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effect of 1 y of treatment with calcium (3 grams) and vitamin D3 (1400 IU)
effect of 1 y of treatment with calcium (3 grams) and vitamin D3 (1400 IU)
Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
Bone mineral density and bone markers in patients with a recent low-
energy fracture: effect of 1 y of treatment with calcium and vitamin
D.
Hitz MF, Jensen JE, Eskildsen PC.
Medical Department, Roskilde University Hospital Koge, Koge, Denmark,
and the Calcium- and Bone-Metabolic Unit, Endocrine Department,
Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
spine are known consequences of osteoporosis.
OBJECTIVE: We evaluated the effect of 1 y of
treatment with calcium and vitamin D on bone mineral density (BMD) and
bone markers in patients with a recent low-energy fracture. DESIGN: In
a
double-blinded design, patients with fracture of the hip (lower-
extremity
fracture, or LEF) or upper extremity (UEF) were randomly assigned to
receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
(200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine
(LBMD) were evaluated by dual-energy X-ray absorptiometry, and
physical performance was assessed by the timed Up & Go test. Serum
concentrations of 25-hydroxycholecalciferol, parathyroid hormone
(PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-
terminal propeptide of collagen type I were measured. RESULTS: A total
of
122 patients were included (84% women; x +/- SD age: 70 +/- 11 y); 68%
completed the study. In an intention-to-treat analysis, LBMD increased
in the intervention group and decreased in the placebo group, and the
difference between the groups was significant after 12 mo: 0.931 +/-
0.211 compared with 0.848 +/- 0.194 (P < 0.05). No significant change
was shown for HBMD. The effect of treatment was more pronounced in
patients aged <70 y. The intervention decreased bone turnover. PTH
was significantly lower in the intervention group (P < 0.01) for the
LEF
patients. ICTP and change in LBMD were significantly related to
physical
performance.
CONCLUSIONS: A 1-y intervention with calcium and vitamin D reduced
bone turnover, significantly increased BMD in patients younger than 70
y, and decreased bone loss in older patients. The effect of treatment
was related to physical performance.
PMID: 17616788 [PubMed - in process]
Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
Bone mineral density and bone markers in patients with a recent low-
energy fracture: effect of 1 y of treatment with calcium and vitamin
D.
Hitz MF, Jensen JE, Eskildsen PC.
Medical Department, Roskilde University Hospital Koge, Koge, Denmark,
and the Calcium- and Bone-Metabolic Unit, Endocrine Department,
Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
spine are known consequences of osteoporosis.
OBJECTIVE: We evaluated the effect of 1 y of
treatment with calcium and vitamin D on bone mineral density (BMD) and
bone markers in patients with a recent low-energy fracture. DESIGN: In
a
double-blinded design, patients with fracture of the hip (lower-
extremity
fracture, or LEF) or upper extremity (UEF) were randomly assigned to
receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
(200 IU cholecalciferol). BMD of the hip (HBMD) and lumbar spine
(LBMD) were evaluated by dual-energy X-ray absorptiometry, and
physical performance was assessed by the timed Up & Go test. Serum
concentrations of 25-hydroxycholecalciferol, parathyroid hormone
(PTH), telepeptide of type I collagen (ICTP), osteocalcin, and N-
terminal propeptide of collagen type I were measured. RESULTS: A total
of
122 patients were included (84% women; x +/- SD age: 70 +/- 11 y); 68%
completed the study. In an intention-to-treat analysis, LBMD increased
in the intervention group and decreased in the placebo group, and the
difference between the groups was significant after 12 mo: 0.931 +/-
0.211 compared with 0.848 +/- 0.194 (P < 0.05). No significant change
was shown for HBMD. The effect of treatment was more pronounced in
patients aged <70 y. The intervention decreased bone turnover. PTH
was significantly lower in the intervention group (P < 0.01) for the
LEF
patients. ICTP and change in LBMD were significantly related to
physical
performance.
CONCLUSIONS: A 1-y intervention with calcium and vitamin D reduced
bone turnover, significantly increased BMD in patients younger than 70
y, and decreased bone loss in older patients. The effect of treatment
was related to physical performance.
PMID: 17616788 [PubMed - in process]
Re: effect of 1 y of treatment with calcium (3 grams) and vitamin D3 (1400 IU)
trigonometry1972@gmail . com wrote:
> Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
> Bone mineral density and bone markers in patients with a recent low-
> energy fracture: effect of 1 y of treatment with calcium and vitamin D.
