Group: sci.med.diseases.osteoporosis

Osteoporosis information exhange.

Add group to favorites Add group to favorites
   indietro Back to post list     indietro Send new message to group
Search:
Pg.
1

Post Subject:

No improvement on Fosamax after 2 years

Reply from: garagecapital
Date: 13 Dec 2007, 15:38
No improvement on Fosamax after 2 years

I was diagnosed with osteoporosis and osteopenia in various joints. I
am a 52 year old male and it appears to be an idiopathic case. Did
fosamax for two years, was retested and no change except for some very
minor improvement in the back where I had some osteopenia. The
osteoporosis was in the hip. Do I continue thinking well at least I
have arrested it. Or do I look for a new treatment to improve the
scores. I have had some reflux issues which my doc said might
neutralize fosamax's effects. He even mentioned Forteo -- but with the
cancer risk, wow, I can't see taking that at least not at my age with
my minor osteoporosis scores.If I was 72 or breaking bones left and
right .... Thoughts.

Reply from: Juhana Harju
Date: 13 Dec 2007, 16:22
Re: No improvement on Fosamax after 2 years

garagecapital wrote:
> I was diagnosed with osteoporosis and osteopenia in various joints. I
> am a 52 year old male and it appears to be an idiopathic case. Did
> fosamax for two years, was retested and no change except for some very
> minor improvement in the back where I had some osteopenia. The
> osteoporosis was in the hip. Do I continue thinking well at least I
> have arrested it. Or do I look for a new treatment to improve the
> scores. I have had some reflux issues which my doc said might
> neutralize fosamax's effects. He even mentioned Forteo -- but with the
> cancer risk, wow, I can't see taking that at least not at my age with
> my minor osteoporosis scores. If I was 72 or breaking bones left and
> right .... Thoughts.

Have you had your bone turnover markers and testosterone levels assessed?

What kind of diet do you have? Do you supplement with calcium and a
sufficient dose of vitamin D? Do you exercise?

--
Juhana

Ravintoblogini:
http :// ruohikolla.blogspot,com /


Reply from: garagecapital
Date: 14 Dec 2007, 01:31
Re: No improvement on Fosamax after 2 years

On Dec 13, 10:22 am, "Juhana Harju" <n...@mail.fi> wrote:
> garagecapital wrote:
> > I was diagnosed with osteoporosis and osteopenia in various joints. I
> > am a 52 year old male and it appears to be an idiopathic case. Did
> > fosamax for two years, was retested and no change except for some very
> > minor improvement in the back where I had some osteopenia. The
> > osteoporosis was in the hip. Do I continue thinking well at least I
> > have arrested it. Or do I look for a new treatment to improve the
> > scores. I have had some reflux issues which my doc said might
> > neutralize fosamax's effects. He even mentioned Forteo -- but with the
> > cancer risk, wow, I can't see taking that at least not at my age with
> > my minor osteoporosis scores. If I was 72 or breaking bones left and
> > right .... Thoughts.
>
> Have you had your bone turnover markers and testosterone levels assessed?
>
> What kind of diet do you have? Do you supplement with calcium and a
> sufficient dose of vitamin D? Do you exercise?
>
> --
> Juhana
>
> Ravintoblogini: http :// ruohikolla.blogspot,com /

T levels are relative normal, had an endo work up, calcium, pituary,
et-ceterera, and all was ok. Hence the idopathic finding. But tell me
more about bone markers?

Reply from: trigonometry1972@gmail,com
Date: 14 Dec 2007, 07:25
Re: No improvement on Fosamax after 2 years

