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Proteinuria
Proteinuria manifests when one goes to altitude and when one goes to
altitude one manifests increased red blood cell production /
erythrocytosis / polycythemia / hemochromatosis / iron overload..
"Proteinuria at high altitude.Proteinuria at high altitude. A Bradwell
and J Delamere. Full text ... Pines A. High-altitude acclimatization
and proteinuria in East Africa. ...
w w w .pubmedcentral.nih.gov/articlerender.fcgi?artid=1599488 - "
Proteinuria is a marker used by .. them .. to assess disease
activity / severity.
Proteinuria is a .. bad .. thing ..
Proteinuria appears in kidney disease .. in fact it is THE marker to
assess kidney function.
"Coincidentally" .. to .. **everyone** .. it seems .. increased red
blood cell production .. CAUSES .. kidney disease ..
Soooo .. the increased red blood cell production / erythrocytosis /
polycythemia / hemochromatosis / iron overload .. destroys the
kidneys ..
Pretty simple.
* kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
altitude one manifests increased red blood cell production /
erythrocytosis / polycythemia / hemochromatosis / iron overload..
"Proteinuria at high altitude.Proteinuria at high altitude. A Bradwell
and J Delamere. Full text ... Pines A. High-altitude acclimatization
and proteinuria in East Africa. ...
w w w .pubmedcentral.nih.gov/articlerender.fcgi?artid=1599488 - "
Proteinuria is a marker used by .. them .. to assess disease
activity / severity.
Proteinuria is a .. bad .. thing ..
Proteinuria appears in kidney disease .. in fact it is THE marker to
assess kidney function.
"Coincidentally" .. to .. **everyone** .. it seems .. increased red
blood cell production .. CAUSES .. kidney disease ..
Soooo .. the increased red blood cell production / erythrocytosis /
polycythemia / hemochromatosis / iron overload .. destroys the
kidneys ..
Pretty simple.
* kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
<<snip>>
Serum ferritin levels are increased in patients with glomerular
diseases and proteinuria
<<snip>>
NDT Advance Access originally published online on August 17, 2004
Nephrology Dialysis Transplantation 2004 19(11):2754-2760; doi:10.1093/
ndt/gfh454
Nephrol Dial Transplant Vol. 19 No. 11 =A9 ERA-EDTA 2004; all rights
reserved
---------------------------------------------------------------------------=
-----
Original Article
Serum ferritin levels are increased in patients with glomerular
diseases and proteinuria
Amanda J. W. Branten1, Dorine W. Swinkels2, Ina S. Klasen2 and Jack F.
M=2E Wetzels1
1 Department of Medicine, Division of Nephrology and 2 Department of
Clinical Chemistry, University Medical Center, Nijmegen, The
Netherlands
Correspondence and offprint requests to: A. J. W. Branten, MD,
Department of Medicine, Division of Nephrology 545, University Medical
Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Email: A.Branten@nier.umcn.nl
Abstract
Background. Ferritin is a high molecular weight protein which reflects
body iron stores, but may also rise in the case of an acute phase
response. Recently, ferritin has been identified as a predictive
factor in the development and progression of atherosclerosis. This is
the first report on serum ferritin levels in patients with
proteinuria.
Methods. We have analysed the data of 142 male patients with a
glomerular disease, and proteinuria exceeding 1 g/day. In all
patients, we measured various parameters related to proteinuria, serum
ferritin and serum iron. Serum =DF2-microglobulin and the Modification
of Diet in Renal Disease (MDRD) equation were used as measures of the
glomerular filtration rate (GFR).
Results. Mean age (=B1SD) was 46=B115 years, MDRD-GFR 57=B125 ml/min/1.73 m2
and median proteinuria 8.0 g/day [interquartile range (IQR) 3.6-13].
Serum albumin (29=B19 g/l) and transferrin levels (1.7=B10.5 g/l) were
low, and cholesterol levels were elevated (median 7.3, IQR 5.9-9.5
mmol/l). Median serum ferritin was 148 =B5g/l (IQR 89-282), and exceeded
280 =B5g/l, the upper limit of normal, in 36 patients (25%). Elevated
serum ferritin levels could not be explained by an acute phase
response as determined by C-reactive protein, or haemochromatosis (DNA
analysis). Regression analysis showed an independent relationship
between ferritin levels and serum cholesterol, GFR and serum
transferrin.