> Hitz MF, Jensen JE, Eskildsen PC.
>
> BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
> spine are known consequences of osteoporosis.
>
> OBJECTIVE: We evaluated the effect of 1 y of
> treatment with calcium and vitamin D on bone mineral density (BMD) and
> bone markers in patients with a recent low-energy fracture. DESIGN: In
> a double-blinded design, patients with fracture of the hip
> (lower-extremity
> fracture, or LEF) or upper extremity (UEF) were randomly assigned to
> receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
> (200 IU cholecalciferol).
I have some concerns about taking that much (3 g) calcium in addition to the
amout of calcium present in diet. Overdosing of calcium can have adverse
effects. To my knowledge the body can not use more than approxomately 1800
mg of calcium daily. On the other hand, I am happy to see that they I
finally raising the dose of vitamin D in trials.
--
Juhana
trigonometry1972@gmail . com wrote:
> Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
> Bone mineral density and bone markers in patients with a recent low-
> energy fracture: effect of 1 y of treatment with calcium and vitamin D.
> Hitz MF, Jensen JE, Eskildsen PC.
>
> BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
> spine are known consequences of osteoporosis.
>
> OBJECTIVE: We evaluated the effect of 1 y of
> treatment with calcium and vitamin D on bone mineral density (BMD) and
> bone markers in patients with a recent low-energy fracture. DESIGN: In
> a double-blinded design, patients with fracture of the hip
> (lower-extremity
> fracture, or LEF) or upper extremity (UEF) were randomly assigned to
> receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
> (200 IU cholecalciferol).
I have some concerns about taking that much (3 g) calcium in addition to the
amout of calcium present in diet. Overdosing of calcium can have adverse
effects. To my knowledge the body can not use more than approxomately 1800
mg of calcium daily. On the other hand, I am happy to see that they I
finally raising the dose of vitamin D in trials.
--
Juhana
Re: effect of 1 y of treatment with calcium (3 grams) and vitamin D3 (1400 IU)
On Jul 29, 12:02 pm, "Juhana Harju" <n...@mail.fi> wrote:
> trigonometry1...@gmail . com wrote:
> > Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
> > Bone mineral density and bone markers in patients with a recent low-
> > energy fracture: effect of 1 y of treatment with calcium and vitamin D.
> > Hitz MF, Jensen JE, Eskildsen PC.
>
> > BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
> > spine are known consequences of osteoporosis.
>
> > OBJECTIVE: We evaluated the effect of 1 y of
> > treatment with calcium and vitamin D on bone mineral density (BMD) and
> > bone markers in patients with a recent low-energy fracture. DESIGN: In
> > a double-blinded design, patients with fracture of the hip
> > (lower-extremity
> > fracture, or LEF) or upper extremity (UEF) were randomly assigned to
> > receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
> > (200 IU cholecalciferol).
>
> I have some concerns about taking that much (3 g) calcium in addition to the
> amout of calcium present in diet. Overdosing of calcium can have adverse
> effects. To my knowledge the body can not use more than approxomately 1800
> mg of calcium daily. On the other hand, I am happy to see that they I
> finally raising the dose of vitamin D in trials.
>
> --
> Juhana
Bone is also composed of Calcium Phosphate, phosphorus itself is
somewhat deficient in the modern diet so that has to be taken care of
too. Perhaps bone broth or an MCHC supplement might work, it has that
bone protein matrix included as well.
On Jul 29, 12:02 pm, "Juhana Harju" <n...@mail.fi> wrote:
> trigonometry1...@gmail . com wrote:
> > Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
> > Bone mineral density and bone markers in patients with a recent low-
> > energy fracture: effect of 1 y of treatment with calcium and vitamin D.
> > Hitz MF, Jensen JE, Eskildsen PC.
>
> > BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
> > spine are known consequences of osteoporosis.
>
> > OBJECTIVE: We evaluated the effect of 1 y of
> > treatment with calcium and vitamin D on bone mineral density (BMD) and
> > bone markers in patients with a recent low-energy fracture. DESIGN: In
> > a double-blinded design, patients with fracture of the hip
> > (lower-extremity
> > fracture, or LEF) or upper extremity (UEF) were randomly assigned to
> > receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or placebo
> > (200 IU cholecalciferol).
