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Bloodletting Versus Erythrocytapheresis
Bloodletting Versus Erythrocytapheresis
Therapeutic erythrocytapheresis versus phlebotomy in the initial
treatment of hereditary hemochromatosis - A pilot study.
Transfus Apher Sci. 2007; 36(3):261-7 (ISSN: 1473-0502)
Rombout-Sestrienkova E; van Noord PA; van Deursen CT; Sybesma BJ;
Nillesen-Meertens AE; Koek GH
Sanquin Blood Bank Southeast Region, Geatano Martinolaan 95, 6229 GS
Maastricht, The Netherlands.
Hereditary Hemochromatosis (HH) is a genetic disorder of iron
metabolism, resulting in excessive iron overload.
Currently, phlebotomy is the standard effective treatment that
prevents progression of tissue damage.
Aim of the therapy is to reach ferritin levels between 20 and
50mugl(-1).
In patients with total iron stores of more than 30g, intensive
treatment by means of weekly phlebotomies during 2-3 years is required
to reach this aim.
More recently mechanical removal of erythrocytes through therapeutic
erythrocytapheresis (TE) has become a new therapeutic modality.
By means of TE, up to 1000ml erythrocytes per session can be removed,
depending on patient characteristics, compared to 250ml erythrocytes
per phlebotomy.
Thus, TE potentially offers a more efficient method of removing iron
overload with less procedures in a shorter treatment period. In a
pilot study between 2002 and 2005, results from a group of HH patients
treated with TE (N=6) were compared to the results of a historical
control group of HH patients (N=6) treated with phlebotomy.
The results showed a reduction of almost 70% in both the total number
and the duration of treatments in the TE group.
Although, the procedure costs compared on the basis of a single TE
session were higher, the total costs for the whole treatment were
comparable or cheaper with the use of TE.
Future prospective studies are needed to compare both therapies in a
randomized setting.
Subject Headings
Major Subject Heading(s) Minor Subject Heading(s)
PreMedline Identifier: 17569592
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Tom
Jesus Was A Vegetarian!
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Man Is A Herbivore!
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Therapeutic erythrocytapheresis versus phlebotomy in the initial
treatment of hereditary hemochromatosis - A pilot study.
Transfus Apher Sci. 2007; 36(3):261-7 (ISSN: 1473-0502)
Rombout-Sestrienkova E; van Noord PA; van Deursen CT; Sybesma BJ;
Nillesen-Meertens AE; Koek GH
Sanquin Blood Bank Southeast Region, Geatano Martinolaan 95, 6229 GS
Maastricht, The Netherlands.
Hereditary Hemochromatosis (HH) is a genetic disorder of iron
metabolism, resulting in excessive iron overload.
Currently, phlebotomy is the standard effective treatment that
prevents progression of tissue damage.
Aim of the therapy is to reach ferritin levels between 20 and
50mugl(-1).
In patients with total iron stores of more than 30g, intensive
treatment by means of weekly phlebotomies during 2-3 years is required
to reach this aim.
More recently mechanical removal of erythrocytes through therapeutic
erythrocytapheresis (TE) has become a new therapeutic modality.
By means of TE, up to 1000ml erythrocytes per session can be removed,
depending on patient characteristics, compared to 250ml erythrocytes
per phlebotomy.
Thus, TE potentially offers a more efficient method of removing iron
overload with less procedures in a shorter treatment period. In a
pilot study between 2002 and 2005, results from a group of HH patients
treated with TE (N=6) were compared to the results of a historical
control group of HH patients (N=6) treated with phlebotomy.
The results showed a reduction of almost 70% in both the total number
and the duration of treatments in the TE group.
Although, the procedure costs compared on the basis of a single TE
session were higher, the total costs for the whole treatment were
comparable or cheaper with the use of TE.
Future prospective studies are needed to compare both therapies in a
randomized setting.
Subject Headings
Major Subject Heading(s) Minor Subject Heading(s)
PreMedline Identifier: 17569592
Who loves ya.
Tom
Jesus Was A Vegetarian!
* tinyurl . com /2r2nkh
Man Is A Herbivore!
* tinyurl . com /a3cc3
DEAD PEOPLE WALKING
* tinyurl . com /zk9fk
