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Magnesium increased BMC in healthy girls
Magnesium increased BMC in healthy girls
Magnesium supplementation was found to increase bone mineral content (BMC)
in healthy girls in a one year trial.
Comment: Magnesium supplementation has a slightly beneficial effect on bone
mineral density in adults, too.
-------------------------------------------------------------------------------------------------
J Clin Endocrinol Metab. 2006 Oct 3; [Epub ahead of print]
A randomized controlled study of effects of dietary magnesium oxide
supplementation on bone mineral content in healthy girls.
Carpenter TO, Delucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J,
Petersen KF, Befroy D, Cohen D.
Context. The role of magnesium (Mg) as a determinant of bone mass has not
been extensively explored. Limited studies suggest that dietary Mg intake
and bone mineral density are correlated in adults, but no data from
interventional studies in children and adolescents are available. Objective.
To determine if Mg supplementation in peri-adolescent girls enhances accrual
of bone mass. Design. Prospective, placebo-controlled, randomized, one-year
double-blind trial of Mg supplementation. Setting. Clinical Research Center
in University Medical School. Patients or Other Participants. Healthy 8-14
yr-old Caucasian girls were recruited from community pediatricians' offices.
Dietary diaries from over 120 volunteers were analyzed and those with
dietary Mg intake of less than 220 mg/day were invited to participate in the
intervention. Intervention. Magnesium (300 mg elemental Mg per day in 2
divided doses) or placebo, given orally, for 12 months. Main Outcome
Measure. The primary outcome measure was interval change in bone mineral
content (BMC) of the total hip, femoral neck, Ward's area and lumbar spine
(L1-L4) after 12 months of Mg supplementation. Results. Significantly
increased accrual (P = 0.05) in integrated hip BMC occurred in the
Mg-supplemented vs. placebo group. Trends for a positive Mg effect were
evident in the pre- and early puberty and in mid-late puberty. Lumbar spinal
BMC accrual was slightly (but not significantly) greater in the Mg-treated
group. Compliance was excellent; 73% of capsules were ingested as inferred
by pill counts. Serum mineral levels, calciotropic hormones, and bone
markers were similar between groups. Conclusions. Oral Mg oxide capsules are
safe and well-tolerated. A positive effect of Mg supplementation on
integrated hip BMC was evident in this small cohort. PMID: 17018656
* tinyurl . com /y6hc9b
--
Juhana
Magnesium supplementation was found to increase bone mineral content (BMC)
in healthy girls in a one year trial.
Comment: Magnesium supplementation has a slightly beneficial effect on bone
mineral density in adults, too.
-------------------------------------------------------------------------------------------------
J Clin Endocrinol Metab. 2006 Oct 3; [Epub ahead of print]
A randomized controlled study of effects of dietary magnesium oxide
supplementation on bone mineral content in healthy girls.
Carpenter TO, Delucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J,
Petersen KF, Befroy D, Cohen D.
Context. The role of magnesium (Mg) as a determinant of bone mass has not
been extensively explored. Limited studies suggest that dietary Mg intake
and bone mineral density are correlated in adults, but no data from
interventional studies in children and adolescents are available. Objective.
To determine if Mg supplementation in peri-adolescent girls enhances accrual
of bone mass. Design. Prospective, placebo-controlled, randomized, one-year
double-blind trial of Mg supplementation. Setting. Clinical Research Center
in University Medical School. Patients or Other Participants. Healthy 8-14
yr-old Caucasian girls were recruited from community pediatricians' offices.