Conclusions. Serum ferritin levels are elevated in patients with overt
proteinuria. The independent negative relationship between serum
ferritin and transferrin points to a specific process and suggests
that increased production of ferritin may compensate for the loss of
the iron-binding protein transferrin, thus reducing the amount of free
iron. Further studies are needed to elucidate the role of ferritin in
patients with proteinuria, especially because of the suggested
association between ferritin and atherosclerosis.
Keywords: ferritin; glomerulopathy; iron; proteinuria
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
On Sep 29, 5:59 pm, ironjustice <teamtan...@hotmail . com > wrote:
> Proteinuria manifests when one goes to altitude and when one goes to
> altitude one manifests increased red blood cell production /
> erythrocytosis / polycythemia / hemochromatosis / iron overload..
>
> "Proteinuria at high altitude.Proteinuria at high altitude. A Bradwell
> and J Delamere. Full text ... Pines A. High-altitude acclimatization
> and proteinuria in East Africa. ...w w w .pubmedcentral.nih.gov/articlerende=
r=2Efcgi?artid=3D1599488- "
>
> Proteinuria is a marker used by .. them .. to assess disease
> activity / severity.
>
> Proteinuria is a .. bad .. thing ..
>
> Proteinuria appears in kidney disease .. in fact it is THE marker to
> assess kidney function.
>
> "Coincidentally" .. to .. **everyone** .. it seems .. increased red
> blood cell production .. CAUSES .. kidney disease ..
>
> Soooo .. the increased red blood cell production / erythrocytosis /
> polycythemia / hemochromatosis / iron overload .. destroys the
> kidneys ..
>
> Pretty simple.
>
> * kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
Serum ferritin levels are increased in patients with glomerular
diseases and proteinuria
<<snip>>
NDT Advance Access originally published online on August 17, 2004
Nephrology Dialysis Transplantation 2004 19(11):2754-2760; doi:10.1093/
ndt/gfh454
Nephrol Dial Transplant Vol. 19 No. 11 =A9 ERA-EDTA 2004; all rights
reserved
---------------------------------------------------------------------------=
-----
Original Article
Serum ferritin levels are increased in patients with glomerular
diseases and proteinuria
Amanda J. W. Branten1, Dorine W. Swinkels2, Ina S. Klasen2 and Jack F.
M=2E Wetzels1
1 Department of Medicine, Division of Nephrology and 2 Department of
Clinical Chemistry, University Medical Center, Nijmegen, The
Netherlands
Correspondence and offprint requests to: A. J. W. Branten, MD,
Department of Medicine, Division of Nephrology 545, University Medical
Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Email: A.Branten@nier.umcn.nl
Abstract
Background. Ferritin is a high molecular weight protein which reflects
body iron stores, but may also rise in the case of an acute phase
response. Recently, ferritin has been identified as a predictive
factor in the development and progression of atherosclerosis. This is
the first report on serum ferritin levels in patients with
proteinuria.
Methods. We have analysed the data of 142 male patients with a
glomerular disease, and proteinuria exceeding 1 g/day. In all
patients, we measured various parameters related to proteinuria, serum
ferritin and serum iron. Serum =DF2-microglobulin and the Modification
of Diet in Renal Disease (MDRD) equation were used as measures of the
glomerular filtration rate (GFR).
Results. Mean age (=B1SD) was 46=B115 years, MDRD-GFR 57=B125 ml/min/1.73 m2
and median proteinuria 8.0 g/day [interquartile range (IQR) 3.6-13].
Serum albumin (29=B19 g/l) and transferrin levels (1.7=B10.5 g/l) were
low, and cholesterol levels were elevated (median 7.3, IQR 5.9-9.5
mmol/l). Median serum ferritin was 148 =B5g/l (IQR 89-282), and exceeded
280 =B5g/l, the upper limit of normal, in 36 patients (25%). Elevated
serum ferritin levels could not be explained by an acute phase
response as determined by C-reactive protein, or haemochromatosis (DNA
analysis). Regression analysis showed an independent relationship
between ferritin levels and serum cholesterol, GFR and serum
transferrin.
