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Cialis/Viagra for LUTS?
Cialis/Viagra for LUTS?
* w w w .medscape . com /viewarticle/537510
"The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
An exciting new development in the medical therapy of LUTS and BPH is
the use of phosphodiesterase inhibitors, specifically inhibitors of
the PDE-5 isoenzyme. These drugs, which are currently approved for the
treatment of men with erectile dysfunction, work by inducing
relaxation of the smooth muscle in the cavernous tissue of the penis.
It is known that there is a considerable abundance of PDE-5 also in
the prostate presumably involved in smooth muscle tone regulation as
well. It seemed plausible that inhibition of the PDE-5 in the prostate
might lead to smooth muscle relaxation by a mechanism similar to the
one postulated for alpha receptor blocker. Indeed, in addition to
other reports, there have been noncontrolled publications emphasizing
the improvement in LUTS symptoms in men treated with sildenafil
citrate for BPH.[7,8]
At this year's meeting, the results of 3 studies on the use of PDE-5
inhibitors for the treatment of BPH/LUTS were reported. Roehrborn and
coworkers[9] presented the results of a double-blind, randomized,
parallel-group study of the effect of tadalafil on men with LUTS due
to BPH. After a 4-week placebo run-in to evaluate treatment
compliance, the 281 men who met eligibility criteria were randomized
to receive either tadalafil 5 mg for 6 weeks followed by an escalation
to 20 mg for a further 6 weeks or placebo for 12 weeks. From the
screening visit to the endpoint, tadalafil improved the IPSS by 6.2
points (5 mg) and 7.1 points (20 mg) compared with a placebo effect of
3.9 and 4.5 points, respectively (Table). Improvements in quality-of-
life scores and BPH impact indices were similar for the tadalafil and
placebo groups. However, tadalafil surprisingly had no effects on
maximum urinary flow rate or postvoid residual. The drug, which was
well tolerated, had an additional beneficial effect -- a significant
improvement in the International Index of Erectile Function (IIEF)
score....
In a very similar trial,[10] sildenafil citrate was given in doses of
50 and 100 mg at bedtime or prior to sexual activity daily to 366 men
over the age of 45 with an IIEF score of less than 25 and IPSS of
greater than 12 points. The erectile function domain of the IIEF
improved by 9.2 in the sildenafil group vs 1.9 points in the placebo
group (P < .001), and the IPSS improved by 6.3 in the sildenafil group
vs 1.9 points in the placebo group. All other measures, such as BPH
impact index and quality-of-life score, were better in men receiving
sildenafil than in those on placebo (Figure 2). However, in this as
well as in the tadalafil study, no effect was seen on maximum urinary
flow rate."
Anyone tried it?
D
* w w w .medscape . com /viewarticle/537510
"The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
An exciting new development in the medical therapy of LUTS and BPH is
the use of phosphodiesterase inhibitors, specifically inhibitors of
the PDE-5 isoenzyme. These drugs, which are currently approved for the
treatment of men with erectile dysfunction, work by inducing
relaxation of the smooth muscle in the cavernous tissue of the penis.
It is known that there is a considerable abundance of PDE-5 also in
the prostate presumably involved in smooth muscle tone regulation as
well. It seemed plausible that inhibition of the PDE-5 in the prostate
might lead to smooth muscle relaxation by a mechanism similar to the
one postulated for alpha receptor blocker. Indeed, in addition to
other reports, there have been noncontrolled publications emphasizing
the improvement in LUTS symptoms in men treated with sildenafil
citrate for BPH.[7,8]
At this year's meeting, the results of 3 studies on the use of PDE-5
inhibitors for the treatment of BPH/LUTS were reported. Roehrborn and
coworkers[9] presented the results of a double-blind, randomized,
parallel-group study of the effect of tadalafil on men with LUTS due
to BPH. After a 4-week placebo run-in to evaluate treatment
compliance, the 281 men who met eligibility criteria were randomized
to receive either tadalafil 5 mg for 6 weeks followed by an escalation
to 20 mg for a further 6 weeks or placebo for 12 weeks. From the
screening visit to the endpoint, tadalafil improved the IPSS by 6.2
points (5 mg) and 7.1 points (20 mg) compared with a placebo effect of
3.9 and 4.5 points, respectively (Table). Improvements in quality-of-
life scores and BPH impact indices were similar for the tadalafil and
placebo groups. However, tadalafil surprisingly had no effects on
maximum urinary flow rate or postvoid residual. The drug, which was
well tolerated, had an additional beneficial effect -- a significant
improvement in the International Index of Erectile Function (IIEF)
score....
