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Oxidation and Iron Supplementation
Oxidation and Iron Supplementation
King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King
JC
Daily Supplementation With Iron Icreases Lipid Peroxidation In Young
Women With Low Iron Stores. [JOURNAL ARTICLE]
Exp Biol Med (Maywood) 2008 Apr 11.
The aim of this study was to determine whether women with low iron
stores (plasma ferritin </= 20 microg/L) receiving a daily iron
supplement for 8 wks at a level commonly used to treat poor iron
status develop increased lipid peroxidation as measured by ethane
exhalation rates and plasma malondialdehyde. The women served as their
own control as pre- and post-supplementation periods were compared.
Twelve women participated in the study for a 70-day period and
consumed daily iron supplements (98 mg of iron as ferrous sulfate)
from day 14 to day 70. Baseline blood and expired air samples were
obtained on days 1 and 14; measurements during supplementation were
performed on days 56 and 70, that is at 6 and 8 weeks of
supplementation. Iron status improved during the iron supplementation
period; biochemical indicators of lipid peroxidation also increased.
After 6 wks of iron supplementation, serum ferritin almost doubled and
body iron more than doubled. Hemoglobin levels increased slightly and
other indicators of iron status became normal. However, plasma
malondialdehyde (MDA) and breath ethane exhalation rates (BEER)
increased by more than 40% between baseline and 6 wks of
supplementation; these increases correlated significantly with plasma
iron and ferritin levels. MDA was positively correlated with BEER.
BEER increased further after 8 wks of iron supplementation. The
increased indicators of lipid peroxidation with duration of
supplementation and as iron status improved suggest that providing
daily nearly 100 mg iron may not be a totally innocuous regimen for
correcting iron depletion in women.
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med
(Maywood)]
--------------------------------------------------------------------------------
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King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King
JC
Daily Supplementation With Iron Icreases Lipid Peroxidation In Young
Women With Low Iron Stores. [JOURNAL ARTICLE]
Exp Biol Med (Maywood) 2008 Apr 11.
The aim of this study was to determine whether women with low iron
stores (plasma ferritin </= 20 microg/L) receiving a daily iron
supplement for 8 wks at a level commonly used to treat poor iron
status develop increased lipid peroxidation as measured by ethane
exhalation rates and plasma malondialdehyde. The women served as their
own control as pre- and post-supplementation periods were compared.
Twelve women participated in the study for a 70-day period and
consumed daily iron supplements (98 mg of iron as ferrous sulfate)
from day 14 to day 70. Baseline blood and expired air samples were
obtained on days 1 and 14; measurements during supplementation were
performed on days 56 and 70, that is at 6 and 8 weeks of
supplementation. Iron status improved during the iron supplementation
period; biochemical indicators of lipid peroxidation also increased.
After 6 wks of iron supplementation, serum ferritin almost doubled and
body iron more than doubled. Hemoglobin levels increased slightly and
other indicators of iron status became normal. However, plasma
malondialdehyde (MDA) and breath ethane exhalation rates (BEER)
increased by more than 40% between baseline and 6 wks of
supplementation; these increases correlated significantly with plasma
iron and ferritin levels. MDA was positively correlated with BEER.
BEER increased further after 8 wks of iron supplementation. The
increased indicators of lipid peroxidation with duration of
supplementation and as iron status improved suggest that providing
daily nearly 100 mg iron may not be a totally innocuous regimen for
correcting iron depletion in women.
Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med
(Maywood)]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
