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Iron Chelator For Bone Regrowth
Iron Chelator For Bone Regrowth
New Treatment Boosts Bone Healing and Re-growth
Since phytate binds iron and since bisphosphonate binds iron and since
bisphosphonate is used to heal bone .. I would say this study ..
confirms .. my work ..
IE: phytate WILL grow bone / standin for bisphosphonate.
* w w w .newswise . com /articles/view/536784/
Newswise -- A drug originally used to treat iron poisoning can
significantly boost the body's own ability to heal and re-grow injured
bones, according to researchers at the University of Alabama at
Birmingham (UAB).
The researchers injected the drug deferoxamine (DF), which is designed
to reduce iron overload, into injured mouse bones. They found DF
triggered the growth of new blood vessels, which in turn kicked off
bone re-growth and healing.
In the study, bone density surrounding the injury more than doubled to
2.6 cubic millimeters in treated bones compared to 1.2 cubic
millimeters in untreated bones, the researchers said. The new blood
vessel growth and bone healing was achieved through a cell pathway
that helps the body respond to low oxygen levels, a common problem
when blood supply is affected by bone fracture and disease.
Findings on this cell pathway have broad implications for improving
treatment of bone fractures, bone disease and other musculoskeletal
disorders, said Shawn Gilbert, M.D., an assistant professor of
orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
Ph.D., an instructor in the UAB Department of Pathology, both co-
authors on the study.
"With DF activating this pathway, we've proven a significant point -
it is possible to explore new, safe and more affordable ways kick-
start bone repair," Gilbert said.
"Current treatments use complex proteins, which are expensive to make
and cost thousands of dollars per dose. The type of agent used in this
study is a simple, small molecule drug that costs hundreds, not
thousands," Gilbert said.
The UAB findings are published in the online version of the journal
Proceedings of the National Academy of Sciences and will soon appear
in a print edition.
"The results from this study are a milestone for future studies
looking at other compounds and agents to improve new-blood-vessel
growth in skeletal and other tissues that need adequate blood supply
to regenerate," Wan said.
The UAB tests were performed in conjunction with a bone lengthening
procedure commonly used in children and adults, and has proven to aid
bone healing. The study mice were anesthetized for surgery, and one
leg bone was cut clean through and a pulling device attached
temporarily to stretch the bone gap for the next 10 days.
During the stretching, the bone gap was injected with five DF doses.
Two weeks after the last DF dose, X-rays of the mice legs were taken
to measure bone regeneration.
DF is a drug that binds to excess iron in the body and helps with
excretion through the bowels and bladder, a process sometimes called
iron chelation. DF is used to treat a variety of medical conditions,
including iron overload, transfusion-related blood poisoning and in
combination with dialysis.
In the findings on post-treatment increased bone density, the UAB
researchers found significant increases in the number of new blood
vessels, and excellent connectivity between those vessels. The new
blood vessels are required regenerate bone of equal or better strength
than the original bones.
Gilbert said it follows that this cell pathway is a prime target for
future human studies using DF and other drugs to strengthen the body's
bone-healing potential, especially since poor blood supply is common
in fractures and bone disease.
The research team included UAB investigators from the departments of
Surgery, Pathology, and Biomedical Engineering and from Children's
Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
in Birmingham and Boston University Medical Center. Funding for the
study came from the National Institutes of Health.
--------------------------------------------------------------------------------
(c) 2008 Newswise. All Rights Reserved.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
New Treatment Boosts Bone Healing and Re-growth
Since phytate binds iron and since bisphosphonate binds iron and since
bisphosphonate is used to heal bone .. I would say this study ..
confirms .. my work ..
IE: phytate WILL grow bone / standin for bisphosphonate.
* w w w .newswise . com /articles/view/536784/
Newswise -- A drug originally used to treat iron poisoning can
significantly boost the body's own ability to heal and re-grow injured
bones, according to researchers at the University of Alabama at
Birmingham (UAB).
The researchers injected the drug deferoxamine (DF), which is designed
to reduce iron overload, into injured mouse bones. They found DF
triggered the growth of new blood vessels, which in turn kicked off
bone re-growth and healing.
In the study, bone density surrounding the injury more than doubled to
2.6 cubic millimeters in treated bones compared to 1.2 cubic
millimeters in untreated bones, the researchers said. The new blood
vessel growth and bone healing was achieved through a cell pathway
that helps the body respond to low oxygen levels, a common problem
when blood supply is affected by bone fracture and disease.
Findings on this cell pathway have broad implications for improving
treatment of bone fractures, bone disease and other musculoskeletal
disorders, said Shawn Gilbert, M.D., an assistant professor of
orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
Ph.D., an instructor in the UAB Department of Pathology, both co-
authors on the study.
"With DF activating this pathway, we've proven a significant point -
it is possible to explore new, safe and more affordable ways kick-
start bone repair," Gilbert said.
"Current treatments use complex proteins, which are expensive to make
and cost thousands of dollars per dose. The type of agent used in this
study is a simple, small molecule drug that costs hundreds, not
thousands," Gilbert said.
The UAB findings are published in the online version of the journal
Proceedings of the National Academy of Sciences and will soon appear
in a print edition.
"The results from this study are a milestone for future studies
looking at other compounds and agents to improve new-blood-vessel
growth in skeletal and other tissues that need adequate blood supply
to regenerate," Wan said.
The UAB tests were performed in conjunction with a bone lengthening
procedure commonly used in children and adults, and has proven to aid
bone healing. The study mice were anesthetized for surgery, and one
leg bone was cut clean through and a pulling device attached
temporarily to stretch the bone gap for the next 10 days.
During the stretching, the bone gap was injected with five DF doses.
Two weeks after the last DF dose, X-rays of the mice legs were taken
to measure bone regeneration.
DF is a drug that binds to excess iron in the body and helps with
excretion through the bowels and bladder, a process sometimes called
iron chelation. DF is used to treat a variety of medical conditions,
including iron overload, transfusion-related blood poisoning and in
combination with dialysis.
In the findings on post-treatment increased bone density, the UAB
researchers found significant increases in the number of new blood
vessels, and excellent connectivity between those vessels. The new
blood vessels are required regenerate bone of equal or better strength
than the original bones.
Gilbert said it follows that this cell pathway is a prime target for
future human studies using DF and other drugs to strengthen the body's
bone-healing potential, especially since poor blood supply is common
in fractures and bone disease.
The research team included UAB investigators from the departments of
Surgery, Pathology, and Biomedical Engineering and from Children's
Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
in Birmingham and Boston University Medical Center. Funding for the
study came from the National Institutes of Health.
--------------------------------------------------------------------------------
(c) 2008 Newswise. All Rights Reserved.
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
Re: Iron Chelator For Bone Regrowth
On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
wrote:"Current treatments use complex proteins, which are expensive to
makeand cost thousands of dollars per dose. The type of agent used in
this study is a simple, small molecule drug that costs hundreds, not
thousands," Gilbert said. <<
Somebody better step in here quick .. this drug also has side
effects .. blinding you to be one.
NOW with the problem with bisphosphonates ?
They are going to be ACTIVELY recruiting for studies of this in ..
those bisphosphonate related diseases ..
EVERYONE with .. arthritis ..
Whereas .. phytate .. already proven to BE gras / generally regarded
as safe ... ? IE: won't blind you .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> New Treatment Boosts Bone Healing and Re-growth
> Since phytate binds iron and since bisphosphonate binds iron and since
> bisphosphonate is used to heal bone .. I would say this study ..
> confirms .. my work ..
>
> IE: phytate WILL grow bone / standin for bisphosphonate.
>
> * w w w .newswise . com /articles/view/536784/
>
> Newswise -- A drug originally used to treat iron poisoning can
> significantly boost the body's own ability to heal and re-grow injured
> bones, according to researchers at the University of Alabama at
> Birmingham (UAB).
>
> The researchers injected the drug deferoxamine (DF), which is designed
> to reduce iron overload, into injured mouse bones. They found DF
> triggered the growth of new blood vessels, which in turn kicked off
> bone re-growth and healing.
>
> In the study, bone density surrounding the injury more than doubled to
> 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> millimeters in untreated bones, the researchers said. The new blood
> vessel growth and bone healing was achieved through a cell pathway
> that helps the body respond to low oxygen levels, a common problem
> when blood supply is affected by bone fracture and disease.
>
> Findings on this cell pathway have broad implications for improving
> treatment of bone fractures, bone disease and other musculoskeletal
> disorders, said Shawn Gilbert, M.D., an assistant professor of
> orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> Ph.D., an instructor in the UAB Department of Pathology, both co-
> authors on the study.
>
> "With DF activating this pathway, we've proven a significant point -
> it is possible to explore new, safe and more affordable ways kick-
> start bone repair," Gilbert said.
>
> "Current treatments use complex proteins, which are expensive to make
> and cost thousands of dollars per dose. The type of agent used in this
> study is a simple, small molecule drug that costs hundreds, not
> thousands," Gilbert said.
>
> The UAB findings are published in the online version of the journal
> Proceedings of the National Academy of Sciences and will soon appear
> in a print edition.
>
> "The results from this study are a milestone for future studies
> looking at other compounds and agents to improve new-blood-vessel
> growth in skeletal and other tissues that need adequate blood supply
> to regenerate," Wan said.
>
> The UAB tests were performed in conjunction with a bone lengthening
> procedure commonly used in children and adults, and has proven to aid
> bone healing. The study mice were anesthetized for surgery, and one
> leg bone was cut clean through and a pulling device attached
> temporarily to stretch the bone gap for the next 10 days.
>
> During the stretching, the bone gap was injected with five DF doses.
> Two weeks after the last DF dose, X-rays of the mice legs were taken
> to measure bone regeneration.
>
> DF is a drug that binds to excess iron in the body and helps with
> excretion through the bowels and bladder, a process sometimes called
> iron chelation. DF is used to treat a variety of medical conditions,
> including iron overload, transfusion-related blood poisoning and in
> combination with dialysis.
>
> In the findings on post-treatment increased bone density, the UAB
> researchers found significant increases in the number of new blood
> vessels, and excellent connectivity between those vessels. The new
> blood vessels are required regenerate bone of equal or better strength
> than the original bones.
>
> Gilbert said it follows that this cell pathway is a prime target for
> future human studies using DF and other drugs to strengthen the body's
> bone-healing potential, especially since poor blood supply is common
> in fractures and bone disease.
>
> The research team included UAB investigators from the departments of
> Surgery, Pathology, and Biomedical Engineering and from Children's
> Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> in Birmingham and Boston University Medical Center. Funding for the
> study came from the National Institutes of Health.
>
> --------------------------------------------------------------------------=
------
>
> (c) 2008 Newswise. All Rights Reserved.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
wrote:"Current treatments use complex proteins, which are expensive to
makeand cost thousands of dollars per dose. The type of agent used in
this study is a simple, small molecule drug that costs hundreds, not
thousands," Gilbert said. <<
Somebody better step in here quick .. this drug also has side
effects .. blinding you to be one.
NOW with the problem with bisphosphonates ?
They are going to be ACTIVELY recruiting for studies of this in ..
those bisphosphonate related diseases ..
EVERYONE with .. arthritis ..
Whereas .. phytate .. already proven to BE gras / generally regarded
as safe ... ? IE: won't blind you .. ?
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> New Treatment Boosts Bone Healing and Re-growth
> Since phytate binds iron and since bisphosphonate binds iron and since
> bisphosphonate is used to heal bone .. I would say this study ..
> confirms .. my work ..
>
> IE: phytate WILL grow bone / standin for bisphosphonate.
>
> * w w w .newswise . com /articles/view/536784/
>
> Newswise -- A drug originally used to treat iron poisoning can
> significantly boost the body's own ability to heal and re-grow injured
> bones, according to researchers at the University of Alabama at
> Birmingham (UAB).
>
> The researchers injected the drug deferoxamine (DF), which is designed
> to reduce iron overload, into injured mouse bones. They found DF
> triggered the growth of new blood vessels, which in turn kicked off
> bone re-growth and healing.
>
> In the study, bone density surrounding the injury more than doubled to
> 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> millimeters in untreated bones, the researchers said. The new blood
> vessel growth and bone healing was achieved through a cell pathway
> that helps the body respond to low oxygen levels, a common problem
> when blood supply is affected by bone fracture and disease.
>
> Findings on this cell pathway have broad implications for improving
> treatment of bone fractures, bone disease and other musculoskeletal
> disorders, said Shawn Gilbert, M.D., an assistant professor of
> orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> Ph.D., an instructor in the UAB Department of Pathology, both co-
> authors on the study.