In a very similar trial,[10] sildenafil citrate was given in doses of
50 and 100 mg at bedtime or prior to sexual activity daily to 366 men
over the age of 45 with an IIEF score of less than 25 and IPSS of
greater than 12 points. The erectile function domain of the IIEF
improved by 9.2 in the sildenafil group vs 1.9 points in the placebo
group (P < .001), and the IPSS improved by 6.3 in the sildenafil group
vs 1.9 points in the placebo group. All other measures, such as BPH
impact index and quality-of-life score, were better in men receiving
sildenafil than in those on placebo (Figure 2). However, in this as
well as in the tadalafil study, no effect was seen on maximum urinary
flow rate."
Anyone tried it?
D
Re: Cialis/Viagra for LUTS?
I take Viagra, and I notice a reduction in prostate pain every time I take
it. I told this to my uro and he didn't look like he believed me.
"Donkey" <chrisgg@volcanomail . com > wrote in message
news:1170955826.631902.256890@q2g2000cwa.googlegroups . com ...
> * w w w .medscape . com /viewarticle/537510
>
> "The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
> An exciting new development in the medical therapy of LUTS and BPH is
> the use of phosphodiesterase inhibitors, specifically inhibitors of
> the PDE-5 isoenzyme. These drugs, which are currently approved for the
> treatment of men with erectile dysfunction, work by inducing
> relaxation of the smooth muscle in the cavernous tissue of the penis.
> It is known that there is a considerable abundance of PDE-5 also in
> the prostate presumably involved in smooth muscle tone regulation as
> well. It seemed plausible that inhibition of the PDE-5 in the prostate
> might lead to smooth muscle relaxation by a mechanism similar to the
> one postulated for alpha receptor blocker. Indeed, in addition to
> other reports, there have been noncontrolled publications emphasizing
> the improvement in LUTS symptoms in men treated with sildenafil
> citrate for BPH.[7,8]
>
> At this year's meeting, the results of 3 studies on the use of PDE-5
> inhibitors for the treatment of BPH/LUTS were reported. Roehrborn and
> coworkers[9] presented the results of a double-blind, randomized,
> parallel-group study of the effect of tadalafil on men with LUTS due
> to BPH. After a 4-week placebo run-in to evaluate treatment
> compliance, the 281 men who met eligibility criteria were randomized
> to receive either tadalafil 5 mg for 6 weeks followed by an escalation
> to 20 mg for a further 6 weeks or placebo for 12 weeks. From the
> screening visit to the endpoint, tadalafil improved the IPSS by 6.2
> points (5 mg) and 7.1 points (20 mg) compared with a placebo effect of
> 3.9 and 4.5 points, respectively (Table). Improvements in quality-of-
> life scores and BPH impact indices were similar for the tadalafil and
> placebo groups. However, tadalafil surprisingly had no effects on
> maximum urinary flow rate or postvoid residual. The drug, which was
> well tolerated, had an additional beneficial effect -- a significant
> improvement in the International Index of Erectile Function (IIEF)
> score....
>
> In a very similar trial,[10] sildenafil citrate was given in doses of
> 50 and 100 mg at bedtime or prior to sexual activity daily to 366 men
> over the age of 45 with an IIEF score of less than 25 and IPSS of
> greater than 12 points. The erectile function domain of the IIEF
> improved by 9.2 in the sildenafil group vs 1.9 points in the placebo
> group (P < .001), and the IPSS improved by 6.3 in the sildenafil group
> vs 1.9 points in the placebo group. All other measures, such as BPH
> impact index and quality-of-life score, were better in men receiving
> sildenafil than in those on placebo (Figure 2). However, in this as
> well as in the tadalafil study, no effect was seen on maximum urinary
> flow rate."