Dietary diaries from over 120 volunteers were analyzed and those with
dietary Mg intake of less than 220 mg/day were invited to participate in the
intervention. Intervention. Magnesium (300 mg elemental Mg per day in 2
divided doses) or placebo, given orally, for 12 months. Main Outcome
Measure. The primary outcome measure was interval change in bone mineral
content (BMC) of the total hip, femoral neck, Ward's area and lumbar spine
(L1-L4) after 12 months of Mg supplementation. Results. Significantly
increased accrual (P = 0.05) in integrated hip BMC occurred in the
Mg-supplemented vs. placebo group. Trends for a positive Mg effect were
evident in the pre- and early puberty and in mid-late puberty. Lumbar spinal
BMC accrual was slightly (but not significantly) greater in the Mg-treated
group. Compliance was excellent; 73% of capsules were ingested as inferred
by pill counts. Serum mineral levels, calciotropic hormones, and bone
markers were similar between groups. Conclusions. Oral Mg oxide capsules are
safe and well-tolerated. A positive effect of Mg supplementation on
integrated hip BMC was evident in this small cohort. PMID: 17018656
* tinyurl . com /y6hc9b
--
Juhana
Re: Magnesium increased BMC in healthy girls
Juhana Harju wrote:
: J Clin Endocrinol Metab. 2006 Oct 3; [Epub ahead of print]
: A randomized controlled study of effects of dietary magnesium oxide
: supplementation on bone mineral content in healthy girls.
:
: The
: primary outcome measure was interval change in bone mineral content
: (BMC) of the total hip, femoral neck, Ward's area and lumbar spine
: (L1-L4) after 12 months of Mg supplementation. Results. Significantly
: increased accrual (P = 0.05) in integrated hip BMC occurred in the
: Mg-supplemented vs. placebo group. Trends for a positive Mg effect
: were evident in the pre- and early puberty and in mid-late puberty.
: Lumbar spinal BMC accrual was slightly (but not significantly)
: greater in the Mg-treated group.
The full study is freely available here:
* jcem.endojournals.org/cgi/rapidpdf/jc.2006-1391v1
It states that magnesium supplementation resulted a 3 % greater bone mineral
content:
"In the entire cohort, Mg supplementation in this group of healthy girls
with relative Mg undernutrition, resulted in an approximately 3% greater
increase in the overall hip measures of BMC during the year of therapy
compared to placebo (1.05 ± 0.06g and 0.97 ± 0.06g, in Mg-treated vs.
placebo-treated girls, respectively; Figure 1A, Table 3). This effect of Mg
supplementation on BMC was significant ( F1,38 = 3.97; p = 0.0534; Table
3)."
In a study of post-menopausal osteoporotic women, magnesium supplementation
was associated with BMD increases in 60 % of those treated (Stendig-Lindberg
G, Tepper R, Leichter I. Trabecular bone density in a two year controlled
trial of peroral magnesium in osteoporosis. Magnesium Research 1993;
6:155-163).
--
Juhana
Juhana Harju wrote:
: J Clin Endocrinol Metab. 2006 Oct 3; [Epub ahead of print]
: A randomized controlled study of effects of dietary magnesium oxide
: supplementation on bone mineral content in healthy girls.
:
: The
: primary outcome measure was interval change in bone mineral content
: (BMC) of the total hip, femoral neck, Ward's area and lumbar spine
: (L1-L4) after 12 months of Mg supplementation. Results. Significantly
: increased accrual (P = 0.05) in integrated hip BMC occurred in the
: Mg-supplemented vs. placebo group. Trends for a positive Mg effect
: were evident in the pre- and early puberty and in mid-late puberty.
: Lumbar spinal BMC accrual was slightly (but not significantly)
: greater in the Mg-treated group.
The full study is freely available here:
* jcem.endojournals.org/cgi/rapidpdf/jc.2006-1391v1
It states that magnesium supplementation resulted a 3 % greater bone mineral
content:
"In the entire cohort, Mg supplementation in this group of healthy girls
with relative Mg undernutrition, resulted in an approximately 3% greater
increase in the overall hip measures of BMC during the year of therapy
compared to placebo (1.05 ± 0.06g and 0.97 ± 0.06g, in Mg-treated vs.
placebo-treated girls, respectively; Figure 1A, Table 3). This effect of Mg
supplementation on BMC was significant ( F1,38 = 3.97; p = 0.0534; Table
3)."
In a study of post-menopausal osteoporotic women, magnesium supplementation
was associated with BMD increases in 60 % of those treated (Stendig-Lindberg
G, Tepper R, Leichter I. Trabecular bone density in a two year controlled
trial of peroral magnesium in osteoporosis. Magnesium Research 1993;
6:155-163).
--
Juhana
