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Fuchs's Cornea Dystrophy Questions

Reply from: ray
Date: 11 May 2008, 23:21
Fuchs's Cornea Dystrophy Questions

About 2 months ago overnight I developed intermittent double vision
in both eyes. I went to 3 different eye doctors. The first said
cataracts and referred me to a cataract surgeon. The second said I
need new glasses which didn't help.

The cataract surgeon said Fuchs's Cornea Dystrophy.
The cataract surgeon measured cornea thickness 630 right, 645 left,
cornea pressure 17 R 15 L, Guttata grade 3 plus, cell count not
measured. I am getting the morning fuzzy vision. On a home eye
chart morning vision is 20/40 R 20/50 L. In the afternoon it is
20/20 L 20/25 R. I am using Muro eye drops and ointment at night.
It seems to clear the vision somewhat.

I am a 68 year old male. The cataract surgeon said I have some
cataracts, but with the Fuchs's he would not operate.


Questions:
Is Fuchs's that difficult to diagnose?
How common of a condition is it?
How likely is the cataract surgeon to have the right diagnosis?
Do I need a fourth opinion?
Is the onset usually so sudden (overnight)?
Given my history and current state what is the likely progression of
the disease?

Thanks

Ray

Reply from: Dr Judy
Date: 12 May 2008, 03:16
Re: Fuchs's Cornea Dystrophy Questions

On May 11, 5:21 pm, ray <spamm...@do.not.reply . com > wrote:
> About 2 months ago overnight I developed intermittent double vision
> in both eyes. I went to 3 different eye doctors. The first said
> cataracts and referred me to a cataract surgeon. The second said I
> need new glasses which didn't help.
>
> The cataract surgeon said Fuchs's Cornea Dystrophy.  
> The cataract surgeon measured cornea thickness 630 right, 645 left,
> cornea pressure 17 R 15 L, Guttata grade 3 plus, cell count not
> measured. I am getting the morning fuzzy vision. On a home eye
> chart morning vision is 20/40 R 20/50 L. In the afternoon it is
> 20/20 L 20/25 R. I am using Muro eye drops and ointment at night.
> It seems to clear the vision somewhat.
>
> I am a 68 year old male. The cataract surgeon said I have some
> cataracts, but with the Fuchs's he would not operate.
>
> Questions:
> Is Fuchs's that difficult to diagnose?

Well, the doctor has to look. It also tends to be worse in am and
better later in the day, so might have been missed if you had late day
appointments.

> How common of a condition is it?
> How likely is the cataract surgeon to have the right diagnosis?
Very likely, esp if he is seeing corneal guttata. Muro is the
treatment and since Muro is working, that also confirms the diagnosis.

> Do I need a fourth opinion?
No

> Is the onset usually so sudden (overnight)?
Symptoms can onset quickly

> Given my history and current state what is the likely progression of
> the disease?

Hard to predict. Most people do not progress very quickly. Some go on
to need a corneal transplant, most don't

Judy

Reply from: Don W
Date: 12 May 2008, 03:46
Re: Fuchs's Cornea Dystrophy Questions

Just exactly what causes the "morning fuzziness"?

Don W.




Reply from: Mike Tyner
Date: 12 May 2008, 04:07
Re: Fuchs's Cornea Dystrophy Questions

The corneal stroma swells and loses transparency if water isn't actively
pumped out.

The endothelium contains the pump.

When the lids are closed overnight, oxygenation drops.

Healthy endothelium has enough reserve to keep the cornea clear overnight.

-MT


"Don W" <dwilgus@prodigy . net > wrote in message
news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
> Just exactly what causes the "morning fuzziness"?
>
> Don W.



Reply from: Don W
Date: 14 May 2008, 21:56
Re: Fuchs's Cornea Dystrophy Questions

Thanks.

How might the cornea react to Xalantan with this kind of condition?


Also, is the morning "fuzziness" granular or just overall "fuzzy"? (If that
is clear?).


Don W.