>
> Anyone tried it?
>
> D
>
I take Viagra, and I notice a reduction in prostate pain every time I take
it. I told this to my uro and he didn't look like he believed me.
"Donkey" <chrisgg@volcanomail . com > wrote in message
news:1170955826.631902.256890@q2g2000cwa.googlegroups . com ...
> * w w w .medscape . com /viewarticle/537510
>
> "The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
> An exciting new development in the medical therapy of LUTS and BPH is
> the use of phosphodiesterase inhibitors, specifically inhibitors of
> the PDE-5 isoenzyme. These drugs, which are currently approved for the
> treatment of men with erectile dysfunction, work by inducing
> relaxation of the smooth muscle in the cavernous tissue of the penis.
> It is known that there is a considerable abundance of PDE-5 also in
> the prostate presumably involved in smooth muscle tone regulation as
> well. It seemed plausible that inhibition of the PDE-5 in the prostate
> might lead to smooth muscle relaxation by a mechanism similar to the
> one postulated for alpha receptor blocker. Indeed, in addition to
> other reports, there have been noncontrolled publications emphasizing
> the improvement in LUTS symptoms in men treated with sildenafil
> citrate for BPH.[7,8]
>
> At this year's meeting, the results of 3 studies on the use of PDE-5
> inhibitors for the treatment of BPH/LUTS were reported. Roehrborn and
> coworkers[9] presented the results of a double-blind, randomized,
> parallel-group study of the effect of tadalafil on men with LUTS due
> to BPH. After a 4-week placebo run-in to evaluate treatment
> compliance, the 281 men who met eligibility criteria were randomized
> to receive either tadalafil 5 mg for 6 weeks followed by an escalation
> to 20 mg for a further 6 weeks or placebo for 12 weeks. From the
> screening visit to the endpoint, tadalafil improved the IPSS by 6.2
> points (5 mg) and 7.1 points (20 mg) compared with a placebo effect of
> 3.9 and 4.5 points, respectively (Table). Improvements in quality-of-
> life scores and BPH impact indices were similar for the tadalafil and
> placebo groups. However, tadalafil surprisingly had no effects on
> maximum urinary flow rate or postvoid residual. The drug, which was
> well tolerated, had an additional beneficial effect -- a significant
> improvement in the International Index of Erectile Function (IIEF)
> score....
>
> In a very similar trial,[10] sildenafil citrate was given in doses of
> 50 and 100 mg at bedtime or prior to sexual activity daily to 366 men
> over the age of 45 with an IIEF score of less than 25 and IPSS of
> greater than 12 points. The erectile function domain of the IIEF
> improved by 9.2 in the sildenafil group vs 1.9 points in the placebo
> group (P < .001), and the IPSS improved by 6.3 in the sildenafil group
> vs 1.9 points in the placebo group. All other measures, such as BPH
> impact index and quality-of-life score, were better in men receiving
> sildenafil than in those on placebo (Figure 2). However, in this as
> well as in the tadalafil study, no effect was seen on maximum urinary
> flow rate."
>
> Anyone tried it?
>
> D
>
Re: Cialis/Viagra for LUTS?
Ok, I've been taking generic cialis 5mg/day for a week now and my
impression is that some of my urinary problems have been lessened. At
nights I don't have that slight ache in my bladder that made me want
to go piss before I really needed to. In general the flow is not
really any better, but it seems a bit easier to get started. Side
effects have been a headache and aching muscles after exercise, but
I'm hoping that will pass.
D
Ok, I've been taking generic cialis 5mg/day for a week now and my
impression is that some of my urinary problems have been lessened. At
nights I don't have that slight ache in my bladder that made me want
to go piss before I really needed to. In general the flow is not
really any better, but it seems a bit easier to get started. Side
effects have been a headache and aching muscles after exercise, but
I'm hoping that will pass.
D
Re: Cialis/Viagra for LUTS?
