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Surviving Breast Cancer
Surviving Breast Cancer
High Intake of Dietary Lignans Improves Breast Cancer Survival
Lignans are distributed in seeds, whole grains, berries, fruit,
vegetables, and nuts.
April 25, 2008 (San Diego, California) — A high consumption of lignans
is associated with better survival in postmenopausal women with breast
cancer. Although the dietary intake of lignans did not have any effect
on breast cancer survival in premenopausal women, postmenopausal women
with a high intake of plant lignans were approximately 70% less likely
to die from their breast cancer, according to study data presented
here at the American Association for Cancer Research 2008 Annual
Meeting.
"We can draw fewer conclusions about lignan intake in terms of overall
mortality because, since this was a breast cancer study, most of the
patients died from breast disease," lead author Susan E. McCann, PhD,
from the division of cancer prevention and population sciences at
Roswell Park Cancer Institute, in Buffalo, New York, told Medscape
Oncology. "But a high intake of lignans was associated with about a
50% reduction in mortality from all causes. This included
cardiovascular disease and other cancers."
Lignans are distributed in seeds, whole grains, berries, fruit,
vegetables, and nuts, and have been studied for a possible effect on
breast cancer risk. Several epidemiologic studies have found that the
dietary intake of lignans is associated with a lower risk for breast
cancer but, to date, there have not been any clinical trials
evaluating the effect of lignan intake on breast cancer survival.
Dr. McCann and colleagues examined the association between dietary
lignan intake and breast cancer survival in 1122 women with primary
incident histologically confirmed breast cancer. All of the women were
participants in the Western New York Exposures and Breast Cancer (WEB)
study, a population-based case-control study of women living in Erie
and Niagara counties in Western New York between 1996 and 2001. The
women were followed through December 31, 2004.
Study participants completed an extensive food-frequency
questionnaire, which assessed their diet in the 12 to 24 months before
their cancer diagnosis. The researchers calculated dietary lignan
intake using published food-composition data, and associations between
dietary lignan intake and all-cause, total cancer, and breast cancer
mortality were estimated using the Cox proportional hazards models
after adjustment for confounders such as age, tumor stage, and body
mass index.
By the end of the follow-up period, 130 patients had died —94 from
cancer(of which 84 were breast cancer) and 36 from other causes. "The
women who died from breast cancer tended to be older, tended to have a
more advanced stage of cancer, and were more likely to be nonwhite,"
said Dr. McCann. "They were also more likely to be estrogen-receptor
negative, but it wasn't statistically significant."
There was no association between the consumption of dietary lignans
and all-cause, total cancer, or breast cancer mortality among
premenopausal women. However, postmenopausal women with the highest
intake of lignans showed a statistically significant reduction in the
risk for all-cause mortality (hazard ratio, 0.48) and a significantly
lower risk for breast cancer mortality (hazard ratio, 0.35).
"In this study, lignan intake was derived primarily from dark bread,
peaches, apricots, broccoli, winter squash, oranges, strawberries,
onions, coffee, and tea," said Dr. McCann.
The researchers did not find an association between mortality and the
intake of fruits and vegetables, although a high intake of lignans
might be a marker of a plant-based diet.
"This study is evidence that a healthy diet can contribute to improved
survival in breast cancer and other chronic diseases," she said. "It
provides more evidence that a plant-based diet may help survival in
cancer patients."
American Association for Cancer Research (AACR) 2008 Annual Meeting:
Abstract 4162. Presented April 15, 2008.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
Man Is A Herbivore!
http :// tinyurl,com /a3cc3
DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk
High Intake of Dietary Lignans Improves Breast Cancer Survival
Lignans are distributed in seeds, whole grains, berries, fruit,
vegetables, and nuts.
April 25, 2008 (San Diego, California) — A high consumption of lignans
is associated with better survival in postmenopausal women with breast
cancer. Although the dietary intake of lignans did not have any effect
on breast cancer survival in premenopausal women, postmenopausal women
with a high intake of plant lignans were approximately 70% less likely
to die from their breast cancer, according to study data presented
here at the American Association for Cancer Research 2008 Annual
Meeting.
"We can draw fewer conclusions about lignan intake in terms of overall
mortality because, since this was a breast cancer study, most of the
patients died from breast disease," lead author Susan E. McCann, PhD,
from the division of cancer prevention and population sciences at
Roswell Park Cancer Institute, in Buffalo, New York, told Medscape
Oncology. "But a high intake of lignans was associated with about a
50% reduction in mortality from all causes. This included
cardiovascular disease and other cancers."
Lignans are distributed in seeds, whole grains, berries, fruit,
vegetables, and nuts, and have been studied for a possible effect on
breast cancer risk. Several epidemiologic studies have found that the
dietary intake of lignans is associated with a lower risk for breast
cancer but, to date, there have not been any clinical trials
evaluating the effect of lignan intake on breast cancer survival.
Dr. McCann and colleagues examined the association between dietary
lignan intake and breast cancer survival in 1122 women with primary
incident histologically confirmed breast cancer. All of the women were
participants in the Western New York Exposures and Breast Cancer (WEB)
study, a population-based case-control study of women living in Erie
and Niagara counties in Western New York between 1996 and 2001. The
women were followed through December 31, 2004.
Study participants completed an extensive food-frequency
questionnaire, which assessed their diet in the 12 to 24 months before
their cancer diagnosis. The researchers calculated dietary lignan
intake using published food-composition data, and associations between
dietary lignan intake and all-cause, total cancer, and breast cancer
mortality were estimated using the Cox proportional hazards models
after adjustment for confounders such as age, tumor stage, and body
mass index.
By the end of the follow-up period, 130 patients had died —94 from
cancer(of which 84 were breast cancer) and 36 from other causes. "The
women who died from breast cancer tended to be older, tended to have a
more advanced stage of cancer, and were more likely to be nonwhite,"
said Dr. McCann. "They were also more likely to be estrogen-receptor
negative, but it wasn't statistically significant."
There was no association between the consumption of dietary lignans
and all-cause, total cancer, or breast cancer mortality among
premenopausal women. However, postmenopausal women with the highest
intake of lignans showed a statistically significant reduction in the
risk for all-cause mortality (hazard ratio, 0.48) and a significantly
lower risk for breast cancer mortality (hazard ratio, 0.35).
"In this study, lignan intake was derived primarily from dark bread,
peaches, apricots, broccoli, winter squash, oranges, strawberries,
onions, coffee, and tea," said Dr. McCann.
The researchers did not find an association between mortality and the
intake of fruits and vegetables, although a high intake of lignans
might be a marker of a plant-based diet.
"This study is evidence that a healthy diet can contribute to improved
survival in breast cancer and other chronic diseases," she said. "It
provides more evidence that a plant-based diet may help survival in
cancer patients."
American Association for Cancer Research (AACR) 2008 Annual Meeting:
Abstract 4162. Presented April 15, 2008.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http :// tinyurl,com /2r2nkh
Man Is A Herbivore!
http :// tinyurl,com /a3cc3
DEAD PEOPLE WALKING
http :// tinyurl,com /zk9fk