Conclusions. Serum ferritin levels are elevated in patients with overt
proteinuria. The independent negative relationship between serum
ferritin and transferrin points to a specific process and suggests
that increased production of ferritin may compensate for the loss of
the iron-binding protein transferrin, thus reducing the amount of free
iron. Further studies are needed to elucidate the role of ferritin in
patients with proteinuria, especially because of the suggested
association between ferritin and atherosclerosis.
Keywords: ferritin; glomerulopathy; iron; proteinuria
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
On Sep 29, 5:59 pm, ironjustice <teamtan...@hotmail . com > wrote:
> Proteinuria manifests when one goes to altitude and when one goes to
> altitude one manifests increased red blood cell production /
> erythrocytosis / polycythemia / hemochromatosis / iron overload..
>
> "Proteinuria at high altitude.Proteinuria at high altitude. A Bradwell
> and J Delamere. Full text ... Pines A. High-altitude acclimatization
> and proteinuria in East Africa. ...w w w .pubmedcentral.nih.gov/articlerende=
r=2Efcgi?artid=3D1599488- "
>
> Proteinuria is a marker used by .. them .. to assess disease
> activity / severity.
>
> Proteinuria is a .. bad .. thing ..
>
> Proteinuria appears in kidney disease .. in fact it is THE marker to
> assess kidney function.
>
> "Coincidentally" .. to .. **everyone** .. it seems .. increased red
> blood cell production .. CAUSES .. kidney disease ..
>
> Soooo .. the increased red blood cell production / erythrocytosis /
> polycythemia / hemochromatosis / iron overload .. destroys the
> kidneys ..
>
> Pretty simple.
>
> * kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
Titre du document / Document title
Hyperuricemia, hypertension, and proteinuria associated with high-
altitude polycythemia
Auteur(s) / Author(s)
JEFFERSON J. Ashley ; ESCUDERO Elizabeth ; HURTADO Maria-Elena ; PANDO
KELLY Jackeline ; SWENSON Erik R. ; WENER Mark H. ; BURNIER Michel ;
MAILLARD Marc ; SCHREINER George F. ; SCHOENE Robert B. ; HURTADO
Abdias ; JOHNSON Richard J. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
Department of Medicine and Laboratory Medicine, University of
Washington Medical Center, Seattle, WA, ETATS-UNIS
The Carlos Monge Cassinelli Nephrology Center, Hospital Loayza,
Division of Nephrology, University Cayetano Heredia, Lima, PEROU
Division of Hypertension and Vascular Medicine, Centre Hospitalier
Universitaire Vaudois, Lausanne, SUISSE
Scios Inc, Sunnyvale, CA, ETATS-UNIS
Department of Medicine, Baylor College of Medicine, Houston, TX, ETATS-
UNIS
R=E9sum=E9 / Abstract
Chronic exposure to high altitude is associated with the development
of erythrocytosis, proteinuria, and, in some cases, hyperuricemia. We
examined the relationship between high-altitude polycythemia and
proteinuria and hyperuricemia in Cerro de Pasco, Peru (altitude, 4,300
m). We studied 25 adult men with hematocrits less than 65% and 27
subjects with excessive erythrocytosis (EE; hematocrit > 65%) living
in Cerro de Pasco, Peru and compared them with 28 control subjects
living in Lima, Peru (at sea level) and after 48 hours of exposure to
high altitude. Serum urate levels were significantly elevated in
patients with EE at altitude, and gout occurred in 4 of 27 of these
subjects. Urate level strongly correlated with hematocrit (r =3D 0.71; P
< 0.0001). Urate production (24-hour urine urate excretion and urine
urate-creatinine ratio) was increased in this group compared with
those at sea level. Fractional urate excretion was not increased, and
fractional lithium excretion was reduced, in keeping with increased
proximal reabsorption of filtrate. Significantly higher blood
pressures and decreased renin levels in the EE group were in keeping
with increased proximal sodium reabsorption. Serum urate levels
correlated with mean blood pressure (r =3D 0.50; P < 0.0001).
Significant proteinuria was more prevalent in the EE group despite
normal renal function. Hyperuricemia is common in subjects living at
high altitude and associated with EE, hypertension, and proteinuria.
