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Alpha-tocopherol Versus Oxidative Stress
Alpha-tocopherol Versus Oxidative Stress
Oxidative stress and anemia in chronic hemodialysis: the promise of
bioreactive membranes.
Cruz DN, de Cal M, Ronco C
Contrib Nephrol 2008.:89-98.
Patients with advanced chronic kidney disease are characterized by an
imbalance between pro- and antioxidant factors, and increased
oxidative stress has been associated with complications of end-stage
renal disease such as atherosclerosis, Beta2-microglobulin amyloidosis
and anemia. Antioxidants such as vitamin E work by inhibiting LDL
oxidation by oxidants and by limiting cellular response to oxidized
LDL, and are potentially useful adjuncts to the usual medical therapy
provided to such patients.
In chronic hemodialysis (HD) patients, vitamin E therapy may be
administered in the form of dietary supplementation, or as an integral
part of the HD procedure in the form of bioreactive dialysis
membranes, in which the blood surface has been modified with alpha-
tocopherol.
Since blood membrane interaction plays a key role in generating
oxidative stress, direct free radical scavenging at the membrane site
is a logical approach.
Dialysis with vitamin E-coated membranes (VECM) is associated with an
improvement in circulating biomarkers of lipid peroxidation.
Other than antioxidant activity, the modified surface appears to
render these dialyzers more biocompatible, in that cellulose-based
membranes behave similar to synthetic dialyzers in terms of cytokine
induction.
In small studies in chromic HD patients, both dietary vitamin E
supplementation as well as use of VECM have been associated with
reduced RBC fragility, prolonged RBC lifespan, and improvements in
hemoglobin and rHuEpo requirements.
Newer VECM based on polysulfone bring us further down the road towards
complete biocompatibility, and represent a promising therapy against
oxidative stress in chronic HD patients.
Contributions to nephrology [Contrib Nephrol]
--------------------------------------------------------------------------------
More from this journal
Oxidative stress and anemia in chronic hemodialysis: the promise of
bioreactive membranes.
Cruz DN, de Cal M, Ronco C
Contrib Nephrol 2008.:89-98.
Patients with advanced chronic kidney disease are characterized by an
imbalance between pro- and antioxidant factors, and increased
oxidative stress has been associated with complications of end-stage
renal disease such as atherosclerosis, Beta2-microglobulin amyloidosis
and anemia. Antioxidants such as vitamin E work by inhibiting LDL
oxidation by oxidants and by limiting cellular response to oxidized
LDL, and are potentially useful adjuncts to the usual medical therapy
provided to such patients.
In chronic hemodialysis (HD) patients, vitamin E therapy may be
administered in the form of dietary supplementation, or as an integral
part of the HD procedure in the form of bioreactive dialysis
membranes, in which the blood surface has been modified with alpha-
tocopherol.
Since blood membrane interaction plays a key role in generating
oxidative stress, direct free radical scavenging at the membrane site
is a logical approach.
Dialysis with vitamin E-coated membranes (VECM) is associated with an
improvement in circulating biomarkers of lipid peroxidation.
Other than antioxidant activity, the modified surface appears to
render these dialyzers more biocompatible, in that cellulose-based
membranes behave similar to synthetic dialyzers in terms of cytokine
induction.
In small studies in chromic HD patients, both dietary vitamin E
supplementation as well as use of VECM have been associated with
reduced RBC fragility, prolonged RBC lifespan, and improvements in
hemoglobin and rHuEpo requirements.
Newer VECM based on polysulfone bring us further down the road towards
complete biocompatibility, and represent a promising therapy against
oxidative stress in chronic HD patients.
Contributions to nephrology [Contrib Nephrol]
--------------------------------------------------------------------------------
More from this journal