>
> "With DF activating this pathway, we've proven a significant point -
> it is possible to explore new, safe and more affordable ways kick-
> start bone repair," Gilbert said.
>
> "Current treatments use complex proteins, which are expensive to make
> and cost thousands of dollars per dose. The type of agent used in this
> study is a simple, small molecule drug that costs hundreds, not
> thousands," Gilbert said.
>
> The UAB findings are published in the online version of the journal
> Proceedings of the National Academy of Sciences and will soon appear
> in a print edition.
>
> "The results from this study are a milestone for future studies
> looking at other compounds and agents to improve new-blood-vessel
> growth in skeletal and other tissues that need adequate blood supply
> to regenerate," Wan said.
>
> The UAB tests were performed in conjunction with a bone lengthening
> procedure commonly used in children and adults, and has proven to aid
> bone healing. The study mice were anesthetized for surgery, and one
> leg bone was cut clean through and a pulling device attached
> temporarily to stretch the bone gap for the next 10 days.
>
> During the stretching, the bone gap was injected with five DF doses.
> Two weeks after the last DF dose, X-rays of the mice legs were taken
> to measure bone regeneration.
>
> DF is a drug that binds to excess iron in the body and helps with
> excretion through the bowels and bladder, a process sometimes called
> iron chelation. DF is used to treat a variety of medical conditions,
> including iron overload, transfusion-related blood poisoning and in
> combination with dialysis.
>
> In the findings on post-treatment increased bone density, the UAB
> researchers found significant increases in the number of new blood
> vessels, and excellent connectivity between those vessels. The new
> blood vessels are required regenerate bone of equal or better strength
> than the original bones.
>
> Gilbert said it follows that this cell pathway is a prime target for
> future human studies using DF and other drugs to strengthen the body's
> bone-healing potential, especially since poor blood supply is common
> in fractures and bone disease.
>
> The research team included UAB investigators from the departments of
> Surgery, Pathology, and Biomedical Engineering and from Children's
> Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> in Birmingham and Boston University Medical Center. Funding for the
> study came from the National Institutes of Health.
>
> --------------------------------------------------------------------------=
------
>
> (c) 2008 Newswise. All Rights Reserved.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
Re: Iron Chelator For Bone Regrowth
On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
drug originally used to treat iron poisoning <<
Bisphosphonate grows bone and it is an iron binder .. deferoxamine
binds irion and it grows bone .. CLA grows bone and is an iron
binder .. bringing us again to .. plain old iron binding
bisphosphonate .. **phytate** .
---------------------
* w w w .jacn.org/cgi/content/full/19/4/478S
Journal of the American College of Nutrition, Vol. 19, No. 4,
478S-486S (2000)
Published by the American College of Nutrition
Conjugated Linoleic Acid and Bone Biology
Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
Purdue University, Department of Food Science, Lipid Chemistry and
Molecular Biology Laboratory, West Lafayette, Indiana, and Department
of Anatomy, Indiana University School of Medicine, Indianapolis,
Indiana
Address reprint requests to: Dr. B.A. Watkins, Department of Food
Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
University, W. Lafayette, IN, 47907. E-mail:
watkins@foodsci.purdue.edu.
ABSTRACT
Osteoporosis, osteoarthritis and inflammatory joint disease afflict
millions of people worldwide. Inflammatory cytokines inhibit
chondrocyte proliferation and induce cartilage degradation for which
part of the response is mediated by PGE2. Excess production of PGE2 is
linked to osteoporosis and arthritis and is associated with bone and
proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
facilitate bone and cartilage formation. Recent investigations with
growing rats given butter fat and supplements of CLA demonstrated an
increased rate of bone formation and reduced ex vivo bone PGE2
production, respectively. Furthermore, the supplements of CLA isomers
resulted in their enrichment in lipids of various bone compartments of
animals. The effects of CLA on bone biology in rats (IGF action and
cytokines) appear to be dependent on the level of n-6 and n-3 fatty
acids in the diet; however, these studies generally showed that CLA
decreased ex vivo bone PGE2 production and in osteoblast-like
cultures. Anti-inflammatory diets, including nutraceutical
applications of CLA, may be beneficial in moderating cyclooygenase 2
(COX-2) activity or expression (influencing PGE2 biosynthesis) and
might help to reduce rheumatoid arthritis (secondary osteoporosis).
This review summarizes findings of CLA on bone modeling in rats and
effects on cellular functions of osteoblasts and chondrocytes. These
experiments indicate that CLA isomers possess anti-inflammatory
activity in bone by moderating prostanoid formation.
Key words: bone, cartilage, conjugated linoleic acid, rat
Food Chemistry
Volume 100, Issue 3 , 2007, Pages 972-976
p-Complex formation of conjugated linoleic acid with iron
Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
aDepartment of Food Science, University of Massachusetts, 100
Holdsworth Way, Amherst, MA 01003, United States
bDepartment of Agricultural Chemistry, Gyeongsang National
University,
Chinju 660-701, Republic of Korea
cFood Research Institute, University of Wisconsin-Madison, 1925
Willow
Drive, Madison, WI 53706, United States
Received 1 August 2005; revised 3 November 2005; accepted 10
November
2005. Available online 20 January 2006.
Abstract
Conjugated linoleic acid (CLA) is known to have several beneficial
biological effects in animal models, including anticarcinogenic and
antiatherosclerotic effects, antiobesity, and antioxidant activity.
However, reports of its antioxidant activities have been
inconsistent.
In this study, we investigated the possible occurrence of p-bonding
between CLA and iron. CLA methyl ester was reacted with triiron
dodecacarbonyl and confirmed to form p-complexes with iron
tricarbonyl. This study may suggest the possible involvement of CLA
in
oxidation by way of interacting with iron.
Keywords: Conjugated linoleic acid; CLA; Iron
Corresponding author. Tel.: +1 413 545 1018 ; fax:
+1 413 545 1262.
doi:10.1016/j.foodchem.2005.11.006
Copyright (c) 2005 Elsevier Ltd All rights reserved
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> wrote:"Current treatments use complex proteins, which are expensive to
> makeand cost thousands of dollars per dose. The type of agent used in
> this study is a simple, small molecule drug that costs hundreds, not
> thousands," Gilbert said. <<
>
> Somebody better step in here quick .. this drug also has side
> effects .. blinding you to be one.
> NOW with the problem with bisphosphonates ?
> They are going to be ACTIVELY recruiting for studies of this in ..
> those bisphosphonate related diseases ..
>
> EVERYONE with .. arthritis ..
>
> Whereas .. phytate .. already proven to BE gras / generally regarded
> as safe ... ? IE: won't blind you .. ?
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > New Treatment Boosts Bone Healing and Re-growth
> > Since phytate binds iron and since bisphosphonate binds iron and since
> > bisphosphonate is used to heal bone .. I would say this study ..
> > confirms .. my work ..
>
> > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > * w w w .newswise . com /articles/view/536784/
>
> > Newswise -- A drug originally used to treat iron poisoning can
> > significantly boost the body's own ability to heal and re-grow injured
> > bones, according to researchers at the University of Alabama at
> > Birmingham (UAB).
>
> > The researchers injected the drug deferoxamine (DF), which is designed
> > to reduce iron overload, into injured mouse bones. They found DF
> > triggered the growth of new blood vessels, which in turn kicked off
> > bone re-growth and healing.
>
> > In the study, bone density surrounding the injury more than doubled to
> > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > millimeters in untreated bones, the researchers said. The new blood
> > vessel growth and bone healing was achieved through a cell pathway
> > that helps the body respond to low oxygen levels, a common problem
> > when blood supply is affected by bone fracture and disease.
>
> > Findings on this cell pathway have broad implications for improving
> > treatment of bone fractures, bone disease and other musculoskeletal
> > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > authors on the study.
>
> > "With DF activating this pathway, we've proven a significant point -
> > it is possible to explore new, safe and more affordable ways kick-
> > start bone repair," Gilbert said.
>
> > "Current treatments use complex proteins, which are expensive to make
> > and cost thousands of dollars per dose. The type of agent used in this
> > study is a simple, small molecule drug that costs hundreds, not
> > thousands," Gilbert said.
>
> > The UAB findings are published in the online version of the journal
> > Proceedings of the National Academy of Sciences and will soon appear
> > in a print edition.
>
> > "The results from this study are a milestone for future studies
> > looking at other compounds and agents to improve new-blood-vessel
> > growth in skeletal and other tissues that need adequate blood supply
> > to regenerate," Wan said.
>
> > The UAB tests were performed in conjunction with a bone lengthening
> > procedure commonly used in children and adults, and has proven to aid
> > bone healing. The study mice were anesthetized for surgery, and one
> > leg bone was cut clean through and a pulling device attached
> > temporarily to stretch the bone gap for the next 10 days.
>
> > During the stretching, the bone gap was injected with five DF doses.
> > Two weeks after the last DF dose, X-rays of the mice legs were taken
> > to measure bone regeneration.
>
> > DF is a drug that binds to excess iron in the body and helps with
> > excretion through the bowels and bladder, a process sometimes called
> > iron chelation. DF is used to treat a variety of medical conditions,
> > including iron overload, transfusion-related blood poisoning and in
> > combination with dialysis.
>
> > In the findings on post-treatment increased bone density, the UAB
> > researchers found significant increases in the number of new blood
> > vessels, and excellent connectivity between those vessels. The new
> > blood vessels are required regenerate bone of equal or better strength
> > than the original bones.
>
> > Gilbert said it follows that this cell pathway is a prime target for
> > future human studies using DF and other drugs to strengthen the body's
> > bone-healing potential, especially since poor blood supply is common
> > in fractures and bone disease.
>
> > The research team included UAB investigators from the departments of
> > Surgery, Pathology, and Biomedical Engineering and from Children's
> > Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> > in Birmingham and Boston University Medical Center. Funding for the
> > study came from the National Institutes of Health.
>
> > ------------------------------------------------------------------------=
--------
>
> > (c) 2008 Newswise. All Rights Reserved.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk- Hide quoted text -
>
> - Show quoted text -
On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
drug originally used to treat iron poisoning <<
Bisphosphonate grows bone and it is an iron binder .. deferoxamine
binds irion and it grows bone .. CLA grows bone and is an iron
binder .. bringing us again to .. plain old iron binding
bisphosphonate .. **phytate** .
---------------------
* w w w .jacn.org/cgi/content/full/19/4/478S
Journal of the American College of Nutrition, Vol. 19, No. 4,
478S-486S (2000)
Published by the American College of Nutrition
Conjugated Linoleic Acid and Bone Biology
Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
Purdue University, Department of Food Science, Lipid Chemistry and
Molecular Biology Laboratory, West Lafayette, Indiana, and Department
of Anatomy, Indiana University School of Medicine, Indianapolis,
Indiana
Address reprint requests to: Dr. B.A. Watkins, Department of Food
Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
University, W. Lafayette, IN, 47907. E-mail:
watkins@foodsci.purdue.edu.
ABSTRACT
Osteoporosis, osteoarthritis and inflammatory joint disease afflict
millions of people worldwide. Inflammatory cytokines inhibit
chondrocyte proliferation and induce cartilage degradation for which
part of the response is mediated by PGE2. Excess production of PGE2 is
linked to osteoporosis and arthritis and is associated with bone and
proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
facilitate bone and cartilage formation. Recent investigations with
growing rats given butter fat and supplements of CLA demonstrated an
increased rate of bone formation and reduced ex vivo bone PGE2
production, respectively. Furthermore, the supplements of CLA isomers
resulted in their enrichment in lipids of various bone compartments of
animals. The effects of CLA on bone biology in rats (IGF action and
cytokines) appear to be dependent on the level of n-6 and n-3 fatty
acids in the diet; however, these studies generally showed that CLA
decreased ex vivo bone PGE2 production and in osteoblast-like
cultures. Anti-inflammatory diets, including nutraceutical
applications of CLA, may be beneficial in moderating cyclooygenase 2
(COX-2) activity or expression (influencing PGE2 biosynthesis) and
might help to reduce rheumatoid arthritis (secondary osteoporosis).
This review summarizes findings of CLA on bone modeling in rats and
effects on cellular functions of osteoblasts and chondrocytes. These
experiments indicate that CLA isomers possess anti-inflammatory
activity in bone by moderating prostanoid formation.
