116 Of 132 Patients Died

116 Of 132 Patients Died

What made them think hyperviscosity would NOT lead to stroke death.
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Obstructive Sleep Apnoea a Risk Factor for Death in Stroke Patients:
Presented at ATS

By Marvin Ross

TORONTO -- May 21, 2008 -- Stroke patients with obstructive sleep
apnoea (OSA) have shorter survival times than do those who do not have
OSA or who have central sleep apnoea, according to a study presented
here at the 104th International Conference of the American Thoracic
Society (ATS).

The findings were presented on May 19 by Karl A. Franklin, MD, PhD,
Professor, Department of Respiratory Medicine, University Hospital,
Umea, Sweden.

Dr. Franklin and colleagues conducted overnight sleep apnoea studies
15 to 31 days post-stroke on 132 of 151 patients admitted for in-
hospital stroke rehabilitation between April 1, 1995 and May 1, 1997.
Patients were followed for a median of 10 years.

The primary outcome was death. No patient was lost to follow-up.
Obstructive sleep apnoea and central sleep apnoea were both defined
when the obstructive apnoea-hypopnoea index and the central apnoea-
hypopnoea indices were >15. Patients with indices below 15 served as
controls.

Of 132 enrolled patients, 116 died during follow-up. The risk of death
was higher in the 23 patients with OSA than in controls (adjusted
hazard ratio [AHR], 1.76; 95% confidence interval [CI], 1.05-2.95; P
= .03). This finding was independent of age, gender, body mass index,
smoking status, hypertension, diabetes mellitus, atrial fibrillation,
Mini Mental State Examination, and Barthel activity of daily living.

There was no difference in mortality between the 28 patients with
central sleep apnoea and controls (AHR, 1.07; 95% CI, 0.65-1.76; P = .
053).

"These findings are particularly interesting because obstructive sleep
apnoea is a treatable condition," Dr. Franklin said.

Evaluating patients for the presence of obstructive sleep apnoea post-
stroke and treating that condition may help to increase survival for
these patients, the researchers concluded.


[Presentation title: Obstructive Sleep Apnea Is a Risk Factor for
Death in Stroke Patients - A 10-Year Follow-Up. Abstract 3264]

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Tom


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