On Dec 13, 4:31 pm, garagecapital <garagecapi...@gmail,com > wrote:
> On Dec 13, 10:22 am, "Juhana Harju" <n...@mail.fi> wrote:
>
>
>
> > garagecapital wrote:
> > > I was diagnosed with osteoporosis and osteopenia in various joints. I
> > > am a 52 year old male and it appears to be an idiopathic case. Did
> > > fosamax for two years, was retested and no change except for some very
> > > minor improvement in the back where I had some osteopenia. The
> > > osteoporosis was in the hip. Do I continue thinking well at least I
> > > have arrested it. Or do I look for a new treatment to improve the
> > > scores. I have had some reflux issues which my doc said might
> > > neutralize fosamax's effects. He even mentioned Forteo -- but with the
> > > cancer risk, wow, I can't see taking that at least not at my age with
> > > my minor osteoporosis scores. If I was 72 or breaking bones left and
> > > right .... Thoughts.
>
> > Have you had your bone turnover markers and testosterone levels assessed?
>
> > What kind of diet do you have? Do you supplement with calcium and a
> > sufficient dose of vitamin D? Do you exercise?
>
> > --
> > Juhana
>
> > Ravintoblogini: http :// ruohikolla.blogspot,com /
>
> T levels are relative normal, had an endo work up, calcium, pituary,
> et-ceterera, and all was ok. Hence the idopathic finding. But tell me
> more about bone markers?

Just because an endo said the numbers were OK does NOT mean
the numbers are good. Endos rarely treat low testosterone unless
it is blazingly low. Do you know the actual lab number and
the whether the number were in ng/dL or nmol/L. I'd suggest
it is a factor is the value is in the 300's ng/dL. or lower.

Reply from: garagecapital
Date: 14 Dec 2007, 18:04
Re: No improvement on Fosamax after 2 years

On Dec 14, 1:25 am, trigonometry1...@gmail,com wrote:
> On Dec 13, 4:31 pm, garagecapital <garagecapi...@gmail,com > wrote:
>
>
>
> > On Dec 13, 10:22 am, "Juhana Harju" <n...@mail.fi> wrote:
>
> > > garagecapital wrote:
> > > > I was diagnosed with osteoporosis and osteopenia in various joints. I
> > > > am a 52 year old male and it appears to be an idiopathic case. Did
> > > > fosamax for two years, was retested and no change except for some very
> > > > minor improvement in the back where I had some osteopenia. The
> > > > osteoporosis was in the hip. Do I continue thinking well at least I
> > > > have arrested it. Or do I look for a new treatment to improve the
> > > > scores. I have had some reflux issues which my doc said might
> > > > neutralize fosamax's effects. He even mentioned Forteo -- but with the
> > > > cancer risk, wow, I can't see taking that at least not at my age with
> > > > my minor osteoporosis scores. If I was 72 or breaking bones left and
> > > > right .... Thoughts.
>
> > > Have you had your bone turnover markers and testosterone levels assessed?
>
> > > What kind of diet do you have? Do you supplement with calcium and a
> > > sufficient dose of vitamin D? Do you exercise?
>
> > > --
> > > Juhana
>
> > > Ravintoblogini: http :// ruohikolla.blogspot,com /
>
> > T levels are relative normal, had an endo work up, calcium, pituary,
> > et-ceterera, and all was ok. Hence the idopathic finding. But tell me
> > more about bone markers?
>
> Just because an endo said the numbers were OK does NOT mean
> the numbers are good. Endos rarely treat low testosterone unless
> it is blazingly low. Do you know the actual lab number and
> the whether the number were in ng/dL or nmol/L. I'd suggest
> it is a factor is the value is in the 300's ng/dL. or lower.

454 T

Reply from: trigonometry1972@gmail,com
Date: 15 Dec 2007, 04:15
Re: No improvement on Fosamax after 2 years


Not a stellar number.but it is likely better than mine.
I was last measured several years ago and was in
the mid 300's. When the weather improves I plan to
another check up, this time at a new Doc at a "man's
clinic". I've reason to believe my bone density is still
OK, but the lack of drive from low T makes effective exercise
a challenge. But I have a family member with
bone density issues.

As to the bone markers, I noticed a year or two ago
that a testing company was
offering a suite of tests for markers of the rate of bone turnover.
As we age this rate tends to increase and with less
anabolic hormonal "pressure", bone loss is the result.
Estrogen slows bone breakdown.