"Mike Tyner" <mtyner@mindspring . com > wrote in message
news:BN6dnQqrkNPHO7rVnZ2dnUVZ_r6rnZ2d@giganews . com ...
> The corneal stroma swells and loses transparency if water isn't actively
> pumped out.
>
> The endothelium contains the pump.
>
> When the lids are closed overnight, oxygenation drops.
>
> Healthy endothelium has enough reserve to keep the cornea clear overnight.
>
> -MT
>
>
> "Don W" <dwilgus@prodigy . net > wrote in message
> news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
>> Just exactly what causes the "morning fuzziness"?
>>
>> Don W.
>
>



Reply from: ray
Date: 14 May 2008, 23:17
Re: Fuchs's Cornea Dystrophy Questions

On Wed, 14 May 2008 12:56:02 -0700, "Don W" <dwilgus@prodigy . net >
wrote:

>Thanks.
>
>How might the cornea react to Xalantan with this kind of condition?
>
>
>Also, is the morning "fuzziness" granular or just overall "fuzzy"? (If that
>is clear?).
>
For high contrast items such as point source of light or black print
on white background it is multiple images. In my case sometimes it is
as many as 6 images smeared vertically. For lower contrast it just
looks fuzzy. Removing excess water from the cornea with salt water or
a hair dryer improves vision. What is Xalantan?

>

>Don W.
>
>
>
>
>"Mike Tyner" <mtyner@mindspring . com > wrote in message
>news:BN6dnQqrkNPHO7rVnZ2dnUVZ_r6rnZ2d@giganews . com ...
>> The corneal stroma swells and loses transparency if water isn't actively
>> pumped out.
>>
>> The endothelium contains the pump.
>>
>> When the lids are closed overnight, oxygenation drops.
>>
>> Healthy endothelium has enough reserve to keep the cornea clear overnight.
>>
>> -MT
>>
>>
>> "Don W" <dwilgus@prodigy . net > wrote in message
>> news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
>>> Just exactly what causes the "morning fuzziness"?
>>>
>>> Don W.
>>
>>
>

Reply from: Zetsu
Date: 15 May 2008, 00:05
Re: Fuchs's Cornea Dystrophy Questions

On 14 May, 22:17, ray <spamm...@do.not.reply . com > wrote:
> On Wed, 14 May 2008 12:56:02 -0700, "Don W" <dwil...@prodigy . net >
> wrote:
>
> >Thanks.
>
> >How might the cornea react to Xalantan with this kind of condition?
>
> >Also, is the morning "fuzziness" granular or just overall "fuzzy"? (If that
> >is clear?).
>
> For high contrast items such as point source of light or black print
> on white background it is multiple images. In my case sometimes it is
> as many as 6 images smeared vertically. For lower contrast it just
> looks fuzzy. Removing excess water from the cornea with salt water or
> a hair dryer improves vision. What is Xalantan?
>
>
>
> >Don W.
>
> >"Mike Tyner" <mty...@mindspring . com > wrote in message
> >news:BN6dnQqrkNPHO7rVnZ2dnUVZ r6rnZ2d@giganews . com ...
> >> The corneal stroma swells and loses transparency if water isn't actively
> >> pumped out.
>
> >> The endothelium contains the pump.
>
> >> When the lids are closed overnight, oxygenation drops.
>
> >> Healthy endothelium has enough reserve to keep the cornea clear overnight.
>
> >> -MT
>
> >> "Don W" <dwil...@prodigy . net > wrote in message
> >>news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
> >>> Just exactly what causes the "morning fuzziness"?
>
> >>> Don W.

Wikipedia says:

Latanoprost (pronounced la-TA-noe-prost) ophthalmic solution is a
topical medication used for controlling the progression of glaucoma or
ocular hypertension, by reducing intraocular pressure. It is a
prostaglandin analogue that works by increasing the outflow of aqueous
fluid from the eyes.

It is also known by the brand name of Xalatan manufactured by Pfizer.

Possible side effects:

-May cause reddening of the eyes (hyperemia)
-May cause blurred vision;
-May cause eyelid redness;
-May permanently darken eyelashes;
-May cause eye discomfort;
-May eventually cause permanent darkening of the iris to brown
(heterochromia);
-May cause a temporary burning sensation during use.
-May cause thickening of the eyelashes.
-Rarely, herpes simplex keratitis.

