Polyphosphate Periodontal Potential Promotion

Polyphosphate Periodontal Potential Promotion

This would give some credence to simple old phytate being a bone
former.

"Local delivery may have a therapeutic benefit in periodontal disease"

That would mean .. "get those beans .. peas .. grains .. etc .. DEEP
into those teeth" ..

* tinyurl . com /22pjc7

Hacchou Y, Uematsu T, Ueda O, Usui Y, Uematsu S, Takahashi M,
Uchihashi T, Kawazoe Y, Shiba T, Kurihara S, Yamaoka M, Furusawa K
Inorganic polyphosphate: a possible stimulant of bone formation.
[Journal Article]
J Dent Res 2007 Sep; 86(9):893-7.
Inorganic polyphosphates [Poly(P)] are often distributed in
osteoblasts.
We undertook the present study to verify the hypothesis that Poly(P)
stimulates osteoblasts and facilitates bone formation.
The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and
gene expression and potential mineralization were evaluated by reverse-
transcription polymerase chain-reaction. Alkaline phosphatase
activity, von Kossa staining, and resorption pit formation analyses
were also determined.
The potential role of Poly(P) in bone formation was assessed in a rat
alveolar bone regeneration model. Poly(P) induced osteopontin,
osteocalcin, collagen 1alpha, and osteoprotegerin expression and
increased alkaline phosphatase activity in MC 3T3-E1 cells.
Dentin slice pit formation decreased with mouse osteoblast and bone
marrow macrophage co-cultivation in the presence of Poly(P).
Promotion of alveolar bone regeneration was observed locally in
Poly(P)-treated rats.
These findings suggest that Poly(P) plays a role in osteoblastic
differentiation, activation, and bone mineralization.
Thus, local poly(P) delivery may have a therapeutic benefit in
periodontal disease.

Journal of dental research [J Dent Res]

--------------------------------------------------------------------------------

Who loves ya.
Tom


Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com


Man Is A Herbivore!
* tinyurl . com /a3cc3


DEAD PEOPLE WALKING
* tinyurl . com /zk9fk

Re: Polyphosphate Periodontal Potential Promotion

On Jan 10, 11:52 am, ironjustice <ironjust...@cashette . com > wrote:
simple old phytate <<

I guess this answers the question of lecithin being a bone former.

Sooo .. sitting around eating foods with lecithin .. as opposed to big
dollars and / or brisk exercise and gymnastic training.

"Lecithin will eventually break down to release inorganic phosphate"

Unfortunately for those of us trying to master phosphate chemistry,
the world of organic phosphates is far larger than inorganic
phosphates. Many common biochemicals contain phosphate esters, and
every living cell will contain some. Such molecules as DNA, ATP,
phospholipids such as lecithin, and many proteins contain phosphate.
In these molecules, the basic phosphate structure is covalently
attached to the remainder of the organic molecule through one or more
phosphate ester bonds. These bonds are stable for some period of time
in water, but will eventually break down to release inorganic
phosphate from the organic part of the molecule, a process that can be
sped up through the action of acids, bases or enzymes. Addition and
removal of phosphate from ATP, for example, is a highly regulated
process taking place in all organisms.


Who loves ya.
Tom


Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com


Man Is A Herbivore!
* tinyurl . com /a3cc3


DEAD PEOPLE WALKING
* tinyurl . com /zk9fk





> This would give some credence to simple old phytate being a bone
> former.
>
> "Local delivery may have a therapeutic benefit in periodontal disease"
>
> That would mean .. "get those beans .. peas .. grains .. etc ..  DEEP
> into those teeth" ..
>
> * tinyurl . com /22pjc7
>
> Hacchou Y, Uematsu T, Ueda O, Usui Y, Uematsu S, Takahashi M,
> Uchihashi T, Kawazoe Y, Shiba T, Kurihara S, Yamaoka M, Furusawa K
> Inorganic polyphosphate: a possible stimulant of bone formation.
> [Journal Article]
> J Dent Res 2007 Sep; 86(9):893-7.
> Inorganic polyphosphates [Poly(P)] are often distributed in
> osteoblasts.
> We undertook the present study to verify the hypothesis that Poly(P)
> stimulates osteoblasts and facilitates bone formation.
> The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and
> gene expression and potential mineralization were evaluated by reverse-
> transcription polymerase chain-reaction. Alkaline phosphatase
> activity, von Kossa staining, and resorption pit formation analyses
> were also determined.
> The potential role of Poly(P) in bone formation was assessed in a rat
> alveolar bone regeneration model. Poly(P) induced osteopontin,
> osteocalcin, collagen 1alpha, and osteoprotegerin expression and
> increased alkaline phosphatase activity in MC 3T3-E1 cells.
> Dentin slice pit formation decreased with mouse osteoblast and bone
> marrow macrophage co-cultivation in the presence of Poly(P).
> Promotion of alveolar bone regeneration was observed locally in
> Poly(P)-treated rats.
> These findings suggest that Poly(P) plays a role in osteoblastic
> differentiation, activation, and bone mineralization.
> Thus, local poly(P) delivery may have a therapeutic benefit in
> periodontal disease.
>
> Journal of dental research [J Dent Res]
>
> --------------------------------------------------------------------------=
------
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk

Re: Polyphosphate Periodontal Potential Promotion

On Jan 10, 12:14 pm, ironjustice <ironjust...@cashette . com > wrote:
lecithin <<

Anybody learn how to get this stuff off a spoon .. let me know ..

