Magnetic Iron Measurements

Magnetic Iron Measurements

"Arag=C3=B3n"

Journal of Magnetism and Magnetic Materials
Volume 316, Issue 2, September 2007, Pages 126-131
Proceedings of the Joint European Magnetic Symposia

doi:10.1016/j.jmmm.2007.02.032
Copyright =C2=A9 2007 Elsevier B.V. All rights reserved.
Biological tissue magnetism in the frame of iron overload diseases

Francisco J. L=C3=A1zaroa, b, , , Luc=C3=ADa Guti=C3=A9rreza, Ana R. Abad=
=C3=ADac, Mar=C3=ADa
S=2E Romerod and A. L=C3=B3peze
aDepartamento de Ciencia y Tecnolog=C3=ADa de Materiales y Fluidos,
Universidad de Zaragoza, Zaragoza 50018, Spain
bInstituto de Nanociencia de Arag=C3=B3n, Universidad de Zaragoza, Zaragoza
50009, Spain
cDepartamento de Farmacolog=C3=ADa y Fisiolog=C3=ADa, Universidad de Zarago=
za,
Zaragoza 50013, Spain
dDepartamento de Medicina y Psiquiatr=C3=ADa, Universidad de Zaragoza,
Zaragoza 50009, Spain
eCNAM-Salesianos Zaragoza, Zaragoza 50009, Spain

Available online 27 February 2007.

Abstract

The conspicuous magnetic properties of iron, paradoxically, rarely
participate in the methods routinely employed in the clinical
environment to detect iron containing species in tissues. In the
organism iron is just a trace metal and it mostly occurs as part of
haemoproteins or ferritin, which show paramagnetic, diamagnetic or
antiferromagnetic behaviour, hence resulting in a very low
contribution to the tissue susceptibility. Detailed magnetic
measurements make it nowadays possible to identify such species in
tissues that correspond to individuals with iron overload pathologies.
Since, as alternatives to the conventional biopsy, magnetism-based
noninvasive techniques to diagnose and manage such diseases are
recently under development, the deep knowledge of the magnetic
properties of the different forms of iron in tissues is of high
applied interest.

Keywords: Ferritin; AC susceptibility; Superparamagnetism;
Noninvasive; Iron overload

PACS classification codes: 75.20.=E2=88=92g; 75.40.Gb; 75.50.Tt; 87.19.Xx;
87.80.Tq



Corresponding author. Departamento de Ciencia y Tecnolog=C3=ADa de
Materiales y Fluidos, Universidad de Zaragoza, Zaragoza 50018, Spain.
Tel.: +34 976 761000; fax: +34 976 761957.

Journal of Magnetism and Magnetic Materials
Volume 316, Issue 2, September 2007, Pages 126-131
Proceedings of the Joint European Magnetic Symposia


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