[ * en.wikipedia.org/wiki/Xalatan]

Reply from: Don W
Date: 15 May 2008, 00:06
Re: Fuchs's Cornea Dystrophy Questions

Interesting about too much fluid in the cornea. I always got the impression
the it was my cornea (outside) surface that needed a few blinks to become
more "optically smooth".

How far apart are your multiple images? Degrees, minutes? Those types of
multiple images I do not have.

Xalatan is a glaucoma drug that reduces eye pressure, namely the anterior
chamber (hopefully the posterior tracks), before higher pressure affects the
optic nerve, which affects blood flow to the eye. The drug, goes thru the
entire cornea (and that would include the endothelium). (As far as I
understand it -- no medical type).

Don W.

PS. What is funny about the usage of that drug is that I squeeze out as
much moisture as possible from the eye and then apply the drop. So that I
can get the maximum use out of a singular drop. One is advised not to
double drop since it tends to wash out the medication from the eye.
Interesting, I thought.





"ray" <spammers@do.not.reply . com > wrote in message
news:hflm24hs4fqcgvk7llnc9aujlqun5c9iea@4ax . com ...
> On Wed, 14 May 2008 12:56:02 -0700, "Don W" <dwilgus@prodigy . net >
> wrote:
>
>>Thanks.
>>
>>How might the cornea react to Xalantan with this kind of condition?
>>
>>
>>Also, is the morning "fuzziness" granular or just overall "fuzzy"? (If
>>that
>>is clear?).
>>
> For high contrast items such as point source of light or black print
> on white background it is multiple images. In my case sometimes it is
> as many as 6 images smeared vertically. For lower contrast it just
> looks fuzzy. Removing excess water from the cornea with salt water or
> a hair dryer improves vision. What is Xalantan?
>
>>
>
>>Don W.
>>
>>
>>
>>
>>"Mike Tyner" <mtyner@mindspring . com > wrote in message
>>news:BN6dnQqrkNPHO7rVnZ2dnUVZ_r6rnZ2d@giganews . com ...
>>> The corneal stroma swells and loses transparency if water isn't actively
>>> pumped out.
>>>
>>> The endothelium contains the pump.
>>>
>>> When the lids are closed overnight, oxygenation drops.
>>>
>>> Healthy endothelium has enough reserve to keep the cornea clear
>>> overnight.
>>>
>>> -MT
>>>
>>>
>>> "Don W" <dwilgus@prodigy . net > wrote in message
>>> news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
>>>> Just exactly what causes the "morning fuzziness"?
>>>>
>>>> Don W.
>>>
>>>
>>



Reply from: Zetsu
Date: 15 May 2008, 00:17
Re: Fuchs's Cornea Dystrophy Questions

Sorry for going off topic for a second, but why do some people spell
the word 'through' as 'thru'? I mean, if you're going to truncate one
word why not just go all out instead of using a half measure. Why not
replace the whole post with words like 4 instead of 'for' or 'u'
instead of 'you'. Or is this how Americans normally spell the word? I
must say, it's much more convenient to say 'thru' instead of 'through'
but being a semantic kind of person I can't help but notice these
small things where people neglect the rules of standard English.
Consistency in speech is always helpful to foreign speakers, too.

Reply from: ray
Date: 15 May 2008, 01:10
Re: Fuchs's Cornea Dystrophy Questions

On Wed, 14 May 2008 15:06:53 -0700, "Don W" <dwilgus@prodigy . net >
wrote:

>Interesting about too much fluid in the cornea. I always got the impression
>the it was my cornea (outside) surface that needed a few blinks to become
>more "optically smooth".
>
>How far apart are your multiple images? Degrees, minutes? Those types of
>multiple images I do not have.

A traffic stop light will have 2 red lights spaced the same distance
apart as the distance between amber and red. A cross road (black
cross on yellow sign) will have 2 black crosses bars with yellow in
between the thickness of a crossbar. From 10 feet a 1/8" green LED
will be a series of dots about an inch high. Normal text in a book
will have a readable ghost image 1/2 the height of text. I am getting
used to it.

My corneal pressure is 16, with 12 to 21 normal.