Key words: bone, cartilage, conjugated linoleic acid, rat
Food Chemistry
Volume 100, Issue 3 , 2007, Pages 972-976
p-Complex formation of conjugated linoleic acid with iron
Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
aDepartment of Food Science, University of Massachusetts, 100
Holdsworth Way, Amherst, MA 01003, United States
bDepartment of Agricultural Chemistry, Gyeongsang National
University,
Chinju 660-701, Republic of Korea
cFood Research Institute, University of Wisconsin-Madison, 1925
Willow
Drive, Madison, WI 53706, United States
Received 1 August 2005; revised 3 November 2005; accepted 10
November
2005. Available online 20 January 2006.
Abstract
Conjugated linoleic acid (CLA) is known to have several beneficial
biological effects in animal models, including anticarcinogenic and
antiatherosclerotic effects, antiobesity, and antioxidant activity.
However, reports of its antioxidant activities have been
inconsistent.
In this study, we investigated the possible occurrence of p-bonding
between CLA and iron. CLA methyl ester was reacted with triiron
dodecacarbonyl and confirmed to form p-complexes with iron
tricarbonyl. This study may suggest the possible involvement of CLA
in
oxidation by way of interacting with iron.
Keywords: Conjugated linoleic acid; CLA; Iron
Corresponding author. Tel.: +1 413 545 1018 ; fax:
+1 413 545 1262.
doi:10.1016/j.foodchem.2005.11.006
Copyright (c) 2005 Elsevier Ltd All rights reserved
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> wrote:"Current treatments use complex proteins, which are expensive to
> makeand cost thousands of dollars per dose. The type of agent used in
> this study is a simple, small molecule drug that costs hundreds, not
> thousands," Gilbert said. <<
>
> Somebody better step in here quick .. this drug also has side
> effects .. blinding you to be one.
> NOW with the problem with bisphosphonates ?
> They are going to be ACTIVELY recruiting for studies of this in ..
> those bisphosphonate related diseases ..
>
> EVERYONE with .. arthritis ..
>
> Whereas .. phytate .. already proven to BE gras / generally regarded
> as safe ... ? IE: won't blind you .. ?
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > New Treatment Boosts Bone Healing and Re-growth
> > Since phytate binds iron and since bisphosphonate binds iron and since
> > bisphosphonate is used to heal bone .. I would say this study ..
> > confirms .. my work ..
>
> > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > * w w w .newswise . com /articles/view/536784/
>
> > Newswise -- A drug originally used to treat iron poisoning can
> > significantly boost the body's own ability to heal and re-grow injured
> > bones, according to researchers at the University of Alabama at
> > Birmingham (UAB).
>
> > The researchers injected the drug deferoxamine (DF), which is designed
> > to reduce iron overload, into injured mouse bones. They found DF
> > triggered the growth of new blood vessels, which in turn kicked off
> > bone re-growth and healing.
>
> > In the study, bone density surrounding the injury more than doubled to
> > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > millimeters in untreated bones, the researchers said. The new blood
> > vessel growth and bone healing was achieved through a cell pathway
> > that helps the body respond to low oxygen levels, a common problem
> > when blood supply is affected by bone fracture and disease.
>
> > Findings on this cell pathway have broad implications for improving
> > treatment of bone fractures, bone disease and other musculoskeletal
> > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > authors on the study.
>
> > "With DF activating this pathway, we've proven a significant point -
> > it is possible to explore new, safe and more affordable ways kick-
> > start bone repair," Gilbert said.
>
> > "Current treatments use complex proteins, which are expensive to make
> > and cost thousands of dollars per dose. The type of agent used in this
> > study is a simple, small molecule drug that costs hundreds, not
> > thousands," Gilbert said.
>
> > The UAB findings are published in the online version of the journal
> > Proceedings of the National Academy of Sciences and will soon appear
> > in a print edition.
>
> > "The results from this study are a milestone for future studies
> > looking at other compounds and agents to improve new-blood-vessel
> > growth in skeletal and other tissues that need adequate blood supply
> > to regenerate," Wan said.
>
> > The UAB tests were performed in conjunction with a bone lengthening
> > procedure commonly used in children and adults, and has proven to aid
> > bone healing. The study mice were anesthetized for surgery, and one
> > leg bone was cut clean through and a pulling device attached
> > temporarily to stretch the bone gap for the next 10 days.
>
> > During the stretching, the bone gap was injected with five DF doses.
> > Two weeks after the last DF dose, X-rays of the mice legs were taken
> > to measure bone regeneration.
>
> > DF is a drug that binds to excess iron in the body and helps with
> > excretion through the bowels and bladder, a process sometimes called
> > iron chelation. DF is used to treat a variety of medical conditions,
> > including iron overload, transfusion-related blood poisoning and in
> > combination with dialysis.
>
> > In the findings on post-treatment increased bone density, the UAB
> > researchers found significant increases in the number of new blood
> > vessels, and excellent connectivity between those vessels. The new
> > blood vessels are required regenerate bone of equal or better strength
> > than the original bones.
>
> > Gilbert said it follows that this cell pathway is a prime target for
> > future human studies using DF and other drugs to strengthen the body's
> > bone-healing potential, especially since poor blood supply is common
> > in fractures and bone disease.
>
> > The research team included UAB investigators from the departments of
> > Surgery, Pathology, and Biomedical Engineering and from Children's
> > Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> > in Birmingham and Boston University Medical Center. Funding for the
> > study came from the National Institutes of Health.
>
> > ------------------------------------------------------------------------=
--------
>
> > (c) 2008 Newswise. All Rights Reserved.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk- Hide quoted text -
>
> - Show quoted text -
Re: Iron Chelator For Bone Regrowth
On Jan 11, 5:24 pm, ironjustice <teamtan...@hotmail . com >
wrote:**phytate** <<
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days"
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> drug originally used to treat iron poisoning <<
>
> Bisphosphonate grows bone and it is an iron binder .. deferoxamine
> binds irion and it grows bone .. CLA grows bone and is an iron
> binder .. bringing us again to .. plain old iron binding
> bisphosphonate .. **phytate** .
> --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> Journal of the American College of Nutrition, Vol. 19, No. 4,
> 478S-486S (2000)
> Published by the American College of Nutrition
>
> Conjugated Linoleic Acid and Bone Biology
> Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> Purdue University, Department of Food Science, Lipid Chemistry and
> Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> of Anatomy, Indiana University School of Medicine, Indianapolis,
> Indiana
>
> Address reprint requests to: Dr. B.A. Watkins, Department of Food
> Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> University, W. Lafayette, IN, 47907. E-mail:
> watk...@foodsci.purdue.edu.
>
> ABSTRACT
> Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> millions of people worldwide. Inflammatory cytokines inhibit
> chondrocyte proliferation and induce cartilage degradation for which
> part of the response is mediated by PGE2. Excess production of PGE2 is
> linked to osteoporosis and arthritis and is associated with bone and
> proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> facilitate bone and cartilage formation. Recent investigations with
> growing rats given butter fat and supplements of CLA demonstrated an
> increased rate of bone formation and reduced ex vivo bone PGE2
> production, respectively. Furthermore, the supplements of CLA isomers
> resulted in their enrichment in lipids of various bone compartments of
> animals. The effects of CLA on bone biology in rats (IGF action and
> cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> acids in the diet; however, these studies generally showed that CLA
> decreased ex vivo bone PGE2 production and in osteoblast-like
> cultures. Anti-inflammatory diets, including nutraceutical
> applications of CLA, may be beneficial in moderating cyclooygenase 2
> (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> might help to reduce rheumatoid arthritis (secondary osteoporosis).
> This review summarizes findings of CLA on bone modeling in rats and
> effects on cellular functions of osteoblasts and chondrocytes. These
> experiments indicate that CLA isomers possess anti-inflammatory
> activity in bone by moderating prostanoid formation.
>
> Key words: bone, cartilage, conjugated linoleic acid, rat
>
> Food Chemistry
> Volume 100, Issue 3 , 2007, Pages 972-976
>
> p-Complex formation of conjugated linoleic acid with iron
>
> Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> aDepartment of Food Science, University of Massachusetts, 100
> Holdsworth Way, Amherst, MA 01003, United States
> bDepartment of Agricultural Chemistry, Gyeongsang National
> University,
> Chinju 660-701, Republic of Korea
> cFood Research Institute, University of Wisconsin-Madison, 1925
> Willow
> Drive, Madison, WI 53706, United States
>
> Received 1 August 2005; revised 3 November 2005; accepted 10
> November
> 2005. Available online 20 January 2006.
>
> Abstract
> Conjugated linoleic acid (CLA) is known to have several beneficial
> biological effects in animal models, including anticarcinogenic and
> antiatherosclerotic effects, antiobesity, and antioxidant activity.
> However, reports of its antioxidant activities have been
> inconsistent.
> In this study, we investigated the possible occurrence of p-bonding
> between CLA and iron. CLA methyl ester was reacted with triiron
> dodecacarbonyl and confirmed to form p-complexes with iron
> tricarbonyl. This study may suggest the possible involvement of CLA
> in
> oxidation by way of interacting with iron.
>
> Keywords: Conjugated linoleic acid; CLA; Iron
>
> Corresponding author. Tel.: =
+1 413 545 1018 =
; fax:
> +1 413 545 1262.
> doi:10.1016/j.foodchem.2005.11.006
> Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > wrote:"Current treatments use complex proteins, which are expensive to
> > makeand cost thousands of dollars per dose. The type of agent used in
> > this study is a simple, small molecule drug that costs hundreds, not
> > thousands," Gilbert said. <<
>
> > Somebody better step in here quick .. this drug also has side
> > effects .. blinding you to be one.
> > NOW with the problem with bisphosphonates ?
> > They are going to be ACTIVELY recruiting for studies of this in ..
> > those bisphosphonate related diseases ..
>
> > EVERYONE with .. arthritis ..
>
> > Whereas .. phytate .. already proven to BE gras / generally regarded
> > as safe ... ? IE: won't blind you .. ?
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > New Treatment Boosts Bone Healing and Re-growth
> > > Since phytate binds iron and since bisphosphonate binds iron and since=
> > > bisphosphonate is used to heal bone .. I would say this study ..
> > > confirms .. my work ..
>
> > > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > > * w w w .newswise . com /articles/view/536784/
>
> > > Newswise -- A drug originally used to treat iron poisoning can
> > > significantly boost the body's own ability to heal and re-grow injured=
> > > bones, according to researchers at the University of Alabama at
> > > Birmingham (UAB).
>
> > > The researchers injected the drug deferoxamine (DF), which is designed=
> > > to reduce iron overload, into injured mouse bones. They found DF
> > > triggered the growth of new blood vessels, which in turn kicked off
> > > bone re-growth and healing.
>
> > > In the study, bone density surrounding the injury more than doubled to=
> > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > millimeters in untreated bones, the researchers said. The new blood
> > > vessel growth and bone healing was achieved through a cell pathway
> > > that helps the body respond to low oxygen levels, a common problem
> > > when blood supply is affected by bone fracture and disease.
>
> > > Findings on this cell pathway have broad implications for improving
> > > treatment of bone fractures, bone disease and other musculoskeletal
> > > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> > > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > > authors on the study.
>
> > > "With DF activating this pathway, we've proven a significant point -
> > > it is possible to explore new, safe and more affordable ways kick-
> > > start bone repair," Gilbert said.
>
> > > "Current treatments use complex proteins, which are expensive to make
> > > and cost thousands of dollars per dose. The type of agent used in this=
> > > study is a simple, small molecule drug that costs hundreds, not
> > > thousands," Gilbert said.
>
> > > The UAB findings are published in the online version of the journal
> > > Proceedings of the National Academy of Sciences and will soon appear
> > > in a print edition.
>
> > > "The results from this study are a milestone for future studies
> > > looking at other compounds and agents to improve new-blood-vessel
> > > growth in skeletal and other tissues that need adequate blood supply
> > > to regenerate," Wan said.
>
> > > The UAB tests were performed in conjunction with a bone lengthening
> > > procedure commonly used in children and adults, and has proven to aid
> > > bone healing. The study mice were anesthetized for surgery, and one
> > > leg bone was cut clean through and a pulling device attached
> > > temporarily to stretch the bone gap for the next 10 days.
>
> > > During the stretching, the bone gap was injected with five DF doses.
> > > Two weeks after the last DF dose, X-rays of the mice legs were taken
> > > to measure bone regeneration.
>
> > > DF is a drug that binds to excess iron in the body and helps with
> > > excretion through the bowels and bladder, a process sometimes called
> > > iron chelation. DF is used to treat a variety of medical conditions,
> > > including iron overload, transfusion-related blood poisoning and in
> > > combination with dialysis.
>
> > > In the findings on post-treatment increased bone density, the UAB
> > > researchers found significant increases in the number of new blood
> > > vessels, and excellent connectivity between those vessels. The new
> > > blood vessels are required regenerate bone of equal or better strength=
> > > than the original bones.