The increase in uric acid levels appears to be caused by increased
urate generation secondary to systemic hypoxia, although a relative
impairment in renal excretion also may contribute.
Revue / Journal Title
American journal of kidney diseases (Am. j. kidney dis.) ISSN
0272-6386
Source / Source
2002, vol. 39, no6, pp. 1135-1142 (36 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Orlando, FL, ETATS-UNIS (1981) (Revue)
Mots-cl=E9s anglais / English Keywords
Hemopathy ; Urinary system disease ; Cardiovascular disease ;
Metabolic diseases ; Enzyme ; Oxidoreductases ; Oxygen ; Purine ;
Human ; Hypoxia ; Uric acid ; Hematocrite ; Serum ; Quantitative
analysis ; Urate oxidase ; Chronic ; High altitude ; Polycythemia ;
Association ; Proteinuria ; Hypertension ; Hyperuricemia ;
Mots-cl=E9s fran=E7ais / French Keywords
H=E9mopathie ; Appareil urinaire pathologie ; Appareil circulatoire
pathologie ; M=E9tabolisme pathologie ; Enzyme ; Oxidoreductases ;
Oxyg=E8ne ; Purine ; Homme ; Hypoxie ; Urique acide ; H=E9matocrite ;
S=E9rum ; Analyse quantitative ; Urate oxidase ; Chronique ; Haute
altitude ; Polyglobulie ; Association ; Prot=E9inurie ; Hypertension
art=E9rielle ; Hyperuric=E9mie ;
Mots-cl=E9s espagnols / Spanish Keywords
Hemopat=EDa ; Aparato urinario patolog=EDa ; Aparato circulatorio
patolog=EDa ; Metabolismo patolog=EDa ; Enzima ; Oxidoreductases ;
Ox=EDgeno ; Purina ; Hombre ; Hipoxia ; Urico =E1cido ; Hematocrito ;
Suero ; An=E1lisis cuantitativo ; Urate oxidase ; Cr=F3nico ; Gran
altura ; Policitemia ; Asociaci=F3n ; Proteinuria ; Hipertensi=F3n
arterial ; Hiperuricemia ;
Localisation / Location
INIST-CNRS, Cote INIST : 19098, 35400010824325.0020
Copyright 2007 INIST-CNRS. All rights reserved
Toute reproduction ou diffusion m=EAme partielle, par quelque proc=E9d=E9 ou
sur tout support que ce soit, ne pourra =EAtre faite sans l'accord
pr=E9alable =E9crit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.
N=BA notice refdoc (ud4) : 13701434
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Hyperuricemia, hypertension, and proteinuria associated with high-
altitude polycythemia
Auteur(s) / Author(s)
JEFFERSON J. Ashley ; ESCUDERO Elizabeth ; HURTADO Maria-Elena ; PANDO
KELLY Jackeline ; SWENSON Erik R. ; WENER Mark H. ; BURNIER Michel ;
MAILLARD Marc ; SCHREINER George F. ; SCHOENE Robert B. ; HURTADO
Abdias ; JOHNSON Richard J. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
Department of Medicine and Laboratory Medicine, University of
Washington Medical Center, Seattle, WA, ETATS-UNIS
The Carlos Monge Cassinelli Nephrology Center, Hospital Loayza,
Division of Nephrology, University Cayetano Heredia, Lima, PEROU
Division of Hypertension and Vascular Medicine, Centre Hospitalier
Universitaire Vaudois, Lausanne, SUISSE
Scios Inc, Sunnyvale, CA, ETATS-UNIS
Department of Medicine, Baylor College of Medicine, Houston, TX, ETATS-
UNIS
R=E9sum=E9 / Abstract
Chronic exposure to high altitude is associated with the development
of erythrocytosis, proteinuria, and, in some cases, hyperuricemia. We
examined the relationship between high-altitude polycythemia and
proteinuria and hyperuricemia in Cerro de Pasco, Peru (altitude, 4,300
m). We studied 25 adult men with hematocrits less than 65% and 27
subjects with excessive erythrocytosis (EE; hematocrit > 65%) living
in Cerro de Pasco, Peru and compared them with 28 control subjects
living in Lima, Peru (at sea level) and after 48 hours of exposure to
high altitude. Serum urate levels were significantly elevated in
patients with EE at altitude, and gout occurred in 4 of 27 of these
subjects. Urate level strongly correlated with hematocrit (r =3D 0.71; P
< 0.0001). Urate production (24-hour urine urate excretion and urine
urate-creatinine ratio) was increased in this group compared with
those at sea level. Fractional urate excretion was not increased, and
fractional lithium excretion was reduced, in keeping with increased
proximal reabsorption of filtrate. Significantly higher blood
pressures and decreased renin levels in the EE group were in keeping
with increased proximal sodium reabsorption. Serum urate levels
correlated with mean blood pressure (r =3D 0.50; P < 0.0001).