Reply from: garagecapital
Date: 15 Dec 2007, 15:41
Re: No improvement on Fosamax after 2 years

On Dec 14, 10:15 pm, trigonometry1...@gmail,com wrote:
> Not a stellar number.but it is likely better than mine.
> I was last measured several years ago and was in
> the mid 300's. When the weather improves I plan to
> another check up, this time at a new Doc at a "man's
> clinic". I've reason to believe my bone density is still
> OK, but the lack of drive from low T makes effective exercise
> a challenge. But I have a family member with
> bone density issues.
>
> As to the bone markers, I noticed a year or two ago
> that a testing company was
> offering a suite of tests for markers of the rate of bone turnover.
> As we age this rate tends to increase and with less
> anabolic hormonal "pressure", bone loss is the result.
> Estrogen slows bone breakdown.

mid 300s would be close to a t-recommendation from more aggressive
docs. No one would prescribe T for me with 454 T levels and other
hormones in normal range, although, curiously, my estrogen is 13,
which is quite low, but still in range, for a guy. And all the more
reason to ask the doc about bone markers.


Reply from: garagecapital
Date: 14 Dec 2007, 01:31
Re: No improvement on Fosamax after 2 years

On Dec 13, 10:22 am, "Juhana Harju" <n...@mail.fi> wrote:
> garagecapital wrote:
> > I was diagnosed with osteoporosis and osteopenia in various joints. I
> > am a 52 year old male and it appears to be an idiopathic case. Did
> > fosamax for two years, was retested and no change except for some very
> > minor improvement in the back where I had some osteopenia. The
> > osteoporosis was in the hip. Do I continue thinking well at least I
> > have arrested it. Or do I look for a new treatment to improve the
> > scores. I have had some reflux issues which my doc said might
> > neutralize fosamax's effects. He even mentioned Forteo -- but with the
> > cancer risk, wow, I can't see taking that at least not at my age with
> > my minor osteoporosis scores. If I was 72 or breaking bones left and
> > right .... Thoughts.
>
> Have you had your bone turnover markers and testosterone levels assessed?
>
> What kind of diet do you have? Do you supplement with calcium and a
> sufficient dose of vitamin D? Do you exercise?
>
> --
> Juhana
>
> Ravintoblogini: http :// ruohikolla.blogspot,com /

I supplement with calcium citrate and magnesium.

Reply from: Juhana Harju
Date: 14 Dec 2007, 08:08
Re: No improvement on Fosamax after 2 years

garagecapital wrote:
> On Dec 13, 10:22 am, "Juhana Harju" <n...@mail.fi> wrote:
>> garagecapital wrote:
>>> I was diagnosed with osteoporosis and osteopenia in various joints.
>>> I am a 52 year old male and it appears to be an idiopathic case. Did
>>> fosamax for two years, was retested and no change except for some
>>> very minor improvement in the back where I had some osteopenia. The
>>> osteoporosis was in the hip. Do I continue thinking well at least I
>>> have arrested it. Or do I look for a new treatment to improve the
>>> scores. I have had some reflux issues which my doc said might
>>> neutralize fosamax's effects. He even mentioned Forteo -- but with
>>> the cancer risk, wow, I can't see taking that at least not at my
>>> age with my minor osteoporosis scores. If I was 72 or breaking
>>> bones left and right .... Thoughts.
>>
>> Have you had your bone turnover markers and testosterone levels
>> assessed?
>>
>> What kind of diet do you have? Do you supplement with calcium and a
>> sufficient dose of vitamin D? Do you exercise?
>>
> I supplement with calcium citrate and magnesium.

Supplementing with vitamin D3 is very important, too. Vitamin D dose should
ideally be based on the assessment of circulating vitamin D levels
[25(OH)D]. Optimal levels needed to prevent fractures are at least 80 nmol/l
(32 ng/dl), preferrably 90-100 nmol/l (36-40 ng/dl).

Other minerals in addition to calcium and magnesium that might be helpful
are boron, zinc and silicon. Higher dietary silicon intake particularly has
been associated with higher bone mineral density. Some good sources of
silicon include beer, string beans and bananas.

--
Juhana

Ravintoblogini:
http :// ruohikolla.blogspot,com /


Reply from: Larry
Date: 13 Dec 2007, 17:16
Re: No improvement on Fosamax after 2 years

First of all, osteoporosis/osteopenia is not a disease of the joints.

