Iron Restriction For Health

Iron Restriction For Health

"Restriction of iron may have positive effects on health in general
and aging in particular"

Galaris D, Mantzaris M, Amorgianiotis C
Oxidative stress and aging: the potential role of iron. [Journal
Article]
Hormones (Athens) 2008 Apr-Jun; 7(2):114-22.



According to the free radical theory of aging proposed by Denham
Harman more than 50 years ago, oxidatively modified cellular
components accumulate continuously in the cells during the organism's
lifespan leading to progressive decline of cellular functions. Since
then, it has been shown that proteins, lipids, nucleic acids and other
cell components undergo reversible and/or irreversible oxidative
modifications during aging. Moreover, oxidized cell components can
undergo further oxidative modifications leading to formation of
products that cell degradation systems are incapable of removing.
Accumulation of such non-degradable aggregates further inhibits the
functionality of degradation systems, thus aggravating the effects and
leading to a vicious cycle. In this presentation, we propose that the
availability of intracellular iron in its redox active form (labile
iron) represents the main catalyst that mediates extensive oxidative
modifications of cellular components and ultimately leads to their
accumulation and consequent cellular dysfunction. It is tempting to
speculate that regulated restriction of labile iron may have positive
effects on health in general and aging in particular.
Hormones (Athens, Greece) [Hormones (Athens)]
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