>
>Xalatan is a glaucoma drug that reduces eye pressure, namely the anterior
>chamber (hopefully the posterior tracks), before higher pressure affects the
>optic nerve, which affects blood flow to the eye. The drug, goes thru the
>entire cornea (and that would include the endothelium). (As far as I
>understand it -- no medical type).
>
>Don W.
>
>PS. What is funny about the usage of that drug is that I squeeze out as
>much moisture as possible from the eye and then apply the drop. So that I
>can get the maximum use out of a singular drop. One is advised not to
>double drop since it tends to wash out the medication from the eye.
>Interesting, I thought.
>
>
>
>
>
>"ray" <spammers@do.not.reply . com > wrote in message
>news:hflm24hs4fqcgvk7llnc9aujlqun5c9iea@4ax . com ...
>> On Wed, 14 May 2008 12:56:02 -0700, "Don W" <dwilgus@prodigy . net >
>> wrote:
>>
>>>Thanks.
>>>
>>>How might the cornea react to Xalantan with this kind of condition?
>>>
>>>
>>>Also, is the morning "fuzziness" granular or just overall "fuzzy"? (If
>>>that
>>>is clear?).
>>>
>> For high contrast items such as point source of light or black print
>> on white background it is multiple images. In my case sometimes it is
>> as many as 6 images smeared vertically. For lower contrast it just
>> looks fuzzy. Removing excess water from the cornea with salt water or
>> a hair dryer improves vision. What is Xalantan?
>>
>>>
>>
>>>Don W.
>>>
>>>
>>>
>>>
>>>"Mike Tyner" <mtyner@mindspring . com > wrote in message
>>>news:BN6dnQqrkNPHO7rVnZ2dnUVZ_r6rnZ2d@giganews . com ...
>>>> The corneal stroma swells and loses transparency if water isn't actively
>>>> pumped out.
>>>>
>>>> The endothelium contains the pump.
>>>>
>>>> When the lids are closed overnight, oxygenation drops.
>>>>
>>>> Healthy endothelium has enough reserve to keep the cornea clear
>>>> overnight.
>>>>
>>>> -MT
>>>>
>>>>
>>>> "Don W" <dwilgus@prodigy . net > wrote in message
>>>> news:AkNVj.3320$nW2.1546@nlpi064.nbdc.sbc . com ...
>>>>> Just exactly what causes the "morning fuzziness"?
>>>>>
>>>>> Don W.
>>>>
>>>>
>>>
>

Reply from: Don W
Date: 15 May 2008, 04:04
Re: Fuchs's Cornea Dystrophy Questions

>>multiple images I do not have.
>
> A traffic stop light will have 2 red lights spaced the same distance
> apart as the distance between amber and red. A cross road (black
> cross on yellow sign) will have 2 black crosses bars with yellow in
> between the thickness of a crossbar. From 10 feet a 1/8" green LED
> will be a series of dots about an inch high. Normal text in a book
> will have a readable ghost image 1/2 the height of text. I am getting
> used to it.
>
> My corneal pressure is 16, with 12 to 21 normal.

For a "standard E" (20/20 vision) the subtended angle is 5 minutes or 0.083
degree. Your 1 inch at 10 feet is 0.48 degree. These are remarkable
offsets. All caused by deformations in the cornea? (Or in the lens??).
Seems like they should be able to nail down the cause.

Don W.




Reply from: Mike Tyner
Date: 15 May 2008, 05:47
Re: Fuchs's Cornea Dystrophy Questions


"Don W" <dwilgus@prodigy . net > wrote

> degree. Your 1 inch at 10 feet is 0.48 degree. These are remarkable
> offsets. All caused by deformations in the cornea? (Or in the lens??).
> Seems like they should be able to nail down the cause.

It isn't considered useful, because it wouldn't alter the treatment.

If the diplopia is lenticular (my vote), his acuity is apparently still too
good to expect insurance to cover cataract surgery.

If it's corneal, rigid contact lenses would eliminate the diplopia but he
probably wouldn't like wearing rigid contacts and no surgeon wants to
recommend contacts to a presbyope with symptomatic Fuchs.

It would take about two minutes to numb his cornea, pop on a rigid contact
lens and prove the origin of the diplopia. But that's not so easy to justify
if you have to buy (design, order, wait for) a gas perm contact lens just
for a one-shot diagnostic fit.