I have to wash it with a weaker oil and then STILL don't get it off ..

One of its' drawbacks .. but very good in vegetable soup ..


Who loves ya.
Tom


Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com


Man Is A Herbivore!
* tinyurl . com /a3cc3


DEAD PEOPLE WALKING
* tinyurl . com /zk9fk





> On Jan 10, 11:52 am, ironjustice <ironjust...@cashette . com > wrote:
> simple old phytate <<
>
> I guess this answers the question of lecithin being a bone former.
>
> Sooo .. sitting around eating foods with lecithin .. as opposed to big
> dollars and / or brisk exercise and gymnastic training.
>
> "Lecithin will eventually break down to release inorganic phosphate"
>
> Unfortunately for those of us trying to master phosphate chemistry,
> the world of organic phosphates is far larger than inorganic
> phosphates. Many common biochemicals contain phosphate esters, and
> every living cell will contain some. Such molecules as DNA, ATP,
> phospholipids such as lecithin, and many proteins contain phosphate.
> In these molecules, the basic phosphate structure is covalently
> attached to the remainder of the organic molecule through one or more
> phosphate ester bonds. These bonds are stable for some period of time
> in water, but will eventually break down to release inorganic
> phosphate from the organic part of the molecule, a process that can be
> sped up through the action of acids, bases or enzymes. Addition and
> removal of phosphate from ATP, for example, is a highly regulated
> process taking place in all organisms.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk
>
>
>
> > This would give some credence to simple old phytate being a bone
> > former.
>
> > "Local delivery may have a therapeutic benefit in periodontal disease"
>
> > That would mean .. "get those beans .. peas .. grains .. etc ..  DEEP
> > into those teeth" ..
>
> > * tinyurl . com /22pjc7
>
> > Hacchou Y, Uematsu T, Ueda O, Usui Y, Uematsu S, Takahashi M,
> > Uchihashi T, Kawazoe Y, Shiba T, Kurihara S, Yamaoka M, Furusawa K
> > Inorganic polyphosphate: a possible stimulant of bone formation.
> > [Journal Article]
> > J Dent Res 2007 Sep; 86(9):893-7.
> > Inorganic polyphosphates [Poly(P)] are often distributed in
> > osteoblasts.
> > We undertook the present study to verify the hypothesis that Poly(P)
> > stimulates osteoblasts and facilitates bone formation.
> > The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and
> > gene expression and potential mineralization were evaluated by reverse-
> > transcription polymerase chain-reaction. Alkaline phosphatase
> > activity, von Kossa staining, and resorption pit formation analyses
> > were also determined.
> > The potential role of Poly(P) in bone formation was assessed in a rat
> > alveolar bone regeneration model. Poly(P) induced osteopontin,
> > osteocalcin, collagen 1alpha, and osteoprotegerin expression and
> > increased alkaline phosphatase activity in MC 3T3-E1 cells.
> > Dentin slice pit formation decreased with mouse osteoblast and bone
> > marrow macrophage co-cultivation in the presence of Poly(P).
> > Promotion of alveolar bone regeneration was observed locally in
> > Poly(P)-treated rats.
> > These findings suggest that Poly(P) plays a role in osteoblastic
> > differentiation, activation, and bone mineralization.
> > Thus, local poly(P) delivery may have a therapeutic benefit in
> > periodontal disease.
>
> > Journal of dental research [J Dent Res]
>
> > ------------------------------------------------------------------------=
--------
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> > Man Is A Herbivore! * tinyurl . com /a3cc3
>
> > DEAD PEOPLE WALKING * tinyurl . com /zk9fk- Hide quoted text -
>
> - Show quoted text -

Re: Polyphosphate Periodontal Potential Promotion

On Jan 10, 11:52 am, ironjustice <ironjust...@cashette . com > wrote:
Inorganic polyphosphates [Poly(P)] are often distributed in
osteoblasts.
We undertook the present study to verify the hypothesis that Poly(P)
stimulates
osteoblasts and facilitates bone formation. <<

Poly(P) binds up uranium JUST like / coincidentally .. simple old
phytate.
Giving more credence to them$$$$ .. being .. phytate in disguise.

Vazquez GJ, Dodge CJ, Francis AJ
Interactions of uranium with polyphosphate. [JOURNAL ARTICLE]
Chemosphere 2007 Jul 26.