Donkey wrote:
> "The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
> An exciting new development in the medical therapy of LUTS and BPH is
> the use of phosphodiesterase inhibitors, specifically inhibitors of
> the PDE-5 isoenzyme. . . . . .
> . . . However, tadalafil surprisingly had no effects on
> maximum urinary flow rate or postvoid residual.
> Anyone tried it?
Delurking for a moment:
I have BPH, which sometimes flares up when I'm under stress or when I
eat certain foods, although I've never been able to pinpoint all the
causes.
A quarter tablet Cialis (20 mg Chinese IP brand) relaxes me and makes it
easier to get started peeing and, unlike the above, it also increases
the flow. I only take it when needed, which is not that often now,
maybe every other month for a day or three.
About two years ago, I was going to ask my Uro for a laser fix, since my
flow problem had gotten so bad. Also at that time, my GP wanted to
change my cholesterol medication to a Statin, and I objected and decided
to try Niacin and see if that worked. I'm taking traditional Niacin
(not the timed release or the no-flush variety, which is rather hard to
find in the US) and one of the unexpected side effects is that, too,
increased my flow. I'm peeing like I was 40 years younger and my
chloresterol now tests better than prior.
I googled this group and only found one other reference to Niacin
releaving the symptoms of BPH and that was quite a few years ago.
Ignatz.
Donkey wrote:
> "The Use of Phosphodiesterase-5 Inhibitors in the Treatment of LUTS
> An exciting new development in the medical therapy of LUTS and BPH is
> the use of phosphodiesterase inhibitors, specifically inhibitors of
> the PDE-5 isoenzyme. . . . . .
> . . . However, tadalafil surprisingly had no effects on
> maximum urinary flow rate or postvoid residual.
> Anyone tried it?
Delurking for a moment:
I have BPH, which sometimes flares up when I'm under stress or when I
eat certain foods, although I've never been able to pinpoint all the
causes.
A quarter tablet Cialis (20 mg Chinese IP brand) relaxes me and makes it
easier to get started peeing and, unlike the above, it also increases
the flow. I only take it when needed, which is not that often now,
maybe every other month for a day or three.
About two years ago, I was going to ask my Uro for a laser fix, since my
flow problem had gotten so bad. Also at that time, my GP wanted to
change my cholesterol medication to a Statin, and I objected and decided
to try Niacin and see if that worked. I'm taking traditional Niacin
(not the timed release or the no-flush variety, which is rather hard to
find in the US) and one of the unexpected side effects is that, too,
increased my flow. I'm peeing like I was 40 years younger and my
chloresterol now tests better than prior.
I googled this group and only found one other reference to Niacin
releaving the symptoms of BPH and that was quite a few years ago.
Ignatz.
Re: Cialis/Viagra for LUTS?
> About two years ago, I was going to ask my Uro for a laser fix, since my
> flow problem had gotten so bad. Also at that time, my GP wanted to
> change my cholesterol medication to a Statin, and I objected and decided
> to try Niacin and see if that worked. I'm taking traditional Niacin
> (not the timed release or the no-flush variety, which is rather hard to
> find in the US) and one of the unexpected side effects is that, too,
> increased my flow. I'm peeing like I was 40 years younger and my
> chloresterol now tests better than prior.
Ignatz,
You can get 'SLO-NIACIN' at Walmart's . I take two per day for my
cholesterol and also take Pravastatin. Seems to keep my cholesterol in
check.
(I still have bad BHP probs thought)
-Mel
> About two years ago, I was going to ask my Uro for a laser fix, since my
> flow problem had gotten so bad. Also at that time, my GP wanted to
> change my cholesterol medication to a Statin, and I objected and decided
> to try Niacin and see if that worked. I'm taking traditional Niacin
> (not the timed release or the no-flush variety, which is rather hard to
> find in the US) and one of the unexpected side effects is that, too,
> increased my flow. I'm peeing like I was 40 years younger and my
> chloresterol now tests better than prior.
Ignatz,
You can get 'SLO-NIACIN' at Walmart's . I take two per day for my
cholesterol and also take Pravastatin. Seems to keep my cholesterol in
check.
(I still have bad BHP probs thought)
-Mel
