Inflammatory markers predict fracture fisk

Inflammatory markers predict fracture fisk

Presence of several inflammatory markers at the same time predict fracture
risk in elderly people.

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Inflammatory Markers and Incident Fracture Risk in Older Men and Women: The
Health Aging and Body Composition Study

Cauley JA et al.

The inflammation of aging hypothesis purports that aging is the accumulation
of damage, which results, in part, from chronic activation of inflammation
process. We tested this hypothesis in relationship to fractures in 2985 men
and women enrolled in the Health ABC study. Results showed that subjects
with the greatest number of inflammatory markers have the highest risk of
fracture. - -

Introduction: Cytokines play major roles in regulating bone remodeling in
the bone microenvironment, but their relationship to fractures is
uncertain. - -

Results and Conclusions: Subjects who fractured were more likely to be white
and female. Baseline markers of inflammation were higher among subjects who
subsequently experienced an incident fracture. In multivariate models, the
relative risk of fracture (95% CIs) for subjects with the highest
inflammatory markers (quartile 4) compared with those with lower
inflammatory markers (quartiles 1, 2, and 3) was 1.34 (0.99, 1.82) for CRP;
1.28 (0.95-1.74) for IL-6; 1.28 (0.97-1.70) for TNF-alpha; 1.52 (1.04-2.21)
for IL-2 sR; 1.33 (0.90-1.96) for IL-6 sR; 1.73 (1.18-2.55) for TNF sR1 and
1.48 (1.01-2.20) for TNF sR2. In subjects with three or more (out of seven)
high inflammatory markers, the relative risk of fracture was 2.65
(1.44-4.89) in comparison with subjects with no elevated markers. (p trend =
0.001). We conclude that elevated inflammatory markers are prognostic for
fractures, extending the inflammation hypothesis of aging to osteoporotic
fractures.

* w w w .jbmronline.org/doi/abs/10.1359/jbmr.070409

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