Secondly, have you been seen by an endocrinologist who specializes in
metabolic bone disorders? There are many possible causes for secondary
osteoporosis that should be tested for ... and may be correctable by
treating the primary disorder. The fact that you saw little improvement
from Fosamax tell us that you have a rather significant bone resorption
rate. Although, it is typical to find some minor improvement in bone
density followed by a leveling off once the damage is done.

Lastly, there are compounds similar to Fosamax given in IV form that are
much stronger such as Pamidronate and Zoledronate. But again, you should
be tested by an endo and get a treatment recommendation from him/her.

garagecapital wrote:
> I was diagnosed with osteoporosis and osteopenia in various joints. I
> am a 52 year old male and it appears to be an idiopathic case. Did
> fosamax for two years, was retested and no change except for some very
> minor improvement in the back where I had some osteopenia. The
> osteoporosis was in the hip. Do I continue thinking well at least I
> have arrested it. Or do I look for a new treatment to improve the
> scores. I have had some reflux issues which my doc said might
> neutralize fosamax's effects. He even mentioned Forteo -- but with the
> cancer risk, wow, I can't see taking that at least not at my age with
> my minor osteoporosis scores.If I was 72 or breaking bones left and
> right .... Thoughts.

Reply from: garagecapital
Date: 14 Dec 2007, 01:35
Re: No improvement on Fosamax after 2 years

On Dec 13, 11:16 am, Larry <la...@nospam,net > wrote:
> First of all, osteoporosis/osteopenia is not a disease of the joints.
>
> Secondly, have you been seen by an endocrinologist who specializes in
> metabolic bone disorders? There are many possible causes for secondary
> osteoporosis that should be tested for ... and may be correctable by
> treating the primary disorder. The fact that you saw little improvement
> from Fosamax tell us that you have a rather significant bone resorption
> rate. Although, it is typical to find some minor improvement in bone
> density followed by a leveling off once the damage is done.
>
> Lastly, there are compounds similar to Fosamax given in IV form that are
> much stronger such as Pamidronate and Zoledronate. But again, you should
> be tested by an endo and get a treatment recommendation from him/her.
>
> garagecapital wrote:
> > I was diagnosed with osteoporosis and osteopenia in various joints. I
> > am a 52 year old male and it appears to be an idiopathic case. Did
> > fosamax for two years, was retested and no change except for some very
> > minor improvement in the back where I had some osteopenia. The
> > osteoporosis was in the hip. Do I continue thinking well at least I
> > have arrested it. Or do I look for a new treatment to improve the
> > scores. I have had some reflux issues which my doc said might
> > neutralize fosamax's effects. He even mentioned Forteo -- but with the
> > cancer risk, wow, I can't see taking that at least not at my age with
> > my minor osteoporosis scores.If I was 72 or breaking bones left and
> > right .... Thoughts.

I am a bit nervous about taking any of the drugs via IV, as they raise
the risk of dead jaw. Like Forteo, I think IV osteo drugs are a last
resort for me.

Reply from: Larry
Date: 14 Dec 2007, 14:56
Re: No improvement on Fosamax after 2 years

The risk of dead jaw is there with oral also. And even with the IV
drugs, current studies show at max a 10-15% risk ... and there are
things you can do to mitigate it. Or would you prefer to incur the risk
of broken bones?

garagecapital wrote:
> On Dec 13, 11:16 am, Larry <la...@nospam,net > wrote:
>
>>First of all, osteoporosis/osteopenia is not a disease of the joints.
>>
>>Secondly, have you been seen by an endocrinologist who specializes in
>>metabolic bone disorders? There are many possible causes for secondary
>>osteoporosis that should be tested for ... and may be correctable by
>>treating the primary disorder. The fact that you saw little improvement
>>from Fosamax tell us that you have a rather significant bone resorption
>>rate. Although, it is typical to find some minor improvement in bone
>>density followed by a leveling off once the damage is done.
>>
>>Lastly, there are compounds similar to Fosamax given in IV form that are
>>much stronger such as Pamidronate and Zoledronate. But again, you should
>>be tested by an endo and get a treatment recommendation from him/her.
>>
>>garagecapital wrote:
>>
>>>I was diagnosed with osteoporosis and osteopenia in various joints. I
>>>am a 52 year old male and it appears to be an idiopathic case. Did
>>>fosamax for two years, was retested and no change except for some very
>>>minor improvement in the back where I had some osteopenia. The
>>>osteoporosis was in the hip. Do I continue thinking well at least I
>>>have arrested it. Or do I look for a new treatment to improve the
>>>scores. I have had some reflux issues which my doc said might
>>>neutralize fosamax's effects. He even mentioned Forteo -- but with the
>>>cancer risk, wow, I can't see taking that at least not at my age with
>>>my minor osteoporosis scores.If I was 72 or breaking bones left and
>>>right .... Thoughts.
>
>
> I am a bit nervous about taking any of the drugs via IV, as they raise
> the risk of dead jaw. Like Forteo, I think IV osteo drugs are a last
> resort for me.