Significant proteinuria was more prevalent in the EE group despite
normal renal function. Hyperuricemia is common in subjects living at
high altitude and associated with EE, hypertension, and proteinuria.
The increase in uric acid levels appears to be caused by increased
urate generation secondary to systemic hypoxia, although a relative
impairment in renal excretion also may contribute.
Revue / Journal Title
American journal of kidney diseases (Am. j. kidney dis.) ISSN
0272-6386
Source / Source
2002, vol. 39, no6, pp. 1135-1142 (36 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, Orlando, FL, ETATS-UNIS (1981) (Revue)
Mots-cl=E9s anglais / English Keywords
Hemopathy ; Urinary system disease ; Cardiovascular disease ;
Metabolic diseases ; Enzyme ; Oxidoreductases ; Oxygen ; Purine ;
Human ; Hypoxia ; Uric acid ; Hematocrite ; Serum ; Quantitative
analysis ; Urate oxidase ; Chronic ; High altitude ; Polycythemia ;
Association ; Proteinuria ; Hypertension ; Hyperuricemia ;
Mots-cl=E9s fran=E7ais / French Keywords
H=E9mopathie ; Appareil urinaire pathologie ; Appareil circulatoire
pathologie ; M=E9tabolisme pathologie ; Enzyme ; Oxidoreductases ;
Oxyg=E8ne ; Purine ; Homme ; Hypoxie ; Urique acide ; H=E9matocrite ;
S=E9rum ; Analyse quantitative ; Urate oxidase ; Chronique ; Haute
altitude ; Polyglobulie ; Association ; Prot=E9inurie ; Hypertension
art=E9rielle ; Hyperuric=E9mie ;
Mots-cl=E9s espagnols / Spanish Keywords
Hemopat=EDa ; Aparato urinario patolog=EDa ; Aparato circulatorio
patolog=EDa ; Metabolismo patolog=EDa ; Enzima ; Oxidoreductases ;
Ox=EDgeno ; Purina ; Hombre ; Hipoxia ; Urico =E1cido ; Hematocrito ;
Suero ; An=E1lisis cuantitativo ; Urate oxidase ; Cr=F3nico ; Gran
altura ; Policitemia ; Asociaci=F3n ; Proteinuria ; Hipertensi=F3n
arterial ; Hiperuricemia ;
Localisation / Location
INIST-CNRS, Cote INIST : 19098, 35400010824325.0020
Copyright 2007 INIST-CNRS. All rights reserved
Toute reproduction ou diffusion m=EAme partielle, par quelque proc=E9d=E9 ou
sur tout support que ce soit, ne pourra =EAtre faite sans l'accord
pr=E9alable =E9crit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.
N=BA notice refdoc (ud4) : 13701434
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
If you will notice this hemoglobin decrease .. coincidentally ..
mirrors that hemoglobin which does NOT .. kill you.
Hemoglobin of 13.5 kills you .. "significant reduction in the mean
haemoglobin concentration (from 13.5=B11.74 g/dl to 12.2=B12.19 g/dl;
P=3D0.001)."
<<snip>>
decrease in haemoglobin was the major side-effect
<<snip>>
Nephrol Dial Transplant (2000) 15: 82-86
=A9 2000 European Renal Association-European Dialysis and Transplant
Association
Long-term anti-proteinuric effect of Losartan in renal transplant
recipients treated for hypertension
Jes=FAs Calvi=F1o, Xose M. Lens, Rafael Romero and Domingo S=E1nchez-
Guisande
Division of Nephrology, Complexo Hospitalario Universitario de
Santiago, Santiago de Compostela, Spain
Correspondence and offprint requests to: Jes=FAs Calvi=F1o, Division of
Nephrology, Complexo Hospitalario Universitario de Santiago, C/
Galeras s/n, E-15705 Santiago de Compostela, Spain.
