On Apr 24, 8:30 am, BoneLady <srsuppor...@gmail.com> wrote:
> On Apr 23, 4:58 pm, Larry <la...@nospam.net> wrote:> BoneLady wrote:
> > > Are you interested in an alternative to prescription drugs for
> > > osteoporosis? athttp://strontiumforbones.blogspot.com/. My
> > > > Can I just ask ... since this is not a prescription that is dispense=
d by
> > a pharmacy and prescribed by a doctor, and has never been through any
> > kind of clinical trial, how would we really know whether there are side
> > effects or not?
>
> > Larry
>
> Clinical studies utilizing different forms of strontium have been
> conducted since the l950s.Regardless of the form, it is the elemental
> strontium that is beneficial for bones.Visit my website for links to
> some of the clinical trials.I have been taking strontium citrate for
> three months with no side effects except mild constipation, which I
> relieved by increasing my fiber intake. BoneLady athttp://strontiumforbone=
s.blogspot.com/
The strontium ranelate related research funded by
those promoting it medical use is careful to
ignore the fact that it is the strontium is the active
ingredient and the ranelate is mirrorly the chelating
agent, IMO. To insist the ranelate chelate is the
only active form is the product of dishonest legalism not
hard edge science, IMO.
Here is a piece of cell culture work that suggest
what I just wrote.
0581 The Effects of Strontium Citrate on Osteoblast
Proliferation and Differentiation
A. BEUTTENMULLER, and R. DZIAK, SDM
College of Dental Sciences,
Buffalo, NY, USA
Recent research has shown that stable strontium
as well as some strontium salts increase bone
metabolism in osteoblasts obtained from rodent
calvaria cultures and that this element, particularly
in the form of strontium ranelate, may be useful
in the treatment of osteoporosis and other
diseases of bone remodeling.
Objectives: To assess the effects of strontium citrate,
a product commonly available as a nutritional supplement,
on the proliferation and differentiation of osteoblastic
cells obtained from human alveolar bone.
Methods: Primary osteoblasts, obtained with patients'
consent from human alveolar bone residues at the time
of third molar extractions and explanted in culture,
were seeded at a concentration of 105 cells/ml in
24 well polystyrene plates in BGJb media
containing 10% FCS. After the cells reached a
semiconfluent stage, strontium citrate
(bibasic anhydrous, pure grade from Jost Chemical)
at various concentrations (0.05-1.0 mM) was added.
The experiments performed included a MTT test
which assesses viability/proliferation with a
measure of mitochondrial activity and a
biochemical assay for alkaline phosphate
activity, an early maker of osteoblastic
cell differentiation. Measurements were
performed at 24, 48, and 72hrs.
Results: The data were analyzed using ANOVA.
The MTT test showed the cells to be responsive to
strontium citrate with significant increases
(p<0.05) in cellular activity/proliferation at
24 and 48 hrs. Alkaline phosphatase activity was
significantly enhanced (p<0.05) at 48 and 72 hrs
with strontium citrate concentrations in the
test range. Conclusion: The data support the
hypothesis that strontium citrate increases
the proliferative/alkaline phosphatase activity
of human osteoblastic cells from alveolar bone.
The results validate previous research that has
been done with other forms of strontium in
clinical studies and rodent calvarial cells and
indicates that strontium citrate could be a
promising agent in treating oral as well as
systemic bone disorders.
Funded by Dental Medicine Centennial Fund
___________________
By the way topical strontium is a more effective
agent against sensitive teeth than is fluoride.
I speak from personal experience.