Reply from: garagecapital
Date: 14 Dec 2007, 18:05
Re: No improvement on Fosamax after 2 years

On Dec 14, 8:56 am, Larry <la...@nospam,net > wrote:
> The risk of dead jaw is there with oral also. And even with the IV
> drugs, current studies show at max a 10-15% risk ... and there are
> things you can do to mitigate it. Or would you prefer to incur the risk
> of broken bones?
>
> garagecapital wrote:
> > On Dec 13, 11:16 am, Larry <la...@nospam,net > wrote:
>
> >>First of all, osteoporosis/osteopenia is not a disease of the joints.
>
> >>Secondly, have you been seen by an endocrinologist who specializes in
> >>metabolic bone disorders? There are many possible causes for secondary
> >>osteoporosis that should be tested for ... and may be correctable by
> >>treating the primary disorder. The fact that you saw little improvement
> >>from Fosamax tell us that you have a rather significant bone resorption
> >>rate. Although, it is typical to find some minor improvement in bone
> >>density followed by a leveling off once the damage is done.
>
> >>Lastly, there are compounds similar to Fosamax given in IV form that are
> >>much stronger such as Pamidronate and Zoledronate. But again, you should
> >>be tested by an endo and get a treatment recommendation from him/her.
>
> >>garagecapital wrote:
>
> >>>I was diagnosed with osteoporosis and osteopenia in various joints. I
> >>>am a 52 year old male and it appears to be an idiopathic case. Did
> >>>fosamax for two years, was retested and no change except for some very
> >>>minor improvement in the back where I had some osteopenia. The
> >>>osteoporosis was in the hip. Do I continue thinking well at least I
> >>>have arrested it. Or do I look for a new treatment to improve the
> >>>scores. I have had some reflux issues which my doc said might
> >>>neutralize fosamax's effects. He even mentioned Forteo -- but with the
> >>>cancer risk, wow, I can't see taking that at least not at my age with
> >>>my minor osteoporosis scores.If I was 72 or breaking bones left and
> >>>right .... Thoughts.
>
> > I am a bit nervous about taking any of the drugs via IV, as they raise
> > the risk of dead jaw. Like Forteo, I think IV osteo drugs are a last
> > resort for me.

What should I ask about bone markers?

Reply from: Juhana Harju
Date: 14 Dec 2007, 18:15
Re: No improvement on Fosamax after 2 years


On Dec 14, 8:56 am, Larry <la...@nospam,net > wrote:

> The risk of dead jaw is there with oral also.

Do you have any reference to support that?

--
Juhana

Ravintoblogini:
http :// ruohikolla.blogspot,com /

Reply from: Larry
Date: 14 Dec 2007, 23:44
Re: No improvement on Fosamax after 2 years

Not handy, but there are many. All you have to do is to search for ONJ
and find one of the studies that details the causes and Hx of the
patients in the study. The risk is still there, but it is lower with the
oral bisphosphonates than with IV.

Juhana Harju wrote:

>
> On Dec 14, 8:56 am, Larry <la...@nospam,net > wrote:
>
>> The risk of dead jaw is there with oral also.
>
>
> Do you have any reference to support that?
>


Pg.
1



Login:
  Username:    Password: 
 
   Lost Password? click here!
Thread:
     garagecapital
       garagecapital
    Juhana Harju
  Larry
    Larry
     garagecapital
      Juhana Harju
       Larry
       Juhana Harju
      Larry
  Alan T