>
> > > Gilbert said it follows that this cell pathway is a prime target for
> > > future human studies using DF and other drugs to strengthen the body's=
> > > bone-healing potential, especially since poor blood supply is common
> > > in fractures and bone disease.
>
> > > The research team included UAB investigators from the departments of
> > > Surgery, Pathology, and Biomedical Engineering and from Children's
> > > Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> > > in Birmingham and Boston University Medical Center. Funding for the
> > > study came from the National Institutes of Health.
>
> > > ----------------------------------------------------------------------=
----------
>
> > > (c) 2008 Newswise. All Rights Reserved.
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk-Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -
On Jan 11, 5:24 pm, ironjustice <teamtan...@hotmail . com >
wrote:**phytate** <<
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days"
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> drug originally used to treat iron poisoning <<
>
> Bisphosphonate grows bone and it is an iron binder .. deferoxamine
> binds irion and it grows bone .. CLA grows bone and is an iron
> binder .. bringing us again to .. plain old iron binding
> bisphosphonate .. **phytate** .
> --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> Journal of the American College of Nutrition, Vol. 19, No. 4,
> 478S-486S (2000)
> Published by the American College of Nutrition
>
> Conjugated Linoleic Acid and Bone Biology
> Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> Purdue University, Department of Food Science, Lipid Chemistry and
> Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> of Anatomy, Indiana University School of Medicine, Indianapolis,
> Indiana
>
> Address reprint requests to: Dr. B.A. Watkins, Department of Food
> Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> University, W. Lafayette, IN, 47907. E-mail:
> watk...@foodsci.purdue.edu.
>
> ABSTRACT
> Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> millions of people worldwide. Inflammatory cytokines inhibit
> chondrocyte proliferation and induce cartilage degradation for which
> part of the response is mediated by PGE2. Excess production of PGE2 is
> linked to osteoporosis and arthritis and is associated with bone and
> proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> facilitate bone and cartilage formation. Recent investigations with
> growing rats given butter fat and supplements of CLA demonstrated an
> increased rate of bone formation and reduced ex vivo bone PGE2
> production, respectively. Furthermore, the supplements of CLA isomers
> resulted in their enrichment in lipids of various bone compartments of
> animals. The effects of CLA on bone biology in rats (IGF action and
> cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> acids in the diet; however, these studies generally showed that CLA
> decreased ex vivo bone PGE2 production and in osteoblast-like
> cultures. Anti-inflammatory diets, including nutraceutical
> applications of CLA, may be beneficial in moderating cyclooygenase 2
> (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> might help to reduce rheumatoid arthritis (secondary osteoporosis).
> This review summarizes findings of CLA on bone modeling in rats and
> effects on cellular functions of osteoblasts and chondrocytes. These
> experiments indicate that CLA isomers possess anti-inflammatory
> activity in bone by moderating prostanoid formation.
>
> Key words: bone, cartilage, conjugated linoleic acid, rat
>
> Food Chemistry
> Volume 100, Issue 3 , 2007, Pages 972-976
>
> p-Complex formation of conjugated linoleic acid with iron
>
> Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> aDepartment of Food Science, University of Massachusetts, 100
> Holdsworth Way, Amherst, MA 01003, United States
> bDepartment of Agricultural Chemistry, Gyeongsang National
> University,
> Chinju 660-701, Republic of Korea
> cFood Research Institute, University of Wisconsin-Madison, 1925
> Willow
> Drive, Madison, WI 53706, United States
>
> Received 1 August 2005; revised 3 November 2005; accepted 10
> November
> 2005. Available online 20 January 2006.
>
> Abstract
> Conjugated linoleic acid (CLA) is known to have several beneficial
> biological effects in animal models, including anticarcinogenic and
> antiatherosclerotic effects, antiobesity, and antioxidant activity.
> However, reports of its antioxidant activities have been
> inconsistent.
> In this study, we investigated the possible occurrence of p-bonding
> between CLA and iron. CLA methyl ester was reacted with triiron
> dodecacarbonyl and confirmed to form p-complexes with iron
> tricarbonyl. This study may suggest the possible involvement of CLA
> in
> oxidation by way of interacting with iron.
>
> Keywords: Conjugated linoleic acid; CLA; Iron
>
> Corresponding author. Tel.: =
+1 413 545 1018 =
; fax:
> +1 413 545 1262.
> doi:10.1016/j.foodchem.2005.11.006
> Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > wrote:"Current treatments use complex proteins, which are expensive to
> > makeand cost thousands of dollars per dose. The type of agent used in
> > this study is a simple, small molecule drug that costs hundreds, not
> > thousands," Gilbert said. <<
>
> > Somebody better step in here quick .. this drug also has side
> > effects .. blinding you to be one.
> > NOW with the problem with bisphosphonates ?
> > They are going to be ACTIVELY recruiting for studies of this in ..
> > those bisphosphonate related diseases ..
>
> > EVERYONE with .. arthritis ..
>
> > Whereas .. phytate .. already proven to BE gras / generally regarded
> > as safe ... ? IE: won't blind you .. ?
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > New Treatment Boosts Bone Healing and Re-growth
> > > Since phytate binds iron and since bisphosphonate binds iron and since=
> > > bisphosphonate is used to heal bone .. I would say this study ..
> > > confirms .. my work ..
>
> > > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > > * w w w .newswise . com /articles/view/536784/
>
> > > Newswise -- A drug originally used to treat iron poisoning can
> > > significantly boost the body's own ability to heal and re-grow injured=
> > > bones, according to researchers at the University of Alabama at
> > > Birmingham (UAB).
>
> > > The researchers injected the drug deferoxamine (DF), which is designed=
> > > to reduce iron overload, into injured mouse bones. They found DF
> > > triggered the growth of new blood vessels, which in turn kicked off
> > > bone re-growth and healing.
>
> > > In the study, bone density surrounding the injury more than doubled to=
> > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > millimeters in untreated bones, the researchers said. The new blood
> > > vessel growth and bone healing was achieved through a cell pathway
> > > that helps the body respond to low oxygen levels, a common problem
> > > when blood supply is affected by bone fracture and disease.
>
> > > Findings on this cell pathway have broad implications for improving
> > > treatment of bone fractures, bone disease and other musculoskeletal
> > > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.
> > > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > > authors on the study.
>
> > > "With DF activating this pathway, we've proven a significant point -
> > > it is possible to explore new, safe and more affordable ways kick-
> > > start bone repair," Gilbert said.
>
> > > "Current treatments use complex proteins, which are expensive to make
> > > and cost thousands of dollars per dose. The type of agent used in this=
> > > study is a simple, small molecule drug that costs hundreds, not
> > > thousands," Gilbert said.
>
> > > The UAB findings are published in the online version of the journal
> > > Proceedings of the National Academy of Sciences and will soon appear
> > > in a print edition.
>
> > > "The results from this study are a milestone for future studies
> > > looking at other compounds and agents to improve new-blood-vessel
> > > growth in skeletal and other tissues that need adequate blood supply
> > > to regenerate," Wan said.
>
> > > The UAB tests were performed in conjunction with a bone lengthening
> > > procedure commonly used in children and adults, and has proven to aid
> > > bone healing. The study mice were anesthetized for surgery, and one
> > > leg bone was cut clean through and a pulling device attached
> > > temporarily to stretch the bone gap for the next 10 days.
>
> > > During the stretching, the bone gap was injected with five DF doses.
> > > Two weeks after the last DF dose, X-rays of the mice legs were taken
> > > to measure bone regeneration.
>
> > > DF is a drug that binds to excess iron in the body and helps with
> > > excretion through the bowels and bladder, a process sometimes called
> > > iron chelation. DF is used to treat a variety of medical conditions,
> > > including iron overload, transfusion-related blood poisoning and in
> > > combination with dialysis.
>
> > > In the findings on post-treatment increased bone density, the UAB
> > > researchers found significant increases in the number of new blood
> > > vessels, and excellent connectivity between those vessels. The new
> > > blood vessels are required regenerate bone of equal or better strength=
> > > than the original bones.
>
> > > Gilbert said it follows that this cell pathway is a prime target for
> > > future human studies using DF and other drugs to strengthen the body's=
> > > bone-healing potential, especially since poor blood supply is common
> > > in fractures and bone disease.
>
> > > The research team included UAB investigators from the departments of
> > > Surgery, Pathology, and Biomedical Engineering and from Children's
> > > Hospital of Alabama, Birmingham, the Veterans Affairs Medical Center
> > > in Birmingham and Boston University Medical Center. Funding for the
> > > study came from the National Institutes of Health.
>
> > > ----------------------------------------------------------------------=
----------
>
> > > (c) 2008 Newswise. All Rights Reserved.
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk-Hide quoted text -
>
> > - Show quoted text -- Hide quoted text -
>
> - Show quoted text -
Re: Iron Chelator For Bone Regrowth
On Jan 11, 9:34 pm, ironjustice <teamtan...@hotmail . com > wrote:
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days" <<
Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
* tinyurl . com /2rup87
This article shows .. clearly .. the TARGETING of the .. iron .. IN
those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
anemia .. in two weeks.
Clin Exp Rheumatol. 1986
Jan-Mar;4(1):25-9. Related Articles, Links
Antianemic and potential anti-inflammatory activity of
desferrioxamine: possible usefulness in rheumatoid arthritis.
Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
In order to study the role of excessive synovial iron sequestration
in
the production of anemia in rheumatoid arthritis (RA), the antianemic
efficacy and anti-inflammatory effect of desferrioxamine administered
in a
short-term
treatment (14 days), were evaluated in 10 patients suffering from
classic or definite RA and hyposideremic anemia.
Treatment with desferrioxamine showed an
elevated urinary iron excretion, a significant increase of serum
iron, UIBC and hemoglobin, and a marked progressive decrease
of serum ferritin. A moderate improvement of the pain intensity,
morning
stiffness and Ritchie's index was also observed.
The results obtained suggest that excessive reticuloendothelial
iron deposits occur in RA and that the iron uptake can be an
important factor in the production of anemia.
Desferrioxamine seems to be useful in
the treatment of patients suffering from RA and anemia, in order to
release iron from synovial tissue, reduce the inflammatory process
and improve anemia, changing an anemia which is typically resistant
to the martial therapy into an iron-sensitive anemia.
Publication Types:
Clinical Trial
PMID: 3516495 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------
Desferrioxamine maleateDesferrioxamine is a medicine that binds to
excess iron in the body. ... In these cases, desferrioxamine may be
given at the time of the blood transfusion, ...
w w w .tiscali.co.uk/lifestyle/healthfitness/health advice/netdoctor/arc...
- 42k - Cached - Similar pages
Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
otherwise
known as desferrioxamine or desferal, is a chelating agent used to
remove excess iron from the body. It acts by binding free iron in ...
en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > drug originally used to treat iron poisoning <<
>
> > Bisphosphonate grows bone and it is an iron binder .. deferoxamine
> > binds irion and it grows bone .. CLA grows bone and is an iron
> > binder .. bringing us again to .. plain old iron binding
> > bisphosphonate .. **phytate** .
> > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > 478S-486S (2000)
> > Published by the American College of Nutrition
>
> > Conjugated Linoleic Acid and Bone Biology
> > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > Purdue University, Department of Food Science, Lipid Chemistry and
> > Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > Indiana
>
> > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > University, W. Lafayette, IN, 47907. E-mail:
> > watk...@foodsci.purdue.edu.
>
> > ABSTRACT
> > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > millions of people worldwide. Inflammatory cytokines inhibit
> > chondrocyte proliferation and induce cartilage degradation for which
> > part of the response is mediated by PGE2. Excess production of PGE2 is
> > linked to osteoporosis and arthritis and is associated with bone and
> > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > facilitate bone and cartilage formation. Recent investigations with
> > growing rats given butter fat and supplements of CLA demonstrated an
> > increased rate of bone formation and reduced ex vivo bone PGE2
> > production, respectively. Furthermore, the supplements of CLA isomers
> > resulted in their enrichment in lipids of various bone compartments of
> > animals. The effects of CLA on bone biology in rats (IGF action and
> > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > acids in the diet; however, these studies generally showed that CLA
> > decreased ex vivo bone PGE2 production and in osteoblast-like
> > cultures. Anti-inflammatory diets, including nutraceutical
> > applications of CLA, may be beneficial in moderating cyclooygenase 2
> > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > This review summarizes findings of CLA on bone modeling in rats and
> > effects on cellular functions of osteoblasts and chondrocytes. These
> > experiments indicate that CLA isomers possess anti-inflammatory
> > activity in bone by moderating prostanoid formation.