Background. Hypertension is common after renal transplantation.
Angiotensin II type 1 receptor antagonists are a new class of agents
that, without the side-effects mediated by kinins, have shown their
efficacy in the treatment of hypertension and heart failure. The aim
of the study was to assess the efficacy and safety of Losartan for the
treatment of hypertension and to evaluate its long-term effect on
graft function in a group of stable renal transplant patients.
Methods. Eighteen non-diabetic renal transplant recipients evaluated
at our unit for more than 1 year after transplantation (13-155 months)
were enrolled. Losartan was administered for a period of 14.2=B16.86 (6-
28) months at a dose of 25-100 mg/day depending on the
antihypertensive response obtained.
Results. Losartan satisfactorily lowered systemic blood pressure.
Overall graft function remained stable and a significant reduction in
proteinuria was observed throughout the period on Losartan (1.0=B10.87
vs 0.4=B10.83 g/l, P=3D0.003). No serious side-effects were reported
except for a significant reduction in the mean haemoglobin
concentration (from 13.5=B11.74 g/dl to 12.2=B12.19 g/dl; P=3D0.001).
Conclusions. A satisfactory antihypertensive effect was observed with
long-term therapy with Losartan. A significant reduction in
proteinuria without adversely affecting graft function was the main
beneficial effect observed. Losartan was generally well tolerated and
a decrease in haemoglobin was the major side-effect.
Keywords: Losartan; hypertension; renal transplantation; proteinuria;
anaemia
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
mirrors that hemoglobin which does NOT .. kill you.
Hemoglobin of 13.5 kills you .. "significant reduction in the mean
haemoglobin concentration (from 13.5=B11.74 g/dl to 12.2=B12.19 g/dl;
P=3D0.001)."
<<snip>>
decrease in haemoglobin was the major side-effect
<<snip>>
Nephrol Dial Transplant (2000) 15: 82-86
=A9 2000 European Renal Association-European Dialysis and Transplant
Association
Long-term anti-proteinuric effect of Losartan in renal transplant
recipients treated for hypertension
Jes=FAs Calvi=F1o, Xose M. Lens, Rafael Romero and Domingo S=E1nchez-
Guisande
Division of Nephrology, Complexo Hospitalario Universitario de
Santiago, Santiago de Compostela, Spain
Correspondence and offprint requests to: Jes=FAs Calvi=F1o, Division of
Nephrology, Complexo Hospitalario Universitario de Santiago, C/
Galeras s/n, E-15705 Santiago de Compostela, Spain.
Background. Hypertension is common after renal transplantation.
Angiotensin II type 1 receptor antagonists are a new class of agents
that, without the side-effects mediated by kinins, have shown their
efficacy in the treatment of hypertension and heart failure. The aim
of the study was to assess the efficacy and safety of Losartan for the
treatment of hypertension and to evaluate its long-term effect on
graft function in a group of stable renal transplant patients.
Methods. Eighteen non-diabetic renal transplant recipients evaluated
at our unit for more than 1 year after transplantation (13-155 months)
were enrolled. Losartan was administered for a period of 14.2=B16.86 (6-
28) months at a dose of 25-100 mg/day depending on the
antihypertensive response obtained.
Results. Losartan satisfactorily lowered systemic blood pressure.
Overall graft function remained stable and a significant reduction in
proteinuria was observed throughout the period on Losartan (1.0=B10.87
vs 0.4=B10.83 g/l, P=3D0.003). No serious side-effects were reported
except for a significant reduction in the mean haemoglobin
concentration (from 13.5=B11.74 g/dl to 12.2=B12.19 g/dl; P=3D0.001).
Conclusions. A satisfactory antihypertensive effect was observed with
long-term therapy with Losartan. A significant reduction in
proteinuria without adversely affecting graft function was the main
beneficial effect observed. Losartan was generally well tolerated and
a decrease in haemoglobin was the major side-effect.
Keywords: Losartan; hypertension; renal transplantation; proteinuria;
anaemia
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