They say "it's academic" meaning "it ain't worth the trouble."

-MT



Reply from: ray
Date: 15 May 2008, 16:09
Re: Fuchs's Cornea Dystrophy Questions

On Wed, 14 May 2008 22:47:28 -0500, "Mike Tyner"
<mtyner@mindspring . com > wrote:

>
>"Don W" <dwilgus@prodigy . net > wrote
>
>> degree. Your 1 inch at 10 feet is 0.48 degree. These are remarkable
>> offsets. All caused by deformations in the cornea? (Or in the lens??).
>> Seems like they should be able to nail down the cause.
>
>It isn't considered useful, because it wouldn't alter the treatment.
>
>If the diplopia is lenticular (my vote), his acuity is apparently still too
>good to expect insurance to cover cataract surgery.
>
>If it's corneal, rigid contact lenses would eliminate the diplopia but he
>probably wouldn't like wearing rigid contacts and no surgeon wants to
>recommend contacts to a presbyope with symptomatic Fuchs.
>
>It would take about two minutes to numb his cornea, pop on a rigid contact
>lens and prove the origin of the diplopia. But that's not so easy to justify
>if you have to buy (design, order, wait for) a gas perm contact lens just
>for a one-shot diagnostic fit.
>
>They say "it's academic" meaning "it ain't worth the trouble."
>
>-MT
>

I agree. My eyesight is not that bad, I can live with it. The latest
medical advice is to wait until it gets worse and they will do
cataract surgery and replace the endothelium layer of the cornea at
the same time. I am in no hurry to do that. The problem with waiting
too long is that blisters will form too many scars on the cornea
requiring the replacement of the whole cornea. There are a few scars
on the cornea that I can not explain. I am going for a cell count
soon which may help to determine how bad the Fuchs is. Thanks for
your input.

Reply from: Don W
Date: 15 May 2008, 19:52
Re: Fuchs's Cornea Dystrophy Questions

How would Fuchs' and the use of Xalatan (to lower IOP) go together?

Complement or complicate the situation??

Don W.




Reply from: ray
Date: 15 May 2008, 15:55
Re: Fuchs's Cornea Dystrophy Questions

On Wed, 14 May 2008 19:04:44 -0700, "Don W" <dwilgus@prodigy . net >
wrote:

>>>multiple images I do not have.
>>
>> A traffic stop light will have 2 red lights spaced the same distance
>> apart as the distance between amber and red. A cross road (black
>> cross on yellow sign) will have 2 black crosses bars with yellow in
>> between the thickness of a crossbar. From 10 feet a 1/8" green LED
>> will be a series of dots about an inch high. Normal text in a book
>> will have a readable ghost image 1/2 the height of text. I am getting
>> used to it.
>>
>> My corneal pressure is 16, with 12 to 21 normal.
>
> For a "standard E" (20/20 vision) the subtended angle is 5 minutes or 0.083
>degree. Your 1 inch at 10 feet is 0.48 degree. These are remarkable
>offsets. All caused by deformations in the cornea? (Or in the lens??).
>Seems like they should be able to nail down the cause.
>
>Don W.
>

You are talking about medical people. I have read on the average it
takes 6 diagnosis to get it right. That was how many it took to find
a torn rotator cuff in my arm. For my vision the first doctor said
cataracts, the second said wrong glasses, the third said Fuch's. They
all used the same examination procedure. Others with Fuch's have said
it took more than 6 doctors to find it. I think it highly likely that
I have Fuch's as the major problem and cataracts. I am not sure that
with my symptoms that it is a complete explanation. The vision is not
as bad as the numbers would suggest because the distortion is only
vertical, the vision waxes and wanes and what I described it when it
is at its worst.


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   Don W
    Mike Tyner
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      ray
       Zetsu
       Don W
        Zetsu
        ray
         Don W
          Mike Tyner
           ray
           Don W
          ray
           John Hasenkam
            Mike Tyner
             John Hasenkam
              Don W
               John Hasenkam
                Don W
                 John Hasenkam
                  John Hasenkam
                   Don W
         Zetsu