>
> > Key words: bone, cartilage, conjugated linoleic acid, rat
>
> > Food Chemistry
> > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > p-Complex formation of conjugated linoleic acid with iron
>
> > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > aDepartment of Food Science, University of Massachusetts, 100
> > Holdsworth Way, Amherst, MA 01003, United States
> > bDepartment of Agricultural Chemistry, Gyeongsang National
> > University,
> > Chinju 660-701, Republic of Korea
> > cFood Research Institute, University of Wisconsin-Madison, 1925
> > Willow
> > Drive, Madison, WI 53706, United States
>
> > Received 1 August 2005; revised 3 November 2005; accepted 10
> > November
> > 2005. Available online 20 January 2006.
>
> > Abstract
> > Conjugated linoleic acid (CLA) is known to have several beneficial
> > biological effects in animal models, including anticarcinogenic and
> > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > However, reports of its antioxidant activities have been
> > inconsistent.
> > In this study, we investigated the possible occurrence of p-bonding
> > between CLA and iron. CLA methyl ester was reacted with triiron
> > dodecacarbonyl and confirmed to form p-complexes with iron
> > tricarbonyl. This study may suggest the possible involvement of CLA
> > in
> > oxidation by way of interacting with iron.
>
> > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > Corresponding author. Tel.: +1 ... =
; fax:
> > +1 413 545 1262.
> > doi:10.1016/j.foodchem.2005.11.006
> > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > wrote:"Current treatments use complex proteins, which are expensive to=
> > > makeand cost thousands of dollars per dose. The type of agent used in
> > > this study is a simple, small molecule drug that costs hundreds, not
> > > thousands," Gilbert said. <<
>
> > > Somebody better step in here quick .. this drug also has side
> > > effects .. blinding you to be one.
> > > NOW with the problem with bisphosphonates ?
> > > They are going to be ACTIVELY recruiting for studies of this in ..
> > > those bisphosphonate related diseases ..
>
> > > EVERYONE with .. arthritis ..
>
> > > Whereas .. phytate .. already proven to BE gras / generally regarded
> > > as safe ... ? IE: won't blind you .. ?
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > New Treatment Boosts Bone Healing and Re-growth
> > > > Since phytate binds iron and since bisphosphonate binds iron and sin=
ce
> > > > bisphosphonate is used to heal bone .. I would say this study ..
> > > > confirms .. my work ..
>
> > > > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > > > * w w w .newswise . com /articles/view/536784/
>
> > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > significantly boost the body's own ability to heal and re-grow injur=
ed
> > > > bones, according to researchers at the University of Alabama at
> > > > Birmingham (UAB).
>
> > > > The researchers injected the drug deferoxamine (DF), which is design=
ed
> > > > to reduce iron overload, into injured mouse bones. They found DF
> > > > triggered the growth of new blood vessels, which in turn kicked off
> > > > bone re-growth and healing.
>
> > > > In the study, bone density surrounding the injury more than doubled =
to
> > > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > > millimeters in untreated bones, the researchers said. The new blood
> > > > vessel growth and bone healing was achieved through a cell pathway
> > > > that helps the body respond to low oxygen levels, a common problem
> > > > when blood supply is affected by bone fracture and disease.
>
> > > > Findings on this cell pathway have broad implications for improving
> > > > treatment of bone fractures, bone disease and other musculoskeletal
> > > > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > > > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.=
> > > > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > > > authors on the study.
>
> > > > "With DF activating this pathway, we've proven a significant point -=
> > > > it is possible to explore new, safe and more affordable ways kick-
> > > > start bone repair," Gilbert said.
>
> > > > "Current treatments use complex proteins, which are expensive to mak=
e
> > > > and cost thousands of dollars per dose. The type of agent used in th=
is
> > > > study is a simple, small molecule drug that costs hundreds, not
> > > > thousands," Gilbert said.
>
> > > > The UAB findings are published in the online version of the journal
> > > > Proceedings of the National Academy of Sciences and will soon appear=
> > > > in a print edition.
>
> > > > "The results from this study are a milestone for future studies
> > > > looking at other compounds and agents to improve new-blood-vessel
> > > > growth in skeletal and other tissues that need adequate blood supply=
> > > > to regenerate," Wan said.
>
> > > > The UAB tests were performed in conjunction with a bone lengthening
> > > > procedure commonly used in children and adults, and has proven to ai=
d
> > > > bone healing. The study mice were anesthetized for surgery, and one
> > > > leg bone was cut clean through and a pulling device attached
> > > > temporarily to stretch the bone gap for the next 10 days.
>
> > > > During the stretching, the bone gap was injected with five DF doses.=
> > > > Two weeks after the last DF dose, X-rays of the mice legs were taken=
> > > > to measure bone regeneration.
>
> > > > DF is a drug that binds to excess iron in the body and helps with
> > > > excretion through the bowels and bladder, a process sometimes called=
> > > > iron chelation. DF is used to treat a variety of medical conditions,=
> > > > including iron overload, transfusion-related blood poisoning and in
> > > > combination with dialysis.
>
> > > > In the findings on post-treatment increased bone density, the UAB
> > > > researchers found significant increases in the number of new blood
> > > > vessels, and excellent connectivity between those vessels. The new
> > > > blood vessels are required regenerate bone of equal or better streng=
th
> > > > than the original bones.
>
> > > > Gilbert said it follows that this cell pathway is a prime target for=
> > > > future human studies using DF and other drugs to strengthen the body=
's
> > > > bone-healing potential, especially since poor blood supply is common=
> > > > in fractures and bone disease.
>
> > > > The research team included UAB investigators from the departments of=
> > > > Surgery, Pathology, and Biomedical Engineering and from Children's
> > > > Hospital of Alabama, Birmingham,
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
On Jan 11, 9:34 pm, ironjustice <teamtan...@hotmail . com > wrote:
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days" <<
Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
* tinyurl . com /2rup87
This article shows .. clearly .. the TARGETING of the .. iron .. IN
those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
anemia .. in two weeks.
Clin Exp Rheumatol. 1986
Jan-Mar;4(1):25-9. Related Articles, Links
Antianemic and potential anti-inflammatory activity of
desferrioxamine: possible usefulness in rheumatoid arthritis.
Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
In order to study the role of excessive synovial iron sequestration
in
the production of anemia in rheumatoid arthritis (RA), the antianemic
efficacy and anti-inflammatory effect of desferrioxamine administered
in a
short-term
treatment (14 days), were evaluated in 10 patients suffering from
classic or definite RA and hyposideremic anemia.
Treatment with desferrioxamine showed an
elevated urinary iron excretion, a significant increase of serum
iron, UIBC and hemoglobin, and a marked progressive decrease
of serum ferritin. A moderate improvement of the pain intensity,
morning
stiffness and Ritchie's index was also observed.
The results obtained suggest that excessive reticuloendothelial
iron deposits occur in RA and that the iron uptake can be an
important factor in the production of anemia.
Desferrioxamine seems to be useful in
the treatment of patients suffering from RA and anemia, in order to
release iron from synovial tissue, reduce the inflammatory process
and improve anemia, changing an anemia which is typically resistant
to the martial therapy into an iron-sensitive anemia.
Publication Types:
Clinical Trial
PMID: 3516495 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------
Desferrioxamine maleateDesferrioxamine is a medicine that binds to
excess iron in the body. ... In these cases, desferrioxamine may be
given at the time of the blood transfusion, ...
w w w .tiscali.co.uk/lifestyle/healthfitness/health advice/netdoctor/arc...
- 42k - Cached - Similar pages
Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
otherwise
known as desferrioxamine or desferal, is a chelating agent used to
remove excess iron from the body. It acts by binding free iron in ...
en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > drug originally used to treat iron poisoning <<
>
> > Bisphosphonate grows bone and it is an iron binder .. deferoxamine
> > binds irion and it grows bone .. CLA grows bone and is an iron
> > binder .. bringing us again to .. plain old iron binding
> > bisphosphonate .. **phytate** .
> > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > 478S-486S (2000)
> > Published by the American College of Nutrition
>
> > Conjugated Linoleic Acid and Bone Biology
> > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > Purdue University, Department of Food Science, Lipid Chemistry and
> > Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > Indiana
>
> > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > University, W. Lafayette, IN, 47907. E-mail:
> > watk...@foodsci.purdue.edu.
>
> > ABSTRACT
> > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > millions of people worldwide. Inflammatory cytokines inhibit
> > chondrocyte proliferation and induce cartilage degradation for which
> > part of the response is mediated by PGE2. Excess production of PGE2 is
> > linked to osteoporosis and arthritis and is associated with bone and
> > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > facilitate bone and cartilage formation. Recent investigations with
> > growing rats given butter fat and supplements of CLA demonstrated an
> > increased rate of bone formation and reduced ex vivo bone PGE2
> > production, respectively. Furthermore, the supplements of CLA isomers
> > resulted in their enrichment in lipids of various bone compartments of
> > animals. The effects of CLA on bone biology in rats (IGF action and
> > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > acids in the diet; however, these studies generally showed that CLA
> > decreased ex vivo bone PGE2 production and in osteoblast-like
> > cultures. Anti-inflammatory diets, including nutraceutical
> > applications of CLA, may be beneficial in moderating cyclooygenase 2
> > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > This review summarizes findings of CLA on bone modeling in rats and
> > effects on cellular functions of osteoblasts and chondrocytes. These
> > experiments indicate that CLA isomers possess anti-inflammatory
> > activity in bone by moderating prostanoid formation.
>
> > Key words: bone, cartilage, conjugated linoleic acid, rat
>
> > Food Chemistry
> > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > p-Complex formation of conjugated linoleic acid with iron
>
> > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > aDepartment of Food Science, University of Massachusetts, 100
> > Holdsworth Way, Amherst, MA 01003, United States
> > bDepartment of Agricultural Chemistry, Gyeongsang National
> > University,
> > Chinju 660-701, Republic of Korea
> > cFood Research Institute, University of Wisconsin-Madison, 1925
> > Willow
> > Drive, Madison, WI 53706, United States
>
> > Received 1 August 2005; revised 3 November 2005; accepted 10
> > November
> > 2005. Available online 20 January 2006.
>
> > Abstract
> > Conjugated linoleic acid (CLA) is known to have several beneficial
> > biological effects in animal models, including anticarcinogenic and
> > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > However, reports of its antioxidant activities have been
> > inconsistent.
> > In this study, we investigated the possible occurrence of p-bonding
> > between CLA and iron. CLA methyl ester was reacted with triiron
> > dodecacarbonyl and confirmed to form p-complexes with iron
> > tricarbonyl. This study may suggest the possible involvement of CLA
> > in
> > oxidation by way of interacting with iron.
>
> > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > Corresponding author. Tel.: +1 ... =
; fax:
> > +1 413 545 1262.
> > doi:10.1016/j.foodchem.2005.11.006
> > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > wrote:"Current treatments use complex proteins, which are expensive to=
> > > makeand cost thousands of dollars per dose. The type of agent used in
> > > this study is a simple, small molecule drug that costs hundreds, not
> > > thousands," Gilbert said. <<
>
> > > Somebody better step in here quick .. this drug also has side
> > > effects .. blinding you to be one.
> > > NOW with the problem with bisphosphonates ?
> > > They are going to be ACTIVELY recruiting for studies of this in ..
> > > those bisphosphonate related diseases ..
>
> > > EVERYONE with .. arthritis ..
>
> > > Whereas .. phytate .. already proven to BE gras / generally regarded
> > > as safe ... ? IE: won't blind you .. ?
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > New Treatment Boosts Bone Healing and Re-growth
> > > > Since phytate binds iron and since bisphosphonate binds iron and sin=
ce
> > > > bisphosphonate is used to heal bone .. I would say this study ..
> > > > confirms .. my work ..
>
> > > > IE: phytate WILL grow bone / standin for bisphosphonate.
>
> > > > * w w w .newswise . com /articles/view/536784/
>
> > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > significantly boost the body's own ability to heal and re-grow injur=
ed
> > > > bones, according to researchers at the University of Alabama at
> > > > Birmingham (UAB).
>
> > > > The researchers injected the drug deferoxamine (DF), which is design=
ed
> > > > to reduce iron overload, into injured mouse bones. They found DF
> > > > triggered the growth of new blood vessels, which in turn kicked off
> > > > bone re-growth and healing.
>
> > > > In the study, bone density surrounding the injury more than doubled =
to
> > > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > > millimeters in untreated bones, the researchers said. The new blood
> > > > vessel growth and bone healing was achieved through a cell pathway
> > > > that helps the body respond to low oxygen levels, a common problem
> > > > when blood supply is affected by bone fracture and disease.