>
> I have some concerns about taking that much (3 g) calcium in addition to the
> amout of calcium present in diet. Overdosing of calcium can have adverse
> effects. To my knowledge the body can not use more than approxomately 1800
> mg of calcium daily. On the other hand, I am happy to see that they I
> finally raising the dose of vitamin D in trials.
>
> --
> Juhana
Bone is also composed of Calcium Phosphate, phosphorus itself is
somewhat deficient in the modern diet so that has to be taken care of
too. Perhaps bone broth or an MCHC supplement might work, it has that
bone protein matrix included as well.
Re: effect of 1 y of treatment with calcium (3 grams) and vitamin D3 (1400 IU)
Ice Man wrote:
> On Jul 29, 12:02 pm, "Juhana Harju" <n...@mail.fi> wrote:
>> trigonometry1...@gmail . com wrote:
>>> Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
>>> Bone mineral density and bone markers in patients with a recent low-
>>> energy fracture: effect of 1 y of treatment with calcium and
>>> vitamin D. Hitz MF, Jensen JE, Eskildsen PC.
>>
>>> BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
>>> spine are known consequences of osteoporosis.
>>
>>> OBJECTIVE: We evaluated the effect of 1 y of
>>> treatment with calcium and vitamin D on bone mineral density (BMD)
>>> and bone markers in patients with a recent low-energy fracture.
>>> DESIGN: In a double-blinded design, patients with fracture of the
>>> hip (lower-extremity
>>> fracture, or LEF) or upper extremity (UEF) were randomly assigned to
>>> receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or
>>> placebo (200 IU cholecalciferol).
>>
>> I have some concerns about taking that much (3 g) calcium in
>> addition to the amout of calcium present in diet. Overdosing of
>> calcium can have adverse effects. To my knowledge the body can not
>> use more than approxomately 1800 mg of calcium daily. On the other
>> hand, I am happy to see that they I finally raising the dose of
>> vitamin D in trials.
>
> Bone is also composed of Calcium Phosphate, phosphorus itself is
> somewhat deficient in the modern diet so that has to be taken care of
> too. Perhaps bone broth or an MCHC supplement might work, it has that
> bone protein matrix included as well.
Quite the contrary. In general Western diets contain too much of
phosphorus in relation to calcium. However, some people are in the risk of
being deficient in phosphorus. People on bisphosphonate medication and
avoiding dairy products at the same time might get too little of this
mineral.
--
Juhana
Ice Man wrote:
> On Jul 29, 12:02 pm, "Juhana Harju" <n...@mail.fi> wrote:
>> trigonometry1...@gmail . com wrote:
>>> Am. J. Clin. Nutr. 2007 Jul;86(1):251-9.
>>> Bone mineral density and bone markers in patients with a recent low-
>>> energy fracture: effect of 1 y of treatment with calcium and
>>> vitamin D. Hitz MF, Jensen JE, Eskildsen PC.
>>
>>> BACKGROUND: Low-energy fractures of the hip, forearm, shoulder, and
>>> spine are known consequences of osteoporosis.
>>
>>> OBJECTIVE: We evaluated the effect of 1 y of
>>> treatment with calcium and vitamin D on bone mineral density (BMD)
>>> and bone markers in patients with a recent low-energy fracture.
>>> DESIGN: In a double-blinded design, patients with fracture of the
>>> hip (lower-extremity
>>> fracture, or LEF) or upper extremity (UEF) were randomly assigned to
>>> receive 3000 mg calcium carbonate + 1400 IU cholecalciferol or
>>> placebo (200 IU cholecalciferol).
>>
>> I have some concerns about taking that much (3 g) calcium in
>> addition to the amout of calcium present in diet. Overdosing of
>> calcium can have adverse effects. To my knowledge the body can not
>> use more than approxomately 1800 mg of calcium daily. On the other
>> hand, I am happy to see that they I finally raising the dose of
>> vitamin D in trials.
>
> Bone is also composed of Calcium Phosphate, phosphorus itself is
> somewhat deficient in the modern diet so that has to be taken care of
> too. Perhaps bone broth or an MCHC supplement might work, it has that
> bone protein matrix included as well.
Quite the contrary. In general Western diets contain too much of
phosphorus in relation to calcium. However, some people are in the risk of
being deficient in phosphorus. People on bisphosphonate medication and
avoiding dairy products at the same time might get too little of this
mineral.
--
Juhana
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