Inorganic polyphosphates (PolyP) are simple linear phosphate (PO(4)
(3-)) polymers which are produced by a variety of microorganisms.
One of their functions is to complex metals resulting in their
precipitation.
We investigated the interaction of phosphate and low-molecular-weight
PolyP (1400-1900Da) with uranyl ion at various pHs.
Potentiometric titration of uranyl ion in the presence of phosphate
showed two sharp inflection points at pHs 4 and 8 due to uranium
hydrolysis reaction and interaction with phosphate.
Titration of uranyl ion and PolyP revealed a broad inflection point
starting at pH 4 indicating that complexation of U-PolyP occurs over a
wide range of pHs with no uranium hydrolysis.
EXAFS analysis of the U-HPO(4) complex revealed that an insoluble
uranyl phosphate species was formed below pH 6; at higher pH (8)
uranium formed a precipitate consisting of hydroxophosphato species.
In contrast, adding uranyl ion to PolyP resulted in formation of U-
PolyP complex over the entire pH range studied.
At low pH (6) an insoluble U-PolyP complex having a monodentate
coordination of phosphate with uranium was observed. Above pH 6
however, a soluble bidentate complex with phosphate and uranium was
predominant.
These results show that the complexation and solubility of uranium
with PO(4) and PolyP are dependent upon pH.

Chemosphere
----------------------------------------------------------------------------=
----

Cebrian D, Tapia A, Real A, Morcillo MA
INOSITOL HEXAPHOSPHATE: A POTENTIAL CHELATING AGENT FOR URANIUM.
[JOURNAL ARTICLE]
Radiat Prot Dosimetry 2007 Jul 12.
Chelation therapy is an optimal method to reduce the radionuclide-
related risks.
In the case of uranium incorporation, the treatment of choice is so
far i.v infusion of a 1.4% sodium bicarbonate solution, but the
efficacy has been proved to be not very high.
In this study, we examine the efficacy of some substances:
bicarbonate, citrate, diethylenetriamine pentaacetic acid (DTPA),
ethidronate (EHBP) and inositol hexaphosphate (phytic acid) to chelate
uranium using a test developed by Braun et al.
Different concentrations of phytic acid, an abundant component of
plant seeds that is widely distributed in animal cells and tissues in
substantial levels, were tested and compared to the same
concentrations of sodium citrate, bicarbonate, EHBP and DTPA.
The results showed a strong affinity of inositol hexaphosphate for
uranium, suggesting that it could be an effective chelating agent for
uranium in vivo.

Radiat Prot Dosimetry
----------------------------------------------------------------------------=
----

Who loves ya.
Tom


Jesus Was A Vegetarian!
* jesuswasavegetarian.7h . com


Man Is A Herbivore!
* tinyurl . com /a3cc3


DEAD PEOPLE WALKING
* tinyurl . com /zk9fk

> This would give some credence to simple old phytate being a bone
> former.
>
> "Local delivery may have a therapeutic benefit in periodontal disease"
>
> That would mean .. "get those beans .. peas .. grains .. etc ..  DEEP
> into those teeth" ..
>
> * tinyurl . com /22pjc7
>
> Hacchou Y, Uematsu T, Ueda O, Usui Y, Uematsu S, Takahashi M,
> Uchihashi T, Kawazoe Y, Shiba T, Kurihara S, Yamaoka M, Furusawa K
> Inorganic polyphosphate: a possible stimulant of bone formation.
> [Journal Article]
> J Dent Res 2007 Sep; 86(9):893-7.
> Inorganic polyphosphates [Poly(P)] are often distributed in
> osteoblasts.
> We undertook the present study to verify the hypothesis that Poly(P)
> stimulates osteoblasts and facilitates bone formation.
> The osteoblast-like cell line MC 3T3-E1 was cultured with Poly(P), and
> gene expression and potential mineralization were evaluated by reverse-
> transcription polymerase chain-reaction. Alkaline phosphatase
> activity, von Kossa staining, and resorption pit formation analyses
> were also determined.
> The potential role of Poly(P) in bone formation was assessed in a rat
> alveolar bone regeneration model. Poly(P) induced osteopontin,
> osteocalcin, collagen 1alpha, and osteoprotegerin expression and
> increased alkaline phosphatase activity in MC 3T3-E1 cells.
> Dentin slice pit formation decreased with mouse osteoblast and bone
> marrow macrophage co-cultivation in the presence of Poly(P).
> Promotion of alveolar bone regeneration was observed locally in
> Poly(P)-treated rats.
> These findings suggest that Poly(P) plays a role in osteoblastic
> differentiation, activation, and bone mineralization.
> Thus, local poly(P) delivery may have a therapeutic benefit in
> periodontal disease.
>
> Journal of dental research [J Dent Res]
>
> --------------------------------------------------------------------------=
------
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! * jesuswasavegetarian.7h . com
>
> Man Is A Herbivore! * tinyurl . com /a3cc3
>
> DEAD PEOPLE WALKING * tinyurl . com /zk9fk