>
> > > > Findings on this cell pathway have broad implications for improving
> > > > treatment of bone fractures, bone disease and other musculoskeletal
> > > > disorders, said Shawn Gilbert, M.D., an assistant professor of
> > > > orthopedic surgery in the UAB School of Medicine, and Chao Wan, M.D.=
> > > > Ph.D., an instructor in the UAB Department of Pathology, both co-
> > > > authors on the study.
>
> > > > "With DF activating this pathway, we've proven a significant point -=
> > > > it is possible to explore new, safe and more affordable ways kick-
> > > > start bone repair," Gilbert said.
>
> > > > "Current treatments use complex proteins, which are expensive to mak=
e
> > > > and cost thousands of dollars per dose. The type of agent used in th=
is
> > > > study is a simple, small molecule drug that costs hundreds, not
> > > > thousands," Gilbert said.
>
> > > > The UAB findings are published in the online version of the journal
> > > > Proceedings of the National Academy of Sciences and will soon appear=
> > > > in a print edition.
>
> > > > "The results from this study are a milestone for future studies
> > > > looking at other compounds and agents to improve new-blood-vessel
> > > > growth in skeletal and other tissues that need adequate blood supply=
> > > > to regenerate," Wan said.
>
> > > > The UAB tests were performed in conjunction with a bone lengthening
> > > > procedure commonly used in children and adults, and has proven to ai=
d
> > > > bone healing. The study mice were anesthetized for surgery, and one
> > > > leg bone was cut clean through and a pulling device attached
> > > > temporarily to stretch the bone gap for the next 10 days.
>
> > > > During the stretching, the bone gap was injected with five DF doses.=
> > > > Two weeks after the last DF dose, X-rays of the mice legs were taken=
> > > > to measure bone regeneration.
>
> > > > DF is a drug that binds to excess iron in the body and helps with
> > > > excretion through the bowels and bladder, a process sometimes called=
> > > > iron chelation. DF is used to treat a variety of medical conditions,=
> > > > including iron overload, transfusion-related blood poisoning and in
> > > > combination with dialysis.
>
> > > > In the findings on post-treatment increased bone density, the UAB
> > > > researchers found significant increases in the number of new blood
> > > > vessels, and excellent connectivity between those vessels. The new
> > > > blood vessels are required regenerate bone of equal or better streng=
th
> > > > than the original bones.
>
> > > > Gilbert said it follows that this cell pathway is a prime target for=
> > > > future human studies using DF and other drugs to strengthen the body=
's
> > > > bone-healing potential, especially since poor blood supply is common=
> > > > in fractures and bone disease.
>
> > > > The research team included UAB investigators from the departments of=
> > > > Surgery, Pathology, and Biomedical Engineering and from Children's
> > > > Hospital of Alabama, Birmingham,
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
Re: Iron Chelator For Bone Regrowth
On Jan 12, 1:08 pm, ironjustice <teamtan...@hotmail . com > wrote:
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days" <<
Did anyone see the irony in this .. link .. ?
The whole link was about how phytate is USED to treat ..
hypercalcium .. ?
I've been arguing that phytate resembles bisphosphonates .. a
treatment for hypercalcium and didn't even notice the .. link.
Phytate and bisphosphonates are used to treat hypercalcium .. and
phytate is an iron binder .. and bisphosphonate is an iron binder ..
and bisphosphonates grow bone .. and iron binders grow bone .. and
sooo .. phytate .. should / WILL grow .. bone ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
>
> Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
>
> * tinyurl . com /2rup87
>
> This article shows .. clearly .. the TARGETING of the .. iron .. IN
> those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
> anemia .. in two weeks.
>
> Clin Exp Rheumatol. 1986
> Jan-Mar;4(1):25-9. Related Articles, Links
>
> Antianemic and potential anti-inflammatory activity of
> desferrioxamine: possible usefulness in rheumatoid arthritis.
>
> Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
>
> In order to study the role of excessive synovial iron sequestration
> in
> the production of anemia in rheumatoid arthritis (RA), the antianemic
> efficacy and anti-inflammatory effect of desferrioxamine administered
> in a
> short-term
> treatment (14 days), were evaluated in 10 patients suffering from
> classic or definite RA and hyposideremic anemia.
> Treatment with desferrioxamine showed an
> elevated urinary iron excretion, a significant increase of serum
> iron, UIBC and hemoglobin, and a marked progressive decrease
> of serum ferritin. A moderate improvement of the pain intensity,
> morning
> stiffness and Ritchie's index was also observed.
> The results obtained suggest that excessive reticuloendothelial
> iron deposits occur in RA and that the iron uptake can be an
> important factor in the production of anemia.
> Desferrioxamine seems to be useful in
> the treatment of patients suffering from RA and anemia, in order to
> release iron from synovial tissue, reduce the inflammatory process
> and improve anemia, changing an anemia which is typically resistant
> to the martial therapy into an iron-sensitive anemia.
>
> Publication Types:
> Clinical Trial
>
> PMID: 3516495 [PubMed - indexed for MEDLINE]
>
> --------------------------------------------------------------------------=
>
> Desferrioxamine maleateDesferrioxamine is a medicine that binds to
> excess iron in the body. ... In these cases, desferrioxamine may be
> given at the time of the blood transfusion, ...w w w .tiscali.co.uk/lifestyle=
/healthfitness/health advice/netdoctor/arc...
> - 42k - Cached - Similar pages
>
> Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
> otherwise
> known as desferrioxamine or desferal, is a chelating agent used to
> remove excess iron from the body. It acts by binding free iron in ...
> en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
>
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > > drug originally used to treat iron poisoning <<
>
> > > Bisphosphonate growsboneand it is an iron binder .. deferoxamine
> > > binds irion and it growsbone.. CLA growsboneand is an iron
> > > binder .. bringing us again to .. plain old iron binding
> > > bisphosphonate .. **phytate** .
> > > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > > 478S-486S (2000)
> > > Published by the American College of Nutrition
>
> > > Conjugated Linoleic Acid andBoneBiology
> > > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > > Purdue University, Department of Food Science, Lipid Chemistry and
> > > Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> > > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > > Indiana
>
> > > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > > University, W. Lafayette, IN, 47907. E-mail:
> > > watk...@foodsci.purdue.edu.
>
> > > ABSTRACT
> > > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > > millions of people worldwide. Inflammatory cytokines inhibit
> > > chondrocyte proliferation and induce cartilage degradation for which
> > > part of the response is mediated by PGE2. Excess production of PGE2 is=
> > > linked to osteoporosis and arthritis and is associated withboneand
> > > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > > facilitateboneand cartilage formation. Recent investigations with
> > > growing rats given butter fat and supplements of CLA demonstrated an
> > > increased rate ofboneformation and reduced ex vivobonePGE2
> > > production, respectively. Furthermore, the supplements of CLA isomers
> > > resulted in their enrichment in lipids of variousbonecompartments of
> > > animals. The effects of CLA onbonebiology in rats (IGF action and
> > > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > > acids in the diet; however, these studies generally showed that CLA
> > > decreased ex vivobonePGE2 production and in osteoblast-like
> > > cultures. Anti-inflammatory diets, including nutraceutical
> > > applications of CLA, may be beneficial in moderating cyclooygenase 2
> > > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > > This review summarizes findings of CLA onbonemodeling in rats and
> > > effects on cellular functions of osteoblasts and chondrocytes. These
> > > experiments indicate that CLA isomers possess anti-inflammatory
> > > activity inboneby moderating prostanoid formation.
>
> > > Key words:bone, cartilage, conjugated linoleic acid, rat
>
> > > Food Chemistry
> > > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > > p-Complex formation of conjugated linoleic acid with iron
>
> > > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > > aDepartment of Food Science, University of Massachusetts, 100
> > > Holdsworth Way, Amherst, MA 01003, United States
> > > bDepartment of Agricultural Chemistry, Gyeongsang National
> > > University,
> > > Chinju 660-701, Republic of Korea
> > > cFood Research Institute, University of Wisconsin-Madison, 1925
> > > Willow
> > > Drive, Madison, WI 53706, United States
>
> > > Received 1 August 2005; revised 3 November 2005; accepted 10
> > > November
> > > 2005. Available online 20 January 2006.
>
> > > Abstract
> > > Conjugated linoleic acid (CLA) is known to have several beneficial
> > > biological effects in animal models, including anticarcinogenic and
> > > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > > However, reports of its antioxidant activities have been
> > > inconsistent.
> > > In this study, we investigated the possible occurrence of p-bonding
> > > between CLA and iron. CLA methyl ester was reacted with triiron
> > > dodecacarbonyl and confirmed to form p-complexes with iron
> > > tricarbonyl. This study may suggest the possible involvement of CLA
> > > in
> > > oxidation by way of interacting with iron.
>
> > > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > > Corresponding author. Tel.: =
+1 ... =
; fax:
> > > +1 ... .
> > > doi:10.1016/j.foodchem.2005.11.006
> > > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > > wrote:"Current treatments use complex proteins, which are expensive =
to
> > > > makeand cost thousands of dollars per dose. The type of agent used i=
n
> > > > this study is a simple, small molecule drug that costs hundreds, not=
> > > > thousands," Gilbert said. <<
>
> > > > Somebody better step in here quick .. this drug also has side
> > > > effects .. blinding you to be one.
> > > > NOW with the problem with bisphosphonates ?
> > > > They are going to be ACTIVELY recruiting for studies of this in ..
> > > > those bisphosphonate related diseases ..
>
> > > > EVERYONE with .. arthritis ..
>
> > > > Whereas .. phytate .. already proven to BE gras / generally regarded=
> > > > as safe ... ? IE: won't blind you .. ?
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > New Treatment BoostsBoneHealing and Re-growth
> > > > > Since phytate binds iron and since bisphosphonate binds iron and s=
ince
> > > > > bisphosphonate is used to healbone.. I would say this study ..
> > > > > confirms .. my work ..
>
> > > > > IE: phytate WILL growbone/ standin for bisphosphonate.
>
> > > > > * w w w .newswise . com /articles/view/536784/
>
> > > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > > significantly boost the body's own ability to heal and re-grow inj=
ured
> > > > > bones, according to researchers at the University of Alabama at
> > > > > Birmingham (UAB).
>
> > > > > The researchers injected the drug deferoxamine (DF), which is desi=
gned
> > > > > to reduce iron overload, into injured mouse bones. They found DF
> > > > > triggered the growth of new blood vessels, which in turn kicked of=
f
> > > > >bonere-growth and healing.
>
> > > > > In the study,bonedensity surrounding the injury more than doubled =
to
> > > > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > > > millimeters in untreated bones, the researchers said. The new bloo=
d
> > > > > vessel growth andbonehealing was achieved through a cell pathway
> > > > > that helps the body respond to low oxygen levels, a common problem=
> > > > > when blood supply is affected bybonefracture and disease.
>
> > > > > Findings on this cell pathway have broad implications for improvin=
g
> > > > > treatment ofbonefractures,bonedisease and other musculoskeletal
> > > > > disorders, said Shawn Gilbert, M.D., an assistant professor of
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
On Jan 12, 1:08 pm, ironjustice <teamtan...@hotmail . com > wrote:
* litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
"A rise of plasma phytate was produced at 15 days" <<
Did anyone see the irony in this .. link .. ?
The whole link was about how phytate is USED to treat ..
hypercalcium .. ?
I've been arguing that phytate resembles bisphosphonates .. a
treatment for hypercalcium and didn't even notice the .. link.
Phytate and bisphosphonates are used to treat hypercalcium .. and
phytate is an iron binder .. and bisphosphonate is an iron binder ..
and bisphosphonates grow bone .. and iron binders grow bone .. and
sooo .. phytate .. should / WILL grow .. bone ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
>
> Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
>
> * tinyurl . com /2rup87
>
> This article shows .. clearly .. the TARGETING of the .. iron .. IN
> those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
> anemia .. in two weeks.
>
> Clin Exp Rheumatol. 1986
> Jan-Mar;4(1):25-9. Related Articles, Links
>
> Antianemic and potential anti-inflammatory activity of
> desferrioxamine: possible usefulness in rheumatoid arthritis.
>
> Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
>
> In order to study the role of excessive synovial iron sequestration
> in
> the production of anemia in rheumatoid arthritis (RA), the antianemic
> efficacy and anti-inflammatory effect of desferrioxamine administered
> in a
> short-term
> treatment (14 days), were evaluated in 10 patients suffering from
> classic or definite RA and hyposideremic anemia.
> Treatment with desferrioxamine showed an
> elevated urinary iron excretion, a significant increase of serum
> iron, UIBC and hemoglobin, and a marked progressive decrease
> of serum ferritin. A moderate improvement of the pain intensity,
> morning
> stiffness and Ritchie's index was also observed.
