Offers Big Hope Against Cancer
Medical News Today, 19 January 2007
< * w w w .medicalnewstoday . com /medicalnews.php?newsid=60958>
Small Molecule Offers Big Hope Against Cancer
ScienceDaily, January 17, 2007
< * w w w .sciencedaily . com /releases/2007/01/070116134001.htm>
Cramping tumours
The Economist, Jan 18th 2007
< * w w w .economist . com /science/displaystory.cfm?story_id=8548706>
Small molecule offers big hope against cancer
physorg . com , January 16, 2007
< * w w w .physorg . com /news88194392.html>
--
Matti Narkia
Re: New research information about cancer: an old cheap drug, Dichloroacetic acid, offers big hope
On Sat, 20 Jan 2007 02:44:45 +0200, Matti Narkia <mna@mbnet.fi> wrote:
>This is not prostate cancer specific information, but I don't
>currently see any reason, why it couldn't apply also for PC.
>
>Cancer cells make their energy throughout the main body of the cell,
>rather than in the mitochondria. This process, glycolysis, is
>inefficient and uses up vast amounts of sugar. Until now it had been
>assumed that cancer cells used glycolysis because their mitochondria
>were irreparably damaged. However, Dr. Evangelos Michelakis of the
>University of Alberta in Edmonton, Canada, and his colleagues
>tested Dichloroacetic acid (DCA) on human lung, breast, brain cancer
>cells and healthy cells cultured outside the body, and found that DCA
>reawakened the mitochondria in cancer cells. The cancer cells then
>withered and died. The healthy cells were unaffected. Tumours in rats
>deliberately infected with human cancer also shrank drastically when
>they were fed DCA-laced water for several weeks.
>
>Although there is still a very long way to go, and financing
>the research of an unpatentable(?) drug could cause a problem, it
>certainly looks interesting, IMHO.
>
>The study is
>
>Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C,
>Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G,
>Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.
>A mitochondria-k(+) channel axis is suppressed in cancer and its
>normalization promotes apoptosis and inhibits cancer growth.
>Cancer Cell. 2007 Jan;11(1):37-51.
>PMID: 17222789 [PubMed - in process]
>< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17222789>
>< * w w w .cancercell.org/content/article/abstract?uid=PIIS1535610806003722>
>
>University of Alberta news releases:
>
>Small molecule offers big hope against cancer
>University of Alberta, News release January 16, 2007
>< * w w w .expressnews.ualberta.ca/article.cfm?id=8153>
>
>Small molecule offers big hope against cancer- Information and Videos
>Videos of Dr.Michelakis' interview.
>University of Alberta, Faculty of Medicine & Dentistry, News release
>January 17, 2007
>< * w w w .med.ualberta.ca/news-publications/article.cfm?id=123>
>
Here's Wikipedia's article about Dichloroacetic acid:
< * en.wikipedia.org/wiki/Dichloroacetic_acid>
Searching Medline for Dichloroacetate OR "Dichloroacetic acid" returns
1051 studies:
< * tinyurl . com /358cpr>
Here's a recent study about the use of oral dichloroacetate (DCA) in
the treatment of children with congenital lactic acidosis caused by
mutations in the pyruvate dehydrogenase complex (PDC):
Berendzen K, Theriaque DW, Shuster J, Stacpoole PW.
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase
complex deficiency.
Mitochondrion. 2006 Jun;6(3):126-35. Epub 2006 May 3.
PMID: 16725381 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16725381>
DCA also has antidiabetic effects in the type 2 diabetes:
Stacpoole PW, Greene YJ.
Dichloroacetate.
Diabetes Care. 1992 Jun;15(6):785-91. Review.
PMID: 1600837 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1600837>
Peer G, Graf H.
[Sodium dichloroacetate--a substance with manifold therapeutic
potential]
Wien Klin Wochenschr. 1990 Feb 2;102(3):65-9. Review. German.
PMID: 2180210 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2180210>
Stacpoole PW.
The pharmacology of dichloroacetate.
Metabolism. 1989 Nov;38(11):1124-44. Review.
PMID: 2554095 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2554095>
Park R, Radosevich PR, Leach WJ, Seto P, Arieff AI.
Metabolic effects of dichloroacetate in diabetic dogs.
Am J Physiol. 1983 Jul;245(1):E94-101.
PMID: 6869532 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6869532>
< * ajpendo.physiology.org/cgi/content/abstract/245/1/E94>
Other interesting DCA studies:
Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL,
Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF.
Dichloroacetate exerts therapeutic effects in transgenic mouse models
of Huntington's disease.
Ann Neurol. 2001 Jul;50(1):112-7.
PMID: 11456300 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11456300>
Oishi K, Yoshioka M, Ozawa R, Yamamoto T, Oya Y, Ogawa M, Kawai M.
