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DHEA as a treatment for osteoporosis in Chinese men
DHEA as a treatment for osteoporosis in Chinese men
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate
by SUN Yiping, MAO Minwei, et al.
Chinese Medical Journal, 2002, Vol. 115 No. 3 : 402-404
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate
The full article is available without charge through a Pubmed link.
Extracts from the article are below.
Patients in the treatment group took dehydroepiandrosterone sulfate
(DHEAS) 100 mg once a day, calcium salt 150 mg three times a day
and Vitamin D3 500 IU once a day.
Patients in the control group took calcium salt
150 mg three times a day and Vitamin D3 500 IU once a day.
The patients were treated for 6 months during which no agent
affecting bone metabolism was taken.
The BMD of L1- 4, femoral neck, ward's triangle, intertrochanter and
total
was measured using a bi- energy X- ray absorption BMD
instrument (HOLOGIO, GDR 2000 ) . Serum calcium, phosphorus and
alkaline phosphates were measured by automatic analyser and
serum osteocalcin (BGP) and pyridinoline (PYD) by EL ISA.
Reagents were from the Metra Biosystems Company.
The differences within batches were 4.8%-10.0%, the differences
among batches were 4.8%-9.0% respec tively. DHEAS, FT, E 2 ,
PTH and IGF- ? were measured with radio- immunoassay .
The differences within batches were
6.0%-9.8%, 3.2%-4.3%, 5%, 2.7%-2.9% , 6.6%-9.9% respectively.
Meanwhile, the differences among batches were
4.9 %-9.5%, 3.4%-5.5%, 7.9%-8.6%, and 3.9%-11.2% respectively.
Kits were supplied by DEPU Company, Tianjin, DRC Company, USA,
Metra Company, USA, and Chiron Company, USA.
BMD differences between pre- treatment and post- treatment
There were no significant differences between the therapeutic and
control
groups in age and BMD at pre- treatment ( P >0.05).BMD of the
therapeutic
group s howed a general increase, except for the femoral
intertrochanter
and total BMD. BMD of L 2 and, L 3 and L 4 increased by
2.65%±0.62%, 2.70%±0.48%, 3.1%±0.31% respectively,
and 2.82%±0.37% on average. BMD of the neck of the femur increased by
2.32%±0.31%. Compared to the control group, all differences were
significant.
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate
by SUN Yiping, MAO Minwei, et al.
Chinese Medical Journal, 2002, Vol. 115 No. 3 : 402-404
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate
The full article is available without charge through a Pubmed link.
Extracts from the article are below.
Patients in the treatment group took dehydroepiandrosterone sulfate
(DHEAS) 100 mg once a day, calcium salt 150 mg three times a day
and Vitamin D3 500 IU once a day.
Patients in the control group took calcium salt
150 mg three times a day and Vitamin D3 500 IU once a day.
The patients were treated for 6 months during which no agent
affecting bone metabolism was taken.
The BMD of L1- 4, femoral neck, ward's triangle, intertrochanter and
total
was measured using a bi- energy X- ray absorption BMD
instrument (HOLOGIO, GDR 2000 ) . Serum calcium, phosphorus and
alkaline phosphates were measured by automatic analyser and
serum osteocalcin (BGP) and pyridinoline (PYD) by EL ISA.
Reagents were from the Metra Biosystems Company.
The differences within batches were 4.8%-10.0%, the differences
among batches were 4.8%-9.0% respec tively. DHEAS, FT, E 2 ,
PTH and IGF- ? were measured with radio- immunoassay .
The differences within batches were
6.0%-9.8%, 3.2%-4.3%, 5%, 2.7%-2.9% , 6.6%-9.9% respectively.
Meanwhile, the differences among batches were
4.9 %-9.5%, 3.4%-5.5%, 7.9%-8.6%, and 3.9%-11.2% respectively.
Kits were supplied by DEPU Company, Tianjin, DRC Company, USA,
Metra Company, USA, and Chiron Company, USA.
BMD differences between pre- treatment and post- treatment
There were no significant differences between the therapeutic and
control
groups in age and BMD at pre- treatment ( P >0.05).BMD of the
therapeutic
group s howed a general increase, except for the femoral
intertrochanter
and total BMD. BMD of L 2 and, L 3 and L 4 increased by
2.65%±0.62%, 2.70%±0.48%, 3.1%±0.31% respectively,
and 2.82%±0.37% on average. BMD of the neck of the femur increased by
2.32%±0.31%. Compared to the control group, all differences were
significant.
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