> The results obtained suggest that excessive reticuloendothelial
> iron deposits occur in RA and that the iron uptake can be an
> important factor in the production of anemia.
> Desferrioxamine seems to be useful in
> the treatment of patients suffering from RA and anemia, in order to
> release iron from synovial tissue, reduce the inflammatory process
> and improve anemia, changing an anemia which is typically resistant
> to the martial therapy into an iron-sensitive anemia.
>
> Publication Types:
> Clinical Trial
>
> PMID: 3516495 [PubMed - indexed for MEDLINE]
>
> --------------------------------------------------------------------------=
>
> Desferrioxamine maleateDesferrioxamine is a medicine that binds to
> excess iron in the body. ... In these cases, desferrioxamine may be
> given at the time of the blood transfusion, ...w w w .tiscali.co.uk/lifestyle=
/healthfitness/health advice/netdoctor/arc...
> - 42k - Cached - Similar pages
>
> Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
> otherwise
> known as desferrioxamine or desferal, is a chelating agent used to
> remove excess iron from the body. It acts by binding free iron in ...
> en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
>
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > > drug originally used to treat iron poisoning <<
>
> > > Bisphosphonate growsboneand it is an iron binder .. deferoxamine
> > > binds irion and it growsbone.. CLA growsboneand is an iron
> > > binder .. bringing us again to .. plain old iron binding
> > > bisphosphonate .. **phytate** .
> > > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > > 478S-486S (2000)
> > > Published by the American College of Nutrition
>
> > > Conjugated Linoleic Acid andBoneBiology
> > > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > > Purdue University, Department of Food Science, Lipid Chemistry and
> > > Molecular Biology Laboratory, West Lafayette, Indiana, and Department
> > > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > > Indiana
>
> > > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > > University, W. Lafayette, IN, 47907. E-mail:
> > > watk...@foodsci.purdue.edu.
>
> > > ABSTRACT
> > > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > > millions of people worldwide. Inflammatory cytokines inhibit
> > > chondrocyte proliferation and induce cartilage degradation for which
> > > part of the response is mediated by PGE2. Excess production of PGE2 is=
> > > linked to osteoporosis and arthritis and is associated withboneand
> > > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > > facilitateboneand cartilage formation. Recent investigations with
> > > growing rats given butter fat and supplements of CLA demonstrated an
> > > increased rate ofboneformation and reduced ex vivobonePGE2
> > > production, respectively. Furthermore, the supplements of CLA isomers
> > > resulted in their enrichment in lipids of variousbonecompartments of
> > > animals. The effects of CLA onbonebiology in rats (IGF action and
> > > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > > acids in the diet; however, these studies generally showed that CLA
> > > decreased ex vivobonePGE2 production and in osteoblast-like
> > > cultures. Anti-inflammatory diets, including nutraceutical
> > > applications of CLA, may be beneficial in moderating cyclooygenase 2
> > > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > > This review summarizes findings of CLA onbonemodeling in rats and
> > > effects on cellular functions of osteoblasts and chondrocytes. These
> > > experiments indicate that CLA isomers possess anti-inflammatory
> > > activity inboneby moderating prostanoid formation.
>
> > > Key words:bone, cartilage, conjugated linoleic acid, rat
>
> > > Food Chemistry
> > > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > > p-Complex formation of conjugated linoleic acid with iron
>
> > > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > > aDepartment of Food Science, University of Massachusetts, 100
> > > Holdsworth Way, Amherst, MA 01003, United States
> > > bDepartment of Agricultural Chemistry, Gyeongsang National
> > > University,
> > > Chinju 660-701, Republic of Korea
> > > cFood Research Institute, University of Wisconsin-Madison, 1925
> > > Willow
> > > Drive, Madison, WI 53706, United States
>
> > > Received 1 August 2005; revised 3 November 2005; accepted 10
> > > November
> > > 2005. Available online 20 January 2006.
>
> > > Abstract
> > > Conjugated linoleic acid (CLA) is known to have several beneficial
> > > biological effects in animal models, including anticarcinogenic and
> > > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > > However, reports of its antioxidant activities have been
> > > inconsistent.
> > > In this study, we investigated the possible occurrence of p-bonding
> > > between CLA and iron. CLA methyl ester was reacted with triiron
> > > dodecacarbonyl and confirmed to form p-complexes with iron
> > > tricarbonyl. This study may suggest the possible involvement of CLA
> > > in
> > > oxidation by way of interacting with iron.
>
> > > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > > Corresponding author. Tel.: =
+1 ... =
; fax:
> > > +1 ... .
> > > doi:10.1016/j.foodchem.2005.11.006
> > > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > > wrote:"Current treatments use complex proteins, which are expensive =
to
> > > > makeand cost thousands of dollars per dose. The type of agent used i=
n
> > > > this study is a simple, small molecule drug that costs hundreds, not=
> > > > thousands," Gilbert said. <<
>
> > > > Somebody better step in here quick .. this drug also has side
> > > > effects .. blinding you to be one.
> > > > NOW with the problem with bisphosphonates ?
> > > > They are going to be ACTIVELY recruiting for studies of this in ..
> > > > those bisphosphonate related diseases ..
>
> > > > EVERYONE with .. arthritis ..
>
> > > > Whereas .. phytate .. already proven to BE gras / generally regarded=
> > > > as safe ... ? IE: won't blind you .. ?
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > New Treatment BoostsBoneHealing and Re-growth
> > > > > Since phytate binds iron and since bisphosphonate binds iron and s=
ince
> > > > > bisphosphonate is used to healbone.. I would say this study ..
> > > > > confirms .. my work ..
>
> > > > > IE: phytate WILL growbone/ standin for bisphosphonate.
>
> > > > > * w w w .newswise . com /articles/view/536784/
>
> > > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > > significantly boost the body's own ability to heal and re-grow inj=
ured
> > > > > bones, according to researchers at the University of Alabama at
> > > > > Birmingham (UAB).
>
> > > > > The researchers injected the drug deferoxamine (DF), which is desi=
gned
> > > > > to reduce iron overload, into injured mouse bones. They found DF
> > > > > triggered the growth of new blood vessels, which in turn kicked of=
f
> > > > >bonere-growth and healing.
>
> > > > > In the study,bonedensity surrounding the injury more than doubled =
to
> > > > > 2.6 cubic millimeters in treated bones compared to 1.2 cubic
> > > > > millimeters in untreated bones, the researchers said. The new bloo=
d
> > > > > vessel growth andbonehealing was achieved through a cell pathway
> > > > > that helps the body respond to low oxygen levels, a common problem=
> > > > > when blood supply is affected bybonefracture and disease.
>
> > > > > Findings on this cell pathway have broad implications for improvin=
g
> > > > > treatment ofbonefractures,bonedisease and other musculoskeletal
> > > > > disorders, said Shawn Gilbert, M.D., an assistant professor of
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
Re: Iron Chelator For Bone Regrowth
On Jan 13, 10:20 am, ironjustice <ironjust...@cashette . com > wrote:
phytate <<
* herbivore.7h . com /leaven.html
These are a few bread recipes ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 12, 1:08 pm, ironjustice <teamtan...@hotmail . com > wrote:
> * litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
> "A rise of plasma phytate was produced at 15 days" <<
>
> Did anyone see the irony in this .. link .. ?
>
> The whole link was about how phytate is USED to treat ..
> hypercalcium .. ?
>
> I've been arguing that phytate resembles bisphosphonates .. a
> treatment for hypercalcium and didn't even notice the .. link.
>
> Phytate and bisphosphonates are used to treat hypercalcium .. and
> phytate is an iron binder .. and bisphosphonate is an iron binder ..
> and bisphosphonates grow bone .. and iron binders grow bone .. and
> sooo .. phytate .. should / WILL grow .. bone ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
>
>
> > Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
>
> > * tinyurl . com /2rup87
>
> > This article shows .. clearly .. the TARGETING of the .. iron .. IN
> > those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
> > anemia .. in two weeks.
>
> > Clin Exp Rheumatol. 1986
> > Jan-Mar;4(1):25-9. Related Articles, Links
>
> > Antianemic and potential anti-inflammatory activity of
> > desferrioxamine: possible usefulness in rheumatoid arthritis.
>
> > Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
>
> > In order to study the role of excessive synovial iron sequestration
> > in
> > the production of anemia in rheumatoid arthritis (RA), the antianemic
> > efficacy and anti-inflammatory effect of desferrioxamine administered
> > in a
> > short-term
> > treatment (14 days), were evaluated in 10 patients suffering from
> > classic or definite RA and hyposideremic anemia.
> > Treatment with desferrioxamine showed an
> > elevated urinary iron excretion, a significant increase of serum
> > iron, UIBC and hemoglobin, and a marked progressive decrease
> > of serum ferritin. A moderate improvement of the pain intensity,
> > morning
> > stiffness and Ritchie's index was also observed.
> > The results obtained suggest that excessive reticuloendothelial
> > iron deposits occur in RA and that the iron uptake can be an
> > important factor in the production of anemia.
> > Desferrioxamine seems to be useful in
> > the treatment of patients suffering from RA and anemia, in order to
> > release iron from synovial tissue, reduce the inflammatory process
> > and improve anemia, changing an anemia which is typically resistant
> > to the martial therapy into an iron-sensitive anemia.
>
> > Publication Types:
> > Clinical Trial
>
> > PMID: 3516495 [PubMed - indexed for MEDLINE]
>
> > ------------------------------------------------------------------------=
--
>
> > Desferrioxamine maleateDesferrioxamine is a medicine that binds to
> > excess iron in the body. ... In these cases, desferrioxamine may be
> > given at the time of the blood transfusion, ...w w w .tiscali.co.uk/lifesty=
le/healthfitness/health advice/netdoctor/arc...
> > - 42k - Cached - Similar pages
>
> > Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
> > otherwise
> > known as desferrioxamine or desferal, is a chelating agent used to
> > remove excess iron from the body. It acts by binding free iron in ...
> > en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > > > drug originally used to treat iron poisoning <<
>
> > > > Bisphosphonate growsboneand it is an iron binder .. deferoxamine
> > > > binds irion and it growsbone.. CLA growsboneand is an iron
> > > > binder .. bringing us again to .. plain old iron binding
> > > > bisphosphonate .. **phytate** .
> > > > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > > > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > > > 478S-486S (2000)
> > > > Published by the American College of Nutrition
>
> > > > Conjugated Linoleic Acid andBoneBiology
> > > > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > > > Purdue University, Department of Food Science, Lipid Chemistry and
> > > > Molecular Biology Laboratory, West Lafayette, Indiana, and Departmen=
t
> > > > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > > > Indiana
>
> > > > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > > > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > > > University, W. Lafayette, IN, 47907. E-mail:
> > > > watk...@foodsci.purdue.edu.
>
> > > > ABSTRACT
> > > > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > > > millions of people worldwide. Inflammatory cytokines inhibit
> > > > chondrocyte proliferation and induce cartilage degradation for which=
> > > > part of the response is mediated by PGE2. Excess production of PGE2 =
is
> > > > linked to osteoporosis and arthritis and is associated withboneand
> > > > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > > > facilitateboneand cartilage formation. Recent investigations with
> > > > growing rats given butter fat and supplements of CLA demonstrated an=
> > > > increased rate ofboneformation and reduced ex vivobonePGE2
> > > > production, respectively. Furthermore, the supplements of CLA isomer=
s
> > > > resulted in their enrichment in lipids of variousbonecompartments of=
> > > > animals. The effects of CLA onbonebiology in rats (IGF action and
> > > > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > > > acids in the diet; however, these studies generally showed that CLA
> > > > decreased ex vivobonePGE2 production and in osteoblast-like
> > > > cultures. Anti-inflammatory diets, including nutraceutical
> > > > applications of CLA, may be beneficial in moderating cyclooygenase 2=
> > > > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > > > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > > > This review summarizes findings of CLA onbonemodeling in rats and
> > > > effects on cellular functions of osteoblasts and chondrocytes. These=
> > > > experiments indicate that CLA isomers possess anti-inflammatory
> > > > activity inboneby moderating prostanoid formation.
>
> > > > Key words:bone, cartilage, conjugated linoleic acid, rat
>
> > > > Food Chemistry
> > > > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > > > p-Complex formation of conjugated linoleic acid with iron
>
> > > > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > > > aDepartment of Food Science, University of Massachusetts, 100
> > > > Holdsworth Way, Amherst, MA 01003, United States
> > > > bDepartment of Agricultural Chemistry, Gyeongsang National
> > > > University,
> > > > Chinju 660-701, Republic of Korea
> > > > cFood Research Institute, University of Wisconsin-Madison, 1925
> > > > Willow
> > > > Drive, Madison, WI 53706, United States
>
> > > > Received 1 August 2005; revised 3 November 2005; accepted 10
> > > > November
> > > > 2005. Available online 20 January 2006.