[Dichloroacetate treatment for adult patients with mitochondrial
disease]
Rinsho Shinkeigaku. 2003 Apr;43(4):154-61. Japanese.
PMID: 12892050 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12892050>
--
Matti Narkia
On Sat, 20 Jan 2007 02:44:45 +0200, Matti Narkia <mna@mbnet.fi> wrote:
>This is not prostate cancer specific information, but I don't
>currently see any reason, why it couldn't apply also for PC.
>
>Cancer cells make their energy throughout the main body of the cell,
>rather than in the mitochondria. This process, glycolysis, is
>inefficient and uses up vast amounts of sugar. Until now it had been
>assumed that cancer cells used glycolysis because their mitochondria
>were irreparably damaged. However, Dr. Evangelos Michelakis of the
>University of Alberta in Edmonton, Canada, and his colleagues
>tested Dichloroacetic acid (DCA) on human lung, breast, brain cancer
>cells and healthy cells cultured outside the body, and found that DCA
>reawakened the mitochondria in cancer cells. The cancer cells then
>withered and died. The healthy cells were unaffected. Tumours in rats
>deliberately infected with human cancer also shrank drastically when
>they were fed DCA-laced water for several weeks.
>
>Although there is still a very long way to go, and financing
>the research of an unpatentable(?) drug could cause a problem, it
>certainly looks interesting, IMHO.
>
>The study is
>
>Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C,
>Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G,
>Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.
>A mitochondria-k(+) channel axis is suppressed in cancer and its
>normalization promotes apoptosis and inhibits cancer growth.
>Cancer Cell. 2007 Jan;11(1):37-51.
>PMID: 17222789 [PubMed - in process]
>< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17222789>
>< * w w w .cancercell.org/content/article/abstract?uid=PIIS1535610806003722>
>
>University of Alberta news releases:
>
>Small molecule offers big hope against cancer
>University of Alberta, News release January 16, 2007
>< * w w w .expressnews.ualberta.ca/article.cfm?id=8153>
>
>Small molecule offers big hope against cancer- Information and Videos
>Videos of Dr.Michelakis' interview.
>University of Alberta, Faculty of Medicine & Dentistry, News release
>January 17, 2007
>< * w w w .med.ualberta.ca/news-publications/article.cfm?id=123>
>
Here's Wikipedia's article about Dichloroacetic acid:
< * en.wikipedia.org/wiki/Dichloroacetic_acid>
Searching Medline for Dichloroacetate OR "Dichloroacetic acid" returns
1051 studies:
< * tinyurl . com /358cpr>
Here's a recent study about the use of oral dichloroacetate (DCA) in
the treatment of children with congenital lactic acidosis caused by
mutations in the pyruvate dehydrogenase complex (PDC):
Berendzen K, Theriaque DW, Shuster J, Stacpoole PW.
Therapeutic potential of dichloroacetate for pyruvate dehydrogenase
complex deficiency.
Mitochondrion. 2006 Jun;6(3):126-35. Epub 2006 May 3.
PMID: 16725381 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=16725381>
DCA also has antidiabetic effects in the type 2 diabetes:
Stacpoole PW, Greene YJ.
Dichloroacetate.
Diabetes Care. 1992 Jun;15(6):785-91. Review.
PMID: 1600837 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1600837>
Peer G, Graf H.
[Sodium dichloroacetate--a substance with manifold therapeutic
potential]
Wien Klin Wochenschr. 1990 Feb 2;102(3):65-9. Review. German.
PMID: 2180210 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2180210>
Stacpoole PW.
The pharmacology of dichloroacetate.
Metabolism. 1989 Nov;38(11):1124-44. Review.
PMID: 2554095 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2554095>
Park R, Radosevich PR, Leach WJ, Seto P, Arieff AI.
Metabolic effects of dichloroacetate in diabetic dogs.
Am J Physiol. 1983 Jul;245(1):E94-101.
PMID: 6869532 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6869532>
< * ajpendo.physiology.org/cgi/content/abstract/245/1/E94>
Other interesting DCA studies:
Andreassen OA, Ferrante RJ, Huang HM, Dedeoglu A, Park L, Ferrante KL,
Kwon J, Borchelt DR, Ross CA, Gibson GE, Beal MF.
Dichloroacetate exerts therapeutic effects in transgenic mouse models
of Huntington's disease.
Ann Neurol. 2001 Jul;50(1):112-7.
PMID: 11456300 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11456300>
Oishi K, Yoshioka M, Ozawa R, Yamamoto T, Oya Y, Ogawa M, Kawai M.
[Dichloroacetate treatment for adult patients with mitochondrial
disease]
Rinsho Shinkeigaku. 2003 Apr;43(4):154-61. Japanese.
PMID: 12892050 [PubMed - indexed for MEDLINE]
< * w w w .ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12892050>
--
Matti Narkia