>
> > > > Abstract
> > > > Conjugated linoleic acid (CLA) is known to have several beneficial
> > > > biological effects in animal models, including anticarcinogenic and
> > > > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > > > However, reports of its antioxidant activities have been
> > > > inconsistent.
> > > > In this study, we investigated the possible occurrence of p-bonding
> > > > between CLA and iron. CLA methyl ester was reacted with triiron
> > > > dodecacarbonyl and confirmed to form p-complexes with iron
> > > > tricarbonyl. This study may suggest the possible involvement of CLA
> > > > in
> > > > oxidation by way of interacting with iron.
>
> > > > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > > > Corresponding author. Tel.: =
+1 ... =
; fax:
> > > > +1 ... .
> > > > doi:10.1016/j.foodchem.2005.11.006
> > > > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > > > wrote:"Current treatments use complex proteins, which are expensiv=
e to
> > > > > makeand cost thousands of dollars per dose. The type of agent used=
in
> > > > > this study is a simple, small molecule drug that costs hundreds, n=
ot
> > > > > thousands," Gilbert said. <<
>
> > > > > Somebody better step in here quick .. this drug also has side
> > > > > effects .. blinding you to be one.
> > > > > NOW with the problem with bisphosphonates ?
> > > > > They are going to be ACTIVELY recruiting for studies of this in ..=
> > > > > those bisphosphonate related diseases ..
>
> > > > > EVERYONE with .. arthritis ..
>
> > > > > Whereas .. phytate .. already proven to BE gras / generally regard=
ed
> > > > > as safe ... ? IE: won't blind you .. ?
>
> > > > > Who loves ya.
> > > > > Tom
>
> > > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > > New Treatment BoostsBoneHealing and Re-growth
> > > > > > Since phytate binds iron and since bisphosphonate binds iron and=
since
> > > > > > bisphosphonate is used to healbone.. I would say this study ..
> > > > > > confirms .. my work ..
>
> > > > > > IE: phytate WILL growbone/ standin for bisphosphonate.
>
> > > > > > * w w w .newswise . com /articles/view/536784/
>
> > > > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > > > significantly boost the body's own ability to heal and re-grow
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
On Jan 13, 10:20 am, ironjustice <ironjust...@cashette . com > wrote:
phytate <<
* herbivore.7h . com /leaven.html
These are a few bread recipes ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
> On Jan 12, 1:08 pm, ironjustice <teamtan...@hotmail . com > wrote:
> * litiasisrenal.uib . es /3inform/fitato/2Ang/fitatTa.html
> "A rise of plasma phytate was produced at 15 days" <<
>
> Did anyone see the irony in this .. link .. ?
>
> The whole link was about how phytate is USED to treat ..
> hypercalcium .. ?
>
> I've been arguing that phytate resembles bisphosphonates .. a
> treatment for hypercalcium and didn't even notice the .. link.
>
> Phytate and bisphosphonates are used to treat hypercalcium .. and
> phytate is an iron binder .. and bisphosphonate is an iron binder ..
> and bisphosphonates grow bone .. and iron binders grow bone .. and
> sooo .. phytate .. should / WILL grow .. bone ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
>
>
> > Hmmm .. about two weeks .. ? Jeez .. I've heard that before ..
>
> > * tinyurl . com /2rup87
>
> > This article shows .. clearly .. the TARGETING of the .. iron .. IN
> > those with arthritis leads to improved .. i-m-p-r-o-v-e-d ..
> > anemia .. in two weeks.
>
> > Clin Exp Rheumatol. 1986
> > Jan-Mar;4(1):25-9. Related Articles, Links
>
> > Antianemic and potential anti-inflammatory activity of
> > desferrioxamine: possible usefulness in rheumatoid arthritis.
>
> > Giordano N, Sancasciani S, Borghi C, Fioravanti A, Marcolongo R.
>
> > In order to study the role of excessive synovial iron sequestration
> > in
> > the production of anemia in rheumatoid arthritis (RA), the antianemic
> > efficacy and anti-inflammatory effect of desferrioxamine administered
> > in a
> > short-term
> > treatment (14 days), were evaluated in 10 patients suffering from
> > classic or definite RA and hyposideremic anemia.
> > Treatment with desferrioxamine showed an
> > elevated urinary iron excretion, a significant increase of serum
> > iron, UIBC and hemoglobin, and a marked progressive decrease
> > of serum ferritin. A moderate improvement of the pain intensity,
> > morning
> > stiffness and Ritchie's index was also observed.
> > The results obtained suggest that excessive reticuloendothelial
> > iron deposits occur in RA and that the iron uptake can be an
> > important factor in the production of anemia.
> > Desferrioxamine seems to be useful in
> > the treatment of patients suffering from RA and anemia, in order to
> > release iron from synovial tissue, reduce the inflammatory process
> > and improve anemia, changing an anemia which is typically resistant
> > to the martial therapy into an iron-sensitive anemia.
>
> > Publication Types:
> > Clinical Trial
>
> > PMID: 3516495 [PubMed - indexed for MEDLINE]
>
> > ------------------------------------------------------------------------=
--
>
> > Desferrioxamine maleateDesferrioxamine is a medicine that binds to
> > excess iron in the body. ... In these cases, desferrioxamine may be
> > given at the time of the blood transfusion, ...w w w .tiscali.co.uk/lifesty=
le/healthfitness/health advice/netdoctor/arc...
> > - 42k - Cached - Similar pages
>
> > Deferoxamine - Wikipedia, the free encyclopediaDeferoxamine,
> > otherwise
> > known as desferrioxamine or desferal, is a chelating agent used to
> > remove excess iron from the body. It acts by binding free iron in ...
> > en.wikipedia.org/wiki/Desferrioxamine - 20k - Cached - Similar pages
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > Who loves ya.
> > > Tom
>
> > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > On Jan 10, 8:34 am, ironjustice <ironjust...@cashette . com > wrote: A
> > > > drug originally used to treat iron poisoning <<
>
> > > > Bisphosphonate growsboneand it is an iron binder .. deferoxamine
> > > > binds irion and it growsbone.. CLA growsboneand is an iron
> > > > binder .. bringing us again to .. plain old iron binding
> > > > bisphosphonate .. **phytate** .
> > > > --------------------- * w w w .jacn.org/cgi/content/full/19/4/478S
>
> > > > Journal of the American College of Nutrition, Vol. 19, No. 4,
> > > > 478S-486S (2000)
> > > > Published by the American College of Nutrition
>
> > > > Conjugated Linoleic Acid andBoneBiology
> > > > Bruce A. Watkins, PhD, FACN and Mark F. Seifert, PhD
> > > > Purdue University, Department of Food Science, Lipid Chemistry and
> > > > Molecular Biology Laboratory, West Lafayette, Indiana, and Departmen=
t
> > > > of Anatomy, Indiana University School of Medicine, Indianapolis,
> > > > Indiana
>
> > > > Address reprint requests to: Dr. B.A. Watkins, Department of Food
> > > > Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue
> > > > University, W. Lafayette, IN, 47907. E-mail:
> > > > watk...@foodsci.purdue.edu.
>
> > > > ABSTRACT
> > > > Osteoporosis, osteoarthritis and inflammatory joint disease afflict
> > > > millions of people worldwide. Inflammatory cytokines inhibit
> > > > chondrocyte proliferation and induce cartilage degradation for which=
> > > > part of the response is mediated by PGE2. Excess production of PGE2 =
is
> > > > linked to osteoporosis and arthritis and is associated withboneand
> > > > proteoglycan loss. PGE2 also influences the IGF-I/IGFBP axis to
> > > > facilitateboneand cartilage formation. Recent investigations with
> > > > growing rats given butter fat and supplements of CLA demonstrated an=
> > > > increased rate ofboneformation and reduced ex vivobonePGE2
> > > > production, respectively. Furthermore, the supplements of CLA isomer=
s
> > > > resulted in their enrichment in lipids of variousbonecompartments of=
> > > > animals. The effects of CLA onbonebiology in rats (IGF action and
> > > > cytokines) appear to be dependent on the level of n-6 and n-3 fatty
> > > > acids in the diet; however, these studies generally showed that CLA
> > > > decreased ex vivobonePGE2 production and in osteoblast-like
> > > > cultures. Anti-inflammatory diets, including nutraceutical
> > > > applications of CLA, may be beneficial in moderating cyclooygenase 2=
> > > > (COX-2) activity or expression (influencing PGE2 biosynthesis) and
> > > > might help to reduce rheumatoid arthritis (secondary osteoporosis).
> > > > This review summarizes findings of CLA onbonemodeling in rats and
> > > > effects on cellular functions of osteoblasts and chondrocytes. These=
> > > > experiments indicate that CLA isomers possess anti-inflammatory
> > > > activity inboneby moderating prostanoid formation.
>
> > > > Key words:bone, cartilage, conjugated linoleic acid, rat
>
> > > > Food Chemistry
> > > > Volume 100, Issue 3 , 2007, Pages 972-976
>
> > > > p-Complex formation of conjugated linoleic acid with iron
>
> > > > Yeonhwa Parka, , , Yeong L. Hab and Michael W. Parizac
>
> > > > aDepartment of Food Science, University of Massachusetts, 100
> > > > Holdsworth Way, Amherst, MA 01003, United States
> > > > bDepartment of Agricultural Chemistry, Gyeongsang National
> > > > University,
> > > > Chinju 660-701, Republic of Korea
> > > > cFood Research Institute, University of Wisconsin-Madison, 1925
> > > > Willow
> > > > Drive, Madison, WI 53706, United States
>
> > > > Received 1 August 2005; revised 3 November 2005; accepted 10
> > > > November
> > > > 2005. Available online 20 January 2006.
>
> > > > Abstract
> > > > Conjugated linoleic acid (CLA) is known to have several beneficial
> > > > biological effects in animal models, including anticarcinogenic and
> > > > antiatherosclerotic effects, antiobesity, and antioxidant activity.
> > > > However, reports of its antioxidant activities have been
> > > > inconsistent.
> > > > In this study, we investigated the possible occurrence of p-bonding
> > > > between CLA and iron. CLA methyl ester was reacted with triiron
> > > > dodecacarbonyl and confirmed to form p-complexes with iron
> > > > tricarbonyl. This study may suggest the possible involvement of CLA
> > > > in
> > > > oxidation by way of interacting with iron.
>
> > > > Keywords: Conjugated linoleic acid; CLA; Iron
>
> > > > Corresponding author. Tel.: =
+1 ... =
; fax:
> > > > +1 ... .
> > > > doi:10.1016/j.foodchem.2005.11.006
> > > > Copyright (c) 2005 Elsevier Ltd All rights reserved
>
> > > > Who loves ya.
> > > > Tom
>
> > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > On Jan 10, 7:26 am, ironjustice <ironjust...@cashette . com >
> > > > > wrote:"Current treatments use complex proteins, which are expensiv=
e to
> > > > > makeand cost thousands of dollars per dose. The type of agent used=
in
> > > > > this study is a simple, small molecule drug that costs hundreds, n=
ot
> > > > > thousands," Gilbert said. <<
>
> > > > > Somebody better step in here quick .. this drug also has side
> > > > > effects .. blinding you to be one.
> > > > > NOW with the problem with bisphosphonates ?
> > > > > They are going to be ACTIVELY recruiting for studies of this in ..=
> > > > > those bisphosphonate related diseases ..
>
> > > > > EVERYONE with .. arthritis ..
>
> > > > > Whereas .. phytate .. already proven to BE gras / generally regard=
ed
> > > > > as safe ... ? IE: won't blind you .. ?
>
> > > > > Who loves ya.
> > > > > Tom
>
> > > > > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > > > > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > > > > DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
> > > > > > New Treatment BoostsBoneHealing and Re-growth
> > > > > > Since phytate binds iron and since bisphosphonate binds iron and=
since
> > > > > > bisphosphonate is used to healbone.. I would say this study ..
> > > > > > confirms .. my work ..
>
> > > > > > IE: phytate WILL growbone/ standin for bisphosphonate.
>
> > > > > > * w w w .newswise . com /articles/view/536784/
>
> > > > > > Newswise -- A drug originally used to treat iron poisoning can
> > > > > > significantly boost the body's own ability to heal and re-grow
>
> ...
>
> read more »- Hide quoted text -
>
> - Show quoted text -
